$489+ Cheap flights from St. Louis (STL) to Medellín
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MDE
Mar 24 — Mar 311
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from St. Louis to MedellínExplore the most affordable flight options available from St. Louis to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
Explore the most affordable flight options available from St. Louis to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:59 pm
STL
- MDE
1 stop16h 50m
Multiple Airlines
Tue 4/2110:51 am
MDE
- STL
2 stops19h 59m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:23 pm
STL
- MDE
2 stops40h 45m
Multiple Airlines
Wed 4/2910:51 am
MDE
- STL
1 stop12h 28m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$495
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:51 pm
STL
- MDE
2 stops25h 36m
Multiple Airlines
Tue 3/311:52 pm
MDE
- STL
1 stop9h 27m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$564
This Booking.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:05 pm
STL
- MDE
2 stops17h 05m
Multiple Airlines
Mon 4/139:55 am
MDE
- STL
2 stops22h 30m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$573
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:06 am
STL
- MDE
1 stop9h 09m
American Airlines
Wed 4/296:00 am
MDE
- STL
1 stop16h 24m
American Airlines
Deal found 2/20![American Airlines logo]()
$580
This Expedia deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:30 am
STL
- MDE
2 stops26h 20m
Multiple Airlines
Sun 5/312:10 pm
MDE
- STL
2 stops29h 54m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$636
Best flights from St. Louis to MedellínDiscover carefully curated flight deals from St. Louis to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
Discover carefully curated flight deals from St. Louis to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:23 pm
STL
- MDE
2 stops40h 45m
Multiple Airlines
Wed 4/2910:51 am
MDE
- STL
1 stop12h 28m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$495
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:20 am
STL
- MDE
2 stops14h 55m
American Airlines
Wed 4/296:00 am
MDE
- STL
2 stops13h 29m
American Airlines
Deal found 2/20![American Airlines logo]()
$585
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/34:49 pm
STL
- MDE
2 stops24h 26m
Avianca
Wed 3/114:45 am
MDE
- STL
2 stops14h 28m
Avianca
Deal found 2/19![Avianca logo]()
$647
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:59 pm
STL
- MDE
1 stop16h 50m
Multiple Airlines
Tue 4/2110:51 am
MDE
- STL
1 stop12h 28m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$508
This Booking.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:05 pm
STL
- MDE
2 stops17h 05m
Multiple Airlines
Mon 4/139:55 am
MDE
- STL
2 stops22h 30m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$573
This Expedia deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:30 am
STL
- MDE
2 stops25h 15m
Multiple Airlines
Sun 5/312:10 pm
MDE
- STL
2 stops29h 54m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$636
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:50 am
STL
- MDE
3 stops27h 23m
Multiple Airlines
Mon 3/301:17 am
MDE
- STL
3 stops17h 19m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$637
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/511:21 am
STL
- MDE
2 stops34h 04m
Multiple Airlines
Sun 4/121:52 pm
MDE
- STL
1 stop17h 59m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$640
Last-minute flights from St. Louis to MedellínDiscover last-minute flight deals from St. Louis to Medellín. Data last updated February 22, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Medellín. Data last updated February 22, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:30 am
STL
- MDE
2 stops21h 35m
Avianca
Thu 2/2611:55 am
MDE
- STL
2 stops23h 18m
Avianca
Deal found 2/20![Avianca logo]()
$706
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
- MDE
2 stops40h 51m
Multiple Airlines
Mon 3/231:52 pm
MDE
- STL
1 stop9h 27m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:14 am
STL
- MDE
1 stop14h 56m
American Airlines
Mon 3/232:10 pm
MDE
- STL
1 stop20h 22m
American Airlines
Deal found 2/20![American Airlines logo]()
$824
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/34:49 pm
STL
- MDE
2 stops24h 26m
Avianca
Wed 3/114:45 am
MDE
- STL
2 stops14h 28m
Avianca
Deal found 2/19![Avianca logo]()
$647
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:14 am
STL
- MDE
1 stop7h 52m
American Airlines
Tue 3/1012:20 am
MDE
- STL
1 stop10h 12m
American Airlines
Deal found 2/21![American Airlines logo]()
$899
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:51 pm
STL
- MDE
2 stops25h 36m
Multiple Airlines
Tue 3/311:52 pm
MDE
- STL
1 stop9h 27m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$564
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/148:53 pm
STL
- MDE
2 stops33h 04m
Multiple Airlines
Sat 3/211:52 pm
MDE
- STL
1 stop9h 45m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$753
Find flight deals from St. Louis to Medellín
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 22, 2026.
Round-trip from | $489 (Kiwi.com) |
|---|---|
Popular in | December |
Cheapest in | September |
Average price | $782 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from St. Louis to Medellín that are best for you.
Fly from
St. Louis
Fly to
Medellín
Route
Depart
Return
Price
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Wed 4/22
8:23 pm-1:08 pm
2 stops40h 45m
Medellín Jose Maria Cordova Intl
Wed 4/29
10:51 am-11:19 pm
1 stop12h 28m
$495
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Fri 4/17
4:59 pm-9:49 am
1 stop16h 50m
Medellín Jose Maria Cordova Intl
Tue 4/21
10:51 am-11:19 pm
1 stop12h 28m
$508
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Mon 4/6
4:05 pm-9:10 am
2 stops17h 05m
Medellín Jose Maria Cordova Intl
Mon 4/13
9:55 am-8:25 am
2 stops22h 30m
$573
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Wed 4/22
5:20 am-8:15 pm
2 stops14h 55m
Medellín Jose Maria Cordova Intl
Wed 4/29
6:00 am-7:29 pm
2 stops13h 29m
$585
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Fri 5/22
7:30 am-8:45 am
2 stops25h 15m
Medellín Jose Maria Cordova Intl
Sun 5/31
2:10 pm-8:04 pm
2 stops29h 54m
$636
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Tue 3/10
9:50 am-1:13 pm
3 stops27h 23m
Medellín Jose Maria Cordova Intl
Mon 3/30
1:17 am-6:36 pm
3 stops17h 19m
$637
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Sun 4/5
11:21 am-9:25 pm
2 stops34h 04m
Medellín Jose Maria Cordova Intl
Sun 4/12
1:52 pm-7:51 am
1 stop17h 59m
$640
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Tue 3/3
4:49 pm-6:15 pm
2 stops24h 26m
Medellín Jose Maria Cordova Intl
Wed 3/11
4:45 am-7:13 pm
2 stops14h 28m
$647
Best time to book a flight from St. Louis to Medellín
Have a flexible travel schedule? Discover the best time to fly to Medellín from St. Louis with our price prediction graph.
STL-CO1
STL-MDE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Medellín
STL-CO1
STL-MDE
What is the cheapest month to book a flight from St. Louis to Medellín?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Medellín (average of $307). Flying from St. Louis to Medellín in March is currently the most expensive (average of $789). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Medellín
Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated February 22, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from St. Louis to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Crew
8.1
Entertainment
7.1
Overall
7.4
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Food
6.6
Crew
8.1
Entertainment
7.1
Overall
7.4
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Food
6.6
Crew
8.1
Entertainment
7.1
Overall
7.4
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Medellín
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Complete your trip
Complete your trip to Medellín by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Medellín by cabin class
Find flights from St. Louis to Medellín, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Medellín flights
Browse other St. Louis and Medellín flight options. Last updated on February 22, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on February 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from St. Louis to Medellín
Discover the top 2 airlines that operate flights from St. Louis to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$565 | Average$655 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$565 | Average$782 | FlexibilityNo cancel fee | On-time71% |