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Missouri

$59+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:20 pm
DSM
-
STL
Nonstop1h 15m
Southwest
Tue 3/38:00 pm
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/27$97
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
-
STL
1 stop6h 10m
Southwest
Wed 3/114:00 pm
STL
-
DSM
1 stop6h 05m
Southwest
Deal found 1/28$117
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:20 am
DSM
-
STL
Nonstop1h 20m
Southwest
Tue 2/248:00 pm
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/28$134
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:57 am
DSM
-
STL
1 stop5h 48m
Delta
Tue 3/36:00 am
STL
-
DSM
1 stop5h 19m
Delta
Deal found 1/27$157
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:44 pm
DSM
-
STL
1 stop4h 04m
American Airlines
Tue 2/245:12 am
STL
-
DSM
1 stop5h 22m
American Airlines
Deal found 1/28$175
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:15 pm
DSM
-
STL
1 stop6h 21m
Delta
Mon 2/236:10 am
STL
-
DSM
1 stop4h 07m
Delta
Deal found 1/26$191
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:15 pm
DSM
-
STL
Nonstop1h 05m
Southwest
Tue 3/310:15 am
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/27$213
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:00 am
DSM
-
MCI
2 stops27h 30m
Multiple Airlines
Sun 3/88:40 pm
MCI
-
DSM
1 stop22h 36m
Multiple Airlines
Deal found 1/28$292
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/124:40 pm
DSM
-
MCI
1 stop5h 20m
Southwest
Mon 6/157:40 pm
MCI
-
DSM
1 stop3h 40m
Southwest
Deal found 1/27$367
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:35 am
DSM
-
MCI
2 stops9h 05m
Southwest
Sun 3/81:45 pm
MCI
-
DSM
2 stops9h 50m
Southwest
Deal found 1/28$380
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:15 pm
DSM
-
MCI
1 stop5h 10m
Southwest
Sat 2/142:55 pm
MCI
-
DSM
1 stop4h 20m
Southwest
Deal found 1/28$431
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/133:39 pm
DSM
-
MCI
1 stop7h 54m
Multiple Airlines
Sat 2/1410:00 am
MCI
-
DSM
2 stops32h 32m
Multiple Airlines
Deal found 1/28$515

Find flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$97
(Southwest)

One-way from

$59
(Southwest)

Popular in

July

Cheapest in

September

Average price

$467

Good round-trip deal

$371 or less

Good one-way deal

$187 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Des Moines to Missouri
Search Deals
One-way flight from Des Moines to Missouri
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to Missouri.
Search Deals
Price to beat on a one-way flight from Des Moines to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/24

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

Tue 3/3

8:00 pm-9:10 pm

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/10

1:55 pm-9:35 pm

1 stop7h 40m

Lambert-St Louis

Wed 3/11

4:00 pm-10:05 pm

1 stop6h 05m

$117

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 2/23

5:20 am-6:40 am

Nonstop1h 20m

Lambert-St Louis

Tue 2/24

8:00 pm-9:10 pm

Nonstop1h 10m

$134

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/24

10:57 am-8:43 pm

2 stops9h 46m

Lambert-St Louis

Tue 3/3

3:40 pm-9:20 pm

1 stop5h 40m

$162

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 2/23

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Tue 2/24

5:12 am-10:34 am

1 stop5h 22m

$175

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/18

5:15 pm-11:36 pm

1 stop6h 21m

Lambert-St Louis

Mon 2/23

6:10 am-10:17 am

1 stop4h 07m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 3/1

6:10 am-2:15 pm

1 stop8h 05m

Lambert-St Louis

Tue 3/3

10:15 am-11:25 am

Nonstop1h 10m

$213

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Thu 3/5

7:00 am-10:30 am

2 stops27h 30m

Kansas City

Sun 3/8

8:40 pm-7:16 pm

1 stop22h 36m

$292

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Fri 2/20

6:10 am-12:20 pm

1 stop6h 10m

Kansas City

Mon 2/23

4:45 pm-10:30 pm

1 stop5h 45m

$367

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Fri 6/12

4:40 pm-10:00 pm

1 stop5h 20m

Kansas City

Mon 6/15

7:40 pm-11:20 pm

1 stop3h 40m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 22 results
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,215 reviews
Southwest
8.0
Very good
4,267 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,205 reviews
Southwest
8.0
Very good
4,267 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 28 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Missouri?

    A quick flight from Des Moines to Missouri can take about 1h 15m. Southwest provides one of the quickest options available for as low as $97. The distance between Des Moines and Missouri is about 259 mi. Most flights are nonstop.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $98. On average you can expect to pay $357. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $97.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$253FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$273FlexibilityNo cancel feeOn-time71%

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