How popular is this Durham to Missouri flight route?

Within the past month, 2 users have taken a look at flights from Durham to Missouri.

How long is the flight from Durham to Missouri?

A quick flight from Durham to Missouri can take about 3h 09m. Frontier provides one of the quickest options available for as low as $199. There are 902 mi between Durham and Missouri. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Durham to Missouri one-way?

To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $55. Delta flights start at $88 while deals on Southwest start at $98 one-way.

In terms of precipitation, rainfall in Missouri ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit Missouri when rainfall is around 2.2 in.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular routes from Durham to Missouri?

When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Kansas City, Raleigh-Durham - Lambert-St Louis or Raleigh-Durham - Springfield-Branson as they are the most popular.

What are the cheapest flights from Durham to Missouri?

Looking for the cheapest flight from Durham to Missouri? While on average our users pay $341, our data indicates the cheapest price to be $148. The most popular route (Raleigh-Durham - Kansas City), is priced around $178.

What are the most reliable airlines from Durham to Missouri?

Before booking your flight to Missouri from Durham, check out the most reliable airlines to get you to your destination on time: Delta (79%), Endeavor Airlines (79%), Southwest( 33%).

What are the most popular airlines that fly from Durham to Missouri?

Before booking your flight from Durham to Missouri check out the most popular airlines for this route: Southwest, Delta or American Airlines.

Can I find deals for flights from Durham to Missouri that include hotel bookings?

Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Durham to Missouri?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

Can I find deals for business class flights from Durham to Missouri?

Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$63+ Flights from Durham to Missouri

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Durham to Missouri with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Mon 12/226:00 amRDU - MCI

1 stop5h 08mFrontier

Wed 12/3111:33 amMCI - RDU

1 stop11h 40mFrontier

Deal found 12/17

$214

Fri 12/266:00 amRDU - MCI

1 stop5h 08mFrontier

Wed 12/3111:33 amMCI - RDU

1 stop11h 40mFrontier

Deal found 12/17

$233

Sun 12/216:00 amRDU - STL

1 stop4h 40mFrontier

Mon 12/2210:40 amSTL - RDU

1 stop5h 17mFrontier

Deal found 12/15

$298

Sat 12/205:00 amRDU - STL

1 stop4h 35mAmerican Airlines

Tue 1/206:46 pmSTL - RDU

1 stop4h 13mAmerican Airlines

Deal found 12/16

$302

Wed 12/314:12 pmRDU - MCI

1 stop6h 34mAmerican Airlines

Sun 1/47:46 pmMCI - RDU

1 stop6h 12mAmerican Airlines

Deal found 12/16

$319

Tue 12/1611:02 amRDU - STL

1 stop6h 04mDelta

Tue 1/66:00 amSTL - RDU

1 stop4h 52mDelta

Deal found 12/16

$327

Thu 12/186:00 amRDU - STL

1 stop4h 40mFrontier

Mon 12/2210:40 amSTL - RDU

1 stop5h 17mFrontier

Deal found 12/15

$343

Wed 12/247:00 amRDU - STL

1 stop3h 59mAmerican Airlines

Sat 12/275:00 amSTL - RDU

1 stop4h 34mAmerican Airlines

Deal found 12/17

$351

Mon 12/226:00 amRDU - MCI

1 stop5h 08mFrontier

Sun 12/2810:02 amMCI - RDU

1 stop5h 49mFrontier

Deal found 12/16

$358

Wed 12/315:50 pmRDU - MCI

1 stop24h 20mMultiple Airlines

Sun 1/46:15 pmMCI - RDU

2 stops25h 37mMultiple Airlines

Deal found 12/16

$363

Thu 12/256:00 amRDU - STL

1 stop4h 40mFrontier

Mon 12/2910:40 amSTL - RDU

1 stop5h 17mFrontier

Deal found 12/16

$367

Fri 12/269:05 amRDU - MCI

1 stop6h 47mAmerican Airlines

Tue 12/306:15 amMCI - RDU

1 stop5h 43mAmerican Airlines

Deal found 12/16

$369

Best flights from Durham to Missouri
Discover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Thu 1/152:48 pmRDU - STL

