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$117+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated July 30, 2025.

Round-trip from

$212
(Mytrip)

One-way from

$117
(FlightHub)

Popular in

January

Cheapest in

September

Average price

$283
From Knoxville McGhee Tyson to Missouri
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One-way flight from Knoxville McGhee Tyson to Missouri
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Highest demand for flights based on searches. 14% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2711:54 amTYS - STL
1 stop5h 12mDelta
Sat 8/306:40 amSTL - TYS
1 stop3h 54mDelta
Deal found 7/28$214
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/3012:42 pmTYS - STL
2 stops7h 39mAmerican Airlines
Sat 9/67:16 amSTL - TYS
1 stop4h 56mAmerican Airlines
Deal found 7/28$220
This FlightHub deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:40 pmTYS - STL
1 stop13h 26mFrontier
Sun 9/287:55 pmSTL - TYS
1 stop22h 50mFrontier
Deal found 7/30$225
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/274:00 pmTYS - SGF
1 stop5h 17mDelta
Sat 12/66:00 amSGF - TYS
1 stop3h 28mDelta
Deal found 7/28$249
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/104:19 pmTYS - MCI
1 stop5h 59mDelta
Sat 9/1311:29 amMCI - TYS
1 stop4h 34mDelta
Deal found 7/28$249
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amTYS - MCI
1 stop4h 56mAmerican Airlines
Sat 10/115:34 amMCI - TYS
1 stop5h 11mAmerican Airlines
Deal found 7/28$258
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/191:22 pmTYS - MCI
1 stop10h 45mMultiple Airlines
Sun 9/215:15 amMCI - TYS
2 stops16h 53mMultiple Airlines
Deal found 7/27$259
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:10 amTYS - SGF
1 stop5h 48mAmerican Airlines
Sat 12/66:14 pmSGF - TYS
1 stop5h 07mAmerican Airlines
Deal found 7/29$279
This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/35:25 pmTYS - MCI
1 stop26h 39mFrontier
Wed 8/67:20 pmMCI - TYS
1 stop20h 09mFrontier
Deal found 7/28$295
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:45 amTYS - SGF
2 stops9h 54mUnited Airlines
Sat 12/69:05 amSGF - TYS
1 stop8h 04mUnited Airlines
Deal found 7/29$299
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/264:40 pmTYS - MCI
1 stop7h 50mUnited Airlines
Tue 9/303:23 pmMCI - TYS
1 stop6h 27mUnited Airlines
Deal found 7/29$319
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/134:15 pmTYS - STL
3 stops22h 17mMultiple Airlines
Sun 8/1710:37 amSTL - TYS
2 stops22h 39mMultiple Airlines
Deal found 7/29$323

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 8/27

11:54 am-4:06 pm

1 stop5h 12m

Lambert-St Louis

Sat 8/30

6:40 am-11:34 am

1 stop3h 54m

$214

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 8/30

12:42 pm-7:21 pm

2 stops7h 39m

Lambert-St Louis

Sat 9/6

7:16 am-1:12 pm

1 stop4h 56m

$220

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 9/25

8:40 pm-9:06 am

1 stop13h 26m

Lambert-St Louis

Sun 9/28

7:55 pm-7:45 pm

1 stop22h 50m

$225

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Thu 11/27

4:00 pm-8:17 pm

1 stop5h 17m

Springfield-Branson

Sat 12/6

6:00 am-10:28 am

1 stop3h 28m

$249

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 9/10

4:19 pm-9:18 pm

1 stop5h 59m

Kansas City

Sat 9/13

11:29 am-5:03 pm

1 stop4h 34m

$249

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 10/1

6:00 am-9:56 am

1 stop4h 56m

Kansas City

Sat 10/11

5:34 am-11:45 am

1 stop5h 11m

$258

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Fri 9/19

1:22 pm-11:07 pm

1 stop10h 45m

Kansas City

Sun 9/21

5:15 am-11:08 pm

2 stops16h 53m

$259

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 11/26

5:10 am-9:58 am

1 stop5h 48m

Springfield-Branson

Sat 12/6

6:14 pm-12:21 am

1 stop5h 07m

$279

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Thu 11/27

5:45 am-2:39 pm

2 stops9h 54m

Springfield-Branson

Sat 12/6

9:05 am-6:09 pm

1 stop8h 04m

$284

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Fri 9/26

4:40 pm-11:30 pm

1 stop7h 50m

Kansas City

Tue 9/30

3:23 pm-10:50 pm

1 stop6h 27m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 27 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 30, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,237 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $117 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $162 and $239, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$343FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$374FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$329FlexibilityNo cancel feeOn-timeN/A

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