$139+ Cheap flights from Knoxville (TYS) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Apr 15 — Apr 221
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to MissouriExplore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/67:25 pm
TYS
- STL
1 stop5h 40m
Southwest
Tue 4/78:25 am
STL
- TYS
1 stop4h 55m
Southwest
Deal found 3/12![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:40 am
TYS
- STL
1 stop7h 55m
Southwest
Tue 5/195:45 am
STL
- TYS
1 stop7h 35m
Southwest
Deal found 3/12![Southwest logo]()
$250
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:54 pm
TYS
- STL
1 stop5h 05m
American Airlines
Mon 5/115:20 am
STL
- TYS
1 stop6h 10m
American Airlines
Deal found 3/12![American Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Sat 5/1610:35 am
STL
- TYS
2 stops6h 55m
Southwest
Deal found 3/12![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:53 am
TYS
- STL
1 stop4h 54m
American Airlines
Tue 5/123:24 pm
STL
- TYS
1 stop6h 32m
American Airlines
Deal found 3/11![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:05 am
TYS
- STL
2 stops6h 55m
Southwest
Tue 4/147:35 am
STL
- TYS
1 stop3h 25m
Southwest
Deal found 3/16![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:49 am
TYS
- MCI
1 stop4h 36m
United Airlines
Wed 4/155:05 pm
MCI
- TYS
1 stop5h 03m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:50 pm
TYS
- STL
1 stop5h 25m
Southwest
Thu 4/161:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Deal found 3/11![Southwest logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- MCI
1 stop22h 02m
Multiple Airlines
Mon 4/274:35 pm
MCI
- TYS
1 stop21h 23m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:05 am
TYS
- MCI
1 stop3h 45m
Southwest
Wed 4/1511:30 am
MCI
- TYS
2 stops7h 10m
Southwest
Deal found 3/11![Southwest logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- MCI
1 stop16h 23m
Multiple Airlines
Thu 4/212:24 pm
MCI
- TYS
1 stop10h 15m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:25 am
TYS
- SGF
1 stop7h 48m
American Airlines
Sat 4/48:25 am
SGF
- TYS
1 stop6h 12m
American Airlines
Deal found 3/13![American Airlines logo]()
$309
Best flights from Knoxville to MissouriDiscover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
Discover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:40 am
TYS
- STL
1 stop7h 55m
Southwest
Tue 5/195:45 am
STL
- TYS
1 stop7h 35m
Southwest
Deal found 3/12![Southwest logo]()
$250
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:49 am
TYS
- MCI
1 stop4h 36m
United Airlines
Wed 4/155:05 pm
MCI
- TYS
1 stop5h 03m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:30 am
TYS
- STL
1 stop3h 37m
Delta
Mon 7/63:42 pm
STL
- TYS
1 stop5h 02m
Delta
Deal found 3/12![Delta logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
- SGF
1 stop17h 44m
Allegiant Air
Sun 4/53:44 pm
SGF
- TYS
1 stop6h 51m
Allegiant Air
Deal found 3/14![Allegiant Air logo]()
$384
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:05 am
TYS
- STL
2 stops6h 55m
Southwest
Tue 4/147:35 am
STL
- TYS
1 stop3h 25m
Southwest
Deal found 3/16![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:05 am
TYS
- STL
2 stops8h 45m
Southwest
Thu 4/1610:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/11![Southwest logo]()
$295
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:56 pm
TYS
- MCI
1 stop7h 29m
United Airlines
Sat 8/86:36 pm
MCI
- TYS
1 stop4h 59m
United Airlines
Deal found 3/14![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Thu 4/1610:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/11![Southwest logo]()
$302
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
TYS
- MCI
1 stop4h 27m
United Airlines
Sat 4/118:00 am
MCI
- TYS
1 stop4h 14m
United Airlines
Deal found 3/10![United Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:53 pm
TYS
- STL
1 stop4h 20m
United Airlines
Tue 4/148:30 am
STL
- TYS
1 stop5h 39m
United Airlines
Deal found 3/12![United Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:00 am
TYS
- MCI
1 stop3h 40m
Southwest
Sat 8/87:10 am
MCI
- TYS
2 stops9h 30m
Southwest
Deal found 3/14![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:40 am
TYS
- MCI
2 stops11h 05m
United Airlines
Sat 4/44:29 pm
MCI
- TYS
1 stop6h 12m
United Airlines
Deal found 3/12![United Airlines logo]()
$366
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:30 am
TYS
- STL
2 stops9h 10m
Southwest
Fri 5/151:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Deal found 3/11![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:20 am
TYS
- MCI
1 stop7h 00m
United Airlines
Thu 6/41:50 pm
MCI
- TYS
1 stop7h 29m
United Airlines
Deal found 3/11![United Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:30 am
TYS
- JLN
1 stop5h 48m
United Airlines
Wed 8/198:42 am
JLN
- TYS
1 stop7h 17m
United Airlines
Deal found 3/11![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/264:56 pm
TYS
- SGF
1 stop7h 46m
United Airlines
Sat 8/293:05 pm
SGF
- TYS
1 stop5h 25m
United Airlines
Deal found 3/11![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2512:05 pm
TYS
- SGF
1 stop5h 16m
United Airlines
Sat 8/293:05 pm
SGF
- TYS
1 stop5h 25m
United Airlines
Deal found 3/14![United Airlines logo]()
$399
Last-minute flights from Knoxville to MissouriDiscover last-minute flight deals from Knoxville to Missouri. Data last updated March 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missouri. Data last updated March 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/232:06 pm
TYS
- STL
1 stop10h 13m
Multiple Airlines
Tue 3/244:51 pm
STL
- TYS
1 stop19h 00m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- MCI
1 stop16h 23m
Multiple Airlines
Thu 4/212:24 pm
MCI
- TYS
1 stop10h 15m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:25 am
TYS
- SGF
1 stop7h 48m
American Airlines
Sat 4/48:25 am
SGF
- TYS
1 stop6h 12m
American Airlines
