HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Missouri

$65+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Durham to Missouri with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated junio 12, 2025.

Round-trip from

$139
(FlightHub)

One-way from

$65
(FlightHub)

Popular in

January

Cheapest in

July

Average price

$294
From Durham to Missouri
Search Deals
One-way flight from Durham to Missouri
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This FlightHub deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/710:36 amRDU - STL
1 stop8h 42mSpirit Airlines
jue. 7/1710:47 amSTL - RDU
1 stop4h 25mSpirit Airlines
Deal found 6/11$139
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/97:30 amRDU - MCI
Nonstop2h 43mDelta
sáb. 7/127:57 pmMCI - RDU
Nonstop2h 26mDelta
Deal found 6/9$177
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/126:20 amRDU - MCI
1 stop4h 05mSouthwest
lun. 7/146:10 pmMCI - RDU
1 stop3h 55mSouthwest
Deal found 6/10$192
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/36:00 amRDU - MCI
1 stop7h 27mAmerican Airlines
dom. 10/54:34 pmMCI - RDU
1 stop5h 21mAmerican Airlines
Deal found 6/12$198
This Booking.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/1812:51 pmRDU - STL
1 stop11h 56mMultiple Airlines
dom. 7/2010:47 amSTL - RDU
1 stop4h 25mMultiple Airlines
Deal found 6/9$207
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/165:00 pmRDU - MCI
1 stop6h 00mUnited Airlines
sáb. 7/196:00 amMCI - RDU
1 stop5h 27mUnited Airlines
Deal found 6/11$222
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/114:07 pmRDU - SGF
1 stop6h 01mAmerican Airlines
sáb. 10/182:06 pmSGF - RDU
1 stop6h 58mAmerican Airlines
Deal found 6/12$231
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/244:55 pmRDU - SGF
1 stop6h 02mUnited Airlines
mar. 9/303:11 pmSGF - RDU
2 stops7h 41mUnited Airlines
Deal found 6/11$236
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/911:07 amRDU - SGF
1 stop5h 05mDelta
lun. 7/146:56 pmSGF - RDU
1 stop4h 24mDelta
Deal found 6/11$249
This FlightHub deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/310:35 amRDU - MCI
1 stop24h 35mSpirit Airlines
jue. 7/1010:30 amMCI - RDU
1 stop4h 42mSpirit Airlines
Deal found 6/9$256
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/78:05 amRDU - STL
Nonstop2h 05mSouthwest
lun. 8/117:50 amSTL - RDU
Nonstop1h 55mSouthwest
Deal found 6/12$257
This FlightHub deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/85:07 pmRDU - STL
1 stop21h 52mFrontier
dom. 8/102:36 pmSTL - RDU
1 stop24h 36mFrontier
Deal found 6/12$269

Cheapflights Fare Finder

Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.

