$59+ Cheap flights from Durham, NC to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Durham to Missouri with Cheapflights
1. Tell us where you want to go
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Cheapest flights from Durham to MissouriExplore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:20 am
RDU
- STL
1 stop25h 31m
Frontier
Wed 2/188:17 pm
STL
- RDU
1 stop20h 38m
Frontier
Deal found 2/3![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:54 pm
RDU
- STL
1 stop12h 57m
Frontier
Mon 2/233:49 pm
STL
- RDU
1 stop21h 09m
Frontier
Deal found 1/31![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Sat 2/288:17 pm
STL
- RDU
1 stop26h 53m
Frontier
Deal found 2/1![Frontier logo]()
$132
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:54 pm
RDU
- STL
1 stop5h 33m
Frontier
Tue 3/33:49 pm
STL
- RDU
1 stop24h 10m
Frontier
Deal found 2/1![Frontier logo]()
$139
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:04 pm
RDU
- STL
1 stop8h 55m
Frontier
Sat 2/2812:36 pm
STL
- RDU
1 stop6h 54m
Frontier
Deal found 2/1![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:50 pm
RDU
- MCI
1 stop16h 13m
Frontier
Sun 3/110:53 am
MCI
- RDU
1 stop12h 17m
Frontier
Deal found 2/1![Frontier logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:10 am
RDU
- MCI
1 stop28h 43m
Frontier
Sun 3/110:53 am
MCI
- RDU
1 stop28h 22m
Frontier
Deal found 2/1![Frontier logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:25 am
RDU
- STL
1 stop25h 26m
Frontier
Fri 2/138:20 pm
STL
- RDU
1 stop26h 50m
Frontier
Deal found 2/2![Frontier logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Sat 2/219:41 am
STL
- RDU
1 stop9h 49m
Frontier
Deal found 2/2![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:54 pm
RDU
- STL
1 stop12h 57m
Multiple Airlines
Mon 2/238:22 pm
STL
- RDU
2 stops19h 49m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/154:07 pm
RDU
- STL
1 stop22h 27m
Frontier
Fri 3/2012:16 pm
STL
- RDU
1 stop10h 55m
Frontier
Deal found 2/3![Frontier logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:08 pm
RDU
- STL
2 stops13h 43m
Multiple Airlines
Sat 2/288:17 pm
STL
- RDU
1 stop26h 53m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$160
Best flights from Durham to MissouriDiscover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Sat 2/288:17 pm
STL
- RDU
2 stops19h 57m
Frontier
Deal found 2/1![Frontier logo]()
$161
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:33 am
RDU
- SGF
1 stop4h 27m
Delta
Sat 4/184:00 pm
SGF
- RDU
1 stop5h 11m
Delta
Deal found 2/1![Delta logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/49:25 pm
RDU
- STL
1 stop14h 05m
Multiple Airlines
Tue 4/74:54 pm
STL
- RDU
2 stops21h 08m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$252
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:41 pm
RDU
- SGF
1 stop5h 50m
American Airlines
Wed 2/256:05 pm
SGF
- RDU
1 stop4h 54m
American Airlines
Deal found 2/2![American Airlines logo]()
$274
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2110:00 am
RDU
- SGF
1 stop5h 40m
United Airlines
Sat 2/282:53 pm
SGF
- RDU
1 stop6h 40m
United Airlines
Deal found 2/3![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/84:25 pm
RDU
- MCI
Nonstop2h 45m
Southwest
Wed 3/115:00 pm
MCI
- RDU
1 stop4h 10m
Southwest
Deal found 2/2![Southwest logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
RDU
- STL
1 stop6h 49m
Frontier
Sun 3/87:52 am
STL
- RDU
1 stop24h 51m
Frontier
Deal found 2/1![Frontier logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Fri 2/273:49 pm
STL
- RDU
1 stop15h 03m
Frontier
Deal found 2/1![Frontier logo]()
$190
This Orbitz deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:46 pm
RDU
- STL
1 stop16h 05m
Frontier
Mon 4/138:16 pm
STL
- RDU
1 stop19h 49m
Frontier
Deal found 2/2![Frontier logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:54 pm
RDU
- STL
1 stop12h 57m
Frontier
Mon 2/168:22 pm
STL
- RDU
1 stop26h 48m
Frontier
Deal found 2/2![Frontier logo]()
$195
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:20 pm
RDU
- SGF
1 stop6h 27m
Delta
Sat 2/286:00 am
SGF
- RDU
1 stop4h 28m
Delta
Deal found 2/2![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:18 am
RDU
- SGF
1 stop8h 39m
United Airlines
Sat 2/283:15 pm
SGF
- RDU
2 stops7h 29m
United Airlines
Deal found 2/2![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:00 am
RDU
- SGF
1 stop6h 24m
American Airlines
Sat 4/186:24 pm
SGF
- RDU
1 stop4h 34m
American Airlines
Deal found 2/2![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:52 pm
RDU
- STL
2 stops13h 58m
Frontier
Sun 4/1911:21 am
STL
- RDU
1 stop11h 54m
Frontier
Deal found 2/3![Frontier logo]()
$210
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:15 pm
RDU
- SGF
2 stops9h 45m
United Airlines
Sat 4/256:30 pm
SGF
- RDU
1 stop5h 00m
United Airlines
