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$228+ Cheap flights from Knoxville (TYS) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
Dec 25 — Jan 11
Thu 12/25
Thu 1/1
1 adult, Economy
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Find flight deals from Knoxville to Mexico City

Cheapest flights from Knoxville to Mexico City
Explore the most affordable flight options available from Knoxville to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 25, 2025.

This Mytrip deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:30 amTYS - MEX
2 stops20h 00mMultiple Airlines
Tue 1/203:45 pmMEX - TYS
2 stops23h 12mMultiple Airlines
Deal found 11/24$487
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:20 pmTYS - MEX
1 stop16h 35mAmerican Airlines
Tue 1/206:00 amMEX - TYS
1 stop8h 46mAmerican Airlines
Deal found 11/24$609
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:23 pmTYS - MEX
2 stops48h 47mMultiple Airlines
Sun 1/118:00 amMEX - TYS
1 stop31h 50mMultiple Airlines
Deal found 11/23$610
This American Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:22 pmTYS - MEX
1 stop6h 33mAmerican Airlines
Sun 12/146:45 amMEX - TYS
1 stop16h 56mAmerican Airlines
Deal found 11/23$684
This United Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/29:40 amTYS - MEX
2 stops10h 15mUnited Airlines
Thu 12/1112:25 pmMEX - TYS
1 stop6h 29mUnited Airlines
Deal found 11/23$714
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:13 pmTYS - MEX
2 stops9h 42mAmerican Airlines
Thu 12/112:55 pmMEX - TYS
1 stop8h 02mAmerican Airlines
Deal found 11/24$718

Cheap flight deals from Knoxville to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 25, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$444
(Kiwi.com)

One-way from

$228
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$657
Provider with most accurate pricing for Knoxville McGhee Tyson-Mexico City Benito Juarez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Mexico City Benito Juarez flights.
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From Knoxville McGhee Tyson to Mexico City Benito Juarez
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One-way flight from Knoxville McGhee Tyson to Mexico City Benito Juarez
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($108 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico City that are best for you.

Fly from

Knoxville

Fly to

Mexico City

Route

Depart

Return

Price

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-10:00 pm

2 stops30h 13m

Mexico City Benito Juarez

Sun 1/25

10:20 pm-5:28 pm

2 stops18h 08m

$454

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-10:00 pm

2 stops30h 13m

Mexico City Benito Juarez

Wed 1/21

11:10 am-8:39 am

2 stops20h 29m

$463

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 12/11

6:30 am-1:30 am

2 stops20h 00m

Mexico City Benito Juarez

Tue 1/20

3:45 pm-3:57 pm

2 stops23h 12m

$487

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 1/29

9:29 am-7:45 pm

2 stops11h 16m

Mexico City Benito Juarez

Sun 2/1

12:40 am-5:28 pm

2 stops15h 48m

$529

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 1/29

5:40 am-11:20 am

1 stop6h 40m

Mexico City Benito Juarez

Mon 2/2

12:35 pm-11:45 pm

1 stop10h 10m

$545

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 1/27

11:10 am-6:55 pm

2 stops8h 45m

Mexico City Benito Juarez

Mon 2/2

9:40 am-7:27 pm

1 stop8h 47m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 1/7

2:25 pm-9:50 pm

1 stop8h 25m

Mexico City Benito Juarez

Wed 1/14

12:25 pm-7:50 pm

1 stop6h 25m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 1/14

11:10 am-6:55 pm

2 stops8h 45m

Mexico City Benito Juarez

Wed 1/21

10:05 am-6:05 pm

1 stop7h 00m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 2/12

5:35 pm-12:05 am

2 stops31h 30m

$271

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 3/14

5:40 am-10:30 am

1 stop6h 50m

$326

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/23

Showing 1-10 of 14 results
1
2

Compare providers for flights from Knoxville to Mexico City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Mexico City in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Mexico City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Mexico City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Mexico City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Mexico City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico City

What is the cheapest month to book a flight from Knoxville to Mexico City?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Mexico City (average of $271). Flying from Knoxville to Mexico City in December is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MEX?

Find hourly flight availability from Knoxville to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 25, 2025.

It’s typically best to fly out from Knoxville to Mexico City in the evening. Doing so could potentially save you 37% on the flight price compared to flying in the afternoon, which is usually more expensive.

How much does it cost to fly round-trip from Knoxville to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated November 25, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Mexico City round-trip?

    Cheapflights users have booked flights from Knoxville to Mexico City round-trip from $318. Another airline that can offer you cheap pricing is American Airlines. Users have found that Delta is 50% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Mexico City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico City.

  • Can I find deals for business class flights from Knoxville to Mexico City?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico City?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Mexico City (average of $271). Flying from Knoxville to Mexico City in December is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mexico City

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Mexico City flights
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Blountville to Mexico City flights

Top 2 airlines flying from Knoxville to Mexico City

Discover the top 2 airlines that operate flights from Knoxville to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$318Average$582FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$455Average$749FlexibilityNo cancel feeOn-time71%

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