$124+ Cheap flights from Missouri to Myrtle Beach (MYR)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MYR
Apr 28 — May 51
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Myrtle Beach with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Myrtle Beach
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to Myrtle BeachExplore the most affordable flight options available from Missouri to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
Explore the most affordable flight options available from Missouri to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:05 am
STL
- MYR
1 stop4h 05m
Southwest
Tue 5/54:05 pm
MYR
- STL
1 stop6h 55m
Southwest
Deal found 3/26![Southwest logo]()
$253
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:35 am
STL
- MYR
1 stop5h 00m
Southwest
Sat 4/257:10 am
MYR
- STL
1 stop10h 15m
Southwest
Deal found 3/26![Southwest logo]()
$259
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:15 pm
STL
- MYR
1 stop6h 15m
Southwest
Sat 4/187:10 am
MYR
- STL
1 stop10h 15m
Southwest
Deal found 3/26![Southwest logo]()
$267
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
STL
- MYR
1 stop4h 35m
American Airlines
Wed 5/276:06 pm
MYR
- STL
2 stops6h 48m
American Airlines
Deal found 3/24![American Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:25 am
STL
- MYR
1 stop4h 32m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/27![Delta logo]()
$272
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:35 am
STL
- MYR
1 stop4h 30m
Southwest
Thu 4/237:20 pm
MYR
- STL
1 stop5h 05m
Southwest
Deal found 3/26![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:27 pm
STL
- MYR
2 stops8h 29m
American Airlines
Mon 5/45:00 am
MYR
- STL
1 stop4h 30m
American Airlines
Deal found 3/27![American Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:50 am
SGF
- MYR
1 stop5h 25m
American Airlines
Sat 8/226:00 pm
MYR
- SGF
1 stop4h 38m
American Airlines
Deal found 3/28![American Airlines logo]()
$285
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
SGF
- MYR
1 stop7h 15m
United Airlines
Sat 8/2210:28 am
MYR
- SGF
2 stops9h 13m
United Airlines
Deal found 3/28![United Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:15 am
STL
- MYR
1 stop5h 13m
American Airlines
Tue 6/26:45 pm
MYR
- STL
1 stop6h 14m
American Airlines
Deal found 3/26![American Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
SGF
- MYR
2 stops8h 30m
American Airlines
Sat 8/294:22 pm
MYR
- SGF
2 stops8h 36m
American Airlines
Deal found 3/26![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
SGF
- MYR
1 stop6h 38m
Delta
Sun 8/306:00 am
MYR
- SGF
1 stop6h 01m
Delta
Deal found 3/26![Delta logo]()
$307
Best flights from Missouri to Myrtle BeachDiscover carefully curated flight deals from Missouri to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
Discover carefully curated flight deals from Missouri to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:35 am
STL
- MYR
1 stop5h 00m
Southwest
Sat 4/257:10 am
MYR
- STL
2 stops7h 25m
Southwest
Deal found 3/26![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:25 am
STL
- MYR
1 stop4h 32m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/27![Delta logo]()
$272
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
SGF
- MYR
1 stop7h 15m
United Airlines
Sat 8/2210:28 am
MYR
- SGF
2 stops9h 13m
United Airlines
Deal found 3/28![United Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:18 pm
SGF
- MYR
1 stop4h 22m
American Airlines
Sat 9/127:14 am
MYR
- SGF
1 stop4h 12m
American Airlines
Deal found 3/28![American Airlines logo]()
$307
This CheapOair deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:45 am
MCI
- MYR
2 stops10h 48m
Spirit Airlines
Sat 4/116:28 pm
MYR
- MCI
1 stop18h 01m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:58 pm
SGF
- MYR
1 stop3h 57m
Delta
Thu 8/64:16 pm
MYR
- SGF
1 stop6h 54m
Delta
Deal found 3/26![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:45 am
STL
- MYR
