$128+ Cheap flights from Des Moines (DSM) to Louisiana
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Louisiana with Cheapflights
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Cheapest flights from Des Moines to LouisianaExplore the most affordable flight options available from Des Moines to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Des Moines to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:12 pm -
1 stop7h 15m
Wed 10/218:06 am -
1 stop7h 05m
Deal found 9/14![American Airlines logo]()
$255
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
1 stop7h 55m
Sat 10/175:00 am -
1 stop7h 00m
Deal found 9/17![Southwest logo]()
$260
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:27 am -
1 stop5h 30m
Mon 10/195:20 am -
1 stop5h 22m
Deal found 9/15![Delta logo]()
$272
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:54 pm -
1 stop4h 41m
Sat 10/175:20 am -
1 stop5h 22m
Deal found 9/17![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:50 pm -
1 stop10h 30m
Wed 11/116:00 am -
1 stop8h 15m
Deal found 9/16![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:30 pm -
1 stop7h 25m
Mon 12/146:00 am -
1 stop8h 15m
Deal found 9/16![Southwest logo]()
$298
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:30 pm -
1 stop7h 30m
Fri 12/46:10 am -
1 stop5h 15m
Deal found 9/13![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:10 pm -
1 stop7h 15m
Mon 12/146:00 am -
1 stop8h 15m
Deal found 9/15![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop5h 12m
Sat 10/175:15 am -
2 stops7h 16m
Deal found 9/17![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop7h 28m
Sat 11/1410:24 am -
1 stop4h 57m
Deal found 9/16![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:14 pm -
1 stop6h 25m
Sun 10/45:15 pm -
1 stop5h 57m
Deal found 9/18![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:41 am -
1 stop7h 14m
Wed 9/305:28 pm -
1 stop5h 44m
Deal found 9/14![American Airlines logo]()
$399
Best flights from Des Moines to LouisianaDiscover carefully curated flight deals from Des Moines to Louisiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Des Moines to Louisiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 05m
Sat 11/147:00 am -
1 stop5h 31m
Deal found 9/16![United Airlines logo]()
$255
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops8h 25m
Sat 11/1410:35 am -
2 stops9h 10m
Deal found 9/16![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop7h 28m
Sat 11/1410:24 am -
1 stop4h 57m
Deal found 9/16![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:27 pm -
2 stops9h 32m
Wed 10/216:01 pm -
1 stop5h 47m
Deal found 9/14![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 25m
Tue 12/86:40 am -
2 stops7h 35m
Deal found 9/13![Southwest logo]()
$341
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:15 pm -
1 stop4h 46m
Wed 2/106:00 am -
2 stops10h 50m
Deal found 9/16![Delta logo]()
$344
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
2 stops8h 25m
Mon 12/146:00 am -
1 stop8h 15m
Deal found 9/18![Southwest logo]()
$355
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:25 pm -
2 stops7h 40m
Mon 12/141:05 pm -
2 stops8h 55m
Deal found 9/18![Southwest logo]()
$360
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/278:00 am -
1 stop7h 24m
Sat 1/304:00 pm -
1 stop6h 30m
Deal found 9/13![United Airlines logo]()
$408
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/123:10 pm -
1 stop8h 30m
Sat 2/205:00 am -
1 stop6h 20m
Deal found 9/14![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/263:00 pm -
1 stop4h 41m
Sat 1/303:55 pm -
1 stop6h 35m
Deal found 9/13![United Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/185:20 am -
2 stops8h 35m
Thu 1/212:45 pm -
2 stops6h 50m
Deal found 9/16![Southwest logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:01 pm -
1 stop5h 06m
Sat 10/319:30 am -
1 stop4h 50m
Deal found 9/17![United Airlines logo]()
$428
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
2 stops8h 25m
Fri 12/412:10 pm -
2 stops8h 35m
Deal found 9/13![Southwest logo]()
$378
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/142:58 pm -
1 stop6h 49m
Thu 12/176:09 am -
1 stop8h 04m
Deal found 9/16![Delta logo]()
$556
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
2 stops6h 50m
Mon 11/96:00 am -
2 stops7h 10m
Deal found 9/17![Southwest logo]()
$424
Last-minute flights from Des Moines to LouisianaDiscover last-minute flight deals from Des Moines to Louisiana. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisiana. Data last updated September 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:41 am -
1 stop7h 14m
Wed 9/305:28 pm -
1 stop5h 44m
Deal found 9/14![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:14 pm -
1 stop6h 25m
Sun 10/45:15 pm -
1 stop5h 57m
Deal found 9/18![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:11 pm -
1 stop7h 34m
Wed 10/146:01 pm -
1 stop5h 47m
Deal found 9/18![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:10 pm -
1 stop5h 05m
Tue 10/131:25 pm -
2 stops8h 35m
Deal found 9/13![Southwest logo]()
$336
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
1 stop7h 55m
Sat 10/175:00 am -
1 stop7h 00m
Deal found 9/17![Southwest logo]()
$260
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:27 am -
1 stop5h 30m
Mon 10/195:20 am -
1 stop5h 22m
Deal found 9/15![Delta logo]()
$272
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop5h 12m
Sat 10/175:15 am -
2 stops7h 16m
Deal found 9/17![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:54 pm -
1 stop4h 41m
Sat 10/175:20 am -
1 stop5h 22m
Deal found 9/17![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:12 pm -
1 stop7h 15m
Wed 10/218:06 am -
1 stop7h 05m
Deal found 9/14![American Airlines logo]()
$255
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:27 pm -
2 stops9h 32m
Wed 10/216:01 pm -
1 stop5h 47m
Deal found 9/14![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:10 pm -
1 stop9h 35m
Sat 10/3110:20 am -
2 stops7h 25m
