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$169+ Cheap flights from Knoxville (TYS) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico

Keep the following information in mind while searching for Knoxville to Mexico flight deals. Data was last updated junio 12, 2025.

Round-trip from

$318
(Mytrip)

One-way from

$169
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$592
From Knoxville McGhee Tyson to Mexico
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One-way flight from Knoxville McGhee Tyson to Mexico
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Highest demand for flights based on searches. 16% potential increase in price ($142 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to Mexico

Cheapest flights from Knoxville to Mexico
Explore the most affordable flight options available from Knoxville to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/183:34 pmTYS - CUN
1 stop17h 52mMultiple Airlines
jue. 8/2112:38 pmCUN - TYS
1 stop6h 44mMultiple Airlines
Deal found 6/10$318
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/236:45 amTYS - MEX
1 stop17h 15mMultiple Airlines
jue. 6/2611:05 amMEX - TYS
1 stop10h 28mMultiple Airlines
Deal found 6/10$392
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/1610:54 amTYS - GDL
2 stops28h 18mMultiple Airlines
mar. 8/267:03 amGDL - TYS
2 stops25h 01mMultiple Airlines
Deal found 6/9$480
This Aeromexico deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/138:35 amTYS - CUN
1 stop6h 35mAeromexico
vie. 8/222:00 pmCUN - TYS
1 stop8h 48mAeromexico
Deal found 6/12$483
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/128:22 pmTYS - CUN
1 stop14h 18mAmerican Airlines
jue. 7/1710:20 amCUN - TYS
2 stops7h 52mAmerican Airlines
Deal found 6/11$488
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/175:45 amTYS - CUN
1 stop9h 25mDelta
vie. 8/229:13 amCUN - TYS
2 stops13h 35mDelta
Deal found 6/12$501
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/165:45 amTYS - GDL
1 stop7h 36mDelta
mar. 8/268:30 amGDL - TYS
2 stops13h 18mDelta
Deal found 6/9$518
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/28:22 pmTYS - CZM
2 stops20h 12mAmerican Airlines
sáb. 8/94:25 pmCZM - TYS
1 stop5h 54mAmerican Airlines
Deal found 6/12$525
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/85:30 amTYS - MEX
2 stops11h 45mDelta
mar. 7/159:25 amMEX - TYS
2 stops9h 51mDelta
Deal found 6/11$545
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/86:05 amTYS - MEX
1 stop8h 50mAmerican Airlines
mar. 7/155:35 amMEX - TYS
2 stops13h 04mAmerican Airlines
Deal found 6/11$550
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/25:40 amTYS - PVR
1 stop8h 30mAmerican Airlines
mar. 12/231:00 pmPVR - TYS
1 stop10h 20mAmerican Airlines
Deal found 6/10$573
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/257:00 amTYS - SJD
1 stop8h 50mUnited Airlines
vie. 8/111:32 amSJD - TYS
1 stop8h 55mUnited Airlines
Deal found 6/10$573

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico that are best for you.

Fly from

Knoxville

Fly to

Mexico

Route

Depart

Return

Price

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

lun. 8/18

3:34 pm-8:26 am

1 stop17h 52m

Cancun

jue. 8/21

12:38 pm-8:22 pm

1 stop6h 44m

$318

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

lun. 6/23

6:45 am-10:00 pm

1 stop17h 15m

Mexico City Benito Juarez

jue. 6/26

11:05 am-11:33 pm

1 stop10h 28m

$392

KnoxvilleGuadalajara

TYS - GDL

TYSGDL

Knoxville McGhee Tyson

sáb. 8/16

10:54 am-1:12 pm

2 stops28h 18m

Guadalajara Miguel Hidal

mar. 8/26

7:03 am-10:04 am

2 stops25h 01m

$480

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

mié. 8/13

8:35 am-2:10 pm

1 stop6h 35m

Cancun

vie. 8/22

2:00 pm-11:48 pm

1 stop8h 48m

$483

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

sáb. 7/12

8:22 pm-9:40 am

1 stop14h 18m

Cancun

jue. 7/17

10:20 am-7:12 pm

2 stops7h 52m

$488

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

dom. 8/17

5:45 am-2:10 pm

1 stop9h 25m

Cancun

vie. 8/22

9:13 am-11:48 pm

2 stops13h 35m

$501

KnoxvilleGuadalajara

TYS - GDL

TYSGDL

Knoxville McGhee Tyson

sáb. 8/16

5:45 am-11:21 am

1 stop7h 36m

Guadalajara Miguel Hidal

mar. 8/26

12:46 pm-11:48 pm

1 stop9h 02m

$518

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

sáb. 8/2

8:22 pm-2:34 pm

2 stops20h 12m

Cozumel

sáb. 8/9

4:25 pm-12:19 am

1 stop5h 54m

$525

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

mar. 7/8

5:30 am-3:15 pm

2 stops11h 45m

Mexico City Benito Juarez

mar. 7/15

9:25 am-9:16 pm

2 stops9h 51m

$545

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

mar. 7/8

6:05 am-12:55 pm

1 stop8h 50m

Mexico City Benito Juarez

mar. 7/15

5:35 am-8:39 pm

2 stops13h 04m

$550

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 40 results
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Best time to book a flight from Knoxville to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico

What is the cheapest month to book a flight from Knoxville to Mexico?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $388). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MX?

Find hourly flight availability from Knoxville to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from Knoxville to Mexico, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Mexico by month

Plan your trip to Mexico by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mexico ranges from 0.0 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. January is typically the driest time to visit Mexico when rainfall is around 0.0 in.

Temperature in Mexico by month

Plan your trip to Mexico by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mexico, use this chart to help with planning. For those seeking warmer temperatures, May is the ideal time of year to visit, when temperatures reach an average of 66.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated junio 12, 2025.
See what other customers who have flown with Delta, Aeromexico and United Airlines from Knoxville to Mexico have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Aeromexico
7.5
Good
1,706 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
WestJet
7.2
Good
2,868 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mexico?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Mexico. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Mexico one-way?

    $273 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $278 and $429, respectively.

  • What are the most popular routes from Knoxville to Mexico?

    The most popular route from Knoxville to Mexico is Knoxville McGhee Tyson - Cancun. You may also consider Knoxville McGhee Tyson - Mexico City Benito Juarez or Knoxville McGhee Tyson - Cozumel.

  • Can I find deals for flights from Knoxville to Mexico that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico.

  • Can I find deals for business class flights from Knoxville to Mexico?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $388). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to Mexico

Discover the top 4 airlines that operate flights from Knoxville to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$442Average$594FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$449Average$583FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$639FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$466Average$668FlexibilityNo cancel feeOn-time69%

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