2 stops9h 25m
Southwest
Sat 6/65:45 pm
MYR
- STL
1 stop6h 25m
Southwest
Deal found 3/24![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
SGF
- MYR
1 stop6h 38m
Delta
Sun 8/306:00 am
MYR
- SGF
1 stop6h 01m
Delta
Deal found 3/26![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:10 pm
STL
- MYR
1 stop7h 00m
Southwest
Tue 7/147:55 am
MYR
- STL
1 stop4h 20m
Southwest
Deal found 3/25![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:00 am
MCI
- MYR
1 stop5h 17m
United Airlines
Sat 5/23:14 pm
MYR
- MCI
1 stop7h 50m
United Airlines
Deal found 3/26![United Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:30 pm
SGF
- MYR
1 stop7h 09m
Delta
Sat 9/126:45 pm
MYR
- SGF
1 stop4h 44m
Delta
Deal found 3/25![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:25 pm
STL
- MYR
1 stop5h 55m
Southwest
Sat 7/255:45 pm
MYR
- STL
1 stop6h 25m
Southwest
Deal found 3/26![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:15 am
MCI
- MYR
1 stop7h 02m
United Airlines
Wed 4/223:15 pm
MYR
- MCI
1 stop7h 44m
United Airlines
Deal found 3/24![United Airlines logo]()
$405
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:30 pm
STL
- MYR
1 stop5h 09m
Delta
Wed 8/1911:10 am
MYR
- STL
1 stop6h 39m
Delta
Deal found 3/24![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:25 am
MCI
- MYR
1 stop6h 50m
Southwest
Fri 5/83:45 pm
MYR
- MCI
2 stops8h 10m
Southwest
Deal found 3/27![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:30 pm
STL
- MYR
1 stop5h 09m
Delta
Tue 8/1811:00 am
MYR
- STL
1 stop5h 43m
Delta
Deal found 3/27![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:00 am
MCI
- MYR
2 stops8h 13m
United Airlines
Sat 5/911:30 am
MYR
- MCI
2 stops10h 11m
United Airlines
Deal found 3/24![United Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 pm
STL
- MYR
1 stop4h 24m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/28![Delta logo]()
$351
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:16 am
COU
- MYR
2 stops10h 40m
American Airlines
Sun 4/126:04 am
MYR
- COU
2 stops10h 54m
American Airlines
Deal found 3/24![American Airlines logo]()
$592
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:21 am
STL
- MYR
1 stop7h 09m
Delta
Tue 6/27:55 pm
MYR
- STL
1 stop5h 04m
Delta
Deal found 3/28![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:25 am
MCI
- MYR
2 stops7h 05m
Southwest
Sat 4/1811:50 am
MYR
- MCI
2 stops9h 10m
Southwest
Deal found 3/27![Southwest logo]()
$429
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:16 am
COU
- MYR
1 stop4h 13m
American Airlines
Sun 7/54:17 pm
MYR
- COU
1 stop7h 23m
American Airlines
Deal found 3/24![American Airlines logo]()
$594
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:20 pm
MCI
- MYR
1 stop4h 15m
Southwest
Sat 6/66:35 am
MYR
- MCI
1 stop11h 15m
Southwest
Deal found 3/25![Southwest logo]()
$430
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:30 pm
STL
- MYR
1 stop5h 09m
Delta
Thu 9/311:00 am
MYR
- STL
1 stop5h 43m
Delta
Deal found 3/25![Delta logo]()
$365
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:50 pm
MCI
- MYR
1 stop4h 50m
Southwest
Fri 7/39:10 pm
MYR
- MCI
1 stop4h 00m
Southwest
Deal found 3/27![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/111:45 pm
MCI
- MYR
1 stop4h 45m
Southwest
Tue 6/167:15 pm
MYR
- MCI
1 stop5h 10m
Southwest
Deal found 3/25![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:00 am
COU
- MYR
1 stop5h 17m
United Airlines
Sun 4/123:15 pm
MYR
- COU
1 stop7h 46m
United Airlines
Deal found 3/24![United Airlines logo]()
$654
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 am
COU
- MYR
2 stops27h 59m
United Airlines
Sun 7/510:34 am
MYR
- COU
2 stops28h 56m
United Airlines
Deal found 3/24![United Airlines logo]()
$906
Last-minute flights from Missouri to Myrtle BeachDiscover last-minute flight deals from Missouri to Myrtle Beach. Data last updated March 29, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Myrtle Beach. Data last updated March 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:47 pm
