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$117+ Cheap flights from Syracuse (SYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
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Find flight deals from Syracuse to Missouri

Cheapest flights from Syracuse to Missouri
Explore the most affordable flight options available from Syracuse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amSYR - STL
1 stop4h 50mDelta
Sat 12/276:25 pmSTL - SYR
1 stop3h 51mDelta
Deal found 11/16$249
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:01 pmSYR - MCI
1 stop5h 46mDelta
Tue 1/205:09 pmMCI - SYR
1 stop5h 42mDelta
Deal found 11/17$259
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:12 amSYR - MCI
2 stops8h 33mAmerican Airlines
Mon 12/225:20 pmMCI - SYR
1 stop6h 01mAmerican Airlines
Deal found 11/17$264
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:55 pmSYR - MCI
2 stops44h 44mMultiple Airlines
Fri 1/169:42 amMCI - SYR
1 stop8h 14mMultiple Airlines
Deal found 11/16$273
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:57 pmSYR - SGF
1 stop5h 51mAmerican Airlines
Tue 12/94:28 pmSGF - SYR
1 stop6h 03mAmerican Airlines
Deal found 11/15$280
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:01 pmSYR - MCI
1 stop5h 46mDelta
Sun 12/76:29 amMCI - SYR
1 stop4h 39mDelta
Deal found 11/16$284
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:41 pmSYR - STL
1 stop14h 07mAmerican Airlines
Sun 1/44:53 pmSTL - SYR
1 stop5h 45mAmerican Airlines
Deal found 11/16$287
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:01 pmSYR - MCI
1 stop5h 46mDelta
Fri 1/164:00 pmMCI - SYR
1 stop6h 51mDelta
Deal found 11/17$289
This Mytrip deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:55 pmSYR - MCI
2 stops21h 01mMultiple Airlines
Mon 12/87:01 pmMCI - SYR
1 stop16h 04mMultiple Airlines
Deal found 11/17$300
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:16 pmSYR - MCI
1 stop7h 03mDelta
Wed 12/33:27 pmMCI - SYR
1 stop7h 06mDelta
Deal found 11/17$307
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2411:34 amSYR - MCI
1 stop5h 56mUnited Airlines
Wed 12/310:00 amMCI - SYR
2 stops12h 19mUnited Airlines
Deal found 11/16$312
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/110:48 amSYR - STL
2 stops8h 48mMultiple Airlines
Fri 12/59:54 amSTL - SYR
1 stop8h 41mMultiple Airlines
Deal found 11/16$315

Cheap flight deals from Syracuse to Missouri

Keep the following information in mind while searching for Syracuse to Missouri flight deals. Data was last updated November 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$117
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$378
Provider with most accurate pricing for Syracuse Hancock Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Lambert-St Louis flights.
Search Deals
From Syracuse Hancock Intl to Missouri
Search Deals
One-way flight from Syracuse Hancock Intl to Missouri
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Syracuse to Missouri that are best for you.

Fly from

Syracuse

Fly to

Missouri

Route

Depart

Return

Price

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Tue 1/6

6:00 am-11:05 am

1 stop6h 05m

Lambert-St Louis

Wed 1/28

10:19 am-3:51 pm

1 stop4h 32m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 1/10

12:06 pm-5:02 pm

1 stop5h 56m

Lambert-St Louis

Sat 1/17

6:00 am-11:26 am

1 stop4h 26m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 12/18

6:00 am-9:50 am

1 stop4h 50m

Lambert-St Louis

Sat 12/27

6:25 pm-11:16 pm

1 stop3h 51m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Tue 1/6

2:15 pm-8:32 pm

2 stops7h 17m

Lambert-St Louis

Wed 1/28

6:44 pm-11:54 pm

1 stop4h 10m

$254

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Sat 2/28

6:09 am-12:18 pm

1 stop7h 09m

Kansas City

Tue 3/3

6:30 am-12:02 pm

1 stop4h 32m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Mon 12/15

6:00 am-12:55 pm

1 stop7h 55m

Kansas City

Mon 12/22

5:20 pm-12:21 am

1 stop6h 01m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Wed 12/17

7:01 pm-11:47 pm

1 stop5h 46m

Kansas City

Fri 1/16

4:00 pm-11:51 pm

1 stop6h 51m

$259

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

Thu 1/15

7:00 am-11:49 am

1 stop5h 49m

Springfield-Branson

Mon 1/19

5:39 pm-11:27 pm

1 stop4h 48m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Thu 3/12

6:18 am-11:16 am

1 stop5h 58m

Kansas City

Tue 3/24

5:40 pm-11:01 pm

1 stop4h 21m

$259

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

Tue 12/2

3:57 pm-8:48 pm

1 stop5h 51m

Springfield-Branson

Tue 12/9

4:28 pm-11:31 pm

1 stop6h 03m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 48 results
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Best time to book a flight from Syracuse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Missouri

What is the cheapest month to book a flight from Syracuse to Missouri?

Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to MO?

Find hourly flight availability from Syracuse to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 17, 2025.

One of the essential ways to save on airfare from Syracuse to Missouri is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 45% on airfare.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 17, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,014 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Syracuse to Missouri?

    If you book a flight to Missouri from Syracuse, you will be flying from Hancock Intl, which is the city’s only airport. Syracuse Hancock Intl (SYR) is located 4.8 mi from the center of Syracuse.

  • How long is the flight from Syracuse to Missouri?

    Airlines like Delta, American Airlines, and United Airlines fly from Syracuse to Missouri in about 5h 56m. The time it takes to get you to your destination can typically vary by up to 1h 39m. The distance between Syracuse and Missouri is about 801 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Syracuse to Missouri one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $117. Users have also found prices from $268 and $305 on United Airlines and American Airlines, respectively.

  • What are the most popular routes from Syracuse to Missouri?

    Most travelers choose Syracuse Hancock Intl - Kansas City, Syracuse Hancock Intl - Columbia Regional or Syracuse Hancock Intl - Springfield-Branson when deciding on the best route from Syracuse to Missouri.

  • Can I find deals for flights from Syracuse to Missouri that include hotel bookings?

    Yes. In addition to deals on Syracuse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Missouri.

  • Can I find deals for business class flights from Syracuse to Missouri?

    Yes. Cheapflights offers flight deals from Syracuse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Missouri?

    Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Syracuse to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Syracuse to Missouri

Discover the top 3 airlines that operate flights from Syracuse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$397FlexibilityNo cancel feeOn-time71%
DeltaCheapest$247Average$338FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$285Average$487FlexibilityNo cancel feeOn-time69%

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