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$448+ Cheap flights from Knoxville (TYS) to Mexico City (MEX)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MEX
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$448
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$562
From Knoxville McGhee Tyson to Mexico City Benito Juarez
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Highest demand for flights based on searches. 23% potential increase in price ($212 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Mexico City

Cheapest flights from Knoxville to Mexico City
Explore the most affordable flight options available from Knoxville to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - MEX
1 stop23h 48mMultiple Airlines
Thu 11/68:10 amMEX - TYS
1 stop9h 12mMultiple Airlines
Deal found 9/15$448
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - MEX
2 stops36h 37mMultiple Airlines
Mon 10/278:10 amMEX - TYS
1 stop9h 22mMultiple Airlines
Deal found 9/16$467
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 pmTYS - MEX
2 stops28h 20mMultiple Airlines
Fri 11/711:10 amMEX - TYS
1 stop11h 04mMultiple Airlines
Deal found 9/15$487
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - MEX
1 stop23h 48mMultiple Airlines
Sun 11/910:00 pmMEX - TYS
2 stops24h 14mMultiple Airlines
Deal found 9/16$507
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - MEX
2 stops34h 07mMultiple Airlines
Sun 12/1411:10 amMEX - TYS
1 stop22h 22mMultiple Airlines
Deal found 9/16$534
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:22 pmTYS - MEX
1 stop6h 33mAmerican Airlines
Sun 12/146:45 amMEX - TYS
1 stop16h 56mAmerican Airlines
Deal found 9/16$567
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:15 amTYS - MEX
1 stop16h 00mAmerican Airlines
Mon 10/275:00 amMEX - TYS
1 stop16h 51mAmerican Airlines
Deal found 9/16$572

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico City that are best for you.

Fly from

Knoxville

Fly to

Mexico City

Route

Depart

Return

Price

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 10/30

7:00 am-9:45 pm

2 stops16h 45m

Mexico City Benito Juarez

Thu 11/6

8:10 am-6:22 pm

1 stop9h 12m

$499

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-5:05 pm

1 stop23h 48m

Mexico City Benito Juarez

Sun 11/9

10:00 pm-11:14 pm

2 stops24h 14m

$507

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 10/29

6:00 pm-7:45 pm

1 stop27h 45m

Mexico City Benito Juarez

Thu 11/6

12:40 am-5:22 pm

1 stop15h 42m

$533

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-10:00 pm

2 stops34h 07m

Mexico City Benito Juarez

Sun 12/14

11:10 am-10:32 am

1 stop22h 22m

$534

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 3/10

6:45 am-12:45 pm

1 stop8h 00m

Mexico City Benito Juarez

Wed 3/11

3:45 pm-11:44 pm

1 stop5h 59m

$562

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 3/10

8:47 am-7:50 pm

1 stop13h 03m

Mexico City Benito Juarez

Wed 3/11

8:05 am-9:43 pm

2 stops11h 38m

$562

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 10/21

6:15 am-8:15 pm

1 stop16h 00m

Mexico City Benito Juarez

Mon 10/27

5:00 am-11:51 pm

1 stop16h 51m

$572

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Wed 12/3

11:03 am-9:15 pm

2 stops11h 12m

Mexico City Benito Juarez

Sun 12/14

6:00 am-5:12 pm

2 stops10h 12m

$572

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sun 10/5

6:30 am-11:33 am

1 stop7h 03m

$534

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sun 10/5

5:45 am-2:25 pm

2 stops10h 40m

$694

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 11 results
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Best time to book a flight from Knoxville to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mexico City

What is the cheapest month to book a flight from Knoxville to Mexico City?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico City (average of $387). Flying from Knoxville to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MEX?

Find hourly flight availability from Knoxville to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

It’s typically best to fly out from Knoxville to Mexico City at noon. Doing so could potentially save you 24% on the flight price compared to flying in the afternoon, which is usually more expensive.

How much does it cost to fly round-trip from Knoxville to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Delta, Aeromexico, and American Airlines from Knoxville to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Aeromexico
7.5
Good
1,696 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Mexico City?

    A quick flight from Knoxville to Mexico City can take about 8h. Delta provides one of the quickest options available for as low as $562. Airlines will cover a distance of 1455 mi.

  • What are the cheapest airlines flying from Knoxville to Mexico City round-trip?

    Cheapflights users have booked flights from Knoxville to Mexico City round-trip from $455. Other airlines that can offer you cheap pricing are Delta, from $462, and Aeromexico, from $487. Users have found that American Airlines is 33% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Mexico City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mexico City.

  • Can I find deals for business class flights from Knoxville to Mexico City?

    Yes. Cheapflights offers flight deals from Knoxville to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mexico City?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Mexico City (average of $387). Flying from Knoxville to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Mexico City

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Mexico City flights
Memphis to Mexico City flights
Blountville to Mexico City flights

Top 3 airlines flying from Knoxville to Mexico City

Discover the top 3 airlines that operate flights from Knoxville to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$455Average$698FlexibilityNo cancel feeOn-time71%
DeltaCheapest$462Average$582FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$487Average$837FlexibilityNo cancel feeOn-timeN/A

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