Deal found 2/3![United Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
RDU
- MCI
Nonstop2h 56m
Delta
Thu 4/307:59 pm
MCI
- RDU
Nonstop2h 31m
Delta
Deal found 2/3![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:56 am
RDU
- STL
1 stop5h 26m
American Airlines
Sat 4/116:53 pm
STL
- RDU
1 stop4h 05m
American Airlines
Deal found 2/1![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:20 am
RDU
- COU
1 stop5h 35m
United Airlines
Sun 5/1011:32 am
COU
- RDU
1 stop4h 51m
United Airlines
Deal found 2/2![United Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:55 am
RDU
- MCI
Nonstop2h 49m
Delta
Wed 7/16:55 pm
MCI
- RDU
Nonstop2h 27m
Delta
Deal found 2/2![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:00 am
RDU
- SGF
1 stop5h 50m
American Airlines
Sun 3/86:15 pm
SGF
- RDU
1 stop4h 44m
American Airlines
Deal found 2/2![American Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:46 pm
RDU
- STL
1 stop16h 05m
Frontier
Sun 4/511:21 am
STL
- RDU
1 stop11h 54m
Frontier
Deal found 2/2![Frontier logo]()
$242
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:00 am
RDU
- MCI
Nonstop2h 55m
Delta
Mon 3/307:59 pm
MCI
- RDU
Nonstop2h 25m
Delta
Deal found 2/3![Delta logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/172:53 pm
RDU
- TBN
2 stops21h 57m
Multiple Airlines
Sat 2/212:30 pm
TBN
- RDU
1 stop23h 39m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:20 am
RDU
- COU
1 stop5h 35m
United Airlines
Sun 5/1011:32 am
COU
- RDU
1 stop4h 51m
United Airlines
Deal found 2/2![United Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
RDU
- MCI
Nonstop2h 56m
Delta
Sat 4/187:59 pm
MCI
- RDU
Nonstop2h 31m
Delta
Deal found 2/1![Delta logo]()
$299
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/78:16 pm
RDU
- STL
1 stop12h 48m
Frontier
Tue 2/103:49 pm
STL
- RDU
1 stop24h 10m
Frontier
Deal found 2/2![Frontier logo]()
$253
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
RDU
- MCI
Nonstop2h 55m
Delta
Sat 4/117:59 pm
MCI
- RDU
Nonstop2h 25m
Delta
Deal found 2/2![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/44:06 pm
RDU
- JLN
1 stop8h 22m
United Airlines
Wed 3/188:54 am
JLN
- RDU
1 stop7h 23m
United Airlines
Deal found 2/1![United Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:04 pm
RDU
- STL
1 stop8h 55m
Frontier
Thu 2/2610:11 pm
STL
- RDU
2 stops18h 48m
Frontier
Deal found 2/1![Frontier logo]()
$266
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:00 am
RDU
- MCI
Nonstop2h 55m
Delta
Sun 3/227:59 pm
MCI
- RDU
Nonstop2h 25m
Delta
Deal found 2/3![Delta logo]()
$299
Last-minute flights from Durham to MissouriDiscover last-minute flight deals from Durham to Missouri. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Missouri. Data last updated February 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:25 am
RDU
- STL
1 stop25h 26m
Frontier
Fri 2/138:20 pm
STL
- RDU
1 stop26h 50m
Frontier
Deal found 2/2![Frontier logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:20 am
RDU
- STL
1 stop25h 31m
Frontier
Wed 2/188:17 pm
STL
- RDU
1 stop20h 38m
Frontier
Deal found 2/3![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Sat 2/219:41 am
STL
- RDU
1 stop9h 49m
Frontier
Deal found 2/2![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:50 pm
RDU
- MCI
1 stop16h 13m
Frontier
Sun 3/110:53 am
MCI
- RDU
1 stop12h 17m
Frontier
Deal found 2/1![Frontier logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:54 pm
RDU
- STL
1 stop12h 57m
Frontier
Mon 2/233:49 pm
STL
- RDU
1 stop21h 09m
Frontier
Deal found 1/31![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:54 pm
RDU
- STL
1 stop12h 57m
Multiple Airlines
Mon 2/238:22 pm
STL
- RDU
2 stops19h 49m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:10 am
RDU
- MCI
1 stop28h 43m
Frontier
Sun 3/110:53 am
MCI
- RDU
1 stop28h 22m
Frontier
Deal found 2/1![Frontier logo]()
$152
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:04 pm
RDU
- STL
1 stop8h 55m
Frontier
Sat 2/2812:36 pm
STL
- RDU
1 stop6h 54m
Frontier
Deal found 2/1![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Sat 2/288:17 pm
STL
- RDU
1 stop26h 53m
Frontier
Deal found 2/1![Frontier logo]()
$132
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:54 pm
RDU
- STL
1 stop5h 33m
Frontier
Tue 3/33:49 pm
STL
- RDU
1 stop24h 10m
Frontier
Deal found 2/1![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:08 pm
RDU
- STL
2 stops13h 43m
Multiple Airlines
Sat 2/288:17 pm
STL
- RDU
1 stop26h 53m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/154:07 pm
RDU
- STL
1 stop22h 27m
Frontier
Fri 3/2012:16 pm
STL
- RDU
1 stop10h 55m
Frontier
Deal found 2/3![Frontier logo]()
$157
One-way flights from Durham to MissouriSearch for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Trip.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Deal found 2/2![Frontier logo]()
