$136+ Cheap flights from Des Moines (DSM) to Louisiana
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Jun 28 — Jul 51
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Louisiana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Louisiana
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to LouisianaExplore the most affordable flight options available from Des Moines to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
Explore the most affordable flight options available from Des Moines to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:41 pm
DSM
- BTR
1 stop7h 49m
American Airlines
Mon 8/36:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/24![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:45 pm
DSM
- MSY
1 stop7h 40m
Southwest
Wed 7/295:00 am
MSY
- DSM
1 stop6h 30m
Southwest
Deal found 5/27![Southwest logo]()
$311
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
DSM
- MSY
2 stops7h 59m
American Airlines
Wed 7/296:01 pm
MSY
- DSM
1 stop5h 57m
American Airlines
Deal found 5/26![American Airlines logo]()
$316
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:20 am
DSM
- MSY
1 stop6h 54m
United Airlines
Wed 8/55:35 pm
MSY
- DSM
1 stop5h 21m
United Airlines
Deal found 5/25![United Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:12 am
DSM
- BTR
1 stop5h 31m
American Airlines
Mon 8/36:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/28![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:24 pm
DSM
- MSY
2 stops8h 02m
United Airlines
Wed 7/295:35 pm
MSY
- DSM
1 stop5h 00m
United Airlines
Deal found 5/27![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:15 am
DSM
- MSY
1 stop7h 15m
Southwest
Sat 9/57:15 am
MSY
- DSM
1 stop4h 15m
Southwest
Deal found 5/27![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:40 am
DSM
- MSY
1 stop6h 02m
Delta
Thu 8/63:30 pm
MSY
- DSM
1 stop7h 07m
Delta
Deal found 5/28![Delta logo]()
$333
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- MSY
2 stops7h 45m
Southwest
Thu 8/63:50 pm
MSY
- DSM
1 stop6h 20m
Southwest
Deal found 5/28![Southwest logo]()
$338
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:10 am
DSM
- MSY
2 stops7h 55m
Southwest
Sat 10/310:10 am
MSY
- DSM
2 stops10h 25m
Southwest
Deal found 5/27![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:23 am
DSM
- BTR
1 stop5h 35m
American Airlines
Sat 8/16:47 pm
BTR
- DSM
1 stop5h 11m
American Airlines
Deal found 5/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:12 am
DSM
- BTR
1 stop5h 46m
American Airlines
Mon 8/36:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/28![American Airlines logo]()
$357
Best flights from Des Moines to LouisianaDiscover carefully curated flight deals from Des Moines to Louisiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
Discover carefully curated flight deals from Des Moines to Louisiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:41 am
DSM
- BTR
1 stop7h 06m
Delta
Wed 8/53:57 pm
BTR
- DSM
1 stop6h 40m
Delta
Deal found 5/24![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:15 am
DSM
- MSY
1 stop7h 15m
Southwest
Sat 9/57:15 am
MSY
- DSM
1 stop4h 15m
Southwest
Deal found 5/27![Southwest logo]()
$329
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:00 pm
DSM
- AEX
1 stop4h 38m
United Airlines
Sat 10/315:15 am
AEX
- DSM
2 stops10h 59m
United Airlines
Deal found 5/24![United Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:00 am
DSM
- BTR
2 stops8h 42m
American Airlines
Mon 8/36:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/28![American Airlines logo]()
$423
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am
DSM
- MSY
2 stops8h 30m
Southwest
Sat 10/105:05 am
MSY
- DSM
1 stop7h 05m
Southwest
Deal found 5/27![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 pm
DSM
- MSY
1 stop6h 29m
Delta
Fri 7/35:07 pm
MSY
- DSM
1 stop5h 24m
Delta
Deal found 5/27![Delta logo]()
$346
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:20 am
DSM
- BTR
1 stop7h 09m
United Airlines
Wed 7/84:09 pm
BTR
- DSM
1 stop6h 26m
United Airlines
Deal found 5/25![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:10 am
DSM
- MSY
2 stops6h 45m
Southwest
Wed 8/52:05 pm
MSY
- DSM
2 stops7h 50m
Southwest
Deal found 5/24![Southwest logo]()
$356
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:45 pm
DSM
- MSY
1 stop4h 47m
Delta
Mon 9/284:22 pm
MSY
- DSM
1 stop4h 40m
Delta
Deal found 5/24![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:20 am
DSM
- MSY
1 stop5h 55m
Southwest
Mon 8/32:30 pm
MSY
- DSM
2 stops9h 05m
Southwest
Deal found 5/28![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:02 pm
DSM
- MSY
1 stop5h 01m
United Airlines
Thu 8/132:05 pm
MSY
- DSM
1 stop7h 18m
United Airlines
Deal found 5/25![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/109:23 am
DSM
- BTR
2 stops8h 34m
American Airlines
Sun 6/1411:30 am
BTR
- DSM
1 stop6h 52m
