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$100+ Cheap flights from Syracuse (SYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Syracuse to Missouri

Cheapest flights from Syracuse to Missouri
Explore the most affordable flight options available from Syracuse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Booking.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:40 pmSYR - STL
1 stop21h 40mFrontier
Sat 11/154:33 pmSTL - SYR
1 stop25h 12mFrontier
Deal found 10/25$181
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:31 amSYR - COU
1 stop4h 55mUnited Airlines
Sat 11/153:02 pmCOU - SYR
1 stop5h 00mUnited Airlines
Deal found 10/27$248
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:58 pmSYR - STL
1 stop5h 12mDelta
Sat 12/206:25 pmSTL - SYR
1 stop3h 51mDelta
Deal found 10/27$249
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:07 amSYR - STL
1 stop5h 34mUnited Airlines
Tue 11/183:14 pmSTL - SYR
1 stop4h 48mUnited Airlines
Deal found 10/25$254
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amSYR - MCI
1 stop6h 42mDelta
Sun 12/76:29 amMCI - SYR
1 stop4h 39mDelta
Deal found 10/27$259
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:13 pmSYR - STL
1 stop4h 54mDelta
Sat 11/155:00 pmSTL - SYR
1 stop5h 10mDelta
Deal found 10/26$259
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:34 amSYR - MCI
2 stops24h 44mMultiple Airlines
Sun 12/73:47 pmMCI - SYR
1 stop25h 03mMultiple Airlines
Deal found 10/27$273
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/115:00 pmSYR - MCI
1 stop6h 59mDelta
Fri 12/55:30 pmMCI - SYR
1 stop5h 21mDelta
Deal found 10/26$274
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amSYR - STL
1 stop4h 50mDelta
Sat 12/276:25 pmSTL - SYR
1 stop3h 51mDelta
Deal found 10/28$274
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amSYR - SGF
1 stop6h 36mAmerican Airlines
Mon 11/174:28 pmSGF - SYR
1 stop5h 55mAmerican Airlines
Deal found 10/27$274
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/115:30 amSYR - MCI
2 stops8h 19mAmerican Airlines
Fri 12/51:44 pmMCI - SYR
1 stop7h 48mAmerican Airlines
Deal found 10/26$279
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:45 amSYR - MCI
2 stops9h 36mUnited Airlines
Mon 11/171:47 pmMCI - SYR
2 stops8h 55mUnited Airlines
Deal found 10/27$284

Cheap flight deals from Syracuse to Missouri

Keep the following information in mind while searching for Syracuse to Missouri flight deals. Data was last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$181
(Booking.com)

One-way from

$100
(Booking.com)

Popular in

December

Cheapest in

February

Average price

$318
Provider with most accurate pricing for Syracuse Hancock Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Lambert-St Louis flights.
Search Deals
From Syracuse Hancock Intl to Missouri
Search Deals
One-way flight from Syracuse Hancock Intl to Missouri
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Syracuse to Missouri that are best for you.

Fly from

Syracuse

Fly to

Missouri

Route

Depart

Return

Price

SyracuseColumbia

SYR - COU

SYRCOU

Syracuse Hancock Intl

Tue 11/11

10:31 am-2:26 pm

1 stop4h 55m

Columbia Regional

Sat 11/15

3:02 pm-9:02 pm

1 stop5h 00m

$248

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 1/16

6:29 pm-11:12 pm

1 stop5h 43m

Lambert-St Louis

Mon 1/19

3:54 pm-11:27 pm

1 stop6h 33m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Mon 12/15

7:01 pm-11:42 pm

1 stop5h 41m

Lambert-St Louis

Sat 12/20

6:25 pm-11:16 pm

1 stop3h 51m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 11/14

6:07 am-10:41 am

1 stop5h 34m

Lambert-St Louis

Tue 11/18

3:14 pm-9:02 pm

1 stop4h 48m

$254

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Fri 2/27

11:25 am-6:08 pm

1 stop7h 43m

Kansas City

Tue 3/3

5:40 pm-11:01 pm

1 stop4h 21m

$259

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 11/13

3:23 pm-8:21 pm

1 stop5h 58m

Lambert-St Louis

Sat 11/15

8:39 am-5:17 pm

1 stop7h 38m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Thu 12/4

6:00 am-11:42 am

1 stop6h 42m

Kansas City

Sun 12/7

6:29 am-12:08 pm

1 stop4h 39m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Tue 3/24

9:30 am-1:26 pm

1 stop4h 56m

Kansas City

Sat 3/28

5:00 pm-11:59 pm

1 stop5h 59m

$259

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 11/13

12:13 pm-4:07 pm

1 stop4h 54m

Lambert-St Louis

Sat 11/15

5:00 pm-11:10 pm

1 stop5h 10m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Thu 3/12

6:12 am-10:43 am

1 stop5h 31m

Kansas City

Tue 3/24

4:29 pm-12:14 am

1 stop6h 45m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 39 results
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Best time to book a flight from Syracuse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Missouri

What is the cheapest month to book a flight from Syracuse to Missouri?

Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to MO?

Find hourly flight availability from Syracuse to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

One of the essential ways to save on airfare from Syracuse to Missouri is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 45% on airfare.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 28, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Syracuse to Missouri?

    If you book a flight to Missouri from Syracuse, you will be flying from Hancock Intl, which is the city’s only airport. Syracuse Hancock Intl (SYR) is located 4.8 mi from the center of Syracuse.

  • How long is the flight from Syracuse to Missouri?

    Airlines like United Airlines, American Airlines, and Delta fly from Syracuse to Missouri in about 4h 55m. The time it takes to get you to your destination can typically vary by up to 48m. The distance between Syracuse and Missouri is about 889 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Syracuse to Missouri one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $100. Users have also found prices from $182 and $233 on American Airlines and United Airlines, respectively.

  • What are the most popular routes from Syracuse to Missouri?

    Most travelers choose Syracuse Hancock Intl - Kansas City, Syracuse Hancock Intl - Lambert-St Louis or Syracuse Hancock Intl - Columbia Regional when deciding on the best route from Syracuse to Missouri.

  • Can I find deals for flights from Syracuse to Missouri that include hotel bookings?

    Yes. In addition to deals on Syracuse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Missouri.

  • Can I find deals for business class flights from Syracuse to Missouri?

    Yes. Cheapflights offers flight deals from Syracuse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Missouri?

    Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Syracuse to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Syracuse to Missouri

Discover the top 3 airlines that operate flights from Syracuse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$247Average$339FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$306Average$494FlexibilityNo cancel feeOn-time69%

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