How popular is this Des Moines to Missouri flight route?

The Des Moines to Missouri flight path was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Des Moines to Missouri?

A quick flight from Des Moines to Missouri can take about 3h 40m. Delta provides one of the quickest options available for as low as $327. The distance between Des Moines and Missouri is about 165 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

In terms of precipitation, rainfall in Missouri ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit Missouri when rainfall is around 2.2 in.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Des Moines to Missouri?

The cheapest flight price from Des Moines to Missouri is $128. On average you can expect to pay $341. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $159.

What are the most popular airlines that fly from Des Moines to Missouri?

Before booking your flight from Des Moines to Missouri check out the most popular airlines for this route: Southwest, United Airlines or American Airlines.

What airport do you fly from for flights from Des Moines to Missouri?

Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Missouri?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

Can I find deals for business class flights from Des Moines to Missouri?

Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$72+ Flights from Des Moines to Missouri

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Cheap flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Wed 12/315:06 pmDSM - STL

1 stop5h 16mUnited Airlines

Thu 1/15:02 pmSTL - DSM

1 stop4h 38mUnited Airlines

Deal found 12/30

$555

Wed 12/318:20 amDSM - STL

1 stop5h 00mSouthwest

Fri 1/25:15 pmSTL - DSM

1 stop5h 55mSouthwest

Deal found 12/30

$907

Wed 12/315:06 pmDSM - STL

1 stop5h 16mUnited Airlines

Fri 1/27:00 amSTL - DSM

2 stops15h 30mUnited Airlines

Deal found 12/30

$975

Best flights from Des Moines to Missouri
Discover carefully curated flight deals from Des Moines to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 2, 2026.

Sat 2/1412:28 pmDSM - STL

1 stop4h 14mDelta

Sat 2/217:10 amSTL - DSM

1 stop5h 04mDelta

Deal found 12/30

$159

Wed 1/284:00 pmDSM - STL

1 stop6h 59mAmerican Airlines

Sat 1/319:25 amSTL - DSM

1 stop7h 41mAmerican Airlines

Deal found 12/30

$159

Thu 2/127:32 pmDSM - STL

1 stop17h 37mFrontier

Thu 2/1910:11 pmSTL - DSM

2 stops20h 08mFrontier

Deal found 12/31

$220

Wed 1/213:20 pmDSM - STL

Nonstop1h 15mSouthwest

Wed 1/288:00 pmSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/31

$253

Thu 2/125:00 amDSM - STL

1 stop3h 41mAmerican Airlines

Thu 2/199:37 amSTL - DSM

1 stop3h 28mAmerican Airlines

Deal found 12/31

$159

Wed 1/215:16 pmDSM - STL

1 stop6h 21mDelta

Wed 1/2811:23 amSTL - DSM

1 stop4h 18mDelta

Deal found 12/31

$159

Fri 1/305:51 pmDSM - STL

1 stop5h 08mAmerican Airlines

Sat 1/3111:05 amSTL - DSM

1 stop5h 19mAmerican Airlines

Deal found 12/30

$159

Thu 1/295:16 pmDSM - STL

1 stop6h 21mDelta

Fri 1/306:00 amSTL - DSM

1 stop4h 41mDelta

Deal found 12/31

$159

Fri 2/65:16 pmDSM - STL

1 stop6h 21mDelta

Sun 2/86:10 amSTL - DSM

1 stop4h 09mDelta

Deal found 12/31

$159

Sat 2/148:00 amDSM - MCI

1 stop13h 59mUnited Airlines

Sat 2/218:00 amMCI - DSM

1 stop13h 41mUnited Airlines

Deal found 12/31

$512

Sun 2/155:00 amDSM - STL

1 stop3h 35mAmerican Airlines

Sun 2/229:20 amSTL - DSM

1 stop3h 45mAmerican Airlines

Deal found 12/31

$244

Sun 4/55:25 amDSM - MCI

1 stop3h 40mSouthwest

Fri 4/105:30 amMCI - DSM

1 stop6h 15mSouthwest

Deal found 12/31

$327

Thu 4/165:25 amDSM - MCI

1 stop3h 55mSouthwest

Sun 4/195:25 amMCI - DSM

1 stop6h 05mSouthwest

Deal found 1/1

$347

Fri 5/297:10 pmDSM - MCI

1 stop4h 25mSouthwest

Sun 5/315:25 amMCI - DSM

1 stop6h 05mSouthwest

Deal found 12/30

$347

Sun 4/264:20 pmDSM - MCI

1 stop6h 45mSouthwest

Mon 4/277:05 pmMCI - DSM

1 stop4h 00mSouthwest

Deal found 12/31

$347

Fri 1/166:48 pmDSM - MCI

1 stop24h 59mUnited Airlines

Tue 1/208:00 amMCI - DSM

1 stop13h 50mUnited Airlines

Deal found 1/1

$525

Last-minute flights from Des Moines to Missouri
Discover last-minute flight deals from Des Moines to Missouri. Data last updated January 2, 2026 and is based on user searches.

