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$151+ Cheap flights from Knoxville (TYS) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico

Keep the following information in mind while searching for Knoxville to Mexico flight deals. Data was last updated April 29, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$352
(Mytrip)

One-way from

$151
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$487
Provider with most accurate pricing for Knoxville McGhee Tyson-Mexico City Benito Juarez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Mexico City Benito Juarez flights.
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From Knoxville McGhee Tyson to Mexico
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One-way flight from Knoxville McGhee Tyson to Mexico
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Highest demand for flights based on searches. 16% potential increase in price ($139 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Mexico

Cheapest flights from Knoxville to Mexico
Explore the most affordable flight options available from Knoxville to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1410:04 pmTYS - CUN
1 stop11h 12mMultiple Airlines
Mon 5/199:12 amCUN - TYS
1 stop11h 27mMultiple Airlines
Deal found 4/29$353
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:30 amTYS - GDL
1 stop8h 13mDelta
Sun 5/111:00 pmGDL - TYS
2 stops8h 51mDelta
Deal found 4/29$454
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/612:34 pmTYS - GDL
1 stop12h 21mAmerican Airlines
Sun 5/116:00 amGDL - TYS
1 stop15h 58mAmerican Airlines
Deal found 4/29$459
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/66:38 amTYS - MTY
1 stop10h 52mMultiple Airlines
Sun 6/811:25 amMTY - TYS
1 stop22h 39mMultiple Airlines
Deal found 4/29$460
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:00 amTYS - MEX
1 stop15h 35mMultiple Airlines
Fri 6/207:20 amMEX - TYS
2 stops13h 07mMultiple Airlines
Deal found 4/29$463
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/268:47 amTYS - CUN
1 stop4h 58mDelta
Fri 8/293:07 pmCUN - TYS
1 stop7h 40mDelta
Deal found 4/28$464
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/215:55 amTYS - CZM
1 stop11h 14mAmerican Airlines
Fri 10/314:23 pmCZM - TYS
1 stop5h 24mAmerican Airlines
Deal found 4/29$476
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/217:00 amTYS - CZM
1 stop7h 19mUnited Airlines
Fri 10/311:25 pmCZM - TYS
2 stops18h 20mUnited Airlines
Deal found 4/29$480
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/266:13 amTYS - CUN
2 stops8h 07mAmerican Airlines
Sat 8/3012:40 pmCUN - TYS
2 stops8h 20mAmerican Airlines
Deal found 4/28$493
This Aeromexico deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/112:03 pmTYS - MEX
2 stops11h 57mAeromexico
Thu 7/317:05 amMEX - TYS
2 stops11h 00mAeromexico
Deal found 4/29$538
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/310:05 amTYS - MEX
2 stops12h 09mAmerican Airlines
Fri 7/115:35 amMEX - TYS
2 stops11h 37mAmerican Airlines
Deal found 4/29$542
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:25 pmTYS - CUN
2 stops15h 39mUnited Airlines
Fri 10/104:12 pmCUN - TYS
1 stop21h 38mUnited Airlines
Deal found 4/29$566

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico that are best for you.

Fly from

Knoxville

Fly to

Mexico

Route

Depart

Return

Price

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Wed 5/14

10:04 pm-8:16 am

1 stop11h 12m

Cancun

Mon 5/19

9:12 am-9:39 pm

1 stop11h 27m

$353

KnoxvilleMonterrey

TYS - MTY

TYSMTY

Knoxville McGhee Tyson

Fri 6/6

6:38 am-3:30 pm

1 stop10h 52m

Monterrey Gen Mariano Escobedo

Sun 6/8

11:25 am-12:04 pm

1 stop22h 39m

$460

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Fri 6/13

6:00 am-7:35 pm

1 stop15h 35m

Mexico City Benito Juarez

Fri 6/20

7:20 am-10:27 pm

2 stops13h 07m

$463

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Tue 8/26

8:47 am-12:45 pm

1 stop4h 58m

Cancun

Fri 8/29

3:07 pm-11:47 pm

1 stop7h 40m

$464

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Tue 10/21

5:55 am-3:09 pm

1 stop11h 14m

Cozumel

Fri 10/31

4:23 pm-11:47 pm

1 stop5h 24m

$476

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Tue 10/21

7:00 am-12:19 pm

1 stop7h 19m

Cozumel

Fri 10/31

1:25 pm-9:45 am

2 stops18h 20m

$480

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Tue 8/26

6:13 am-1:20 pm

2 stops8h 07m

Cancun

Sat 8/30

12:40 pm-10:00 pm

2 stops8h 20m

$493

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 7/1

12:03 pm-10:00 pm

2 stops11h 57m

Mexico City Benito Juarez

Thu 7/31

7:05 am-8:05 pm

2 stops11h 00m

$538

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 6/3

10:05 am-8:14 pm

2 stops12h 09m

Mexico City Benito Juarez

Fri 7/11

5:35 am-7:12 pm

2 stops11h 37m

$542

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Sat 10/4

7:25 pm-10:04 am

2 stops15h 39m

Cancun

Fri 10/10

4:12 pm-2:50 pm

1 stop21h 38m

$566

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 33 results
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Best time to book a flight from Knoxville to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico

What is the cheapest month to book a flight from Knoxville to Mexico?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $400). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MX?

Find hourly flight availability from Knoxville to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

When flying from Knoxville to Mexico, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Mexico by month

Plan your trip to Mexico by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mexico ranges from 0.0 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. January is typically the driest time to visit Mexico when rainfall is around 0.0 in.

Temperature in Mexico by month

Plan your trip to Mexico by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mexico, use this chart to help with planning. For those seeking warmer temperatures, May is the ideal time of year to visit, when temperatures reach an average of 66.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 29, 2025.
See what other customers who have flown with Delta, LATAM Airlines and Copa Airlines from Knoxville to Mexico have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,411 reviews
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Aeromexico
7.5
Good
1,698 reviews
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Entertainment

7.9

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mexico?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Mexico. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Mexico one-way?

    $266 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $311 and $311, respectively.

  • What are the most popular routes from Knoxville to Mexico?

    The most popular route from Knoxville to Mexico is Knoxville McGhee Tyson - Cancun. You may also consider Knoxville McGhee Tyson - Cozumel or Knoxville McGhee Tyson - Mexico City Benito Juarez.

  • Can I find deals for flights from Knoxville to Mexico that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico.

  • Can I find deals for business class flights from Knoxville to Mexico?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $400). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico

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Top 4 airlines flying from Knoxville to Mexico

Discover the top 4 airlines that operate flights from Knoxville to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$442Average$678FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$447Average$625FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$642FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$461Average$642FlexibilityNo cancel feeOn-time69%

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