1 stop8h 46mFrontier

Mon 1/198:32 pmSTL - RDU

1 stop26h 19mFrontier

Deal found 12/15

$154

Fri 1/307:19 pmRDU - STL

2 stops12h 32mMultiple Airlines

Mon 2/25:42 pmSTL - RDU

1 stop19h 17mMultiple Airlines

Deal found 12/16

$175

Thu 1/153:08 pmRDU - MCI

1 stop20h 23mSpirit Airlines

Thu 1/2211:26 amMCI - RDU

1 stop25h 47mSpirit Airlines

Deal found 12/17

$195

Fri 1/237:05 amRDU - MCI

Nonstop3h 09mDelta

Fri 1/307:59 pmMCI - RDU

Nonstop2h 25mDelta

Deal found 12/16

$199

Fri 1/167:35 pmRDU - MCI

1 stop5h 00mAmerican Airlines

Mon 1/195:48 amMCI - RDU

1 stop5h 40mAmerican Airlines

Deal found 12/17

$219

Tue 1/136:18 amRDU - COU

2 stops9h 17mUnited Airlines

Tue 1/203:10 pmCOU - RDU

1 stop5h 08mUnited Airlines

Deal found 12/16

$264

Wed 2/185:35 pmRDU - STL

Nonstop2h 20mSouthwest

Tue 2/248:15 amSTL - RDU

Nonstop1h 50mSouthwest

Deal found 12/16

$293

Fri 2/66:10 amRDU - STL

1 stop25h 41mFrontier

Tue 2/103:49 pmSTL - RDU

1 stop21h 09mFrontier

Deal found 12/17

$160

Tue 1/65:08 pmRDU - STL

2 stops30h 25mFrontier

Mon 1/125:11 pmSTL - RDU

1 stop19h 47mFrontier

Deal found 12/16

$162

Fri 2/67:19 pmRDU - STL

2 stops12h 32mMultiple Airlines

Tue 2/103:49 pmSTL - RDU

1 stop21h 09mMultiple Airlines

Deal found 12/17

$188

Thu 1/225:12 pmRDU - STL

1 stop7h 21mFrontier

Mon 1/2610:16 amSTL - RDU

1 stop9h 45mFrontier

Deal found 12/17

$162

Fri 2/67:05 amRDU - MCI

Nonstop3h 09mDelta

Mon 2/97:59 pmMCI - RDU

Nonstop2h 25mDelta

Deal found 12/16

$199

Mon 2/26:10 amRDU - MCI

1 stop6h 40mFrontier

Sat 2/2810:00 amMCI - RDU

1 stop20h 00mFrontier

Deal found 12/15

$164

Thu 2/127:10 amRDU - MCI

Nonstop3h 07mDelta

Sun 3/17:59 pmMCI - RDU

Nonstop2h 23mDelta

Deal found 12/15

$199

Sat 1/248:04 amRDU - SGF

1 stop5h 11mAmerican Airlines

Sat 1/311:13 pmSGF - RDU

1 stop6h 35mAmerican Airlines

Deal found 12/17

$231

Thu 2/197:10 amRDU - MCI

Nonstop3h 07mDelta

Sun 3/157:59 pmMCI - RDU

Nonstop2h 25mDelta

Deal found 12/16

$199

