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$105+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MCI
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2212:50 pmTYS - MCI
1 stop20h 09mMultiple Airlines
Wed 12/248:45 pmMCI - TYS
2 stops23h 46mMultiple Airlines
Deal found 12/16$396
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:05 amTYS - STL
1 stop6h 16mDelta
Sat 1/37:00 amSTL - TYS
1 stop5h 42mDelta
Deal found 12/15$407
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 pmTYS - MCI
1 stop5h 24mDelta
Sun 12/215:43 amMCI - TYS
1 stop4h 26mDelta
Deal found 12/15$433
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:00 pmTYS - MCI
1 stop7h 31mUnited Airlines
Sat 1/33:00 pmMCI - TYS
1 stop7h 42mUnited Airlines
Deal found 12/14$441
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:45 amTYS - MCI
1 stop4h 58mUnited Airlines
Fri 12/266:00 amMCI - TYS
2 stops7h 48mUnited Airlines
Deal found 12/17$455
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:45 amTYS - MCI
2 stops9h 53mUnited Airlines
Sun 1/45:46 pmMCI - TYS
1 stop5h 13mUnited Airlines
Deal found 12/16$456
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:08 pmTYS - SGF
1 stop6h 20mAmerican Airlines
Fri 12/266:24 pmSGF - TYS
1 stop4h 23mAmerican Airlines
Deal found 12/15$457
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:45 amTYS - STL
1 stop6h 42mUnited Airlines
Sat 1/33:10 pmSTL - TYS
1 stop6h 29mUnited Airlines
Deal found 12/15$467
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:46 pmTYS - STL
1 stop18h 16mMultiple Airlines
Sat 1/310:10 pmSTL - TYS
2 stops35h 05mMultiple Airlines
Deal found 12/15$470
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:40 amTYS - MCI
1 stop6h 19mUnited Airlines
Mon 12/227:40 amMCI - TYS
2 stops11h 11mUnited Airlines
Deal found 12/16$477
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2112:21 pmTYS - MCI
1 stop22h 46mMultiple Airlines
Mon 12/226:15 pmMCI - TYS
1 stop13h 03mMultiple Airlines
Deal found 12/16$478
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:37 pmTYS - MCI
1 stop3h 53mDelta
Sun 12/215:43 amMCI - TYS
1 stop4h 26mDelta
Deal found 12/17$495

Find flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$236
(Kiwi.com)

One-way from

$105
(Kiwi.com)

Popular in

November

Cheapest in

July

Average price

$389
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
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From Knoxville McGhee Tyson to Missouri
Search Deals
One-way flight from Knoxville McGhee Tyson to Missouri
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($82 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 1/6

7:22 pm-10:33 pm

2 stops28h 11m

Lambert-St Louis

Mon 1/12

8:50 am-5:28 pm

1 stop7h 38m

$236

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 1/16

6:00 am-10:34 pm

1 stop17h 34m

Lambert-St Louis

Wed 1/21

5:42 pm-6:36 pm

1 stop23h 54m

$251

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Thu 2/12

9:32 pm-10:30 am

1 stop13h 58m

Kansas City

Mon 2/16

11:26 am-10:08 am

1 stop21h 42m

$259

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-10:02 am

1 stop18h 39m

Lambert-St Louis

Wed 1/14

3:43 pm-7:23 pm

1 stop26h 40m

$263

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 2/21

5:30 am-9:22 am

1 stop4h 52m

Kansas City

Tue 2/24

8:05 am-1:51 pm

1 stop4h 46m

$267

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 1/10

11:59 am-2:48 pm

2 stops27h 49m

Lambert-St Louis

Wed 1/14

3:43 pm-7:23 pm

1 stop26h 40m

$267

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 1/21

11:40 am-4:27 pm

1 stop5h 47m

Springfield-Branson

Sat 1/24

3:14 pm-8:52 pm

1 stop4h 38m

$269

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 1/21

10:11 am-4:14 pm

2 stops7h 03m

Springfield-Branson

Sat 1/24

4:29 pm-10:47 pm

1 stop5h 18m

$274

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Mon 1/5

5:40 pm-10:04 pm

1 stop5h 24m

Springfield-Branson

Sat 1/10

5:39 pm-11:21 pm

1 stop4h 42m

$274

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 1/30

5:40 am-8:53 am

1 stop4h 13m

Lambert-St Louis

Fri 2/6

6:00 am-11:08 am

1 stop4h 08m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 40 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $198). Flying from Knoxville to Missouri in November is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 25% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 18, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,091 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Missouri?

    Airlines like Frontier, Delta, and United Airlines fly from Knoxville to Missouri in about 4h 52m. The time it takes to get you to your destination can typically vary by up to 13h 47m. The distance between Knoxville and Missouri is about 634 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Springfield-Branson or Knoxville McGhee Tyson - Lambert-St Louis, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $198). Flying from Knoxville to Missouri in November is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$382FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$331FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$255Average$739FlexibilityNo cancel feeOn-time69%

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