Fri 1/98:30 amDSM - MCI

1 stop15h 03mMultiple Airlines

Tue 1/135:04 pmMCI - DSM

2 stops46h 36mMultiple Airlines

Deal found 1/1

$566

Thu 1/157:00 amDSM - MCI

1 stop51h 13mAmerican Airlines

Mon 1/193:01 pmMCI - DSM

1 stop49h 23mAmerican Airlines

Deal found 12/31

$507

Fri 1/166:48 pmDSM - MCI

1 stop24h 59mUnited Airlines

Tue 1/208:00 amMCI - DSM

1 stop13h 50mUnited Airlines

Deal found 1/1

$525

Sat 1/1710:59 amDSM - STL

1 stop4h 01mDelta

Sun 1/186:10 amSTL - DSM

1 stop4h 09mDelta

Deal found 12/30

$209

Sun 1/188:00 amDSM - STL

1 stop6h 30mUnited Airlines

Tue 1/204:15 pmSTL - DSM

1 stop7h 29mUnited Airlines

Deal found 12/29

$274

Sun 1/188:00 amDSM - MCI

1 stop13h 59mUnited Airlines

Thu 1/2210:00 amMCI - DSM

1 stop11h 50mUnited Airlines

Deal found 1/1

$561

Tue 1/2012:25 pmDSM - STL

1 stop4h 12mDelta

Tue 1/2711:23 amSTL - DSM

1 stop4h 18mDelta

Deal found 12/30

$179

Tue 1/206:10 amDSM - STL

Nonstop1h 20mSouthwest

Tue 1/278:00 pmSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/30

$267

Wed 1/2112:25 pmDSM - STL

1 stop4h 12mDelta

Wed 1/286:35 amSTL - DSM

2 stops9h 06mDelta

Deal found 12/31

$164

Wed 1/213:20 pmDSM - STL

Nonstop1h 15mSouthwest

Wed 1/288:00 pmSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/31

$253

Wed 1/286:10 amDSM - STL

Nonstop1h 20mSouthwest

Sat 1/315:30 amSTL - DSM

1 stop6h 45mSouthwest

Deal found 12/30

$277

Thu 1/295:16 pmDSM - STL

1 stop6h 21mDelta

Fri 1/306:00 amSTL - DSM

1 stop4h 41mDelta

Deal found 12/31

$159

One-way flights from Des Moines to Missouri
Search for one-way flight options from Des Moines to Missouri. Find affordable one-way fares based on user searches. Data last updated January 2, 2026.

Fri 2/277:59 pmDSM - STL

1 stop17h 57mFrontier

Deal found 1/1

$72

Wed 1/2810:30 amDSM - STL

1 stop6h 15mDelta

Deal found 12/30

$80

Thu 2/267:27 pmDSM - STL

1 stop17h 42mFrontier

Deal found 12/30

$104

Thu 2/265:00 amDSM - STL

1 stop5h 03mAmerican Airlines

Deal found 12/30

$110

Sun 2/14:30 pmDSM - STL

2 stops20h 20mMultiple Airlines

Deal found 1/1

$132

Thu 1/296:10 amDSM - STL

Nonstop1h 20mSouthwest

Deal found 12/30

$141

Sat 2/286:10 amDSM - STL

2 stops10h 45mSouthwest

Deal found 1/1

$156

Fri 2/278:29 pmDSM - STL

2 stops27h 30mMultiple Airlines

Deal found 1/1

$158

Sat 3/2812:29 pmDSM - STL

1 stop4h 11mDelta

Deal found 1/1

$165

Fri 1/168:18 pmDSM - MCI

2 stops38h 46mFrontier

Deal found 1/1

$206

Fri 1/165:01 pmDSM - MCI

1 stop17h 12mAmerican Airlines

Deal found 1/1

$209

Fri 1/168:18 pmDSM - MCI

3 stops38h 13mMultiple Airlines

Deal found 1/1

$300

Find flight deals from Des Moines to Missouri

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$159 (Delta)
One-way from	$72 (Kiwi.com)
Popular in	July
Cheapest in	September
Average price	$319
Good round-trip deal	$377 or less
Good one-way deal	$199 or less

Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.