SGF
- MYR
1 stop6h 08m
American Airlines
Sat 4/112:30 pm
MYR
- SGF
1 stop7h 35m
American Airlines
Deal found 3/26![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/412:24 pm
MCI
- MYR
1 stop7h 31m
Multiple Airlines
Sat 4/116:28 pm
MYR
- MCI
1 stop18h 01m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$366
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:24 pm
SGF
- MYR
1 stop4h 33m
American Airlines
Tue 4/142:31 pm
MYR
- SGF
1 stop7h 38m
American Airlines
Deal found 3/25![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:15 pm
STL
- MYR
1 stop6h 15m
Southwest
Sat 4/187:10 am
MYR
- STL
1 stop10h 15m
Southwest
Deal found 3/26![Southwest logo]()
$267
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:28 pm
MCI
- MYR
1 stop5h 28m
American Airlines
Tue 4/216:00 am
MYR
- MCI
1 stop8h 00m
American Airlines
Deal found 3/25![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:55 am
STL
- MYR
1 stop6h 20m
Southwest
Tue 4/214:05 pm
MYR
- STL
1 stop6h 55m
Southwest
Deal found 3/26![Southwest logo]()
$253
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:35 am
STL
- MYR
1 stop4h 30m
Southwest
Thu 4/237:20 pm
MYR
- STL
1 stop5h 05m
Southwest
Deal found 3/26![Southwest logo]()
$276
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:35 am
STL
- MYR
1 stop5h 00m
Southwest
Sat 4/257:10 am
MYR
- STL
1 stop10h 15m
Southwest
Deal found 3/26![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:45 am
STL
- MYR
1 stop5h 32m
United Airlines
Sat 5/93:14 pm
MYR
- STL
1 stop6h 59m
United Airlines
Deal found 3/26![United Airlines logo]()
$292
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:25 am
STL
- MYR
1 stop4h 32m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/27![Delta logo]()
$272
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:27 pm
STL
- MYR
2 stops8h 29m
American Airlines
Mon 5/45:00 am
MYR
- STL
1 stop4h 30m
American Airlines
Deal found 3/27![American Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:28 pm
MCI
- MYR
1 stop4h 29m
American Airlines
Thu 5/79:14 am
MYR
- MCI
1 stop5h 02m
American Airlines
Deal found 3/24![American Airlines logo]()
$351
One-way flights from Missouri to Myrtle BeachSearch for one-way flight options from Missouri to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
Search for one-way flight options from Missouri to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:45 am
STL
- MYR
1 stop5h 32m
United Airlines
Deal found 3/26![United Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:53 am
MCI
- MYR
2 stops34h 36m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:23 pm
STL
- MYR
2 stops19h 08m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:27 pm
STL
- MYR
2 stops26h 31m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:19 am
MCI
- MYR
2 stops35h 10m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$138
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:05 am
STL
- MYR
1 stop4h 05m
Southwest
Deal found 3/25![Southwest logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:23 pm
STL
- MYR
2 stops26h 06m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:53 am
MCI
- MYR
2 stops34h 36m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:24 pm
MCI
- MYR
2 stops37h 41m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:24 pm
MCI
- MYR
2 stops25h 12m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:23 pm
STL
- MYR
2 stops23h 43m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:24 pm
MCI
- MYR
2 stops25h 34m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$146
Find flight deals from Missouri to Myrtle Beach
Keep the following information in mind while searching for Missouri to Myrtle Beach flight deals. Data was last updated March 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $253 (Southwest) |
One-way from | $124 (United Airlines) |
Popular in | March |
Cheapest in | February |