Sun 1/184:07 pmRDU - JLN

1 stop8h 23mUnited Airlines

Sat 1/318:52 amJLN - RDU

1 stop7h 22mUnited Airlines

Deal found 12/17

$264

Mon 2/25:59 pmRDU - MCI

1 stop5h 03mDelta

Sat 2/287:59 pmMCI - RDU

Nonstop2h 23mDelta

Deal found 12/15

$209

Sat 1/241:29 pmRDU - SGF

2 stops9h 15mUnited Airlines

Sat 1/317:45 amSGF - RDU

2 stops9h 12mUnited Airlines

Deal found 12/17

$269

Sun 2/16:00 amRDU - MCI

1 stop6h 00mDelta

Sat 2/287:59 pmMCI - RDU

Nonstop2h 23mDelta

Deal found 12/15

$209

Thu 1/295:35 pmRDU - STL

Nonstop2h 20mSouthwest

Wed 2/48:15 amSTL - RDU

Nonstop1h 50mSouthwest

Deal found 12/16

$312

Sat 1/318:03 amRDU - SGF

1 stop9h 19mUnited Airlines

Wed 2/43:00 pmSGF - RDU

1 stop6h 30mUnited Airlines

Deal found 12/15

$301

Thu 1/2910:00 amRDU - STL

1 stop5h 30mUnited Airlines

Thu 2/58:30 amSTL - RDU

1 stop4h 36mUnited Airlines

Deal found 12/17

$311

Sun 1/412:56 pmRDU - STL

2 stops20h 16mFrontier

Tue 1/65:11 pmSTL - RDU

1 stop22h 41mFrontier

Deal found 12/16

$307

Mon 1/125:18 pmRDU - STL

1 stop6h 40mUnited Airlines

Thu 1/157:00 amSTL - RDU

1 stop8h 21mUnited Airlines

Deal found 12/17

$311

Tue 2/1010:00 amRDU - COU

1 stop5h 35mUnited Airlines

Sat 2/143:10 pmCOU - RDU

1 stop5h 04mUnited Airlines

Deal found 12/16

$328

Wed 1/76:15 amRDU - COU

1 stop5h 27mUnited Airlines

Sat 1/1011:17 amCOU - RDU

1 stop4h 57mUnited Airlines

Deal found 12/15

$328

Wed 3/41:26 pmRDU - JLN

1 stop5h 12mUnited Airlines

Mon 3/98:54 amJLN - RDU

1 stop7h 23mUnited Airlines

Deal found 12/17

$334

Sat 1/104:07 pmRDU - JLN

1 stop8h 23mUnited Airlines

Tue 1/138:52 amJLN - RDU

1 stop7h 12mUnited Airlines

Deal found 12/16

$334

Fri 6/55:22 amRDU - TBN

1 stop7h 28mMultiple Airlines

Sun 6/72:30 pmTBN - RDU

1 stop9h 02mMultiple Airlines

Deal found 12/17

$9,904

Last-minute flights from Durham to Missouri
Discover last-minute flight deals from Durham to Missouri. Data last updated December 18, 2025 and is based on user searches.

