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$75+ Cheap flights from Syracuse (SYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
dic. 31 — ene. 71
mié. 12/31
mié. 1/7
1 adult, Economy
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Find flight deals from Syracuse to Missouri

Cheapest flights from Syracuse to Missouri
Explore the most affordable flight options available from Syracuse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 1, 2025.

This Delta deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/166:00 amSYR - STL
1 stop7h 57mDelta
sáb. 12/206:25 pmSTL - SYR
1 stop3h 51mDelta
Deal found 12/1$279
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/176:40 pmSYR - STL
1 stop5h 26mAmerican Airlines
dom. 12/216:35 pmSTL - SYR
1 stop5h 07mAmerican Airlines
Deal found 11/29$299
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/166:13 amSYR - MCI
1 stop8h 37mAmerican Airlines
sáb. 12/205:19 pmMCI - SYR
1 stop5h 10mAmerican Airlines
Deal found 12/1$309
This Delta deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/186:00 amSYR - STL
1 stop5h 45mDelta
sáb. 12/276:25 pmSTL - SYR
1 stop3h 51mDelta
Deal found 11/30$319
This Delta deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/186:00 amSYR - STL
1 stop5h 45mDelta
dom. 12/215:59 pmSTL - SYR
1 stop4h 18mDelta
Deal found 11/29$339
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/35:23 pmSYR - COU
1 stop4h 59mUnited Airlines
sáb. 12/63:25 pmCOU - SYR
1 stop4h 46mUnited Airlines
Deal found 11/29$343
This Delta deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/212:58 pmSYR - STL
1 stop5h 12mDelta
dom. 12/75:15 pmSTL - SYR
1 stop4h 51mDelta
Deal found 11/29$354
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/197:05 amSYR - MCI
1 stop8h 47mAmerican Airlines
sáb. 1/176:00 amMCI - SYR
1 stop4h 26mAmerican Airlines
Deal found 11/30$365
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/187:05 amSYR - MCI
1 stop8h 47mAmerican Airlines
mar. 12/234:59 pmMCI - SYR
1 stop5h 39mAmerican Airlines
Deal found 11/30$377
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/307:41 pmSYR - STL
1 stop14h 07mAmerican Airlines
dom. 1/44:53 pmSTL - SYR
1 stop5h 45mAmerican Airlines
Deal found 11/30$377
This Delta deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:00 amSYR - STL
1 stop4h 24mDelta
dom. 1/45:59 pmSTL - SYR
1 stop5h 00mDelta
Deal found 11/29$379
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/106:13 amSYR - SGF
1 stop8h 32mAmerican Airlines
dom. 12/216:25 pmSGF - SYR
1 stop5h 17mAmerican Airlines
Deal found 11/29$389

Cheap flight deals from Syracuse to Missouri

Keep the following information in mind while searching for Syracuse to Missouri flight deals. Data was last updated diciembre 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$75
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$478
Provider with most accurate pricing for Syracuse Hancock Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Lambert-St Louis flights.
Search Deals
From Syracuse Hancock Intl to Missouri
Search Deals
One-way flight from Syracuse Hancock Intl to Missouri
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 1, 2025.
Use the filters below to find and compare flights from Syracuse to Missouri that are best for you.

Fly from

Syracuse

Fly to

Missouri

Route

Depart

Return

Price

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

sáb. 1/31

3:00 pm-7:27 pm

1 stop5h 27m

Lambert-St Louis

mié. 2/4

10:19 am-4:19 pm

1 stop5h 00m

$249

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

sáb. 1/31

3:00 pm-9:10 pm

1 stop7h 10m

Springfield-Branson

mié. 2/4

5:00 pm-11:51 pm

1 stop5h 51m

$251

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

jue. 1/15

2:15 pm-9:51 pm

2 stops8h 36m

Lambert-St Louis

jue. 1/22

6:52 am-2:15 pm

1 stop6h 23m

$254

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

jue. 3/12

6:00 am-9:51 am

1 stop4h 51m

Kansas City

mar. 3/24

10:28 am-5:20 pm

1 stop5h 52m

$259

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

sáb. 1/31

11:43 am-7:19 pm

1 stop8h 36m

Kansas City

mié. 2/4

5:09 pm-11:51 pm

1 stop5h 42m

$259

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

mar. 12/16

6:00 am-12:57 pm

1 stop7h 57m

Lambert-St Louis

sáb. 12/20

6:25 pm-11:16 pm

1 stop3h 51m

$279

SyracuseKansas City

SYR - MCI

SYRMCI

Syracuse Hancock Intl

mié. 2/18

7:10 am-11:58 am

1 stop5h 48m

Kansas City

dom. 2/22

6:00 am-3:01 pm

1 stop8h 01m

$284

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

mié. 2/18

4:50 pm-10:09 pm

1 stop6h 19m

Lambert-St Louis

dom. 2/22

6:00 am-11:04 am

1 stop4h 04m

$284

SyracuseSpringfield

SYR - SGF

SYRSGF

Syracuse Hancock Intl

vie. 2/27

4:32 pm-10:29 pm

1 stop6h 57m

Springfield-Branson

lun. 3/2

4:48 pm-12:28 am

1 stop6h 40m

$284

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

mié. 2/18

6:36 pm-11:36 pm

1 stop6h 00m

Lambert-St Louis

sáb. 2/21

5:50 pm-11:13 pm

1 stop4h 23m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

Showing 1-10 of 32 results
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Best time to book a flight from Syracuse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Missouri

What is the cheapest month to book a flight from Syracuse to Missouri?

Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to MO?

Find hourly flight availability from Syracuse to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 1, 2025.

One of the essential ways to save on airfare from Syracuse to Missouri is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 45% on airfare.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated diciembre 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,012 reviews
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,056 reviews
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,039 reviews
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Syracuse to Missouri?

    If you book a flight to Missouri from Syracuse, you will be flying from Hancock Intl, which is the city’s only airport. Syracuse Hancock Intl (SYR) is located 4.8 mi from the center of Syracuse.

  • How long is the flight from Syracuse to Missouri?

    Airlines like Delta, American Airlines, and United Airlines fly from Syracuse to Missouri in about 5h 27m. The time it takes to get you to your destination can typically vary by up to 3h 09m. The distance between Syracuse and Missouri is about 801 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Syracuse to Missouri?

    Most travelers choose Syracuse Hancock Intl - Kansas City, Syracuse Hancock Intl - Lambert-St Louis or Syracuse Hancock Intl - Springfield-Branson when deciding on the best route from Syracuse to Missouri.

  • Can I find deals for flights from Syracuse to Missouri that include hotel bookings?

    Yes. In addition to deals on Syracuse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Missouri.

  • Can I find deals for business class flights from Syracuse to Missouri?

    Yes. Cheapflights offers flight deals from Syracuse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Missouri?

    Currently, June is the cheapest month in which you can book a flight from Syracuse to Missouri (average of $179). Flying from Syracuse to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Syracuse to Missouri

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Top 3 airlines flying from Syracuse to Missouri

Discover the top 3 airlines that operate flights from Syracuse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$394FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$446FlexibilityNo cancel feeOn-time69%
DeltaCheapest$248Average$338FlexibilityNo cancel feeOn-timeN/A

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