Deal found 9/18![Southwest logo]()
$330
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:10 pm -
1 stop5h 05m
Fri 11/65:50 am -
1 stop7h 20m
Deal found 9/15![Southwest logo]()
$323
One-way flights from Des Moines to LouisianaSearch for one-way flight options from Des Moines to Louisiana. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Des Moines to Louisiana. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:27 am -
1 stop4h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$128
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:20 pm -
1 stop8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$133
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/274:17 pm -
1 stop6h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$162
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:52 pm -
1 stop5h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$196
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:45 pm -
1 stop5h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$204
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:27 am -
2 stops8h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/274:25 pm -
2 stops7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$214
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:00 am -
2 stops8h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:17 pm -
3 stops47h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:05 am -
2 stops9h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop4h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![American Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2512:05 pm -
1 stop12h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$356
Find flight deals from Des Moines to Louisiana
Keep the following information in mind while searching for Des Moines to Louisiana flight deals. Data was last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $255 (American Airlines) |
One-way from | $128 (Delta) |
Popular in | July |
Cheapest in | September |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Des Moines to Louisiana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Sat 10/24
2:30 pm-11:00 pm
1 stop8h 30m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$128
Quickest round-trip
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Tue 10/13
11:27 am-3:50 pm
1 stop4h 23m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$128
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Sat 10/17
1:20 pm-9:30 pm
1 stop8h 10m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Wed 11/25
6:52 pm-11:59 pm
1 stop5h 07m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$196
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Sat 10/17
1:27 pm-10:59 pm
2 stops9h 32m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$209
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Wed 11/11
1:27 pm-9:32 pm
1 stop8h 05m
New Orleans Louis Armstrong
Sat 11/14
7:00 am-12:31 pm
1 stop5h 31m
$255
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Mon 11/30
6:17 pm-6:16 pm
2 stops23h 59m
New Orleans Louis Armstrong
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$262
Des MoinesBaton Rouge
DSM Des Moines - BTR Baton Rouge Ryan
DSMBTR
Des Moines
Thu 11/5
6:00 am-10:31 am
1 stop4h 31m
Baton Rouge Ryan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$300
Des MoinesNew Orleans
DSM Des Moines - MSY New Orleans Louis Armstrong
DSMMSY
Des Moines
Wed 11/11
6:00 am-2:25 pm
2 stops8h 25m
New Orleans Louis Armstrong
Sat 11/14
10:35 am-7:45 pm
2 stops9h 10m
$333
Des MoinesBaton Rouge
DSM Des Moines - BTR Baton Rouge Ryan
DSMBTR
Des Moines
Wed 11/11
5:30 am-12:58 pm
1 stop7h 28m
Baton Rouge Ryan
Sat 11/14
10:24 am-3:21 pm
1 stop4h 57m
$339
Showing 1-10 of 28 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Louisiana
Have a flexible travel schedule? Discover the best time to fly to Louisiana from Des Moines with our price prediction graph.
DSM-MSY
DSM-AEX
DSM-BTR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisiana
DSM-USLA
DSM-MSY
DSM-AEX
DSM-BTR
What is the cheapest month to book a flight from Des Moines to Louisiana?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Louisiana (average of $356). Flying from Des Moines to Louisiana in July is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Louisiana?
Airfare is below average for this route at the moment.
Des Moines to Louisiana flights typically cost between $287 and $549 in October.The cheapest round-trip price found within the last 5 days was $255 on American Airlines (Oct 17-Oct 21).
How far ahead should I book a flight from Des Moines to Louisiana?
Booking 59 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Louisiana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Louisiana
Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated September 18, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisiana, such as Southwest,Delta, andUnited Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Louisiana
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Complete your trip
Complete your trip to Louisiana by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Louisiana by cabin class
Find flights from Des Moines to Louisiana, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Louisiana flights
Browse other Des Moines and Louisiana flight options. Last updated on September 18, 2026.
Popular flight searches
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Des Moines to Louisiana flights
Consider these flights traveling from Des Moines to Louisiana.
Top 4 airlines flying from Des Moines to Louisiana
Discover the top 4 airlines that operate flights from Des Moines to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$283 | Average$433 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$290 | Average$420 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$312 | Average$392 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$312 | Average$392 | FlexibilityNo cancel fee | On-time69% |