Search Deals

From Des Moines to Missouri

Search Deals

One-way flight from Des Moines to Missouri

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 8% potential price decrease ($25 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in January 2026

Search Deals

Price to beat on a round-trip flight from Des Moines to Missouri.

Search Deals

Price to beat on a one-way flight from Des Moines to Missouri.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 2/14

12:28 pm-4:42 pm

1 stop4h 14m

Lambert-St Louis

Sat 2/21

7:10 am-12:14 pm

1 stop5h 04m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/28

4:00 pm-10:59 pm

1 stop6h 59m

Lambert-St Louis

Sat 1/31

9:25 am-5:06 pm

1 stop7h 41m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/12

5:00 am-8:41 am

1 stop3h 41m

Lambert-St Louis

Thu 2/19

9:37 am-1:05 pm

1 stop3h 28m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/21

5:16 pm-11:37 pm

1 stop6h 21m

Lambert-St Louis

Wed 1/28

11:23 am-3:41 pm

1 stop4h 18m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/30

5:51 pm-10:59 pm

1 stop5h 08m

Lambert-St Louis

Sat 1/31

11:05 am-4:24 pm

1 stop5h 19m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/29

5:16 pm-11:37 pm

1 stop6h 21m

Lambert-St Louis

Fri 1/30

6:00 am-10:41 am

1 stop4h 41m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 2/6

5:16 pm-11:37 pm

1 stop6h 21m

Lambert-St Louis

Sun 2/8

6:10 am-10:19 am

1 stop4h 09m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/12

7:32 pm-1:09 pm

1 stop17h 37m

Lambert-St Louis

Thu 2/19

10:11 pm-6:19 pm

2 stops20h 08m

$220

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 2/15

5:00 am-8:35 am

1 stop3h 35m

Lambert-St Louis

Sun 2/22

9:20 am-1:05 pm

1 stop3h 45m

$244

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/21

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

Wed 1/28

8:00 pm-9:10 pm

Nonstop1h 10m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/30

Showing 1-10 of 27 results

Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest time of day to fly from DSM to MO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Reviews of airlines servicing Missouri

Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,254 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,132 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,074 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly from for flights from Des Moines to Missouri?
Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.
How popular is this Des Moines to Missouri flight route?
The Des Moines to Missouri flight path was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Des Moines to Missouri?
A quick flight from Des Moines to Missouri can take about 3h 40m. Delta provides one of the quickest options available for as low as $327. The distance between Des Moines and Missouri is about 165 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest flights from Des Moines to Missouri?
The cheapest flight price from Des Moines to Missouri is $128. On average you can expect to pay $341. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $159.
Can I find deals for flights from Des Moines to Missouri that include hotel bookings?
Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Missouri?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.
Can I find deals for business class flights from Des Moines to Missouri?
Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Des Moines to Missouri

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Omaha to Atlanta flights

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Moline to Sky Harbor Intl flights

Des Moines to Tampa flights

Cedar Rapids to Fort Myers flights

Omaha to Hobby flights

Cedar Rapids to Tampa flights

Omaha to Newark flights

Des Moines to George Bush Intcntl flights

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Omaha to San Francisco flights

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Moline to Dallas/Fort Worth flights

Des Moines to Fort Lauderdale flights

Omaha to Los Angeles flights

Des Moines to Seattle flights

Omaha to Dulles Intl flights

Cedar Rapids to Dallas/Fort Worth flights

Des Moines to Newark flights

Omaha to Nashville flights

Moline to Miami flights

Cedar Rapids to Miami flights

Des Moines to Honolulu flights

Complete your trip

Missouri car rentals

Lambert-St Louis Airport car rentals

Kansas City Airport car rentals

Springfield-Branson Airport car rentals

Columbia Regional Airport car rentals

Joplin Airport car rentals

Cape Girardeau Airport car rentals

Fort Leonard Wood Waynesville Regional Airport car rentals

Kirksville Cannon Memorial Airport car rentals

St. Louis car rentals

Kansas City car rentals

Springfield car rentals

Top 3 airlines flying from Des Moines to Missouri

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$97	Average$254	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$218	Average$258	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$218	Average$418	FlexibilityNo cancel fee	On-time69%

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$72+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Missouri with Cheapflights

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Cheap flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to MissouriExplore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Find flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated January 2, 2026.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 2, 2026.

Reviews of airlines servicing Missouri

Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Des Moines to Missouri?

How popular is this Des Moines to Missouri flight route?

How long is the flight from Des Moines to Missouri?

What are the cheapest flights from Des Moines to Missouri?

Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

How can I find direct flights from Des Moines to Missouri?

Can I find deals for business class flights from Des Moines to Missouri?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Des Moines to Missouri

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Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.