$338+ Cheap flights from Knoxville (TYS) to Medellín
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MDE
Dec 5 — Dec 121
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Medellín with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Medellín
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MedellínExplore the most affordable flight options available from Knoxville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
Explore the most affordable flight options available from Knoxville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
This BusinessClass deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:50 am -
2 stops16h 48m
Tue 12/87:30 am -
2 stops13h 13m
Deal found 11/1![GOL logo]()
$761
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
1 stop15h 17m
Tue 12/87:30 am -
1 stop14h 40m
Deal found 11/1![American Airlines logo]()
$811
This BusinessClass deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:05 pm -
2 stops20h 06m
Sat 12/57:30 am -
2 stops11h 23m
Deal found 10/31![GOL logo]()
$867
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:50 am -
2 stops13h 27m
Fri 12/113:12 pm -
2 stops18h 43m
Deal found 11/1![American Airlines logo]()
$868
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:35 pm -
1 stop25h 47m
Thu 12/107:30 am -
1 stop16h 35m
Deal found 11/1![American Airlines logo]()
$894
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:05 am -
1 stop15h 05m
Fri 12/1110:40 am -
2 stops23h 34m
Deal found 11/1![United Airlines logo]()
$903
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:53 am -
1 stop10h 17m
Fri 12/1110:40 am -
1 stop24h 32m
Deal found 11/1![United Airlines logo]()
$909
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:00 am -
2 stops15h 22m
Thu 12/101:30 am -
2 stops20h 18m
Deal found 11/1![American Airlines logo]()
$916
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:05 pm -
2 stops20h 06m
Tue 12/87:30 am -
1 stop14h 40m
Deal found 11/1![American Airlines logo]()
$934
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:22 pm -
1 stop28h 17m
Thu 12/103:12 pm -
1 stop29h 04m
Deal found 11/1![American Airlines logo]()
$942
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:35 pm -
1 stop28h 04m
Fri 12/117:30 am -
1 stop16h 35m
Deal found 11/1![American Airlines logo]()
$947
Best flights from Knoxville to MedellínDiscover carefully curated flight deals from Knoxville to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
Discover carefully curated flight deals from Knoxville to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1611:52 am -
1 stop10h 18m
Tue 2/2310:40 am -
1 stop11h 13m
Deal found 11/1![United Airlines logo]()
$639
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/56:00 am -
1 stop17h 10m
Sat 3/137:00 am -
1 stop16h 59m
Deal found 11/1![American Airlines logo]()
$719
This BusinessClass deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:05 pm -
2 stops20h 06m
Sat 12/57:30 am -
2 stops11h 23m
Deal found 10/31![GOL logo]()
$867
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:30 am -
1 stop15h 40m
Fri 2/2610:40 am -
1 stop11h 13m
Deal found 11/1![United Airlines logo]()
$639
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/155:53 pm -
2 stops28h 17m
Sat 2/2710:40 am -
2 stops23h 12m
Deal found 11/1![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/15:55 pm -
2 stops28h 15m
Fri 2/510:40 am -
2 stops23h 30m
Deal found 11/2![United Airlines logo]()
$855
Last-minute flights from Knoxville to MedellínDiscover last-minute flight deals from Knoxville to Medellín. Data last updated November 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Medellín. Data last updated November 5, 2026 and is based on user searches.
