$59+ Cheap flights from Des Moines (DSM) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Mar 15 — Mar 221
1 adult, Economy
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Find cheap flights from Des Moines to Missouri with Cheapflights
1. Tell us where you want to go
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Cheapest flights from Des Moines to MissouriExplore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:55 pm
DSM
- STL
1 stop9h 25m
Southwest
Mon 4/135:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 2/11![Southwest logo]()
$149
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:01 pm
DSM
- STL
1 stop5h 16m
American Airlines
Mon 5/48:03 pm
STL
- DSM
1 stop3h 46m
American Airlines
Deal found 2/11![American Airlines logo]()
$181
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:04 am
DSM
- STL
1 stop3h 46m
American Airlines
Sat 4/45:12 am
STL
- DSM
1 stop5h 32m
American Airlines
Deal found 2/11![American Airlines logo]()
$182
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:44 pm
DSM
- STL
1 stop4h 04m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:09 am
DSM
- STL
1 stop5h 32m
American Airlines
Mon 5/45:46 am
STL
- DSM
1 stop4h 40m
American Airlines
Deal found 2/11![American Airlines logo]()
$189
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:55 am
DSM
- STL
1 stop4h 53m
Delta
Sat 4/43:05 pm
STL
- DSM
1 stop6h 05m
Delta
Deal found 2/11![Delta logo]()
$191
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
- STL
1 stop3h 51m
American Airlines
Sat 3/75:12 am
STL
- DSM
1 stop5h 32m
American Airlines
Deal found 2/10![American Airlines logo]()
$193
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
- STL
1 stop3h 51m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$195
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:20 pm
DSM
- STL
1 stop6h 50m
Southwest
Mon 3/304:45 pm
STL
- DSM
1 stop6h 30m
Southwest
Deal found 2/10![Southwest logo]()
$196
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
- STL
1 stop3h 57m
Delta
Thu 3/56:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$198
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
- STL
1 stop5h 48m
Delta
Wed 3/46:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$205
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:44 pm
DSM
- STL
1 stop4h 04m
American Airlines
Sun 3/19:20 am
STL
- DSM
1 stop3h 45m
American Airlines
Deal found 2/12![American Airlines logo]()
$206
Best flights from Des Moines to MissouriDiscover carefully curated flight deals from Des Moines to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
Discover carefully curated flight deals from Des Moines to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:01 pm
DSM
- STL
1 stop5h 16m
American Airlines
Mon 5/48:03 pm
STL
- DSM
1 stop3h 46m
American Airlines
Deal found 2/11![American Airlines logo]()
$181
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:55 am
DSM
- STL
1 stop4h 53m
Delta
Sat 4/43:05 pm
STL
- DSM
1 stop6h 05m
Delta
Deal found 2/11![Delta logo]()
$191
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:20 pm
DSM
- STL
1 stop6h 50m
Southwest
Mon 3/304:45 pm
STL
- DSM
1 stop6h 30m
Southwest
Deal found 2/10![Southwest logo]()
$196
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:55 pm
DSM
- STL
1 stop4h 04m
United Airlines
Sun 3/16:25 am
STL
- DSM
1 stop4h 28m
United Airlines
Deal found 2/10![United Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- MCI
1 stop19h 24m
Multiple Airlines
Thu 4/912:24 pm
MCI
- DSM
1 stop9h 42m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:44 pm
DSM
- STL
1 stop4h 04m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$188
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:55 am
DSM
- STL
2 stops6h 03m
Delta
Mon 4/135:35 pm
STL
- DSM
1 stop3h 33m
Delta
Deal found 2/11![Delta logo]()
$196
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:21 pm
DSM
- STL
1 stop5h 47m
United Airlines
Mon 3/309:10 am
STL
- DSM
1 stop5h 15m
United Airlines
Deal found 2/11![United Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:30 am
DSM
- STL
2 stops9h 00m
Southwest
Mon 4/137:20 am
STL
- DSM
1 stop4h 25m
Southwest
Deal found 2/11![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