Tue 1/64:20 pmRDU - STL

1 stop7h 13mFrontier

Mon 1/125:11 pmSTL - RDU

1 stop19h 47mFrontier

Deal found 12/16

$175

Wed 1/75:10 pmRDU - STL

1 stop6h 23mMultiple Airlines

Thu 1/83:43 pmSTL - RDU

1 stop7h 29mMultiple Airlines

Deal found 12/17

$150

Wed 1/75:50 pmRDU - MCI

1 stop17h 41mMultiple Airlines

Fri 1/911:26 amMCI - RDU

2 stops11h 46mMultiple Airlines

Deal found 12/17

$176

Thu 1/83:08 pmRDU - MCI

1 stop20h 23mSpirit Airlines

Sun 1/1111:26 amMCI - RDU

1 stop25h 47mSpirit Airlines

Deal found 12/17

$167

Mon 1/128:45 amRDU - STL

1 stop8h 20mFrontier

Wed 1/148:32 pmSTL - RDU

1 stop10h 55mFrontier

Deal found 12/17

$162

Tue 1/136:10 amRDU - STL

1 stop25h 41mMultiple Airlines

Tue 1/205:42 pmSTL - RDU

1 stop16h 18mMultiple Airlines

Deal found 12/16

$152

Tue 1/132:53 pmRDU - STL

1 stop8h 41mFrontier

Tue 1/205:42 pmSTL - RDU

2 stops29h 09mFrontier

Deal found 12/16

$174

Thu 1/152:48 pmRDU - STL

1 stop8h 46mFrontier

Mon 1/198:32 pmSTL - RDU

1 stop26h 19mFrontier

Deal found 12/15

$154

Fri 1/163:22 pmRDU - STL

1 stop16h 29mFrontier

Mon 1/198:32 pmSTL - RDU

1 stop26h 19mFrontier

Deal found 12/16

$142

Thu 1/299:36 pmRDU - STL

1 stop13h 47mFrontier

Wed 2/43:46 pmSTL - RDU

2 stops23h 31mFrontier

Deal found 12/16

$164

Thu 1/293:08 pmRDU - MCI

1 stop20h 23mMultiple Airlines

Wed 2/45:04 pmMCI - RDU

1 stop26h 47mMultiple Airlines

Deal found 12/16

$178

Fri 1/306:10 amRDU - STL

1 stop25h 41mFrontier

Mon 2/25:42 pmSTL - RDU

1 stop19h 17mFrontier

Deal found 12/16

$147

One-way flights from Durham to Missouri
Search for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Tue 2/32:54 pmRDU - STL

1 stop9h 39mFrontier

Deal found 12/16

$63

Tue 2/102:53 pmRDU - STL

1 stop8h 34mFrontier

Deal found 12/16

$64

Tue 1/64:20 pmRDU - STL

1 stop7h 13mFrontier

Deal found 12/16

$67

Wed 1/78:14 pmRDU - STL

1 stop27h 19mFrontier

Deal found 12/17

$68

Sun 1/189:22 amRDU - STL

1 stop22h 29mFrontier

Deal found 12/16

$69

Sat 2/78:16 pmRDU - STL

1 stop12h 48mFrontier

Deal found 12/16

$70

Mon 1/58:14 pmRDU - STL

1 stop27h 19mFrontier

Deal found 12/16

$71

Sun 2/19:56 pmRDU - STL

1 stop26h 37mFrontier

Deal found 12/16

$74

Fri 2/276:54 pmRDU - STL

1 stop12h 57mFrontier

Deal found 12/17

$75

Sun 1/256:10 amRDU - STL

1 stop25h 41mFrontier

Deal found 12/17

$76

Thu 1/1510:11 pmRDU - STL

1 stop10h 43mFrontier

Deal found 12/17

$80

Mon 1/126:10 amRDU - MCI

1 stop4h 59mFrontier

Deal found 12/16

$81

Find flight deals from Durham to Missouri

Most accurate provider	CheapOair 3 stars
Most trusted provider	CheapOair 3 stars
Round-trip from	$133 (Kiwi.com)
One-way from	$63 (Trip.com)
Popular in	September
Cheapest in	January
Average price	$374

Provider with most accurate pricing for Raleigh-Durham-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Raleigh-Durham-Lambert-St Louis flights.