This BusinessClass deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:05 pm -
2 stops20h 06m
Sat 12/57:30 am -
2 stops11h 23m
Deal found 10/31![GOL logo]()
$867
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:05 pm -
2 stops20h 06m
Tue 12/87:30 am -
1 stop14h 40m
Deal found 11/1![American Airlines logo]()
$934
This BusinessClass deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:50 am -
2 stops16h 48m
Tue 12/87:30 am -
2 stops13h 13m
Deal found 11/1![GOL logo]()
$761
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
1 stop15h 17m
Tue 12/87:30 am -
1 stop14h 40m
Deal found 11/1![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:50 am -
2 stops13h 27m
Fri 12/113:12 pm -
2 stops18h 43m
Deal found 11/1![American Airlines logo]()
$868
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:53 am -
1 stop10h 17m
Fri 12/1110:40 am -
1 stop24h 32m
Deal found 11/1![United Airlines logo]()
$909
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:22 pm -
1 stop28h 17m
Thu 12/103:12 pm -
1 stop29h 04m
Deal found 11/1![American Airlines logo]()
$942
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:00 am -
2 stops16h 10m
Wed 12/910:40 am -
2 stops13h 19m
Deal found 11/1![United Airlines logo]()
$903
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:00 am -
2 stops15h 22m
Thu 12/101:30 am -
2 stops20h 18m
Deal found 11/1![American Airlines logo]()
$916
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:35 pm -
1 stop25h 47m
Thu 12/107:30 am -
1 stop16h 35m
Deal found 11/1![American Airlines logo]()
$894
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:35 pm -
1 stop28h 04m
Fri 12/117:30 am -
1 stop16h 35m
Deal found 11/1![American Airlines logo]()
$947
One-way flights from Knoxville to MedellínSearch for one-way flight options from Knoxville to Medellín. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
Search for one-way flight options from Knoxville to Medellín. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/81:57 pm -
2 stops22h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/911:33 am -
3 stops48h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:12 pm -
1 stop28h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$402
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/229:26 am -
3 stops26h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$414
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:20 am -
2 stops13h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/86:00 am -
1 stop17h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$442
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/77:10 pm -
2 stops28h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$501
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:00 am -
1 stop17h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$527
Find flight deals from Knoxville to Medellín
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 5, 2026.
Round-trip from | $633 (Trip.com) |
|---|---|
One-way from | $338 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
Use the filters below to find and compare flights from Knoxville to Medellín that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Fri 1/8
1:57 pm-12:00 pm
2 stops22h 03m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$338
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Tue 12/22
9:26 am-12:00 pm
3 stops26h 34m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$414
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Wed 12/23
6:12 pm-8:00 pm
2 stops25h 48m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$438
Quickest round-trip
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Sat 1/9
6:00 am-11:36 pm
2 stops17h 36m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$527
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Tue 2/16
11:52 am-10:10 pm
1 stop10h 18m
Medellín Jose Maria Cordova Intl
Tue 2/23
10:40 am-9:53 pm
1 stop11h 13m
$639
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Thu 2/18
6:30 am-10:10 pm
1 stop15h 40m
Medellín Jose Maria Cordova Intl
Fri 2/26
10:40 am-9:53 pm
1 stop11h 13m
$639
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Mon 2/15
5:53 pm-10:10 pm
2 stops28h 17m
Medellín Jose Maria Cordova Intl
Sat 2/27
10:40 am-9:52 am
2 stops23h 12m
$661
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Fri 3/5
6:00 am-11:10 pm
1 stop17h 10m
Medellín Jose Maria Cordova Intl
Sat 3/13
7:00 am-11:59 pm
1 stop16h 59m
$719
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Mon 2/1
5:55 pm-10:10 pm
2 stops28h 15m
Medellín Jose Maria Cordova Intl
Fri 2/5
10:40 am-10:10 am
2 stops23h 30m
$855
KnoxvilleMedellín
TYS Knoxville McGhee Tyson - MDE Medellín Jose Maria Cordova Intl
TYSMDE
Knoxville McGhee Tyson
Sat 11/28
6:05 pm-2:11 pm
2 stops20h 06m
Medellín Jose Maria Cordova Intl
Sat 12/5
7:30 am-6:53 pm
2 stops11h 23m
$867
Sorted by cheapest first
Best time to book a flight from Knoxville to Medellín
Have a flexible travel schedule? Discover the best time to fly to Medellín from Knoxville with our price prediction graph.
TYS-CO1
TYS-MDE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Medellín
TYS-CO1
TYS-MDE
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights