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$178+ Cheap flights from Knoxville (TYS) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico

Keep the following information in mind while searching for Knoxville to Mexico flight deals. Data was last updated September 14, 2025.

Round-trip from

$399
(Kiwi.com)

One-way from

$178
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$562
From Knoxville McGhee Tyson to Mexico
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One-way flight from Knoxville McGhee Tyson to Mexico
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Highest demand for flights based on searches. 23% potential increase in price ($212 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Mexico

Cheapest flights from Knoxville to Mexico
Explore the most affordable flight options available from Knoxville to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:24 pmTYS - CUN
1 stop16h 23mMultiple Airlines
Tue 9/239:16 amCUN - TYS
1 stop28h 19mMultiple Airlines
Deal found 9/12$374
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/209:31 pmTYS - CUN
1 stop11h 40mMultiple Airlines
Tue 9/239:16 amCUN - TYS
1 stop28h 19mMultiple Airlines
Deal found 9/12$386
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:45 amTYS - CUN
1 stop24h 19mMultiple Airlines
Mon 11/32:50 pmCUN - TYS
1 stop19h 43mMultiple Airlines
Deal found 9/12$399
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:44 pmTYS - CUN
2 stops15h 27mMultiple Airlines
Sun 10/59:09 amCUN - TYS
2 stops11h 08mMultiple Airlines
Deal found 9/14$447
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:00 amTYS - MTY
1 stop12h 00mMultiple Airlines
Wed 11/1211:20 amMTY - TYS
2 stops30h 02mMultiple Airlines
Deal found 9/12$471
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:17 pmTYS - MEX
1 stop22h 43mMultiple Airlines
Wed 10/153:45 pmMEX - TYS
1 stop18h 43mMultiple Airlines
Deal found 9/12$476
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:20 pmTYS - MEX
2 stops32h 40mMultiple Airlines
Sat 10/258:10 amMEX - TYS
1 stop27h 23mMultiple Airlines
Deal found 9/13$485
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/711:23 amTYS - GDL
2 stops27h 53mMultiple Airlines
Sun 10/196:36 amGDL - TYS
1 stop10h 56mMultiple Airlines
Deal found 9/13$490
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:18 pmTYS - GDL
1 stop21h 46mAmerican Airlines
Thu 11/206:00 amGDL - TYS
1 stop8h 37mAmerican Airlines
Deal found 9/12$515
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:15 amTYS - CZM
1 stop9h 32mAmerican Airlines
Mon 11/33:00 pmCZM - TYS
1 stop7h 59mAmerican Airlines
Deal found 9/12$528
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/711:23 amTYS - GDL
2 stops27h 53mMultiple Airlines
Sat 10/186:36 amGDL - TYS
1 stop28h 57mMultiple Airlines
Deal found 9/13$529
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:00 amTYS - GDL
1 stop5h 55mAmerican Airlines
Sat 10/187:00 amGDL - TYS
1 stop15h 23mAmerican Airlines
Deal found 9/13$537

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico that are best for you.

Fly from

Knoxville

Fly to

Mexico

Route

Depart

Return

Price

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Mon 10/27

6:27 pm-8:47 am

2 stops15h 20m

Cancun

Mon 11/3

12:11 pm-10:33 am

2 stops22h 22m

$414

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Thu 10/2

5:44 pm-8:11 am

2 stops15h 27m

Cancun

Sun 10/5

9:09 am-9:17 pm

2 stops11h 08m

$447

KnoxvilleMonterrey

TYS - MTY

TYSMTY

Knoxville McGhee Tyson

Thu 11/6

7:00 am-6:00 pm

1 stop12h 00m

Monterrey Gen Mariano Escobedo

Wed 11/12

11:20 am-6:22 pm

2 stops30h 02m

$471

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 10/9

8:17 pm-5:00 pm

1 stop22h 43m

Mexico City Benito Juarez

Wed 10/15

3:45 pm-12:28 pm

1 stop18h 43m

$476

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Wed 3/4

2:30 pm-12:24 pm

2 stops21h 54m

Cancun

Wed 3/11

11:10 am-11:44 pm

1 stop11h 34m

$486

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Tue 1/13

12:00 pm-4:31 pm

1 stop4h 31m

Cancun

Tue 2/3

2:10 pm-11:00 pm

1 stop8h 50m

$486

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Sat 1/10

7:20 pm-12:20 pm

1 stop17h 00m

Cancun

Fri 1/16

4:47 pm-10:32 am

1 stop17h 45m

$486

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Tue 12/2

2:38 pm-9:20 pm

1 stop6h 42m

Cancun

Tue 12/9

8:00 am-2:51 pm

1 stop6h 51m

$486

KnoxvilleGuadalajara

TYS - GDL

TYSGDL

Knoxville McGhee Tyson

Tue 10/7

11:23 am-1:16 pm

2 stops27h 53m

Guadalajara Miguel Hidal

Sun 10/19

6:36 am-7:32 pm

1 stop10h 56m

$490

KnoxvilleCancún

TYS - CUN

TYSCUN

Knoxville McGhee Tyson

Fri 10/3

10:44 am-8:47 am

2 stops47h 03m

Cancun

Wed 10/8

9:09 am-7:23 pm

1 stop9h 14m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 51 results
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Best time to book a flight from Knoxville to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico

What is the cheapest month to book a flight from Knoxville to Mexico?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $387). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MX?

Find hourly flight availability from Knoxville to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

When flying from Knoxville to Mexico, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated September 14, 2025.
Read through reviews of airlines operating flights from Knoxville to Mexico, such as Delta, Aeromexico, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Aeromexico
7.5
Good
1,697 reviews
Delta
8.0
Very good
7,956 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,931 reviews
Delta
8.0
Very good
7,956 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mexico?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Mexico. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Mexico?

    A quick flight from Knoxville to Mexico can take about 4h 31m. Aeromexico provides one of the quickest options available for as low as $486. There are 1035 mi between Knoxville and Mexico. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to Mexico one-way?

    $220 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $289 and $339, respectively.

  • What are the most popular routes from Knoxville to Mexico?

    The most popular route from Knoxville to Mexico is Knoxville McGhee Tyson - Cancun. You may also consider Knoxville McGhee Tyson - Cozumel or Knoxville McGhee Tyson - Mexico City Benito Juarez.

  • Can I find deals for flights from Knoxville to Mexico that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico.

  • Can I find deals for business class flights from Knoxville to Mexico?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico (average of $387). Flying from Knoxville to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to Mexico

Discover the top 4 airlines that operate flights from Knoxville to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$446Average$631FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$618FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$477Average$662FlexibilityNo cancel feeOn-time69%
AeromexicoCheapest$479Average$703FlexibilityNo cancel feeOn-timeN/A

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