American Airlines
Deal found 5/26![American Airlines logo]()
$480
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:45 pm
DSM
- MSY
1 stop7h 40m
Southwest
Sun 7/192:45 pm
MSY
- DSM
2 stops9h 05m
Southwest
Deal found 5/28![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:54 pm
DSM
- BTR
1 stop7h 07m
Delta
Wed 8/510:26 am
BTR
- DSM
1 stop7h 24m
Delta
Deal found 5/26![Delta logo]()
$431
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:20 am
DSM
- BTR
1 stop5h 00m
United Airlines
Wed 8/59:35 am
BTR
- DSM
2 stops11h 47m
United Airlines
Deal found 5/24![United Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:25 am
DSM
- MSY
2 stops9h 35m
Southwest
Mon 8/34:00 pm
MSY
- DSM
2 stops7h 35m
Southwest
Deal found 5/28![Southwest logo]()
$409
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:24 pm
DSM
- BTR
2 stops7h 22m
United Airlines
Sat 8/19:35 am
BTR
- DSM
2 stops11h 53m
United Airlines
Deal found 5/24![United Airlines logo]()
$489
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:40 pm
DSM
- MSY
2 stops7h 10m
Southwest
Sun 7/192:45 pm
MSY
- DSM
2 stops9h 05m
Southwest
Deal found 5/26![Southwest logo]()
$417
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:40 am
DSM
- MSY
2 stops9h 35m
Southwest
Sun 11/86:00 am
MSY
- DSM
2 stops7h 10m
Southwest
Deal found 5/27![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:02 pm
DSM
- AEX
1 stop4h 58m
United Airlines
Wed 9/94:08 pm
AEX
- DSM
2 stops18h 44m
United Airlines
Deal found 5/28![United Airlines logo]()
$601
Last-minute flights from Des Moines to LouisianaDiscover last-minute flight deals from Des Moines to Louisiana. Data last updated May 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisiana. Data last updated May 29, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:01 pm
DSM
- AEX
1 stop4h 54m
United Airlines
Thu 6/44:00 pm
AEX
- DSM
1 stop6h 40m
United Airlines
Deal found 5/27![United Airlines logo]()
$795
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:33 pm
DSM
- AEX
1 stop6h 42m
Delta
Thu 6/412:10 pm
AEX
- DSM
2 stops8h 26m
Delta
Deal found 5/27![Delta logo]()
$801
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/104:48 pm
DSM
- BTR
1 stop5h 21m
American Airlines
Sun 6/146:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/26![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
DSM
- BTR
2 stops9h 34m
United Airlines
Sun 6/146:09 pm
BTR
- DSM
2 stops16h 33m
United Airlines
Deal found 5/26![United Airlines logo]()
$769
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:25 pm
DSM
- BTR
1 stop7h 30m
Delta
Thu 6/184:00 pm
BTR
- DSM
1 stop6h 31m
Delta
Deal found 5/28![Delta logo]()
$603
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:02 pm
DSM
- MSY
1 stop4h 26m
American Airlines
Wed 7/16:50 am
MSY
- DSM
1 stop6h 31m
American Airlines
Deal found 5/26![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:30 pm
DSM
- MSY
2 stops8h 45m
Southwest
Wed 7/12:30 pm
MSY
- DSM
2 stops7h 10m
Southwest
Deal found 5/26![Southwest logo]()
$414
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/254:40 pm
DSM
- MSY
1 stop7h 15m
Southwest
Thu 7/25:40 am
MSY
- DSM
1 stop5h 50m
Southwest
Deal found 5/28![Southwest logo]()
$417
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/264:48 pm
DSM
- MSY
1 stop6h 40m
American Airlines
Mon 6/299:40 am
MSY
- DSM
1 stop6h 23m
American Airlines
Deal found 5/25![American Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/264:40 pm
DSM
- MSY
1 stop7h 15m
Southwest
Mon 6/293:20 pm
MSY
- DSM
2 stops8h 10m
Southwest
Deal found 5/25![Southwest logo]()
$412
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:45 pm
DSM
- MSY
1 stop7h 35m
Southwest
Fri 7/35:40 am
MSY
- DSM
1 stop5h 50m
Southwest
Deal found 5/28![Southwest logo]()
$346
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:23 am
DSM
- MSY
2 stops7h 45m
American Airlines
Fri 7/32:43 pm
MSY
- DSM
2 stops9h 18m
American Airlines
Deal found 5/24![American Airlines logo]()
$356
One-way flights from Des Moines to LouisianaSearch for one-way flight options from Des Moines to Louisiana. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
Search for one-way flight options from Des Moines to Louisiana. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
This Frontier deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/102:19 pm
DSM
- MSY
1 stop6h 44m
Frontier
Deal found 5/26![Frontier logo]()
$136
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:54 am
DSM
- MSY
1 stop4h 31m
Delta
Deal found 5/26![Delta logo]()
$156
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:00 am
DSM
- MSY
2 stops7h 59m
American Airlines
Deal found 5/26![American Airlines logo]()
$161
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/298:00 am
DSM
- MSY
2 stops8h 27m
United Airlines
Deal found 5/28![United Airlines logo]()
$185
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:30 am
