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$106+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(American Airlines)

One-way from

$106
(Southwest)

Good round-trip deal

$368 or less

Good one-way deal

$167 or less
Provider with most accurate pricing for Des Moines-Kansas City flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Kansas City flights.
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From Des Moines to Missouri
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One-way flight from Des Moines to Missouri
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Price to beat on a round-trip flight from Des Moines to Missouri.
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Price to beat on a one-way flight from Des Moines to Missouri.
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Find flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/65:58 pmDSM - STL
1 stop5h 56mAmerican Airlines
Mon 6/98:05 pmSTL - DSM
1 stop3h 47mAmerican Airlines
Deal found 4/29$223
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/274:45 pmDSM - STL
Nonstop1h 05mSouthwest
Sat 5/312:40 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 4/30$224
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/274:45 pmDSM - MCI
1 stop5h 15mSouthwest
Tue 6/36:55 amMCI - DSM
1 stop9h 05mSouthwest
Deal found 4/30$229
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/158:00 amDSM - STL
1 stop6h 37mUnited Airlines
Mon 8/1810:00 amSTL - DSM
1 stop4h 41mUnited Airlines
Deal found 4/29$252
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1512:32 pmDSM - MCI
1 stop22h 16mMultiple Airlines
Mon 5/1911:43 amMCI - DSM
1 stop9h 12mMultiple Airlines
Deal found 4/30$268
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:35 amDSM - STL
1 stop6h 29mDelta
Fri 8/156:45 amSTL - DSM
2 stops9h 52mDelta
Deal found 4/29$344
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:32 pmDSM - STL
2 stops24h 09mMultiple Airlines
Thu 6/199:50 amSTL - DSM
2 stops12h 47mMultiple Airlines
Deal found 4/30$364
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/711:34 amDSM - MCI
1 stop11h 53mUnited Airlines
Mon 9/81:45 pmMCI - DSM
1 stop22h 51mUnited Airlines
Deal found 4/30$540

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 6/6

5:58 pm-11:54 pm

1 stop5h 56m

Lambert-St Louis

Mon 6/9

8:05 pm-11:52 pm

1 stop3h 47m

$223

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/27

4:45 pm-5:50 pm

Nonstop1h 05m

Lambert-St Louis

Sat 5/31

2:40 pm-3:50 pm

Nonstop1h 10m

$224

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Tue 5/27

4:45 pm-10:00 pm

1 stop5h 15m

Kansas City

Tue 6/3

6:55 am-4:00 pm

1 stop9h 05m

$229

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 8/15

8:00 am-2:37 pm

1 stop6h 37m

Lambert-St Louis

Mon 8/18

10:00 am-2:41 pm

1 stop4h 41m

$252

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Thu 5/15

12:32 pm-10:48 am

1 stop22h 16m

Kansas City

Mon 5/19

11:43 am-8:55 pm

1 stop9h 12m

$268

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/13

5:35 am-12:04 pm

1 stop6h 29m

Lambert-St Louis

Fri 8/15

6:45 am-4:37 pm

2 stops9h 52m

$344

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 6/12

6:32 pm-6:41 pm

2 stops24h 09m

Lambert-St Louis

Thu 6/19

9:50 am-10:37 pm

2 stops12h 47m

$364

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Thu 5/15

8:00 am-10:20 pm

1 stop14h 20m

Kansas City

Mon 5/19

6:00 am-9:52 pm

1 stop15h 52m

$720

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/1

5:35 pm-6:50 pm

Nonstop1h 15m

$106

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 7/2

7:00 am-10:33 am

1 stop3h 33m

$111

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 15 results
1
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest month to book a flight from Des Moines to Missouri?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 1, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Des Moines to Missouri. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Frontier
6.0
Okay
3,287 reviews
Southwest
8.0
Very good
4,294 reviews

Boarding

8.2

Crew

8.6

Overall

8.0

Food

7.1

Entertainment

7.6

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 23 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Des Moines to Missouri one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $106. However, be on the lookout for offers from Delta and Frontier, as they are both options that can get you from Des Moines to Missouri for a low price.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $134. On average you can expect to pay $310. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $252.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$117Average$310FlexibilityNo cancel feeOn-time63%
DeltaCheapest$155Average$470FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$268Average$478FlexibilityNo cancel feeOn-time69%

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