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$49+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated September 17, 2025.

Round-trip from

$97
(Southwest)

One-way from

$49
(Southwest)

Popular in

March

Cheapest in

January

Average price

$352

Good round-trip deal

$310 or less

Good one-way deal

$159 or less
From Des Moines to Missouri
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One-way flight from Des Moines to Missouri
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Highest demand for flights based on searches. 20% potential increase in price ($101 potential increase over avg. RT price).
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Cheapest flight prices on average. 16% potential price decrease ($56 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Des Moines to Missouri.
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Price to beat on a one-way flight from Des Moines to Missouri.
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Find flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:35 amDSM - STL
Nonstop1h 10mSouthwest
Tue 10/218:20 amSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/15$97
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2810:15 amDSM - STL
2 stops7h 10mSouthwest
Thu 10/3010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/15$112
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:30 amDSM - STL
1 stop6h 14mAmerican Airlines
Sat 10/188:49 amSTL - DSM
1 stop6h 14mAmerican Airlines
Deal found 9/17$159
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1111:06 amDSM - STL
1 stop4h 25mDelta
Wed 10/156:00 amSTL - DSM
1 stop4h 26mDelta
Deal found 9/16$177
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1112:30 pmDSM - STL
2 stops9h 34mDelta
Thu 10/166:00 amSTL - DSM
1 stop4h 26mDelta
Deal found 9/16$182
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:32 pmDSM - STL
1 stop5h 35mDelta
Tue 10/2111:21 amSTL - DSM
1 stop6h 23mDelta
Deal found 9/16$184
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1112:30 pmDSM - STL
2 stops9h 34mDelta
Fri 10/176:00 amSTL - DSM
1 stop4h 26mDelta
Deal found 9/16$189
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/162:37 pmDSM - STL
1 stop18h 30mFrontier
Tue 10/217:52 pmSTL - DSM
1 stop18h 00mFrontier
Deal found 9/15$199
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/164:35 pmDSM - STL
1 stop7h 15mSouthwest
Thu 10/239:50 amSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/16$213
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:37 pmDSM - STL
1 stop18h 30mFrontier
Tue 10/217:52 pmSTL - DSM
1 stop18h 00mFrontier
Deal found 9/16$215
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:30 amDSM - STL
1 stop4h 19mUnited Airlines
Thu 10/235:00 amSTL - DSM
1 stop5h 32mUnited Airlines
Deal found 9/17$219
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:15 pmDSM - MCI
1 stop5h 05mSouthwest
Thu 10/235:55 amMCI - DSM
1 stop5h 05mSouthwest
Deal found 9/16$327

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/28

6:20 am-7:30 am

Nonstop1h 10m

Lambert-St Louis

Thu 10/30

10:20 pm-11:30 pm

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/16

5:35 am-6:45 am

Nonstop1h 10m

Lambert-St Louis

Tue 10/21

8:20 am-9:30 am

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 11/1

3:48 pm-8:53 pm

1 stop5h 05m

Lambert-St Louis

Sat 11/8

9:38 am-4:51 pm

1 stop7h 13m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 10/11

5:15 pm-10:04 pm

1 stop4h 49m

Lambert-St Louis

Sat 10/18

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/13

6:39 pm-11:41 pm

1 stop5h 02m

Lambert-St Louis

Wed 10/15

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

5:15 pm-11:40 pm

1 stop6h 25m

Lambert-St Louis

Wed 3/4

6:30 am-10:22 am

1 stop3h 52m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/22

5:32 pm-11:07 pm

1 stop5h 35m

Lambert-St Louis

Sun 10/26

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/23

6:05 am-1:22 pm

1 stop7h 17m

Lambert-St Louis

Sun 10/26

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/13

6:39 pm-11:41 pm

1 stop5h 02m

Lambert-St Louis

Thu 10/16

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/14

5:47 am-10:26 am

1 stop4h 39m

Lambert-St Louis

Tue 10/14

3:30 pm-9:03 pm

1 stop5h 33m

$177

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 29 results
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Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest month to book a flight from Des Moines to Missouri?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Missouri?

    A quick flight from Des Moines to Missouri can take about 1h 10m. Southwest provides one of the quickest options available for as low as $97. The distance between Des Moines and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $118. On average you can expect to pay $285. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $97.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$313FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$248FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%

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