DSM
- MSY
1 stop5h 56m
American Airlines
Deal found 5/28![American Airlines logo]()
$214
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:30 am
DSM
- BTR
1 stop6h 49m
Delta
Deal found 5/28![Delta logo]()
$216
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/254:40 pm
DSM
- MSY
2 stops7h 40m
Southwest
Deal found 5/28![Southwest logo]()
$219
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:00 am
DSM
- BTR
2 stops9h 34m
United Airlines
Deal found 5/28![United Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:41 am
DSM
- AEX
1 stop5h 18m
Delta
Deal found 5/28![Delta logo]()
$263
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:00 am
DSM
- AEX
2 stops11h 55m
United Airlines
Deal found 5/28![United Airlines logo]()
$269
This Alaska Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:48 pm
DSM
- MSY
2 stops23h 28m
Alaska Airlines
Deal found 5/26![Alaska Airlines logo]()
$703
Find flight deals from Des Moines to Louisiana
Keep the following information in mind while searching for Des Moines to Louisiana flight deals. Data was last updated May 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $309 (American Airlines) |
One-way from | $136 (Frontier) |
Popular in | May |
Cheapest in | September |
Average price | $464 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Des Moines to Louisiana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Thu 7/9
5:41 am-12:47 pm
1 stop7h 06m
Baton Rouge Ryan
Wed 8/5
3:57 pm-10:37 pm
1 stop6h 40m
$309
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Wed 9/2
7:15 am-2:30 pm
1 stop7h 15m
New Orleans Louis Armstrong
Sat 9/5
7:15 am-11:30 am
1 stop4h 15m
$329
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Wed 10/7
5:35 am-2:05 pm
2 stops8h 30m
New Orleans Louis Armstrong
Sat 10/10
5:05 am-12:10 pm
1 stop7h 05m
$334
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Tue 6/30
5:00 pm-11:29 pm
1 stop6h 29m
New Orleans Louis Armstrong
Fri 7/3
5:07 pm-10:31 pm
1 stop5h 24m
$346
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Wed 8/5
6:10 am-12:55 pm
2 stops6h 45m
New Orleans Louis Armstrong
Wed 8/5
2:05 pm-9:55 pm
2 stops7h 50m
$356
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Tue 7/28
5:20 am-11:15 am
1 stop5h 55m
New Orleans Louis Armstrong
Mon 8/3
2:30 pm-11:35 pm
2 stops9h 05m
$364
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Wed 7/15
3:45 pm-11:25 pm
1 stop7h 40m
New Orleans Louis Armstrong
Sun 7/19
2:45 pm-11:50 pm
2 stops9h 05m
$374
Quickest round-trip
Des MoinesNew Orleans
DSM - MSY
DSMMSY
Des Moines
Fri 9/25
6:45 pm-11:32 pm
1 stop4h 47m
New Orleans Louis Armstrong
Mon 9/28
4:22 pm-9:02 pm
1 stop4h 40m
$377
Des MoinesAlexandria
DSM - AEX
DSMAEX
Des Moines
Wed 10/28
3:00 pm-7:38 pm
1 stop4h 38m
Alexandria
Sat 10/31
5:15 am-4:14 pm
2 stops10h 59m
$384
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Sat 7/4
6:20 am-1:29 pm
1 stop7h 09m
Baton Rouge Ryan
Wed 7/8
4:09 pm-10:35 pm
1 stop6h 26m
$389
Showing 1-10 of 29 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Louisiana
Have a flexible travel schedule? Discover the best time to fly to Louisiana from Des Moines with our price prediction graph.
DSM-MSY
DSM-BTR
DSM-AEX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisiana
DSM-USLA
DSM-MSY
DSM-BTR
DSM-AEX
What is the cheapest month to book a flight from Des Moines to Louisiana?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Louisiana (average of $151). Flying from Des Moines to Louisiana in February is currently the most expensive (average of $318). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Louisiana?
How far ahead should I book a flight from Des Moines to Louisiana?
Booking 40 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Louisiana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Louisiana
Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated May 29, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisiana, such as Southwest,Delta, andUnited Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Des Moines to Louisiana
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisiana by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Louisiana by cabin class
Find flights from Des Moines to Louisiana, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Louisiana flights
Browse other Des Moines and Louisiana flight options. Last updated on May 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Louisiana flights
Consider these flights traveling from Des Moines to Louisiana.
Top 4 airlines flying from Des Moines to Louisiana
Discover the top 4 airlines that operate flights from Des Moines to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$432 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$270 | Average$387 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$312 | Average$392 | FlexibilityNo cancel fee | On-time69% |