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Missouri

$108+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
TYS
-
STL
1 stop6h 48m
American Airlines
Wed 4/295:20 am
STL
-
TYS
1 stop6h 10m
American Airlines
Deal found 1/28$233
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:55 pm
TYS
-
STL
1 stop7h 20m
Southwest
Mon 5/47:35 am
STL
-
TYS
1 stop3h 05m
Southwest
Deal found 1/27$234
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:55 pm
TYS
-
STL
1 stop7h 10m
Southwest
Wed 3/112:25 pm
STL
-
TYS
1 stop4h 40m
Southwest
Deal found 1/27$256
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:40 am
TYS
-
STL
1 stop6h 21m
American Airlines
Wed 3/44:13 pm
STL
-
TYS
1 stop7h 15m
American Airlines
Deal found 1/27$257
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:55 pm
TYS
-
STL
2 stops7h 20m
Southwest
Mon 3/92:35 pm
STL
-
TYS
1 stop5h 40m
Southwest
Deal found 1/27$262
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:10 am
TYS
-
STL
1 stop7h 23m
American Airlines
Sun 3/85:12 am
STL
-
TYS
1 stop5h 18m
American Airlines
Deal found 1/27$267
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:38 pm
TYS
-
MCI
1 stop6h 33m
Delta
Tue 5/128:00 am
MCI
-
TYS
1 stop6h 06m
Delta
Deal found 1/27$267
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:02 pm
TYS
-
SGF
1 stop7h 33m
American Airlines
Wed 3/410:28 am
SGF
-
TYS
1 stop5h 03m
American Airlines
Deal found 1/28$269
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:25 pm
TYS
-
STL
1 stop5h 40m
Southwest
Sun 3/86:35 am
STL
-
TYS
1 stop5h 20m
Southwest
Deal found 1/28$279
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:47 pm
TYS
-
MCI
1 stop7h 12m
American Airlines
Tue 3/35:00 am
MCI
-
TYS
1 stop4h 48m
American Airlines
Deal found 1/27$279
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:32 pm
TYS
-
MCI
1 stop13h 58m
Multiple Airlines
Sun 2/226:03 pm
MCI
-
TYS
1 stop28h 35m
Multiple Airlines
Deal found 1/26$281
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/132:06 pm
TYS
-
STL
1 stop11h 21m
Multiple Airlines
Mon 2/168:22 pm
STL
-
TYS
2 stops36h 46m
Multiple Airlines
Deal found 1/26$283

Find flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(American Airlines)

One-way from

$108
(Kiwi.com)

Popular in

November

Cheapest in

April

Average price

$294
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
Search Deals
From Knoxville McGhee Tyson to Missouri
Search Deals
One-way flight from Knoxville McGhee Tyson to Missouri
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-11:05 pm

1 stop7h 10m

Lambert-St Louis

Wed 3/11

2:25 pm-8:05 pm

1 stop4h 40m

$256

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 3/1

5:40 am-11:01 am

1 stop6h 21m

Lambert-St Louis

Wed 3/4

4:13 pm-12:28 am

1 stop7h 15m

$257

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-11:05 pm

1 stop7h 10m

Lambert-St Louis

Mon 3/9

2:35 pm-9:15 pm

1 stop5h 40m

$257

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/6

5:54 pm-11:50 pm

1 stop6h 56m

Kansas City

Tue 5/12

12:30 pm-6:15 pm

1 stop4h 45m

$267

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/6

7:00 am-12:40 pm

1 stop6h 40m

Kansas City

Tue 5/12

9:38 am-3:19 pm

1 stop4h 41m

$267

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 4/29

12:50 pm-7:20 pm

2 stops7h 30m

Lambert-St Louis

Mon 5/4

1:45 pm-8:20 pm

2 stops5h 35m

$274

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Mon 3/2

5:47 pm-11:59 pm

1 stop7h 12m

Kansas City

Tue 3/3

5:00 am-10:48 am

1 stop4h 48m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-12:05 am

1 stop5h 40m

Lambert-St Louis

Sun 3/8

6:35 am-12:55 pm

1 stop5h 20m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 2/13

2:06 pm-12:27 am

1 stop11h 21m

Lambert-St Louis

Mon 2/16

8:22 pm-10:08 am

2 stops36h 46m

$283

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 3/5

7:25 pm-12:05 am

1 stop5h 40m

Lambert-St Louis

Sun 3/8

5:20 am-12:55 pm

2 stops6h 35m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 42 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $152). Flying from Knoxville to Missouri in November is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 29, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Missouri?

    Airlines like Southwest, American Airlines, and Delta fly from Knoxville to Missouri in about 6h 21m. The time it takes to get you to your destination can typically vary by up to 49m. The distance between Knoxville and Missouri is about 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $152). Flying from Knoxville to Missouri in November is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$365FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$335FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$255Average$760FlexibilityNo cancel feeOn-time69%

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