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Lexington

$166+ Cheap flights from Des Moines to Lexington (DSM - LEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Lexington

Cheapest flights from Des Moines to Lexington
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:55 pm
DSM
-
LEX
1 stop3h 54m
United Airlines
Wed 3/47:00 am
LEX
-
DSM
1 stop4h 53m
United Airlines
Deal found 1/26$269
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 am
DSM
-
LEX
2 stops11h 00m
American Airlines
Wed 3/410:27 am
LEX
-
DSM
1 stop3h 38m
American Airlines
Deal found 1/26$274
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/103:35 pm
DSM
-
LEX
1 stop6h 05m
United Airlines
Sat 2/142:03 pm
LEX
-
DSM
1 stop4h 44m
United Airlines
Deal found 1/26$279
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:25 pm
DSM
-
LEX
1 stop5h 50m
American Airlines
Sat 2/141:14 pm
LEX
-
DSM
2 stops10h 05m
American Airlines
Deal found 1/26$284
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:30 am
DSM
-
LEX
1 stop4h 18m
United Airlines
Sat 2/710:30 am
LEX
-
DSM
1 stop5h 03m
United Airlines
Deal found 1/26$339
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:42 am
DSM
-
LEX
2 stops10h 33m
American Airlines
Sat 2/74:35 pm
LEX
-
DSM
1 stop8h 07m
American Airlines
Deal found 1/26$344
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:58 am
DSM
-
LEX
1 stop4h 23m
American Airlines
Sun 5/36:00 am
LEX
-
DSM
2 stops8h 48m
American Airlines
Deal found 1/27$353
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/273:35 pm
DSM
-
LEX
1 stop6h 05m
United Airlines
Mon 2/28:35 am
LEX
-
DSM
1 stop6h 58m
United Airlines
Deal found 1/26$354
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/274:00 pm
DSM
-
LEX
1 stop5h 10m
American Airlines
Mon 2/212:49 pm
LEX
-
DSM
2 stops9h 18m
American Airlines
Deal found 1/26$359

Find flight deals from Des Moines to Lexington

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(United Airlines)

One-way from

$166
(Kiwi.com)

Popular in

October

Cheapest in

April

Average price

$488
Provider with most accurate pricing for Des Moines-Lexington Blue Grass flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lexington Blue Grass flights.
Search Deals
From Des Moines to Lexington Blue Grass
Search Deals
One-way flight from Des Moines to Lexington Blue Grass
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Des Moines

Fly to

Lexington

Route

Depart

Return

Price

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 2/25

6:55 pm-11:49 pm

1 stop3h 54m

Lexington Blue Grass

Wed 3/4

7:00 am-10:53 am

1 stop4h 53m

$269

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 2/25

5:00 am-5:00 pm

2 stops11h 00m

Lexington Blue Grass

Wed 3/4

10:27 am-1:05 pm

1 stop3h 38m

$274

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 2/10

3:35 pm-10:40 pm

1 stop6h 05m

Lexington Blue Grass

Sat 2/14

2:03 pm-5:47 pm

1 stop4h 44m

$279

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 2/10

4:25 pm-11:15 pm

1 stop5h 50m

Lexington Blue Grass

Sat 2/14

1:14 pm-10:19 pm

2 stops10h 05m

$284

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/29

11:58 am-5:21 pm

1 stop4h 23m

Lexington Blue Grass

Sun 5/3

6:00 am-1:48 pm

2 stops8h 48m

$353

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 4/19

7:00 am-8:55 pm

3 stops36h 55m

$237

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 2/28

5:00 am-2:33 pm

2 stops8h 33m

$254

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 4/19

11:00 am-9:29 pm

1 stop9h 29m

$263

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 2/22

5:00 am-2:33 pm

2 stops8h 33m

$285

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 4/30

6:00 am-11:24 pm

1 stop16h 24m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Lexington

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Lexington in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Lexington flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Lexington flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Lexington flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Lexington flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Lexington flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Lexington

Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lexington

What is the cheapest month to book a flight from Des Moines to Lexington?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $118). Flying from Des Moines to Lexington in December is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Lexington

Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated January 28, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,212 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Overall

7.4

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,212 reviews
United Airlines
7.4
Good
9,212 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Overall

7.4

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.2
Good
11,201 reviews
United Airlines
7.4
Good
9,212 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Overall

7.4

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Lexington?

    United Airlines and American Airlines can get you from Des Moines to Lexington in just under 3h 54m. Your travel time can differ by up to 7h 06m. The distance between Des Moines and Lexington is about 537 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Lexington round-trip?

    United Airlines, at $225, was found to be the cheapest airline from Des Moines to Lexington. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Des Moines to Lexington for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Lexington that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lexington flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lexington?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lexington.

  • Can I find deals for business class flights from Des Moines to Lexington?

    Yes. Cheapflights offers flight deals from Des Moines to Lexington by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Lexington?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $118). Flying from Des Moines to Lexington in December is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Somerset
Berea
Georgetown
Frankfort

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Alternative routes for Des Moines to Lexington

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Top 2 airlines flying from Des Moines to Lexington

Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$225Average$404FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$378FlexibilityNo cancel feeOn-time71%

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