- STL
1 stop3h 51m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:57 am
DSM
- STL
1 stop3h 57m
Delta
Thu 3/56:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$198
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
- STL
1 stop3h 57m
Delta
Thu 3/56:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$198
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:15 pm
DSM
- STL
1 stop6h 21m
Delta
Fri 2/276:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/10![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:35 am
DSM
- MCI
2 stops9h 05m
Southwest
Thu 4/92:50 pm
MCI
- DSM
2 stops8h 15m
Southwest
Deal found 2/9![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
- MCI
1 stop6h 30m
Southwest
Tue 3/174:05 pm
MCI
- DSM
1 stop6h 00m
Southwest
Deal found 2/10![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:35 am
DSM
- MCI
1 stop3h 40m
Southwest
Sun 3/222:35 pm
MCI
- DSM
1 stop8h 00m
Southwest
Deal found 2/10![Southwest logo]()
$607
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:30 am
DSM
- MCI
1 stop17h 47m
United Airlines
Thu 2/265:54 am
MCI
- DSM
1 stop17h 49m
United Airlines
Deal found 2/11![United Airlines logo]()
$773
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:55 pm
DSM
- MCI
1 stop27h 04m
United Airlines
Thu 2/265:54 am
MCI
- DSM
1 stop14h 13m
United Airlines
Deal found 2/9![United Airlines logo]()
$805
Last-minute flights from Des Moines to MissouriDiscover last-minute flight deals from Des Moines to Missouri. Data last updated February 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Missouri. Data last updated February 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:44 pm
DSM
- STL
1 stop4h 04m
American Airlines
Sun 3/19:20 am
STL
- DSM
1 stop3h 45m
American Airlines
Deal found 2/12![American Airlines logo]()
$206
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
- STL
1 stop3h 57m
Delta
Thu 3/56:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$198
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
- STL
1 stop5h 48m
Delta
Wed 3/46:10 am
STL
- DSM
1 stop4h 07m
Delta
Deal found 2/12![Delta logo]()
$205
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:44 pm
DSM
- STL
1 stop4h 04m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
- STL
1 stop3h 51m
American Airlines
Sat 3/75:12 am
STL
- DSM
1 stop5h 32m
American Airlines
Deal found 2/10![American Airlines logo]()
$193
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
- STL
1 stop3h 51m
American Airlines
Sun 3/85:12 am
STL
- DSM
1 stop5h 22m
American Airlines
Deal found 2/12![American Airlines logo]()
$195
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
- MCI
1 stop6h 30m
Southwest
Tue 3/174:05 pm
MCI
- DSM
1 stop6h 00m
Southwest
Deal found 2/10![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:20 pm
DSM
- STL
1 stop6h 50m
Southwest
Mon 3/304:45 pm
STL
- DSM
1 stop6h 30m
Southwest
Deal found 2/10![Southwest logo]()
$196
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:04 am
DSM
- STL
1 stop3h 46m
American Airlines
Sat 4/45:12 am
STL
- DSM
1 stop5h 32m
American Airlines
Deal found 2/11![American Airlines logo]()
$182
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:55 am
DSM
- STL
1 stop4h 53m
Delta
Sat 4/43:05 pm
STL
- DSM
1 stop6h 05m
Delta
Deal found 2/11![Delta logo]()
$191
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:21 pm
DSM
- STL
1 stop5h 47m
United Airlines
Mon 3/309:10 am
STL
- DSM
1 stop5h 15m
United Airlines
Deal found 2/11![United Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:55 pm
DSM
- STL
1 stop9h 25m
Southwest
Mon 4/135:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 2/11![Southwest logo]()
$149
One-way flights from Des Moines to MissouriSearch for one-way flight options from Des Moines to Missouri. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
Search for one-way flight options from Des Moines to Missouri. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
- STL
1 stop4h 05m
Southwest
Deal found 2/11![Southwest logo]()
$59
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- STL
1 stop12h 19m
Frontier
Deal found 2/10![Frontier logo]()
$86
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:00 am
