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Missouri

$67+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MCI
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:55 pmDSM - STL
1 stop4h 21mDelta
Wed 1/75:25 pmSTL - DSM
1 stop3h 59mDelta
Deal found 12/16$208
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:55 pmDSM - STL
1 stop4h 21mDelta
Thu 1/16:05 amSTL - DSM
1 stop5h 23mDelta
Deal found 12/17$219
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:09 pmDSM - STL
1 stop6h 13mAmerican Airlines
Sun 1/48:01 pmSTL - DSM
1 stop3h 29mAmerican Airlines
Deal found 12/16$296
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:35 pmDSM - STL
1 stop5h 09mAmerican Airlines
Fri 1/28:01 pmSTL - DSM
1 stop3h 50mAmerican Airlines
Deal found 12/15$404
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:47 amDSM - MCI
1 stop10h 02mAmerican Airlines
Wed 12/315:12 amMCI - DSM
1 stop33h 41mAmerican Airlines
Deal found 12/17$435
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:51 pmDSM - STL
1 stop4h 56mAmerican Airlines
Tue 12/235:54 amSTL - DSM
1 stop6h 54mAmerican Airlines
Deal found 12/17$521
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:10 pmDSM - STL
2 stops8h 31mDelta
Sun 1/46:05 amSTL - DSM
1 stop5h 23mDelta
Deal found 12/16$531
This Southwest deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:40 amDSM - MCI
1 stop9h 40mSouthwest
Wed 12/316:15 amMCI - DSM
1 stop5h 10mSouthwest
Deal found 12/14$539
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:07 amDSM - STL
1 stop5h 49mAmerican Airlines
Fri 12/265:16 amSTL - DSM
1 stop5h 33mAmerican Airlines
Deal found 12/16$555
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:15 amDSM - MCI
1 stop5h 15mSouthwest
Fri 12/265:45 amMCI - DSM
1 stop5h 15mSouthwest
Deal found 12/16$557
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:11 pmDSM - MCI
1 stop24h 55mMultiple Airlines
Fri 12/268:45 pmMCI - DSM
1 stop22h 59mMultiple Airlines
Deal found 12/17$625
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:50 pmDSM - MCI
1 stop5h 05mSouthwest
Fri 12/265:45 amMCI - DSM
1 stop5h 15mSouthwest
Deal found 12/16$637

Find flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$133
(Southwest)

One-way from

$67
(Southwest)

Popular in

July

Cheapest in

September

Average price

$407

Good round-trip deal

$340 or less

Good one-way deal

$203 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Des Moines to Missouri
Search Deals
One-way flight from Des Moines to Missouri
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Des Moines to Missouri.
Search Deals
Price to beat on a one-way flight from Des Moines to Missouri.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 1/13

6:10 am-7:30 am

Nonstop1h 20m

Lambert-St Louis

Wed 1/14

10:15 am-11:25 am

Nonstop1h 10m

$133

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/30

5:16 pm-11:37 pm

1 stop6h 21m

Lambert-St Louis

Fri 2/6

6:10 am-10:19 am

1 stop4h 09m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 1/5

6:52 pm-11:44 pm

1 stop4h 52m

Lambert-St Louis

Fri 1/9

5:04 pm-11:23 pm

1 stop6h 19m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 1/31

10:59 am-2:38 pm

1 stop3h 39m

Lambert-St Louis

Sat 2/7

3:31 pm-9:24 pm

1 stop5h 53m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/30

11:26 am-5:50 pm

1 stop6h 24m

Lambert-St Louis

Sun 2/1

6:10 am-10:19 am

1 stop4h 09m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/23

5:16 pm-11:37 pm

1 stop6h 21m

Lambert-St Louis

Sun 1/25

6:10 am-10:19 am

1 stop4h 09m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/22

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Mon 1/26

6:35 am-3:41 pm

2 stops9h 06m

$169

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 1/13

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Wed 1/14

6:35 am-3:41 pm

2 stops9h 06m

$198

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sun 1/25

3:53 pm-8:52 am

1 stop16h 59m

Kansas City

Sun 2/1

11:26 am-10:46 pm

1 stop11h 20m

$278

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Wed 2/4

8:35 am-1:15 pm

1 stop4h 40m

Kansas City

Fri 2/6

4:35 pm-10:15 pm

2 stops5h 40m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 27 results
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to Missouri by exploring options for tickets in the evening.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,091 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How long is the flight from Des Moines to Missouri?

    A quick flight from Des Moines to Missouri can take about 1h 20m. Southwest provides one of the quickest options available for as low as $133. The distance between Des Moines and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Missouri

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Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$254FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$394FlexibilityNo cancel feeOn-time69%

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