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$47+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated October 30, 2025.

Most accurate provider

CheapOair
3 stars

Most trusted provider

CheapOair
3 stars

Round-trip from

$110
(Frontier)

One-way from

$47
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$364
Provider with most accurate pricing for Raleigh-Durham-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Raleigh-Durham-Lambert-St Louis flights.
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From Durham to Missouri
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One-way flight from Durham to Missouri
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Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:10 amRDU - MCI
1 stop5h 07mFrontier
Mon 11/1711:12 amMCI - RDU
1 stop10h 46mFrontier
Deal found 10/29$110
This Frontier deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amRDU - STL
1 stop6h 07mFrontier
Thu 12/1112:04 pmSTL - RDU
1 stop11h 08mFrontier
Deal found 10/30$110
This Booking.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:10 amRDU - MCI
1 stop5h 07mFrontier
Wed 11/196:49 pmMCI - RDU
1 stop20h 42mFrontier
Deal found 10/30$121
This Booking.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:14 pmRDU - STL
1 stop27h 19mFrontier
Thu 12/1112:04 pmSTL - RDU
1 stop11h 08mFrontier
Deal found 10/29$121
This Frontier deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:10 amRDU - MCI
1 stop5h 07mFrontier
Fri 11/1411:12 amMCI - RDU
1 stop10h 53mFrontier
Deal found 10/30$127
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:21 pmRDU - STL
1 stop16h 46mFrontier
Thu 11/203:14 pmSTL - RDU
1 stop7h 18mFrontier
Deal found 10/30$136
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:10 amRDU - MCI
1 stop5h 07mFrontier
Sun 11/1611:12 amMCI - RDU
1 stop10h 36mFrontier
Deal found 10/29$143
This Flightnetwork deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:21 pmRDU - STL
1 stop16h 46mFrontier
Wed 11/197:24 pmSTL - RDU
1 stop12h 00mFrontier
Deal found 10/30$148
This Booking.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:00 amRDU - STL
1 stop4h 47mFrontier
Tue 12/93:30 pmSTL - RDU
1 stop24h 14mFrontier
Deal found 10/29$155
This Booking.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:26 pmRDU - MCI
1 stop20h 27mFrontier
Sun 12/148:45 pmMCI - RDU
1 stop19h 46mFrontier
Deal found 10/30$156
This Frontier deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:10 amRDU - MCI
1 stop5h 07mFrontier
Thu 11/1311:12 amMCI - RDU
1 stop10h 46mFrontier
Deal found 10/30$160
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:00 amRDU - STL
1 stop27h 05mMultiple Airlines
Sun 11/2311:08 amSTL - RDU
1 stop7h 36mMultiple Airlines
Deal found 10/30$171

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.

Fly from

Durham

Fly to

Missouri

Route

Depart

Return

Price

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Mon 11/17

5:21 pm-9:07 am

1 stop16h 46m

Lambert-St Louis

Wed 11/19

7:24 pm-8:24 am

1 stop12h 00m

$148

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Tue 3/3

7:55 am-9:41 am

Nonstop2h 46m

Kansas City

Wed 3/4

6:55 pm-10:19 pm

Nonstop2h 24m

$199

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Tue 3/17

7:55 am-9:41 am

Nonstop2h 46m

Kansas City

Wed 3/25

6:55 pm-10:19 pm

Nonstop2h 24m

$199

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Sat 12/6

7:30 am-9:29 am

Nonstop2h 59m

Kansas City

Sat 12/6

5:13 pm-12:18 am

1 stop6h 05m

$209

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Tue 3/17

7:55 am-9:41 am

Nonstop2h 46m

Kansas City

Tue 3/24

7:00 am-1:37 pm

1 stop5h 37m

$209

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Wed 1/21

7:05 am-9:14 am

Nonstop3h 09m

Kansas City

Mon 1/26

7:59 pm-11:24 pm

Nonstop2h 25m

$229

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Tue 4/28

7:55 am-9:44 am

Nonstop2h 49m

Kansas City

Mon 5/4

6:55 pm-10:22 pm

Nonstop2h 27m

$229

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Tue 11/18

3:57 pm-10:05 am

1 stop19h 08m

Lambert-St Louis

Wed 11/19

7:24 pm-8:24 am

1 stop12h 00m

$230

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Wed 12/3

5:14 pm-8:54 pm

1 stop4h 40m

Springfield-Branson

Wed 12/10

8:17 am-1:08 pm

1 stop3h 51m

$231

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Tue 4/28

6:35 am-11:07 am

1 stop5h 32m

Springfield-Branson

Sat 5/2

6:00 am-2:09 pm

1 stop7h 09m

$231

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 59 results
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Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 22% on airfare.

What is the cheapest day to fly from Durham to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Durham to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Durham to Missouri flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 30, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,998 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,998 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,035 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,122 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Missouri flight route?

    Within the past month, 33 users have taken a look at flights from Durham to Missouri.

  • How long is the flight from Durham to Missouri?

    A quick flight from Durham to Missouri can take about 2h 46m. Frontier provides one of the quickest options available for as low as $199. There are 902 mi between Durham and Missouri. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Durham to Missouri one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $65. United Airlines flights start at $110 while deals on Southwest start at $110 one-way.

  • What are the most popular routes from Durham to Missouri?

    When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Kansas City, Raleigh-Durham - Lambert-St Louis or Raleigh-Durham - Springfield-Branson as they are the most popular.

  • What are the cheapest flights from Durham to Missouri?

    Looking for the cheapest flight from Durham to Missouri? While on average our users pay $388, our data indicates the cheapest price to be $154. The most popular route (Raleigh-Durham - Kansas City), is priced around $198.

  • Can I find deals for flights from Durham to Missouri that include hotel bookings?

    Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

  • Can I find deals for business class flights from Durham to Missouri?

    Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Missouri?

    Currently, May is the cheapest month in which you can book a flight from Durham to Missouri (average of $88). Flying from Durham to Missouri in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Durham to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Durham to Missouri

Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$130Average$236FlexibilityNo cancel feeOn-time62%
DeltaCheapest$159Average$324FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$176Average$402FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$196Average$383FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$196Average$384FlexibilityNo cancel feeOn-time69%

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