HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$268+ Cheap flights from Key West to Panama City, FL (EYW - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
Apr 2 — Apr 91
Thu 4/2
Thu 4/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key West to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Key West to Panama City

Cheapest flights from Key West to Panama City
Explore the most affordable flight options available from Key West to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 3, 2026.

This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/611:59 am
EYW
-
ECP
1 stop4h 18m
Delta
Wed 3/116:00 am
ECP
-
EYW
1 stop3h 48m
Delta
Deal found 2/27$419
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:55 pm
EYW
-
ECP
2 stops10h 54m
American Airlines
Wed 3/117:19 am
ECP
-
EYW
1 stop4h 57m
American Airlines
Deal found 2/27$424
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:56 pm
EYW
-
ECP
1 stop5h 43m
Delta
Wed 3/116:00 am
ECP
-
EYW
1 stop3h 48m
Delta
Deal found 3/2$434
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:51 pm
EYW
-
ECP
2 stops8h 58m
American Airlines
Wed 3/114:34 pm
ECP
-
EYW
1 stop5h 03m
American Airlines
Deal found 3/2$439
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:25 pm
EYW
-
ECP
1 stop5h 39m
Delta
Wed 3/187:05 am
ECP
-
EYW
1 stop5h 38m
Delta
Deal found 3/1$450
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:40 pm
EYW
-
ECP
1 stop8h 09m
American Airlines
Wed 3/184:34 pm
ECP
-
EYW
1 stop5h 03m
American Airlines
Deal found 3/1$480
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:56 pm
EYW
-
ECP
2 stops7h 21m
American Airlines
Wed 3/184:34 pm
ECP
-
EYW
1 stop5h 03m
American Airlines
Deal found 3/1$485
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/173:56 pm
EYW
-
ECP
2 stops7h 21m
American Airlines
Sat 3/214:39 pm
ECP
-
EYW
1 stop4h 58m
American Airlines
Deal found 3/1$564

Find flight deals from Key West to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 3, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$564
(American Airlines)

One-way from

$268
(American Airlines)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
Search Deals
From Key West to Panama City NW Florida Beaches
Search Deals
One-way flight from Key West to Panama City NW Florida Beaches
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 3, 2026.
Use the filters below to find and compare flights from Key West to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 3/17

3:56 pm-10:17 pm

2 stops7h 21m

Panama City NW Florida Beaches

Sat 3/21

4:39 pm-10:37 pm

1 stop4h 58m

$564

Key WestPanama City

EYW - ECP

EYWECP

Key West

Mon 5/18

7:30 am-10:49 am

1 stop4h 19m

Panama City NW Florida Beaches

Thu 5/21

1:50 pm-7:49 pm

1 stop4h 59m

$605

Key WestPanama City

EYW - ECP

EYWECP

Key West

Mon 5/18

11:56 am-4:03 pm

1 stop5h 07m

Panama City NW Florida Beaches

Thu 5/21

11:00 am-6:49 pm

1 stop6h 49m

$615

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 3/17

2:24 pm-1:14 pm

3 stops23h 50m

Panama City NW Florida Beaches

Sat 3/21

12:15 pm-3:42 pm

2 stops26h 27m

$859

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sun 7/12

7:33 pm-11:41 pm

1 stop5h 08m

$268

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sun 7/26

7:33 pm-11:41 pm

1 stop5h 08m

$318

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 3/31

3:56 pm-10:17 pm

2 stops7h 21m

$465

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 3/31

2:35 pm-1:23 pm

3 stops23h 48m

$645

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/1

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Key West-Panama City, Florida flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-Panama City, Florida flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Panama City, Florida flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Panama City, Florida?

    American Airlines and Delta can get you from Key West to Panama City, Florida in just under 4h 19m. Your travel time can differ by up to 3h 02m. The distance between Key West and Panama City, Florida is about 471 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Key West to Panama City that include hotel bookings?

    Yes. In addition to deals on Key West to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Panama City.

  • Can I find deals for business class flights from Key West to Panama City?

    Yes. Cheapflights offers flight deals from Key West to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Tampa to Miami flights
Jacksonville to Miami flights
Miami to Orlando flights
Pensacola to Orlando flights
Tampa to Fort Lauderdale flights
Orlando to Pensacola flights
Pensacola to Fort Lauderdale flights
Fort Lauderdale to Orlando flights
Fort Lauderdale to Tampa flights
Miami to Jacksonville flights
Orlando to Fort Lauderdale flights
Orlando to Miami flights
Pensacola to Miami flights
Orlando to Key West flights
Tampa to Key West flights
Miami to Tampa flights
Fort Lauderdale to Jacksonville flights
Jacksonville to Fort Lauderdale flights
Fort Lauderdale to Pensacola flights
Tallahassee to Fort Lauderdale flights
Pensacola to Key West flights
Tampa to Pensacola flights
Miami to Pensacola flights
Fort Lauderdale to Tallahassee flights
West Palm Beach to Jacksonville flights
Miami to Panama City flights
Jacksonville to Key West flights
Tallahassee to Miami flights
Pensacola to Tampa flights
Miami to Tallahassee flights
Miami to Valparaiso flights
Pensacola to West Palm Beach flights
Tampa to West Palm Beach flights
Jacksonville to West Palm Beach flights
Fort Myers to Orlando flights
Valparaiso to Miami flights
Tampa to Jacksonville flights
Fort Myers to Jacksonville flights
Miami to Key West flights
Tampa to Orlando flights
Fort Lauderdale to Gainesville flights
West Palm Beach to Panama City flights
Panama City to Miami flights
Panama City to Orlando flights
West Palm Beach to Valparaiso flights
West Palm Beach to Tampa flights
Miami to Gainesville flights
West Palm Beach to Tallahassee flights
Jacksonville to Fort Myers flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.