Search Deals

From Durham to Missouri

Search Deals

One-way flight from Durham to Missouri

Search Deals

Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Thu 1/15

2:48 pm-10:34 pm

1 stop8h 46m

Lambert-St Louis

Mon 1/19

8:32 pm-11:51 pm

1 stop26h 19m

$154

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Fri 2/6

6:10 am-6:51 am

1 stop25h 41m

Lambert-St Louis

Tue 2/10

3:49 pm-1:58 pm

1 stop21h 09m

$160

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Tue 1/6

5:08 pm-10:33 pm

2 stops30h 25m

Lambert-St Louis

Mon 1/12

5:11 pm-1:58 pm

1 stop19h 47m

$162

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Thu 1/22

5:12 pm-11:33 pm

1 stop7h 21m

Lambert-St Louis

Mon 1/26

10:16 am-9:01 pm

1 stop9h 45m

$162

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Mon 2/2

6:10 am-11:50 am

1 stop6h 40m

Kansas City

Sat 2/28

10:00 am-7:00 am

1 stop20h 00m

$164

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Fri 1/30

7:19 pm-6:51 am

2 stops12h 32m

Lambert-St Louis

Mon 2/2

5:42 pm-1:59 pm

1 stop19h 17m

$175

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Fri 2/6

7:19 pm-6:51 am

2 stops12h 32m

Lambert-St Louis

Tue 2/10

3:49 pm-1:58 pm

1 stop21h 09m

$188

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Thu 1/15

3:08 pm-10:31 am

1 stop20h 23m

Kansas City

Thu 1/22

11:26 am-2:13 pm

1 stop25h 47m

$195

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 1/23

7:05 am-9:14 am

Nonstop3h 09m

Kansas City

Fri 1/30

7:59 pm-11:24 pm

Nonstop2h 25m

$199

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 2/6

7:05 am-9:14 am

Nonstop3h 09m

Kansas City

Mon 2/9

7:59 pm-11:24 pm

Nonstop2h 25m

$199

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 56 results

...

Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 23% on airfare.

What is the cheapest day to fly from Durham to Missouri?

Travelers seeking maximum savings on their Durham to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,250 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,005 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,091 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,054 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Frontier

5.8

Fair

3,081 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How popular is this Durham to Missouri flight route?
Within the past month, 2 users have taken a look at flights from Durham to Missouri.
How long is the flight from Durham to Missouri?
A quick flight from Durham to Missouri can take about 3h 09m. Frontier provides one of the quickest options available for as low as $199. There are 902 mi between Durham and Missouri. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Durham to Missouri one-way?
To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $55. Delta flights start at $88 while deals on Southwest start at $98 one-way.
What are the most popular routes from Durham to Missouri?
When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Kansas City, Raleigh-Durham - Lambert-St Louis or Raleigh-Durham - Springfield-Branson as they are the most popular.
What are the most reliable airlines from Durham to Missouri?
Before booking your flight to Missouri from Durham, check out the most reliable airlines to get you to your destination on time: Delta (79%), Endeavor Airlines (79%), Southwest( 33%).
What are the cheapest flights from Durham to Missouri?
Looking for the cheapest flight from Durham to Missouri? While on average our users pay $341, our data indicates the cheapest price to be $148. The most popular route (Raleigh-Durham - Kansas City), is priced around $178.
Can I find deals for flights from Durham to Missouri that include hotel bookings?
Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Durham to Missouri?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.
Can I find deals for business class flights from Durham to Missouri?
Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Durham to Missouri?
Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Missouri car rentals

Kansas City Airport car rentals

Lambert-St Louis Airport car rentals

Springfield-Branson Airport car rentals

Columbia Regional Airport car rentals

Joplin Airport car rentals

Cape Girardeau Airport car rentals

Fort Leonard Wood Waynesville Regional Airport car rentals

Kirksville Cannon Memorial Airport car rentals

St. Louis car rentals

Kansas City car rentals

Springfield car rentals

Top 5 airlines flying from Durham to Missouri

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$138	Average$247	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$162	Average$333	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$176	Average$396	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$196	Average$381	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$196	Average$330	FlexibilityNo cancel fee	On-time69%

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$63+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Durham to Missouri

Cheapest flights from Durham to MissouriExplore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated December 18, 2025.

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Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.

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Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

What is the cheapest day to fly from Durham to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Durham to Missouri. Price data was last updated on December 16, 2024.

Reviews of airlines servicing Missouri

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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What is the cheapest month to book a flight from Durham to Missouri?

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Alternative routes for Durham to Missouri

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Top 5 airlines flying from Durham to Missouri

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Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.