Deal found 3/13![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:40 am
TYS
- STL
1 stop5h 05m
Southwest
Tue 4/75:45 am
STL
- TYS
1 stop7h 35m
Southwest
Deal found 3/12![Southwest logo]()
$305
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/67:25 pm
TYS
- STL
1 stop5h 40m
Southwest
Tue 4/78:25 am
STL
- TYS
1 stop4h 55m
Southwest
Deal found 3/12![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:15 am
TYS
- STL
1 stop8h 00m
Southwest
Tue 4/141:15 pm
STL
- TYS
1 stop6h 35m
Southwest
Deal found 3/16![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:49 am
TYS
- MCI
1 stop4h 36m
United Airlines
Wed 4/155:05 pm
MCI
- TYS
1 stop5h 03m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:05 am
TYS
- MCI
1 stop3h 45m
Southwest
Wed 4/1511:30 am
MCI
- TYS
2 stops7h 10m
Southwest
Deal found 3/11![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Thu 4/1610:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/11![Southwest logo]()
$302
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:50 pm
TYS
- STL
1 stop5h 25m
Southwest
Thu 4/161:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Deal found 3/11![Southwest logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- MCI
1 stop22h 02m
Multiple Airlines
Mon 4/274:35 pm
MCI
- TYS
1 stop21h 23m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Sun 4/266:15 am
STL
- TYS
1 stop8h 00m
Southwest
Deal found 3/12![Southwest logo]()
$299
One-way flights from Knoxville to MissouriSearch for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
Search for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 3/13![Southwest logo]()
$139
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:30 am
TYS
- STL
1 stop6h 41m
United Airlines
Deal found 3/11![United Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:15 pm
TYS
- STL
2 stops42h 35m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$151
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:57 pm
TYS
- MCI
1 stop6h 06m
United Airlines
Deal found 3/12![United Airlines logo]()
$154
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 3/11![Southwest logo]()
$155
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:55 pm
TYS
- MCI
2 stops5h 30m
Southwest
Deal found 3/12![Southwest logo]()
$159
This Booking.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:28 pm
TYS
- STL
1 stop28h 04m
Frontier
Deal found 3/11![Frontier logo]()
$176
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:00 am
TYS
- STL
1 stop4h 30m
American Airlines
Deal found 3/13![American Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:19 pm
TYS
- MCI
1 stop5h 07m
American Airlines
Deal found 3/14![American Airlines logo]()
$179
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:05 am
TYS
- MCI
2 stops10h 35m
Southwest
Deal found 3/14![Southwest logo]()
$190
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:57 pm
TYS
- MCI
1 stop6h 10m
United Airlines
Deal found 3/15![United Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:00 am
TYS
- STL
2 stops52h 32m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$201
Find flight deals from Knoxville to Missouri
Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated March 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (American Airlines) |
One-way from | $139 (Southwest) |
Popular in | November |
Cheapest in | July |
Average price | $417 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 5/16
6:40 am-1:35 pm
1 stop7h 55m
Lambert-St Louis
Tue 5/19
5:45 am-2:20 pm
1 stop7h 35m
$250
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Wed 4/8
10:49 am-2:25 pm
1 stop4h 36m
Kansas City
Wed 4/15
5:05 pm-11:08 pm
1 stop5h 03m
$279
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 4/7
7:05 am-1:00 pm
2 stops6h 55m
Lambert-St Louis
Tue 4/14
7:35 am-12:00 pm
1 stop3h 25m
$279
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 4/14
7:05 am-2:50 pm
2 stops8h 45m
Lambert-St Louis
Thu 4/16
10:50 am-8:20 pm
2 stops8h 30m
$295
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 4/13
6:45 pm-11:15 pm
1 stop5h 30m
Lambert-St Louis
Thu 4/16
10:50 am-8:20 pm
2 stops8h 30m
$302
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 6/30
5:30 am-8:07 am
1 stop3h 37m
Lambert-St Louis
Mon 7/6
3:42 pm-9:44 pm
1 stop5h 02m
$341
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Sat 8/1
4:56 pm-11:25 pm
1 stop7h 29m
Kansas City
Sat 8/8
6:36 pm-12:35 am
1 stop4h 59m
$341
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Sat 8/1
7:00 am-9:40 am
1 stop3h 40m
Kansas City
Sat 8/8
7:10 am-5:40 pm
2 stops9h 30m
$356
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 4/2
6:30 am-2:40 pm
2 stops9h 10m
Lambert-St Louis
Fri 5/15
1:45 pm-8:20 pm
2 stops5h 35m
$357
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Tue 4/7
7:00 am-10:27 am
1 stop4h 27m
Kansas City
Sat 4/11
8:00 am-1:14 pm
1 stop4h 14m
$363
Showing 1-10 of 38 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missouri
TYS-USMO
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
What is the cheapest month to book a flight from Knoxville to Missouri?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $152). Flying from Knoxville to Missouri in February is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 16, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
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Knoxville and Missouri flights
Browse other Knoxville and Missouri flight options. Last updated on March 16, 2026.
Popular flight searches
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Knoxville to Missouri flights
Consider these flights traveling from Knoxville to Missouri.
Top 3 airlines flying from Knoxville to Missouri
Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$198 | Average$364 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$337 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$249 | Average$545 | FlexibilityNo cancel fee | On-time69% |