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$225+ Cheap flights from Knoxville (TYS) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico

Cheapest flights from Knoxville to Mexico
Explore the most affordable flight options available from Knoxville to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:22 pm
TYS
-
CUN
2 stops16h 58m
Multiple Airlines
Thu 2/2611:55 am
CUN
-
TYS
1 stop10h 12m
Multiple Airlines
Deal found 1/27$350
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:22 pm
TYS
-
CUN
2 stops40h 58m
Multiple Airlines
Thu 2/2611:55 am
CUN
-
TYS
1 stop10h 12m
Multiple Airlines
Deal found 1/27$352
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/219:24 pm
TYS
-
CUN
1 stop14h 56m
Multiple Airlines
Thu 2/2611:55 am
CUN
-
TYS
1 stop10h 12m
Multiple Airlines
Deal found 1/27$355
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:22 pm
TYS
-
CUN
2 stops16h 58m
Multiple Airlines
Tue 3/31:25 pm
CUN
-
TYS
1 stop20h 45m
Multiple Airlines
Deal found 1/27$367
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:11 pm
TYS
-
CUN
2 stops39h 07m
Multiple Airlines
Thu 2/1910:13 am
CUN
-
TYS
1 stop12h 03m
Multiple Airlines
Deal found 1/26$368
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/219:24 pm
TYS
-
CUN
1 stop14h 56m
Multiple Airlines
Wed 2/251:25 pm
CUN
-
TYS
2 stops21h 50m
Multiple Airlines
Deal found 1/27$369
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/219:24 pm
TYS
-
CUN
1 stop14h 56m
Multiple Airlines
Sat 2/289:00 am
CUN
-
TYS
1 stop9h 58m
Multiple Airlines
Deal found 1/27$373
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/202:06 pm
TYS
-
CUN
1 stop17h 44m
Multiple Airlines
Sat 2/289:00 am
CUN
-
TYS
1 stop9h 58m
Multiple Airlines
Deal found 1/27$396
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:22 pm
TYS
-
CUN
2 stops16h 58m
Multiple Airlines
Fri 2/2710:13 am
CUN
-
TYS
1 stop8h 18m
Multiple Airlines
Deal found 1/27$406
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:22 pm
TYS
-
CUN
2 stops16h 58m
Multiple Airlines
Mon 3/210:13 am
CUN
-
TYS
1 stop8h 18m
Multiple Airlines
Deal found 1/27$407
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:35 am
TYS
-
CZM
1 stop9h 22m
Delta
Mon 3/23:10 pm
CZM
-
TYS
1 stop7h 42m
Delta
Deal found 1/27$458
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:02 pm
TYS
-
CZM
2 stops22h 55m
Delta
Mon 3/23:10 pm
CZM
-
TYS
1 stop7h 42m
Delta
Deal found 1/27$463

Find flight deals from Knoxville to Mexico

Keep the following information in mind while searching for Knoxville to Mexico flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$350
(Kiwi.com)

One-way from

$225
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$694
Provider with most accurate pricing for Knoxville McGhee Tyson-Mexico City Benito Juarez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Mexico City Benito Juarez flights.
Search Deals
From Knoxville McGhee Tyson to Mexico
Search Deals
One-way flight from Knoxville McGhee Tyson to Mexico
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($125 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Mexico that are best for you.

Fly from

Knoxville

Fly to

Mexico

Route

Depart

Return

Price

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Mon 2/23

7:22 pm-12:20 pm

2 stops16h 58m

Cancun

Thu 2/26

11:55 am-10:07 pm

1 stop10h 12m

$350

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Fri 2/13

2:06 pm-7:50 am

1 stop17h 44m

Cancun

Tue 2/17

1:25 pm-10:08 am

1 stop20h 43m

$433

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Fri 2/20

5:35 am-1:55 pm

1 stop9h 20m

Cozumel

Tue 3/3

3:10 pm-11:52 pm

1 stop7h 42m

$458

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Mon 2/23

6:35 am-2:57 pm

1 stop9h 22m

Cozumel

Tue 3/3

3:10 pm-11:52 pm

1 stop7h 42m

$458

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Sat 2/21

6:35 am-2:57 pm

1 stop9h 22m

Cozumel

Tue 3/3

3:10 pm-11:52 pm

1 stop7h 42m

$458

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Wed 2/18

5:35 am-1:55 pm

1 stop9h 20m

Cozumel

Tue 3/3

3:10 pm-11:52 pm

1 stop7h 42m

$458

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Tue 2/24

7:02 am-1:55 pm

1 stop7h 53m

Cozumel

Mon 3/2

3:10 pm-11:52 pm

1 stop7h 42m

$458

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Fri 5/1

6:20 pm-1:26 pm

1 stop20h 06m

Cancun

Fri 5/8

9:13 am-10:24 pm

1 stop12h 11m

$459

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Fri 2/20

5:35 am-1:55 pm

1 stop9h 20m

Cozumel

Mon 3/2

4:15 pm-4:17 pm

2 stops23h 02m

$463

KnoxvilleCozumel

TYS - CZM

TYSCZM

Knoxville McGhee Tyson

Sat 2/21

6:35 am-2:57 pm

1 stop9h 22m

Cozumel

Mon 3/2

4:15 pm-4:17 pm

2 stops23h 02m

$463

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 34 results
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Best time to book a flight from Knoxville to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico

What is the cheapest month to book a flight from Knoxville to Mexico?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $203). Flying from Knoxville to Mexico in July is currently the most expensive (average of $382). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Knoxville to Mexico, such as Delta, United Airlines, and Aeromexico. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,127 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,127 reviews
Delta
7.9
Good
8,127 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,127 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Aeromexico
7.4
Good
1,586 reviews
Delta
7.9
Good
8,127 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,206 reviews
Delta
7.9
Good
8,127 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mexico?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Mexico. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Mexico?

    A quick flight from Knoxville to Mexico can take about 7h 50m. Delta provides one of the quickest options available for as low as $565. There are 1655 mi between Knoxville and Mexico. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mexico?

    The most popular route from Knoxville to Mexico is Knoxville McGhee Tyson - Cancun. You may also consider Knoxville McGhee Tyson - Cozumel or Knoxville McGhee Tyson - San José del Cabo Los Cabos.

  • Can I find deals for flights from Knoxville to Mexico that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico.

  • Can I find deals for business class flights from Knoxville to Mexico?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $203). Flying from Knoxville to Mexico in July is currently the most expensive (average of $382). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to Mexico

Discover the top 4 airlines that operate flights from Knoxville to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$318Average$573FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$637FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$477Average$765FlexibilityNo cancel feeOn-time69%
AeromexicoCheapest$486Average$608FlexibilityNo cancel feeOn-timeN/A

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