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$161+ Cheap flights from Syracuse (SYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Syracuse to Missouri

Keep the following information in mind while searching for Syracuse to Missouri flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$161
(Frontier)

One-way from

$161
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$298
Provider with most accurate pricing for Syracuse Hancock Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Lambert-St Louis flights.
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From Syracuse Hancock Intl to Missouri
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One-way flight from Syracuse Hancock Intl to Missouri
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Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Syracuse to Missouri

Cheapest flights from Syracuse to Missouri
Explore the most affordable flight options available from Syracuse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This Frontier deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:15 pm
SYR
-
STL
1 stop27h 12m
Frontier
Wed 3/43:49 pm
STL
-
SYR
1 stop26h 33m
Frontier
Deal found 1/13$161
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:29 pm
SYR
-
STL
2 stops37h 22m
Multiple Airlines
Wed 3/43:49 pm
STL
-
SYR
1 stop26h 33m
Multiple Airlines
Deal found 1/13$221
This Mytrip deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:55 pm
SYR
-
STL
1 stop29h 04m
Frontier
Sun 3/13:49 pm
STL
-
SYR
1 stop26h 30m
Frontier
Deal found 1/13$260
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:14 am
SYR
-
STL
1 stop7h 09m
Delta
Mon 2/166:35 am
STL
-
SYR
1 stop4h 14m
Delta
Deal found 1/14$269
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:57 pm
SYR
-
MCI
1 stop6h 02m
United Airlines
Wed 2/1812:37 pm
MCI
-
SYR
1 stop6h 37m
United Airlines
Deal found 1/14$279
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:15 am
SYR
-
STL
1 stop7h 18m
Delta
Mon 2/26:35 am
STL
-
SYR
1 stop4h 26m
Delta
Deal found 1/14$279
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:17 am
SYR
-
SGF
1 stop6h 18m
American Airlines
Tue 3/176:00 pm
SGF
-
SYR
1 stop4h 44m
American Airlines
Deal found 1/14$279
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:14 am
SYR
-
STL
1 stop7h 09m
Delta
Tue 2/175:00 pm
STL
-
SYR
1 stop6h 07m
Delta
Deal found 1/13$280
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/292:15 pm
SYR
-
STL
2 stops7h 17m
American Airlines
Mon 2/26:00 am
STL
-
SYR
1 stop4h 26m
American Airlines
Deal found 1/14$284
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:15 am
SYR
-
SGF
2 stops11h 00m
Delta
Mon 2/95:00 pm
SGF
-
SYR
1 stop5h 51m
Delta
Deal found 1/14$284
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/112:15 pm
SYR
-
MCI
2 stops9h 24m
American Airlines
Wed 2/186:00 am
MCI
-
SYR
2 stops8h 35m
American Airlines
Deal found 1/14$290
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/305:48 am
SYR
-
STL
1 stop5h 25m
United Airlines
Mon 2/27:00 am
STL
-
SYR
1 stop5h 10m
United Airlines
Deal found 1/13$290

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Syracuse to Missouri that are best for you.

Fly from

Syracuse

Fly to

Missouri

Route

Depart

Return

Price

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 5/28

11:25 am-4:40 pm

1 stop6h 15m

Lambert-St Louis

Tue 6/2

5:30 pm-11:12 pm

1 stop4h 42m

$269

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 2/7

8:00 am-12:29 pm

1 stop5h 29m

Lambert-St Louis

Sun 2/8

8:05 am-4:15 pm

1 stop7h 10m

$269

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Thu 3/12

6:11 pm-11:59 pm

1 stop6h 48m

Kansas City

Tue 3/24

5:00 am-11:11 am

1 stop5h 11m

$279

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Wed 2/11

4:57 pm-9:59 pm

1 stop6h 02m

Kansas City

Wed 2/18

12:37 pm-8:14 pm

1 stop6h 37m

$279

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

Thu 3/12

6:17 am-11:35 am

1 stop6h 18m

Springfield-Branson

Tue 3/17

6:00 pm-11:44 pm

1 stop4h 44m

$279

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Tue 1/27

11:29 am-5:43 pm

1 stop7h 14m

Lambert-St Louis

Sat 1/31

9:57 am-4:15 pm

1 stop5h 18m

$279

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 2/12

6:14 am-12:23 pm

1 stop7h 09m

Lambert-St Louis

Tue 2/17

5:00 pm-12:07 am

1 stop6h 07m

$280

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 2/27

4:11 pm-10:52 pm

1 stop7h 41m

Lambert-St Louis

Sat 2/28

6:06 am-11:36 am

1 stop4h 30m

$280

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

Fri 2/6

6:15 am-4:15 pm

2 stops11h 00m

Springfield-Branson

Mon 2/9

5:00 pm-11:51 pm

1 stop5h 51m

$284

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

Tue 2/24

4:45 pm-11:43 pm

1 stop7h 58m

Kansas City

Tue 3/10

6:00 am-3:35 pm

2 stops8h 35m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Showing 1-10 of 39 results
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Best time to book a flight from Syracuse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Missouri

What is the cheapest month to book a flight from Syracuse to Missouri?

Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 14, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,048 reviews

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,048 reviews
Delta
7.9
Good
8,048 reviews

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,163 reviews
Delta
7.9
Good
8,048 reviews

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,129 reviews
Delta
7.9
Good
8,048 reviews

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Syracuse to Missouri?

    If you book a flight to Missouri from Syracuse, you will be flying from Hancock Intl, which is the city’s only airport. Syracuse Hancock Intl (SYR) is located 4.8 mi from the center of Syracuse.

  • How long is the flight from Syracuse to Missouri?

    Airlines like Delta, United Airlines, and American Airlines fly from Syracuse to Missouri in about 5h 29m. The time it takes to get you to your destination can typically vary by up to 1h 19m. The distance between Syracuse and Missouri is about 801 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Syracuse to Missouri one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $99. Users have also found prices from $118 and $125 on Delta and American Airlines, respectively.

  • What are the most popular routes from Syracuse to Missouri?

    Most travelers choose Syracuse Hancock Intl - Kansas City, Syracuse Hancock Intl - Lambert-St Louis or Syracuse Hancock Intl - Springfield-Branson when deciding on the best route from Syracuse to Missouri.

  • Can I find deals for flights from Syracuse to Missouri that include hotel bookings?

    Yes. In addition to deals on Syracuse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Missouri.

  • Can I find deals for business class flights from Syracuse to Missouri?

    Yes. Cheapflights offers flight deals from Syracuse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Missouri?

    Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Syracuse to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Syracuse to Missouri

Discover the top 3 airlines that operate flights from Syracuse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$384FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$413FlexibilityNo cancel feeOn-time69%
DeltaCheapest$248Average$332FlexibilityNo cancel feeOn-timeN/A

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