Fly from

Durham

Fly to

Missouri

Route

Depart

Return

Price

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

lun. 7/7

10:36 am-6:18 pm

1 stop8h 42m

Lambert-St Louis

jue. 7/17

10:47 am-4:12 pm

1 stop4h 25m

$139

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

mié. 7/9

7:30 am-9:13 am

Nonstop2h 43m

Kansas City

lun. 7/21

7:57 pm-11:23 pm

Nonstop2h 26m

$177

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

sáb. 7/12

6:20 am-9:25 am

1 stop4h 05m

Kansas City

mar. 7/15

5:20 am-11:10 am

1 stop4h 50m

$192

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

vie. 10/3

6:00 am-12:27 pm

1 stop7h 27m

Kansas City

dom. 10/5

4:34 pm-10:55 pm

1 stop5h 21m

$198

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

vie. 7/18

12:51 pm-11:47 pm

1 stop11h 56m

Lambert-St Louis

dom. 7/20

10:47 am-4:12 pm

1 stop4h 25m

$207

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

mié. 7/16

5:00 pm-10:00 pm

1 stop6h 00m

Kansas City

sáb. 7/19

6:00 am-12:27 pm

1 stop5h 27m

$222

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

mié. 7/23

5:00 pm-9:53 pm

1 stop5h 53m

Springfield-Branson

mié. 7/30

8:40 am-3:50 pm

1 stop6h 10m

$231

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

jue. 8/28

5:25 am-9:34 am

1 stop5h 09m

Springfield-Branson

mar. 9/2

5:47 pm-11:59 pm

1 stop5h 12m

$240

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

mié. 7/9

11:07 am-3:12 pm

1 stop5h 05m

Springfield-Branson

lun. 7/14

6:56 pm-12:20 am

1 stop4h 24m

$249

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

jue. 7/3

10:35 am-10:10 am

1 stop24h 35m

Kansas City

jue. 7/10

10:30 am-4:12 pm

1 stop4h 42m

$256

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 35 results
1
2
3
4

Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from Durham to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated junio 12, 2025.
To help decide which airline to fly from Durham to Missouri, see what other customers have to say about Southwest, Delta and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,946 reviews
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Spirit Airlines
6.3
Okay
8,052 reviews
Southwest
8.0
Very good
4,287 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Missouri flight route?

    Within the past month, 22 users have taken a look at flights from Durham to Missouri.

  • What are the cheapest airlines to fly from Durham to Missouri one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $65. Delta flights start at $89 while deals on Southwest start at $94 one-way.

  • What are the most popular routes from Durham to Missouri?

    When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Kansas City, Raleigh-Durham - Lambert-St Louis or Raleigh-Durham - Springfield-Branson as they are the most popular.

  • What are the cheapest flights from Durham to Missouri?

    Looking for the cheapest flight from Durham to Missouri? While on average our users pay $282, our data indicates the cheapest price to be $119. The most popular route (Raleigh-Durham - Kansas City), is priced around $157.

  • Can I find deals for flights from Durham to Missouri that include hotel bookings?

    Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

  • Can I find deals for business class flights from Durham to Missouri?

    Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Durham to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
Raleigh to LaGuardia flights
Raleigh to Seattle flights
Raleigh to O'Hare Intl flights
Charlotte to John F Kennedy Intl flights
Charlotte to Denver flights
Charlotte to LaGuardia flights
Raleigh to Boston flights
Raleigh to John F Kennedy Intl flights
Raleigh to Denver flights
Raleigh to Newark flights
Charlotte to Newark flights
Raleigh to Las Vegas flights
Raleigh to Miami flights
Charlotte to O'Hare Intl flights
Charlotte to Boston flights
Raleigh to Orlando flights
Charlotte to Seattle flights
Raleigh to Hobby flights
Charlotte to Hobby flights
Charlotte to Dallas/Fort Worth flights
Raleigh to Dallas/Fort Worth flights
Raleigh to Fort Lauderdale flights
Raleigh to Atlanta flights
Charlotte to Fort Lauderdale flights
Charlotte to Las Vegas flights
Raleigh to Los Angeles flights
Charlotte to George Bush Intcntl flights
Raleigh to Nashville flights
Charlotte to Orlando flights
Raleigh to George Bush Intcntl flights
Raleigh to San Francisco flights
Charlotte to Miami flights
Raleigh to Providence flights
Charlotte to San Francisco flights
Charlotte to Dulles Intl flights
Greensboro to Newark flights
Greensboro to O'Hare Intl flights
Norfolk to Seattle flights
Raleigh to White Plains flights
Charlotte to Salt Lake City flights
Charlotte to Minneapolis flights
Raleigh to Tampa flights
Greensboro to LaGuardia flights
Raleigh to Love Field flights
Charlotte to Detroit flights
Norfolk to Atlanta flights
Greensboro to Denver flights
Norfolk to John F Kennedy Intl flights
Charlotte to Reagan-National flights
Raleigh to Salt Lake City flights

Top 5 airlines flying from Durham to Missouri

Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$85Average$214FlexibilityNo cancel feeOn-time62%
DeltaCheapest$165Average$331FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$176Average$379FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$186Average$410FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$196Average$339FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.