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$59+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
-
STL
1 stop6h 10m
Southwest
Wed 3/256:20 am
STL
-
DSM
1 stop6h 55m
Southwest
Deal found 2/17$117
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
-
STL
1 stop6h 10m
Southwest
Tue 3/103:10 pm
STL
-
DSM
2 stops6h 55m
Southwest
Deal found 2/17$122
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
-
STL
2 stops9h 00m
Southwest
Wed 3/113:10 pm
STL
-
DSM
2 stops6h 55m
Southwest
Deal found 2/17$127
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:55 am
DSM
-
STL
1 stop4h 53m
Delta
Tue 3/246:29 am
STL
-
DSM
1 stop3h 40m
Delta
Deal found 2/17$181
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:35 am
DSM
-
STL
1 stop3h 25m
Southwest
Mon 4/134:40 pm
STL
-
DSM
1 stop6h 25m
Southwest
Deal found 2/19$186
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:28 pm
DSM
-
STL
1 stop6h 30m
United Airlines
Sun 4/127:45 am
STL
-
DSM
1 stop4h 44m
United Airlines
Deal found 2/18$197
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:24 pm
DSM
-
STL
1 stop5h 41m
United Airlines
Fri 3/67:41 am
STL
-
DSM
1 stop5h 42m
United Airlines
Deal found 2/17$205
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:21 pm
DSM
-
STL
1 stop5h 47m
United Airlines
Tue 3/319:10 am
STL
-
DSM
1 stop5h 15m
United Airlines
Deal found 2/17$208
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:28 pm
DSM
-
STL
1 stop6h 30m
United Airlines
Mon 3/309:10 am
STL
-
DSM
1 stop5h 15m
United Airlines
Deal found 2/17$214
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:20 am
DSM
-
STL
1 stop4h 10m
Southwest
Wed 5/205:35 am
STL
-
DSM
1 stop5h 50m
Southwest
Deal found 2/18$223
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:21 pm
DSM
-
STL
1 stop5h 47m
United Airlines
Sat 4/257:45 am
STL
-
DSM
1 stop4h 44m
United Airlines
Deal found 2/20$227
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:35 am
DSM
-
MCI
1 stop3h 40m
Southwest
Wed 4/15:30 am
MCI
-
DSM
1 stop6h 10m
Southwest
Deal found 2/20$327

Find flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated February 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$117
(Southwest)

One-way from

$59
(Southwest)

Popular in

February

Cheapest in

September

Average price

$635

Good round-trip deal

$354 or less

Good one-way deal

$196 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Des Moines to Missouri
Search Deals
One-way flight from Des Moines to Missouri
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to Missouri.
Search Deals
Price to beat on a one-way flight from Des Moines to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/10

5:30 am-9:35 am

1 stop4h 05m

Lambert-St Louis

Tue 3/10

4:00 pm-10:05 pm

1 stop6h 05m

$117

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/10

5:30 am-3:30 pm

2 stops10h 00m

Lambert-St Louis

Wed 3/25

4:00 pm-10:05 pm

1 stop6h 05m

$122

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/10

5:30 am-2:30 pm

2 stops9h 00m

Lambert-St Louis

Wed 3/11

3:10 pm-10:05 pm

2 stops6h 55m

$127

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/17

6:55 am-11:48 am

1 stop4h 53m

Lambert-St Louis

Tue 3/24

6:29 am-10:09 am

1 stop3h 40m

$181

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 4/6

5:35 am-9:00 am

1 stop3h 25m

Lambert-St Louis

Mon 4/13

4:40 pm-11:05 pm

1 stop6h 25m

$186

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 3/19

5:35 am-9:00 am

1 stop3h 25m

Lambert-St Louis

Thu 3/26

6:15 am-1:40 pm

1 stop7h 25m

$186

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 4/10

3:21 pm-9:47 pm

1 stop6h 26m

Lambert-St Louis

Sun 4/12

7:45 am-12:29 pm

1 stop4h 44m

$197

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

3:24 pm-9:05 pm

1 stop5h 41m

Lambert-St Louis

Fri 3/6

7:41 am-1:23 pm

1 stop5h 42m

$205

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 3/29

3:21 pm-9:08 pm

1 stop5h 47m

Lambert-St Louis

Tue 3/31

9:10 am-2:25 pm

1 stop5h 15m

$208

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/27

3:28 pm-9:58 pm

1 stop6h 30m

Lambert-St Louis

Mon 3/30

9:10 am-2:25 pm

1 stop5h 15m

$214

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 27 results
1
2
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Weekly flight availability from Des Moines to Missouri

Explore weekly flight availability from Des Moines to Missouri. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 21, 2026.

The most flights from DSM to USMO are scheduled on a Thursday (4 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 21, 2026.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,298 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,298 reviews
Southwest
8.0
Very good
4,298 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,335 reviews
Southwest
8.0
Very good
4,298 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,334 reviews
Southwest
8.0
Very good
4,298 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Missouri?

    A quick flight from Des Moines to Missouri can take about 4h 05m. Southwest provides one of the quickest options available for as low as $117. The distance between Des Moines and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $174. On average you can expect to pay $334. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $186.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to San Francisco flights
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Moline to Dallas/Fort Worth flights
Omaha to John F Kennedy Intl flights
Omaha to LaGuardia flights
Des Moines to Reagan-National flights
Cedar Rapids to Seattle flights
Cedar Rapids to Phoenix-Mesa Gateway flights
Cedar Rapids to Sarasota flights
Des Moines to Dulles Intl flights
Omaha to Fort Lauderdale flights
Omaha to Nashville flights
Des Moines to Miami flights
Moline to Denver flights
Des Moines to Newark flights
Omaha to Baltimore flights
Moline to Sky Harbor Intl flights

Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$250FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$218Average$394FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$273FlexibilityNo cancel feeOn-time71%

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