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$126+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/26:33 pmTYS - STL
1 stop29h 00mMultiple Airlines
sáb. 12/67:43 pmSTL - TYS
1 stop19h 14mMultiple Airlines
Deal found 10/29$240
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/167:07 pmTYS - STL
1 stop15h 00mFrontier
jue. 11/207:57 pmSTL - TYS
1 stop18h 56mFrontier
Deal found 10/29$248
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/177:13 pmTYS - MCI
1 stop18h 15mMultiple Airlines
vie. 11/218:28 pmMCI - TYS
1 stop21h 42mMultiple Airlines
Deal found 10/29$264
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:34 pmTYS - MCI
1 stop6h 41mMultiple Airlines
vie. 12/126:30 amMCI - TYS
1 stop9h 32mMultiple Airlines
Deal found 10/30$266
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/129:54 pmTYS - MCI
1 stop12h 51mAllegiant Air
dom. 11/1610:35 amMCI - TYS
1 stop28h 54mAllegiant Air
Deal found 10/28$267
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/167:00 amTYS - STL
2 stops27h 40mMultiple Airlines
jue. 11/204:13 pmSTL - TYS
1 stop28h 17mMultiple Airlines
Deal found 10/29$270
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/149:00 amTYS - STL
1 stop8h 20mMultiple Airlines
dom. 11/162:12 pmSTL - TYS
1 stop22h 45mMultiple Airlines
Deal found 10/29$278
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/125:40 amTYS - STL
1 stop6h 05mDelta
dom. 12/146:39 amSTL - TYS
1 stop4h 08mDelta
Deal found 10/29$279
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:30 amTYS - MCI
1 stop13h 44mMultiple Airlines
sáb. 12/67:01 pmMCI - TYS
2 stops25h 43mMultiple Airlines
Deal found 10/30$284
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/268:04 pmTYS - STL
1 stop5h 01mAmerican Airlines
mié. 12/39:53 amSTL - TYS
1 stop5h 01mAmerican Airlines
Deal found 10/29$285
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/234:46 pmTYS - MCI
1 stop28h 04mMultiple Airlines
lun. 12/2911:13 amMCI - TYS
2 stops23h 18mMultiple Airlines
Deal found 10/28$288
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/178:00 amTYS - STL
1 stop13h 12mMultiple Airlines
jue. 11/209:54 pmSTL - TYS
2 stops16h 59mMultiple Airlines
Deal found 10/30$294

Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(Kiwi.com)

One-way from

$126
(Booking.com)

Popular in

March

Cheapest in

April

Average price

$363
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
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From Knoxville McGhee Tyson to Missouri
Search Deals
One-way flight from Knoxville McGhee Tyson to Missouri
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

mar. 12/2

6:33 pm-10:33 pm

1 stop29h 00m

Lambert-St Louis

sáb. 12/6

7:43 pm-3:57 pm

1 stop19h 14m

$240

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

lun. 11/17

7:13 pm-12:28 pm

1 stop18h 15m

Kansas City

vie. 11/21

8:28 pm-7:10 pm

1 stop21h 42m

$264

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

lun. 12/8

5:34 pm-11:15 pm

1 stop6h 41m

Kansas City

vie. 12/12

6:30 am-5:02 pm

1 stop9h 32m

$266

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

mié. 11/12

9:54 pm-9:45 am

1 stop12h 51m

Kansas City

dom. 11/16

10:35 am-4:29 pm

1 stop28h 54m

$267

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

mié. 4/8

5:30 am-9:40 am

1 stop5h 10m

Kansas City

mié. 4/15

4:15 pm-9:44 pm

1 stop4h 29m

$267

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

mié. 2/18

5:30 am-9:40 am

1 stop5h 10m

Kansas City

sáb. 2/21

8:00 am-1:26 pm

1 stop4h 26m

$267

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

mié. 4/8

10:16 am-5:21 pm

2 stops8h 05m

Kansas City

mié. 4/15

8:00 am-1:18 pm

1 stop4h 18m

$272

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 12/12

5:40 am-10:45 am

1 stop6h 05m

Lambert-St Louis

dom. 12/14

6:39 am-11:47 am

1 stop4h 08m

$279

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

mar. 12/23

4:46 pm-7:50 pm

1 stop28h 04m

Kansas City

lun. 12/29

11:13 am-11:31 am

2 stops23h 18m

$288

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

lun. 11/17

8:00 am-8:12 pm

1 stop13h 12m

Lambert-St Louis

jue. 11/20

9:54 pm-3:53 pm

2 stops16h 59m

$294

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 38 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $198). Flying from Knoxville to Missouri in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Missouri in the morning. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated octubre 30, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Missouri?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Knoxville to Missouri in about 5h 10m. The time it takes to get you to your destination can typically vary by up to 7h 41m. The distance between Knoxville and Missouri is about 634 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $126 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on United Airlines and Allegiant Air, with prices starting from $126 and $158, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Kansas City or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Lambert-St Louis is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $198). Flying from Knoxville to Missouri in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$346FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$401FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$322FlexibilityNo cancel feeOn-timeN/A

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