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$49+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Nov 30 — Dec 71
Sun 11/30
Sun 12/7
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated October 31, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$120
(Mytrip)

One-way from

$49
(Southwest)

Popular in

July

Cheapest in

September

Average price

$230

Good round-trip deal

$297 or less

Good one-way deal

$163 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
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From Des Moines to Missouri
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One-way flight from Des Moines to Missouri
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Highest demand for flights based on searches. 10% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Des Moines to Missouri.
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Price to beat on a one-way flight from Des Moines to Missouri.
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Find flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 31, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:58 pmDSM - MCI
2 stops39h 05mFrontier
Fri 12/198:45 pmMCI - DSM
1 stop22h 59mFrontier
Deal found 10/29$236
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:08 pmDSM - STL
1 stop5h 22mAmerican Airlines
Sat 12/208:01 pmSTL - DSM
1 stop3h 50mAmerican Airlines
Deal found 10/29$318
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:45 amDSM - MCI
1 stop5h 15mSouthwest
Fri 12/196:05 pmMCI - DSM
1 stop5h 05mSouthwest
Deal found 10/29$327
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:34 pmDSM - STL
1 stop18h 33mMultiple Airlines
Tue 11/187:45 pmSTL - DSM
2 stops43h 09mMultiple Airlines
Deal found 10/30$339
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/214:59 pmDSM - STL
1 stop6h 24mDelta
Sat 11/226:00 amSTL - DSM
1 stop4h 20mDelta
Deal found 10/30$351
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:41 pmDSM - STL
1 stop18h 26mMultiple Airlines
Mon 11/179:07 pmSTL - DSM
2 stops59h 22mMultiple Airlines
Deal found 10/29$380
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/261:53 pmDSM - STL
1 stop18h 16mAmerican Airlines
Sun 11/307:58 pmSTL - DSM
1 stop5h 25mAmerican Airlines
Deal found 10/29$414
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/103:45 pmDSM - MCI
1 stop8h 39mMultiple Airlines
Tue 11/116:49 pmMCI - DSM
2 stops52h 14mMultiple Airlines
Deal found 10/30$421
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:50 amDSM - STL
1 stop5h 09mDelta
Mon 11/176:00 amSTL - DSM
1 stop7h 32mDelta
Deal found 10/29$433
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:50 amDSM - STL
2 stops7h 01mDelta
Tue 11/1810:45 amSTL - DSM
2 stops10h 30mDelta
Deal found 10/30$443
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:49 pmDSM - MCI
1 stop18h 17mAmerican Airlines
Fri 12/195:12 amMCI - DSM
1 stop31h 42mAmerican Airlines
Deal found 10/30$465
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:50 amDSM - STL
2 stops7h 03mDelta
Sat 12/206:05 amSTL - DSM
1 stop5h 23mDelta
Deal found 10/29$465

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 31, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

5:15 pm-11:40 pm

1 stop6h 25m

Lambert-St Louis

Wed 3/4

6:30 am-10:22 am

1 stop3h 52m

$157

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 12/12

7:58 pm-10:14 am

1 stop14h 16m

Lambert-St Louis

Fri 12/19

7:43 pm-7:44 pm

1 stop24h 01m

$196

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Fri 12/12

7:58 pm-11:03 am

2 stops39h 05m

Kansas City

Fri 12/19

8:45 pm-7:44 pm

1 stop22h 59m

$236

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 12/4

11:23 am-5:56 pm

1 stop6h 33m

Lambert-St Louis

Sun 12/7

6:00 am-10:38 am

1 stop4h 38m

$243

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 12/12

7:28 pm-10:14 am

2 stops14h 46m

Lambert-St Louis

Fri 12/19

9:50 am-2:57 pm

2 stops29h 07m

$307

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 11/24

1:53 pm-11:56 pm

1 stop10h 03m

Lambert-St Louis

Mon 12/1

7:58 pm-11:44 pm

1 stop3h 46m

$314

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 12/13

2:08 pm-7:30 pm

1 stop5h 22m

Lambert-St Louis

Sat 12/20

8:01 pm-11:51 pm

1 stop3h 50m

$318

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Fri 12/12

5:45 am-11:00 am

1 stop5h 15m

Kansas City

Fri 12/19

6:05 pm-11:10 pm

1 stop5h 05m

$327

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Mon 11/10

3:45 pm-12:24 am

1 stop8h 39m

Kansas City

Tue 11/11

6:49 pm-11:03 pm

2 stops52h 14m

$421

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Fri 12/12

4:49 pm-11:06 am

1 stop18h 17m

Kansas City

Fri 12/19

5:12 am-12:54 pm

1 stop31h 42m

$465

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 26 results
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest month to book a flight from Des Moines to Missouri?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $93). Flying from Des Moines to Missouri in July is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 31, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to Missouri by exploring options for tickets in the evening.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 31, 2025.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,998 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,035 reviews
Southwest
8.0
Very good
4,243 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 30 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Missouri?

    A quick flight from Des Moines to Missouri can take about 5h 15m. Delta provides one of the quickest options available for as low as $327. The distance between Des Moines and Missouri is about 165 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $124. On average you can expect to pay $285. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $157.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $93). Flying from Des Moines to Missouri in July is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$301FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%

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