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$378+ Cheap flights from Columbia, MO (COU) to North Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
COU — RDU
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Columbia to North Carolina

Keep the following information in mind while searching for Columbia to North Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$378
(American Airlines)
From Columbia Regional to North Carolina
Search Deals

Find flight deals from Columbia to North Carolina

Cheapest flights from Columbia to North Carolina
Explore the most affordable flight options available from Columbia to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:33 pmCOU - CLT
1 stop4h 55mAmerican Airlines
Sat 10/412:10 pmCLT - COU
1 stop6h 53mAmerican Airlines
Deal found 9/14$378
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:01 amCOU - TYS
1 stop7h 32mAmerican Airlines
Sat 10/255:35 pmTYS - COU
1 stop18h 32mAmerican Airlines
Deal found 9/13$382
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:05 pmCOU - CLT
1 stop5h 32mAmerican Airlines
Sat 11/221:01 pmCLT - COU
1 stop6h 35mAmerican Airlines
Deal found 9/13$400
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:55 pmCOU - ORF
1 stop7h 26mAmerican Airlines
Wed 12/107:23 amORF - COU
1 stop5h 01mAmerican Airlines
Deal found 9/14$402
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:05 pmCOU - ORF
1 stop7h 13mAmerican Airlines
Fri 11/287:43 amORF - COU
1 stop6h 52mAmerican Airlines
Deal found 9/14$478
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/297:49 pmCOU - AVL
1 stop21h 07mAmerican Airlines
Fri 10/36:30 pmAVL - COU
1 stop19h 36mAmerican Airlines
Deal found 9/13$520
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:00 amCOU - TYS
1 stop25h 10mUnited Airlines
Sun 10/197:00 amTYS - COU
1 stop8h 17mUnited Airlines
Deal found 9/13$542
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:28 pmCOU - TYS
1 stop5h 23mAmerican Airlines
Sun 10/196:03 amTYS - COU
2 stops8h 16mAmerican Airlines
Deal found 9/13$545
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/302:52 pmCOU - CLT
2 stops22h 18mUnited Airlines
Sat 10/46:00 amCLT - COU
2 stops16h 27mUnited Airlines
Deal found 9/14$557
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:00 amCOU - CLT
2 stops25h 02mUnited Airlines
Sat 11/227:44 pmCLT - COU
2 stops19h 42mUnited Airlines
Deal found 9/13$597
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:33 pmCOU - TYS
1 stop4h 48mAmerican Airlines
Sun 9/217:30 amTYS - COU
1 stop5h 30mAmerican Airlines
Deal found 9/14$620
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/27:46 pmCOU - MYR
1 stop19h 55mAmerican Airlines
Fri 11/75:46 pmMYR - COU
1 stop18h 54mAmerican Airlines
Deal found 9/12$626

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Columbia to North Carolina that are best for you.

Fly from

Columbia

Fly to

North Carolina

Route

Depart

Return

Price

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 9/30

6:33 pm-12:28 am

1 stop4h 55m

Charlotte Douglas

Sat 10/4

12:10 pm-6:03 pm

1 stop6h 53m

$378

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 10/21

6:01 am-2:33 pm

1 stop7h 32m

Knoxville McGhee Tyson

Sat 10/25

5:35 pm-11:07 am

1 stop18h 32m

$382

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 11/20

2:05 pm-8:37 pm

1 stop5h 32m

Charlotte Douglas

Sat 11/22

1:01 pm-6:36 pm

1 stop6h 35m

$400

ColumbiaNorfolk

COU - ORF

COUORF

Columbia Regional

Sat 12/6

1:55 pm-10:21 pm

1 stop7h 26m

Norfolk

Wed 12/10

7:23 am-11:24 am

1 stop5h 01m

$402

ColumbiaNorfolk

COU - ORF

COUORF

Columbia Regional

Sun 11/23

2:05 pm-10:18 pm

1 stop7h 13m

Norfolk

Fri 11/28

7:43 am-1:35 pm

1 stop6h 52m

$478

ColumbiaAsheville

COU - AVL

COUAVL

Columbia Regional

Mon 9/29

7:49 pm-5:56 pm

1 stop21h 07m

Asheville Regional

Fri 10/3

6:30 pm-1:06 pm

1 stop19h 36m

$520

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 10/17

8:00 am-10:10 am

1 stop25h 10m

Knoxville McGhee Tyson

Sun 10/19

7:00 am-2:17 pm

1 stop8h 17m

$542

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 9/30

2:52 pm-2:10 pm

2 stops22h 18m

Charlotte Douglas

Sat 10/4

6:00 am-9:27 pm

2 stops16h 27m

$557

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 11/20

8:00 am-10:02 am

2 stops25h 02m

Charlotte Douglas

Sat 11/22

7:44 pm-2:26 pm

2 stops19h 42m

$597

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Sun 11/2

7:46 pm-4:41 pm

1 stop19h 55m

Myrtle Beach Intl

Fri 11/7

5:46 pm-11:40 am

1 stop18h 54m

$626

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 17 results
1
2

Best time to book a flight from Columbia to North Carolina

Have a flexible travel schedule? Discover the best time to fly to North Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to North Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing North Carolina

Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated September 15, 2025.
See what other customers who have flown with American Airlines from Columbia to North Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Food

6.4

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Food

6.4

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Find useful and relevant information for your journey from Columbia to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to North Carolina?

    Columbia Regional (COU) is the airport you will fly out of if you book a flight from Columbia to North Carolina. It is only a 11.1 mi journey to Columbia Regional (COU) from Columbia’s city center.

  • How long is the flight from Columbia, Missouri to North Carolina?

    A quick flight from Columbia, Missouri to North Carolina can take about 4h 55m. American Airlines provides one of the quickest options available for as low as $378. The distance between Columbia, Missouri and North Carolina is about 669 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Columbia, Missouri to North Carolina?

    The most popular flight routes from Columbia, Missouri to North Carolina are Columbia Regional - Knoxville McGhee Tyson, Columbia Regional - Charlotte Douglas and Columbia Regional - Myrtle Beach Intl.

  • Can I find deals for flights from Columbia to North Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to North Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to North Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to North Carolina.

  • Can I find deals for business class flights from Columbia to North Carolina?

    Yes. Cheapflights offers flight deals from Columbia to North Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to North Carolina?

    Currently, August is the cheapest month in which you can book a flight from Columbia, Missouri to North Carolina (average of $206). Flying from Columbia, Missouri to North Carolina in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Columbia to North Carolina

Discover the top airline that operate flights from Columbia to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$320Average$468FlexibilityNo cancel feeOn-time71%

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