$59
This Trip.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/86:10 am
RDU
- STL
1 stop25h 41m
Frontier
Deal found 2/1![Frontier logo]()
$62
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:50 pm
RDU
- STL
1 stop13h 01m
Frontier
Deal found 1/31![Frontier logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:54 pm
RDU
- STL
1 stop12h 57m
Frontier
Deal found 1/31![Frontier logo]()
$67
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:25 am
RDU
- STL
1 stop25h 26m
Frontier
Deal found 1/31![Frontier logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/154:30 pm
RDU
- STL
1 stop15h 21m
Frontier
Deal found 1/31![Frontier logo]()
$71
This Trip.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/14:30 pm
RDU
- MCI
1 stop18h 23m
Frontier
Deal found 2/2![Frontier logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
RDU
- STL
1 stop6h 49m
Frontier
Deal found 2/3![Frontier logo]()
$72
This Trip.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Deal found 2/3![Frontier logo]()
$73
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:50 pm
RDU
- MCI
1 stop16h 13m
Frontier
Deal found 2/1![Frontier logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:10 am
RDU
- MCI
1 stop28h 43m
Frontier
Deal found 2/1![Frontier logo]()
$79
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
RDU
- MCI
1 stop5h 18m
Frontier
Deal found 2/1![Frontier logo]()
$80
Find flight deals from Durham to Missouri
Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $128 (Kiwi.com) |
One-way from | $59 (Trip.com) |
Popular in | June |
Cheapest in | October |
Average price | $384 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.
Fly from
Durham
Fly to
Missouri
Route
Depart
Return
Price
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Wed 2/25
2:53 pm-10:27 pm
1 stop8h 34m
Lambert-St Louis
Sat 2/28
8:17 pm-5:14 pm
2 stops19h 57m
$161
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Fri 3/6
6:00 am-11:49 am
1 stop6h 49m
Lambert-St Louis
Sun 3/8
7:52 am-9:43 am
1 stop24h 51m
$175
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Tue 2/24
2:53 pm-10:27 pm
1 stop8h 34m
Lambert-St Louis
Fri 2/27
3:49 pm-7:52 am
1 stop15h 03m
$190
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Fri 4/10
4:46 pm-7:51 am
1 stop16h 05m
Lambert-St Louis
Mon 4/13
8:16 pm-5:05 pm
1 stop19h 49m
$195
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Fri 2/13
6:54 pm-6:51 am
1 stop12h 57m
Lambert-St Louis
Mon 2/16
8:22 pm-12:10 am
1 stop26h 48m
$195
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Tue 4/14
5:52 pm-6:50 am
2 stops13h 58m
Lambert-St Louis
Sun 4/19
11:21 am-12:15 am
1 stop11h 54m
$210
RaleighSpringfield
RDU - SGF
RDUSGF
Raleigh-Durham
Wed 4/15
11:33 am-3:00 pm
1 stop4h 27m
Springfield-Branson
Sat 4/18
4:00 pm-10:11 pm
1 stop5h 11m
$231
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Fri 4/3
4:46 pm-7:51 am
1 stop16h 05m
Lambert-St Louis
Sun 4/5
11:21 am-12:15 am
1 stop11h 54m
$242
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Sat 4/4
9:25 pm-10:30 am
1 stop14h 05m
Lambert-St Louis
Tue 4/7
4:54 pm-3:02 pm
2 stops21h 08m
$252
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Sat 2/7
8:16 pm-8:04 am
1 stop12h 48m
Lambert-St Louis
Tue 2/10
3:49 pm-4:59 pm
1 stop24h 10m
$253
Showing 1-10 of 59 results
Best time to book a flight from Durham to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
RDU-STL
RDU-MCI
RDU-SGF
RDU-COU
RDU-TBN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Missouri
DU8-USMO
RDU-STL
RDU-MCI
RDU-SGF
RDU-COU
What is the cheapest month to book a flight from Durham to Missouri?
Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $218). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DU8 to MO?
Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.
One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the morning could potentially save you up to 59% on airfare.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 3, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Durham to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Durham to Missouri by cabin class
Find flights from Durham to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Durham and Missouri flights
Browse other Durham and Missouri flight options. Last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Durham after your stay in Missouri
Durham to Missouri flights
Consider these flights traveling from Durham to Missouri.
Top 5 airlines flying from Durham to Missouri
Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$130 | Average$258 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$176 | Average$397 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$373 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$196 | Average$349 | FlexibilityNo cancel fee | On-time69% |