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$119+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated September 15, 2025.

Round-trip from

$209
(Kiwi.com)

One-way from

$119
(Kiwi.com)

Popular in

January

Cheapest in

July

Average price

$303
From Knoxville McGhee Tyson to Missouri
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One-way flight from Knoxville McGhee Tyson to Missouri
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Highest demand for flights based on searches. 14% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - MCI
1 stop22h 38mMultiple Airlines
Mon 10/205:11 pmMCI - TYS
1 stop16h 22mMultiple Airlines
Deal found 9/14$209
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - MCI
1 stop22h 38mFrontier
Wed 10/227:02 pmMCI - TYS
1 stop23h 30mFrontier
Deal found 9/14$216
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - STL
1 stop14h 50mMultiple Airlines
Sun 11/210:57 amSTL - TYS
1 stop10h 36mMultiple Airlines
Deal found 9/13$234
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - MCI
1 stop22h 38mMultiple Airlines
Sun 10/198:55 amMCI - TYS
1 stop10h 40mMultiple Airlines
Deal found 9/14$238
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:17 pmTYS - MCI
1 stop22h 38mFrontier
Sat 10/187:02 pmMCI - TYS
1 stop23h 30mFrontier
Deal found 9/13$241
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:44 amTYS - STL
1 stop3h 23mDelta
Mon 10/202:15 pmSTL - TYS
1 stop5h 58mDelta
Deal found 9/14$249
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amTYS - STL
1 stop5h 21mAmerican Airlines
Tue 10/75:20 amSTL - TYS
1 stop5h 25mAmerican Airlines
Deal found 9/14$254
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amTYS - STL
1 stop7h 51mAmerican Airlines
Sun 10/57:22 amSTL - TYS
1 stop5h 32mAmerican Airlines
Deal found 9/15$259
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:39 amTYS - STL
1 stop7h 12mDelta
Mon 12/17:02 pmSTL - TYS
1 stop3h 50mDelta
Deal found 9/13$264
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:26 pmTYS - MCI
2 stops19h 16mMultiple Airlines
Mon 10/205:11 pmMCI - TYS
1 stop16h 22mMultiple Airlines
Deal found 9/14$265
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/143:48 pmTYS - MCI
1 stop6h 20mDelta
Wed 10/227:00 amMCI - TYS
1 stop6h 43mDelta
Deal found 9/14$267
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:43 pmTYS - STL
1 stop4h 22mAmerican Airlines
Sun 10/197:16 amSTL - TYS
1 stop4h 15mAmerican Airlines
Deal found 9/13$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-9:07 am

1 stop14h 50m

Lambert-St Louis

Sun 11/2

10:57 am-10:33 pm

1 stop10h 36m

$234

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

5:34 pm-9:07 am

2 stops16h 33m

Lambert-St Louis

Sat 10/25

7:52 pm-1:33 pm

1 stop16h 41m

$234

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 10/14

5:44 am-10:26 am

1 stop5h 42m

Lambert-St Louis

Tue 10/21

5:15 pm-11:07 pm

1 stop4h 52m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 11/7

11:22 am-4:36 pm

1 stop6h 14m

Lambert-St Louis

Mon 11/10

5:58 pm-12:08 am

1 stop5h 10m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Sat 10/25

6:00 am-10:28 am

1 stop3h 28m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 10/15

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Wed 10/22

9:10 am-2:43 pm

1 stop4h 33m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 10/17

5:44 am-8:07 am

1 stop3h 23m

Lambert-St Louis

Mon 10/20

6:52 pm-11:46 pm

1 stop3h 54m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Wed 10/29

3:59 pm-11:07 pm

1 stop6h 08m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/2

6:00 am-10:21 am

1 stop5h 21m

Lambert-St Louis

Tue 10/7

5:20 am-11:45 am

1 stop5h 25m

$254

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/2

6:00 am-12:51 pm

1 stop7h 51m

Lambert-St Louis

Sun 10/5

7:22 am-1:54 pm

1 stop5h 32m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 51 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 15, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Missouri?

    Airlines like Delta, American Airlines, and United Airlines fly from Knoxville to Missouri in about 5h 42m. The time it takes to get you to your destination can typically vary by up to 3h 09m. The distance between Knoxville and Missouri is about 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Kansas City or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Lambert-St Louis is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$351FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$398FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$327FlexibilityNo cancel feeOn-timeN/A

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