DSM
- STL
1 stop3h 51m
American Airlines
Deal found 2/10![American Airlines logo]()
$91
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:28 am
DSM
- STL
1 stop6h 04m
Delta
Deal found 2/9![Delta logo]()
$96
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:20 am
DSM
- STL
1 stop6h 57m
Delta
Deal found 2/12![Delta logo]()
$99
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:30 pm
DSM
- STL
1 stop5h 08m
Delta
Deal found 2/10![Delta logo]()
$104
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:20 pm
DSM
- STL
1 stop6h 38m
Delta
Deal found 2/10![Delta logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- STL
1 stop13h 28m
Frontier
Deal found 2/10![Frontier logo]()
$112
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:49 pm
DSM
- STL
1 stop4h 10m
United Airlines
Deal found 2/11![United Airlines logo]()
$121
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:20 pm
DSM
- STL
1 stop5h 48m
United Airlines
Deal found 2/11![United Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- MCI
1 stop24h 21m
Frontier
Deal found 2/10![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/138:21 pm
DSM
- MCI
1 stop23h 34m
Frontier
Deal found 2/10![Frontier logo]()
$216
Find flight deals from Des Moines to Missouri
Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated February 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $149 (Southwest) |
One-way from | $59 (Southwest) |
Popular in | July |
Cheapest in | September |
Average price | $486 |
Good round-trip deal | $348 or less |
Good one-way deal | $187 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.
Fly from
Des Moines
Fly to
Missouri
Route
Depart
Return
Price
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 5/2
5:01 pm-10:17 pm
1 stop5h 16m
Lambert-St Louis
Mon 5/4
8:03 pm-11:49 pm
1 stop3h 46m
$181
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 3/5
7:44 pm-11:48 pm
1 stop4h 04m
Lambert-St Louis
Sun 3/8
5:12 am-10:34 am
1 stop5h 22m
$188
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 3/28
6:55 am-11:48 am
1 stop4h 53m
Lambert-St Louis
Sat 4/4
3:05 pm-9:10 pm
1 stop6h 05m
$191
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 3/6
7:44 pm-11:35 pm
1 stop3h 51m
Lambert-St Louis
Sun 3/8
5:12 am-10:34 am
1 stop5h 22m
$195
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 3/26
4:20 pm-11:10 pm
1 stop6h 50m
Lambert-St Louis
Mon 3/30
4:45 pm-11:15 pm
1 stop6h 30m
$196
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 3/31
6:55 am-12:58 pm
2 stops6h 03m
Lambert-St Louis
Mon 4/13
5:35 pm-9:08 pm
1 stop3h 33m
$196
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 3/4
10:57 am-2:54 pm
1 stop3h 57m
Lambert-St Louis
Thu 3/5
6:10 am-10:17 am
1 stop4h 07m
$198
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 3/3
10:57 am-2:54 pm
1 stop3h 57m
Lambert-St Louis
Thu 3/5
6:10 am-10:17 am
1 stop4h 07m
$198
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 2/25
6:55 pm-10:59 pm
1 stop4h 04m
Lambert-St Louis
Sun 3/1
6:25 am-10:53 am
1 stop4h 28m
$205
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sun 3/29
3:21 pm-9:08 pm
1 stop5h 47m
Lambert-St Louis
Mon 3/30
9:10 am-2:25 pm
1 stop5h 15m
$211
Showing 1-10 of 32 results
Best time to book a flight from Des Moines to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
DSM-STL
DSM-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Missouri
DSM-USMO
DSM-STL
DSM-MCI
What is the cheapest time of day to fly from DSM to MO?
Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 13, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 13, 2026.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and Missouri flights
Browse other Des Moines and Missouri flight options. Last updated on February 13, 2026.
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Des Moines to Missouri flights
Consider these flights traveling from Des Moines to Missouri.
Top 3 airlines flying from Des Moines to Missouri
Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$97 | Average$253 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$218 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$218 | Average$273 | FlexibilityNo cancel fee | On-time71% |