Average price | $482 |
Good round-trip deal | $372 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Missouri to Myrtle Beach that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Wed 4/22
11:35 am-5:35 pm
1 stop5h 00m
Myrtle Beach Intl
Sat 4/25
7:10 am-1:35 pm
2 stops7h 25m
$259
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Tue 4/28
7:25 am-12:57 pm
1 stop4h 32m
Myrtle Beach Intl
Mon 5/4
7:03 pm-11:36 pm
1 stop5h 33m
$272
SpringfieldMyrtle Beach
SGF - MYR
SGFMYR
Springfield-Branson
Tue 8/18
6:00 am-2:15 pm
1 stop7h 15m
Myrtle Beach Intl
Sat 8/22
10:28 am-6:41 pm
2 stops9h 13m
$290
Quickest round-trip
SpringfieldMyrtle Beach
SGF - MYR
SGFMYR
Springfield-Branson
Sun 9/6
6:18 pm-11:40 pm
1 stop4h 22m
Myrtle Beach Intl
Sat 9/12
7:14 am-10:26 am
1 stop4h 12m
$307
SpringfieldMyrtle Beach
SGF - MYR
SGFMYR
Springfield-Branson
Tue 7/28
6:58 pm-11:55 pm
1 stop3h 57m
Myrtle Beach Intl
Thu 8/6
4:16 pm-10:10 pm
1 stop6h 54m
$307
SpringfieldMyrtle Beach
SGF - MYR
SGFMYR
Springfield-Branson
Tue 8/25
6:00 am-1:38 pm
1 stop6h 38m
Myrtle Beach Intl
Sun 8/30
6:00 am-11:01 am
1 stop6h 01m
$307
SpringfieldMyrtle Beach
SGF - MYR
SGFMYR
Springfield-Branson
Sun 9/6
3:30 pm-11:39 pm
1 stop7h 09m
Myrtle Beach Intl
Sat 9/12
6:45 pm-10:29 pm
1 stop4h 44m
$326
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Sat 5/30
5:45 am-4:10 pm
2 stops9h 25m
Myrtle Beach Intl
Sat 6/6
5:45 pm-11:10 pm
1 stop6h 25m
$333
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Tue 7/7
1:10 pm-9:10 pm
1 stop7h 00m
Myrtle Beach Intl
Tue 7/14
7:55 am-11:15 am
1 stop4h 20m
$351
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Mon 7/20
2:25 pm-9:20 pm
1 stop5h 55m
Myrtle Beach Intl
Sat 7/25
5:45 pm-11:10 pm
1 stop6h 25m
$351
Showing 1-10 of 57 resultsSorted by cheapest first
Best time to book a flight from Missouri to Myrtle Beach
Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Missouri with our price prediction graph.
STL-MYR
SGF-MYR
MCI-MYR
COU-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Myrtle Beach
USMO-MYR
STL-MYR
SGF-MYR
MCI-MYR
COU-MYR
What is the cheapest month to book a flight from Missouri to Myrtle Beach?
Currently, September is the cheapest month in which you can book a flight from Missouri to Myrtle Beach (average of $130). Flying from Missouri to Myrtle Beach in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to MYR?
Find hourly flight availability from Missouri to Myrtle Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 29, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Myrtle Beach as you normally would.
How much does it cost to fly round-trip from Missouri to Myrtle Beach?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Myrtle Beach?
Book flights to Myrtle Beach if you plan to visit one of these locationsConway
Surfside Beach
Pawleys Island
Little River
Garden City Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Myrtle Beach flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Missouri to Myrtle Beach
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Myrtle Beach by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Myrtle Beach by cabin class
Find flights from Missouri to Myrtle Beach, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Myrtle Beach
Explore flights to Myrtle Beach departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 29, 2026.
Missouri and Myrtle Beach flights
Browse other Missouri and Myrtle Beach flight options. Last updated on March 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Myrtle Beach flights
Consider these flights traveling from Missouri to Myrtle Beach.
Top 5 airlines flying from Missouri to Myrtle Beach
Discover the top 5 airlines that operate flights from Missouri to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$349 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$420 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$257 | Average$391 | FlexibilityNo cancel fee | On-time63% |