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$59+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated July 31, 2025.

Round-trip from

$170
(FlightHub)

One-way from

$59
(Mytrip)

Popular in

January

Cheapest in

July

Average price

$216
From Durham to Missouri
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One-way flight from Durham to Missouri
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Highest demand for flights based on searches. 24% potential increase in price ($110 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This FlightHub deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/289:27 amRDU - STL
1 stop5h 05mSpirit Airlines
Thu 9/410:35 amSTL - RDU
1 stop27h 00mSpirit Airlines
Deal found 7/31$170
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:39 amRDU - MCI
Nonstop2h 40mDelta
Sun 10/57:28 pmMCI - RDU
Nonstop2h 30mDelta
Deal found 7/31$177
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/71:30 pmRDU - MCI
Nonstop2h 30mSouthwest
Fri 9/125:30 pmMCI - RDU
1 stop3h 45mSouthwest
Deal found 7/31$183
This FlightHub deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/207:00 pmRDU - STL
1 stop19h 07mFrontier
Sat 8/233:02 pmSTL - RDU
1 stop6h 36mFrontier
Deal found 7/31$205
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2310:31 amRDU - MCI
1 stop5h 17mUnited Airlines
Thu 9/48:30 amMCI - RDU
1 stop6h 17mUnited Airlines
Deal found 7/30$217
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1111:40 amRDU - STL
Nonstop2h 10mSouthwest
Sat 10/1810:25 amSTL - RDU
Nonstop1h 50mSouthwest
Deal found 7/31$217
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:35 pmRDU - STL
1 stop4h 20mDelta
Wed 10/2911:21 amSTL - RDU
1 stop5h 13mDelta
Deal found 7/30$227
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amRDU - SGF
1 stop4h 41mAmerican Airlines
Sat 10/184:10 pmSGF - RDU
1 stop6h 47mAmerican Airlines
Deal found 7/30$231
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/298:59 amRDU - MCI
1 stop7h 47mAmerican Airlines
Mon 9/15:01 amMCI - RDU
1 stop4h 18mAmerican Airlines
Deal found 7/31$232
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amRDU - STL
1 stop4h 35mAmerican Airlines
Fri 11/711:35 amSTL - RDU
1 stop6h 18mAmerican Airlines
Deal found 7/29$232
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:10 amRDU - MCI
1 stop5h 17mFrontier
Sun 10/1911:22 amMCI - RDU
1 stop10h 36mFrontier
Deal found 7/30$238
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:56 pmRDU - SGF
1 stop4h 06mDelta
Tue 9/306:00 amSGF - RDU
1 stop7h 03mDelta
Deal found 7/31$248

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.

Fly from

Durham

Fly to

Missouri

Route

Depart

Return

Price

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Thu 8/28

9:27 am-1:32 pm

1 stop5h 05m

Lambert-St Louis

Thu 9/4

10:35 am-2:35 pm

1 stop27h 00m

$170

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 10/3

7:39 am-9:19 am

Nonstop2h 40m

Kansas City

Sun 10/5

7:28 pm-10:58 pm

Nonstop2h 30m

$177

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Sun 9/7

1:30 pm-3:00 pm

Nonstop2h 30m

Kansas City

Fri 9/12

5:30 pm-10:15 pm

1 stop3h 45m

$183

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Wed 8/20

7:00 pm-1:07 pm

1 stop19h 07m

Lambert-St Louis

Sat 8/23

3:02 pm-10:38 pm

1 stop6h 36m

$205

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Sat 8/23

10:31 am-2:48 pm

1 stop5h 17m

Kansas City

Thu 9/4

8:30 am-3:47 pm

1 stop6h 17m

$217

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Sat 10/11

11:40 am-12:50 pm

Nonstop2h 10m

Lambert-St Louis

Sat 10/18

10:25 am-1:15 pm

Nonstop1h 50m

$217

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Sat 10/25

12:35 pm-3:55 pm

1 stop4h 20m

Lambert-St Louis

Wed 10/29

11:21 am-5:34 pm

1 stop5h 13m

$227

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Sat 10/11

6:00 am-9:41 am

1 stop4h 41m

Springfield-Branson

Sat 10/18

4:10 pm-11:57 pm

1 stop6h 47m

$231

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 8/29

8:59 am-3:46 pm

1 stop7h 47m

Kansas City

Mon 9/1

5:01 am-10:19 am

1 stop4h 18m

$232

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Tue 11/4

6:00 am-9:35 am

1 stop4h 35m

Lambert-St Louis

Fri 11/7

11:35 am-6:53 pm

1 stop6h 18m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 39 results
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Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

When flying from Durham to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 31, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Spirit Airlines
6.3
Okay
8,048 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Missouri flight route?

    Within the past month, 26 users have taken a look at flights from Durham to Missouri.

  • What are the cheapest airlines to fly from Durham to Missouri one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $59. Southwest flights start at $89 while deals on American Airlines start at $99 one-way.

  • What are the most popular routes from Durham to Missouri?

    When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Lambert-St Louis, Raleigh-Durham - Kansas City or Raleigh-Durham - Springfield-Branson as they are the most popular.

  • What are the cheapest flights from Durham to Missouri?

    Looking for the cheapest flight from Durham to Missouri? While on average our users pay $303, our data indicates the cheapest price to be $89. The most popular route (Raleigh-Durham - Lambert-St Louis), is priced around $217.

  • Can I find deals for flights from Durham to Missouri that include hotel bookings?

    Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

  • Can I find deals for business class flights from Durham to Missouri?

    Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Durham to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Durham to Missouri

Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$85Average$238FlexibilityNo cancel feeOn-time62%
DeltaCheapest$157Average$334FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$181Average$379FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$188Average$421FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$196Average$343FlexibilityNo cancel feeOn-time69%

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