$299+ Cheap flights from Key West to Panama City, FL (EYW - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
Dec 20 — Dec 271
1 adult, Economy
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Cheapest flights from Key West to Panama CityExplore the most affordable flight options available from Key West to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.
Explore the most affordable flight options available from Key West to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:02 pmEYW - ECP
1 stop3h 57mDelta
Wed 12/171:32 pmECP - EYW
1 stop5h 34mDelta
Deal found 11/19![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/121:33 pmEYW - ECP
2 stops10h 37mAmerican Airlines
Wed 12/1712:08 pmECP - EYW
1 stop4h 44mAmerican Airlines
Deal found 11/19![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:02 pmEYW - ECP
1 stop4h 58mDelta
Wed 12/1010:00 amECP - EYW
1 stop6h 15mDelta
Deal found 11/20![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/68:00 amEYW - ECP
1 stop7h 13mAmerican Airlines
Wed 12/108:30 amECP - EYW
2 stops10h 05mAmerican Airlines
Deal found 11/20![American Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:40 amEYW - ECP
1 stop6h 07mDelta
Sat 11/296:00 amECP - EYW
1 stop7h 03mDelta
Deal found 11/19![Delta logo]()
$399
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:40 amEYW - ECP
1 stop6h 07mDelta
Sun 11/307:02 amECP - EYW
1 stop6h 01mDelta
Deal found 11/19![Delta logo]()
$493
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:00 amEYW - ECP
2 stops28h 33mAmerican Airlines
Sat 11/297:15 amECP - EYW
1 stop7h 58mAmerican Airlines
Deal found 11/19![American Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:00 amEYW - ECP
2 stops28h 33mAmerican Airlines
Sun 11/307:15 amECP - EYW
1 stop7h 58mAmerican Airlines
Deal found 11/19![American Airlines logo]()
$809
Cheap flight deals from Key West to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $317 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Key West to Panama City that are best for you.
Fly from
Key West
Fly to
Panama City
Route
Depart
Return
Price
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 1/23
2:45 pm-7:50 pm
1 stop6h 05m
Panama City NW Florida Beaches
Tue 1/27
12:15 pm-7:40 pm
1 stop6h 25m
$317
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 2/6
7:10 am-11:08 am
1 stop4h 58m
Panama City NW Florida Beaches
Mon 2/9
7:20 am-1:48 pm
1 stop5h 28m
$327
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 12/12
3:02 pm-5:59 pm
1 stop3h 57m
Panama City NW Florida Beaches
Wed 12/17
1:32 pm-8:06 pm
1 stop5h 34m
$329
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 12/12
1:33 pm-11:10 pm
2 stops10h 37m
Panama City NW Florida Beaches
Wed 12/17
12:08 pm-5:52 pm
1 stop4h 44m
$334
Key WestPanama City
EYW - ECP
EYWECP
Key West
Sat 12/6
3:02 pm-7:00 pm
1 stop4h 58m
Panama City NW Florida Beaches
Wed 12/10
10:00 am-5:15 pm
1 stop6h 15m
$359
Key WestPanama City
EYW - ECP
EYWECP
Key West
Sat 12/6
8:00 am-2:13 pm
1 stop7h 13m
Panama City NW Florida Beaches
Wed 12/10
8:30 am-7:35 pm
2 stops10h 05m
$364
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 2/6
11:18 am-1:10 pm
1 stop26h 52m
Panama City NW Florida Beaches
Mon 2/9
1:34 pm-10:57 am
2 stops20h 23m
$659
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 1/23
12:00 pm-9:19 pm
2 stops10h 19m
Panama City NW Florida Beaches
Tue 1/27
12:03 pm-11:56 pm
2 stops10h 53m
$936
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 12/5
7:40 am-12:47 pm
1 stop6h 07m
$299
Key WestPanama City
EYW - ECP
EYWECP
Key West
Fri 12/5
4:10 pm-11:10 pm
2 stops8h 00m
$304
Compare providers for flights from Key West to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Panama City in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Key West-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Key West-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Key West-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach