$63+ Cheap flights from Durham, NC to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Apr 28 — May 51
Round-trip
1 adult, Economy
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Cheapest flights from Durham to MissouriExplore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:10 am
RDU
- MCI
1 stop5h 24m
Frontier
Mon 4/2711:13 am
MCI
- RDU
1 stop11h 12m
Frontier
Deal found 3/26![Frontier logo]()
$140
This Expedia deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:26 pm
RDU
- STL
1 stop7h 57m
Frontier
Mon 5/114:19 pm
STL
- RDU
1 stop16h 02m
Frontier
Deal found 3/26![Frontier logo]()
$140
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:51 pm
RDU
- STL
1 stop6h 28m
Frontier
Mon 4/274:59 pm
STL
- RDU
1 stop22h 57m
Frontier
Deal found 3/25![Frontier logo]()
$141
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:26 pm
RDU
- STL
1 stop7h 57m
Frontier
Sat 5/98:08 pm
STL
- RDU
1 stop14h 23m
Frontier
Deal found 3/27![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Tue 5/122:34 pm
MCI
- RDU
1 stop19h 57m
Frontier
Deal found 3/25![Frontier logo]()
$154
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
RDU
- MCI
1 stop10h 36m
Frontier
Thu 4/3011:53 am
MCI
- RDU
1 stop10h 27m
Frontier
Deal found 3/26![Frontier logo]()
$160
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:11 pm
RDU
- STL
1 stop6h 08m
Frontier
Tue 5/56:41 pm
STL
- RDU
1 stop4h 52m
Frontier
Deal found 3/24![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:10 am
RDU
- MCI
1 stop5h 24m
Frontier
Sun 4/2611:53 am
MCI
- RDU
1 stop19h 53m
Frontier
Deal found 3/26![Frontier logo]()
$163
This Priceline deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Mon 5/256:24 pm
MCI
- RDU
1 stop5h 00m
Frontier
Deal found 3/27![Frontier logo]()
$165
This Priceline deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:54 pm
RDU
- STL
1 stop5h 00m
Frontier
Thu 5/216:33 pm
STL
- RDU
1 stop4h 51m
Frontier
Deal found 3/26![Frontier logo]()
$165
This CheapOair deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:43 pm
RDU
- STL
1 stop12h 11m
Frontier
Mon 4/204:59 pm
STL
- RDU
1 stop22h 57m
Frontier
Deal found 3/29![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:26 pm
RDU
- MCI
1 stop26h 23m
Frontier
Wed 5/136:24 pm
MCI
- RDU
1 stop16h 35m
Frontier
Deal found 3/26![Frontier logo]()
$172
Best flights from Durham to MissouriDiscover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
Discover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Tue 5/510:15 am
STL
- RDU
Nonstop1h 50m
Southwest
Deal found 3/24![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:25 am
RDU
- MCI
1 stop6h 36m
Delta
Mon 4/277:59 pm
MCI
- RDU
Nonstop2h 31m
Delta
Deal found 3/26![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:42 am
RDU
- SGF
2 stops8h 59m
United Airlines
Tue 8/256:00 am
SGF
- RDU
1 stop5h 33m
United Airlines
Deal found 3/28![United Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:45 am
RDU
- SGF
1 stop5h 06m
American Airlines
Sat 4/185:19 am
SGF
- RDU
1 stop4h 52m
American Airlines
Deal found 3/29![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/119:25 pm
RDU
- TBN
2 stops15h 20m
Multiple Airlines
Wed 4/1512:15 pm
TBN
- RDU
1 stop26h 08m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:40 am
RDU
- STL
1 stop6h 45m
Southwest
Tue 4/2110:15 am
STL
- RDU
Nonstop1h 50m
Southwest
Deal found 3/25![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Mon 5/44:40 pm
STL
- RDU
1 stop4h 05m
Southwest
Deal found 3/24![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:15 am
RDU
- COU
1 stop5h 40m
United Airlines
Sat 8/223:05 pm
COU
- RDU
1 stop5h 41m
United Airlines
Deal found 3/25![United Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:33 am
RDU
- MCI
1 stop5h 06m
Delta
Tue 6/167:56 pm
MCI
- RDU
Nonstop2h 34m
Delta
Deal found 3/26![Delta logo]()
$333
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:25 pm
RDU
- COU
1 stop5h 36m
United Airlines
Mon 4/205:00 am
COU
- RDU
1 stop6h 10m
United Airlines
Deal found 3/26![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:25 am
RDU
- STL
Nonstop2h 10m
Southwest
Mon 5/114:00 pm
STL
- RDU
1 stop6h 10m
Southwest
Deal found 3/26![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:40 pm
RDU
- SGF
1 stop4h 31m
Delta
Mon 4/136:55 pm
SGF
- RDU
1 stop4h 23m
Delta
Deal found 3/24![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:42 am
RDU
- COU
2 stops12h 07m
United Airlines
Sat 8/1511:30 am
COU
- RDU
1 stop4h 43m
United Airlines
Deal found 3/25![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
RDU
- COU
2 stops9h 58m
American Airlines
Wed 4/226:00 am
COU
- RDU
1 stop5h 58m
American Airlines
Deal found 3/24![American Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:10 pm
RDU
- MCI
1 stop6h 26m
Delta
Sun 5/247:59 pm
MCI
- RDU
Nonstop2h 29m
Delta
Deal found 3/28![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:15 am
RDU
- MCI
1 stop6h 15m
Southwest
Sun 4/264:00 pm
MCI
- RDU
Nonstop2h 15m
Southwest
Deal found 3/25![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:25 pm
RDU
- COU
1 stop8h 08m
United Airlines
Tue 4/145:00 am
COU
- RDU
1 stop6h 10m
United Airlines
Deal found 3/26![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:28 pm
RDU
- COU
1 stop7h 18m
American Airlines
Sun 6/217:16 am
COU
- RDU
1 stop6h 06m
American Airlines
Deal found 3/27![American Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:55 pm
RDU
- TBN
1 stop17h 50m
Multiple Airlines
Mon 4/272:30 pm
TBN
- RDU
2 stops17h 30m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$472
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:10 am
RDU
- STL
Nonstop2h 10m
Southwest
Sun 4/195:25 am
STL
- RDU
1 stop4h 05m
Southwest
Deal found 3/25![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:23 am
RDU
- MCI
Nonstop2h 52m
Delta
Sun 5/317:59 pm
MCI
- RDU
Nonstop2h 29m
Delta
Deal found 3/28![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:15 am
RDU
- JLN
1 stop7h 57m
United Airlines
Tue 4/148:56 am
JLN
- RDU
2 stops8h 14m
United Airlines
Deal found 3/26![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/277:45 pm
RDU
- STL
Nonstop2h 10m
Southwest
Fri 5/11:45 pm
STL
- RDU
1 stop7h 00m
Southwest
Deal found 3/28![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:25 pm
RDU
- SGF
1 stop5h 39m
United Airlines
Tue 4/143:10 pm
SGF
- RDU
2 stops7h 34m
United Airlines
Deal found 3/26![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:15 pm
RDU
- COU
1 stop7h 25m
American Airlines
Sun 7/266:25 pm
COU
- RDU
1 stop4h 34m
American Airlines
Deal found 3/27![American Airlines logo]()
$489
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:40 pm
RDU
- STL
1 stop6h 30m
Southwest
Mon 6/87:55 pm
STL
- RDU
Nonstop1h 50m
Southwest
Deal found 3/25![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:23 am
RDU
- MCI
Nonstop2h 52m
Delta
Sun 5/177:59 pm
MCI
- RDU
Nonstop2h 29m
Delta
Deal found 3/25![Delta logo]()
$413
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/253:01 pm
RDU
- MCI
1 stop8h 27m
Delta
Tue 6/307:56 pm
MCI
- RDU
Nonstop2h 34m
Delta
Deal found 3/28![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
RDU
- SGF
2 stops8h 35m
United Airlines
Sat 5/28:50 am
SGF
- RDU
1 stop6h 05m
United Airlines
Deal found 3/28![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:20 am
RDU
- MCI
1 stop6h 50m
Southwest
Thu 7/165:20 pm
MCI
- RDU
1 stop6h 40m
Southwest
Deal found 3/28![Southwest logo]()
$359
Last-minute flights from Durham to MissouriDiscover last-minute flight deals from Durham to Missouri. Data last updated March 29, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Missouri. Data last updated March 29, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
RDU
- MCI
1 stop10h 36m
Frontier
Thu 4/3011:53 am
MCI
- RDU
1 stop10h 27m
Frontier
Deal found 3/26![Frontier logo]()
$160
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
RDU
- MCI
1 stop10h 36m
Frontier
Thu 4/1611:53 am
MCI
- RDU
1 stop10h 02m
Frontier
Deal found 3/27![Frontier logo]()
$180
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 pm
RDU
- STL
1 stop25h 26m
Frontier
Mon 4/204:59 pm
STL
- RDU
1 stop18h 55m
Frontier
Deal found 3/25![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:10 am
RDU
- STL
1 stop5h 20m
Frontier
Mon 4/204:59 pm
STL
- RDU
1 stop18h 55m
Frontier
Deal found 3/27![Frontier logo]()
$171
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:10 am
RDU
- MCI
1 stop5h 24m
Frontier
Fri 5/111:19 am
MCI
- RDU
1 stop11h 24m
Frontier
Deal found 3/26![Frontier logo]()
$140
This Expedia deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:43 pm
RDU
- STL
1 stop27h 36m
Frontier
Wed 4/228:23 pm
STL
- RDU
1 stop11h 00m
Frontier
Deal found 3/25![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:10 am
RDU
- MCI
1 stop5h 24m
Frontier
Sun 4/2611:53 am
MCI
- RDU
1 stop19h 53m
Frontier
Deal found 3/26![Frontier logo]()
$163
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:51 pm
RDU
- STL
1 stop6h 28m
Frontier
Mon 4/274:59 pm
STL
- RDU
1 stop22h 57m
Frontier
Deal found 3/25![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:31 pm
RDU
- MCI
1 stop16h 27m
Frontier
Mon 4/2711:13 am
MCI
- RDU
1 stop11h 12m
Frontier
Deal found 3/26![Frontier logo]()
$179
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:11 pm
RDU
- STL
1 stop6h 08m
Frontier
Tue 5/56:41 pm
STL
- RDU
1 stop4h 52m
Frontier
Deal found 3/24![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:00 pm
RDU
- MCI
1 stop19h 58m
Frontier
Wed 5/136:24 pm
MCI
- RDU
1 stop16h 35m
Frontier
Deal found 3/26![Frontier logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:00 pm
RDU
- MCI
1 stop19h 58m
Frontier
Tue 5/122:34 pm
MCI
- RDU
1 stop19h 57m
Frontier
Deal found 3/26![Frontier logo]()
$178
One-way flights from Durham to MissouriSearch for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
Search for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Deal found 3/28![Frontier logo]()
$63
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:10 am
RDU
- MCI
1 stop5h 48m
Frontier
Deal found 3/27![Frontier logo]()
$70
This Priceline deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:11 pm
RDU
- STL
1 stop6h 08m
Frontier
Deal found 3/26![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:10 pm
RDU
- STL
1 stop10h 09m
Frontier
Deal found 3/29![Frontier logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:00 pm
RDU
- MCI
1 stop19h 58m
Frontier
Deal found 3/25![Frontier logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:15 am
RDU
- STL
1 stop27h 40m
Frontier
Deal found 3/27![Frontier logo]()
$78
This Travelocity deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:54 am
RDU
- STL
1 stop13h 25m
Frontier
Deal found 3/24![Frontier logo]()
$79
This WAYA deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:10 am
RDU
- MCI
1 stop5h 48m
Frontier
Deal found 3/27![Frontier logo]()
$81
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:54 pm
RDU
- MCI
1 stop29h 35m
Frontier
Deal found 3/25![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:54 pm
RDU
- STL
1 stop21h 01m
Frontier
Deal found 3/25![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/214:00 pm
RDU
- STL
1 stop15h 50m
Frontier
Deal found 3/24![Frontier logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:10 am
RDU
- STL
1 stop25h 40m
Frontier
Deal found 3/28![Frontier logo]()
$89
Find flight deals from Durham to Missouri
Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated March 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $140 (Frontier) |
One-way from | $63 (Kiwi.com) |
Popular in | September |
Cheapest in | October |
Average price | $411 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Wed 4/29
6:45 pm-8:00 pm
Nonstop2h 15m
Lambert-St Louis
Tue 5/5
10:15 am-1:05 pm
Nonstop1h 50m
$263
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Wed 4/15
5:40 am-11:25 am
1 stop6h 45m
Lambert-St Louis
Tue 4/21
10:15 am-1:05 pm
Nonstop1h 50m
$268
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Wed 4/29
6:45 pm-8:00 pm
Nonstop2h 15m
Lambert-St Louis
Mon 5/4
4:40 pm-9:45 pm
1 stop4h 05m
$269
RaleighKansas City
RDU - MCI
RDUMCI
Raleigh-Durham
Sat 4/25
7:25 am-1:01 pm
1 stop6h 36m
Kansas City
Mon 4/27
7:59 pm-11:30 pm
Nonstop2h 31m
$271
RaleighSpringfield
RDU - SGF
RDUSGF
Raleigh-Durham
Sat 8/22
10:42 am-6:41 pm
2 stops8h 59m
Springfield-Branson
Tue 8/25
6:00 am-12:33 pm
1 stop5h 33m
$296
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Thu 5/7
6:25 am-7:35 am
Nonstop2h 10m
Lambert-St Louis
Mon 5/11
4:00 pm-11:10 pm
1 stop6h 10m
$302
RaleighColumbia
RDU - COU
RDUCOU
Raleigh-Durham
Tue 8/18
6:15 am-10:55 am
1 stop5h 40m
Columbia Regional
Sat 8/22
3:05 pm-9:46 pm
1 stop5h 41m
$318
RaleighColumbia
RDU - COU
RDUCOU
Raleigh-Durham
Fri 4/17
5:25 pm-10:01 pm
1 stop5h 36m
Columbia Regional
Mon 4/20
5:00 am-12:10 pm
1 stop6h 10m
$318
RaleighKansas City
RDU - MCI
RDUMCI
Raleigh-Durham
Thu 4/23
5:15 am-10:30 am
1 stop6h 15m
Kansas City
Sun 4/26
4:00 pm-7:15 pm
Nonstop2h 15m
$318
RaleighColumbia
RDU - COU
RDUCOU
Raleigh-Durham
Tue 8/11
10:42 am-9:49 pm
2 stops12h 07m
Columbia Regional
Sat 8/15
11:30 am-5:13 pm
1 stop4h 43m
$324
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Durham to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
RDU-MCI
RDU-STL
RDU-SGF
RDU-TBN
RDU-COU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Missouri
DU8-USMO
RDU-MCI
RDU-STL
RDU-SGF
RDU-TBN
What is the cheapest month to book a flight from Durham to Missouri?
Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $214). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DU8 to MO?
Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 29, 2026.
One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the morning could potentially save you up to 57% on airfare.
How much does it cost to fly round-trip from Durham to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 29, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Durham to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Durham to Missouri by cabin class
Find flights from Durham to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Durham and Missouri flights
Browse other Durham and Missouri flight options. Last updated on March 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Durham after your stay in Missouri
Durham to Missouri flights
Consider these flights traveling from Durham to Missouri.
Top 5 airlines flying from Durham to Missouri
Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$141 | Average$244 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$176 | Average$375 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$177 | Average$321 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$180 | Average$321 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$196 | Average$374 | FlexibilityNo cancel fee | On-time63% |