HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Lexington

$155+ Cheap flights from Des Moines to Lexington (DSM - LEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Lexington with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Lexington

Cheapest flights from Des Moines to Lexington
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/256:40 amDSM - LEX
1 stop8h 19mAmerican Airlines
lun. 12/298:04 amLEX - DSM
1 stop5h 50mAmerican Airlines
Deal found 12/10$351
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/121:31 pmDSM - LEX
1 stop7h 35mUnited Airlines
jue. 12/188:15 amLEX - DSM
1 stop9h 10mUnited Airlines
Deal found 12/10$424
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/129:31 amDSM - LEX
2 stops47h 57mMultiple Airlines
jue. 12/189:00 amLEX - DSM
1 stop10h 20mMultiple Airlines
Deal found 12/10$543
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/271:59 pmDSM - LEX
1 stop7h 02mAmerican Airlines
mié. 12/316:55 pmLEX - DSM
1 stop4h 12mAmerican Airlines
Deal found 12/11$563
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:05 amDSM - LEX
2 stops9h 28mAmerican Airlines
jue. 12/188:05 amLEX - DSM
2 stops8h 19mAmerican Airlines
Deal found 12/10$647

Find flight deals from Des Moines to Lexington

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(Delta)

One-way from

$155
(Kiwi.com)

Popular in

October

Cheapest in

April

Average price

$495
Provider with most accurate pricing for Des Moines-Lexington Blue Grass flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lexington Blue Grass flights.
Search Deals
From Des Moines to Lexington Blue Grass
Search Deals
One-way flight from Des Moines to Lexington Blue Grass
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Des Moines

Fly to

Lexington

Route

Depart

Return

Price

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

vie. 2/20

10:37 am-4:53 pm

1 stop5h 16m

Lexington Blue Grass

dom. 2/22

10:35 am-4:57 pm

1 stop7h 22m

$269

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

mié. 1/28

7:40 am-6:09 pm

2 stops9h 29m

Lexington Blue Grass

sáb. 1/31

7:23 pm-11:42 pm

1 stop5h 19m

$294

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

sáb. 1/31

7:50 am-1:25 pm

1 stop4h 35m

Lexington Blue Grass

mié. 2/4

11:00 am-2:33 pm

1 stop4h 33m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

jue. 2/19

10:37 am-4:53 pm

1 stop5h 16m

Lexington Blue Grass

dom. 2/22

10:35 am-4:57 pm

1 stop7h 22m

$338

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

jue. 2/19

2:02 pm-11:33 pm

2 stops8h 31m

Lexington Blue Grass

dom. 2/22

6:00 am-1:17 pm

2 stops8h 17m

$349

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

vie. 2/20

7:45 pm-4:10 pm

1 stop19h 25m

Lexington Blue Grass

dom. 2/22

6:00 am-1:17 pm

2 stops8h 17m

$358

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

sáb. 1/10

5:58 pm-8:51 pm

1 stop25h 53m

$155

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

mar. 12/30

5:21 pm-11:07 pm

1 stop4h 46m

$239

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

dom. 1/25

5:16 pm-11:53 pm

1 stop5h 37m

$249

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

mar. 12/30

3:27 pm-11:56 pm

2 stops7h 29m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 17 results
1
2

Compare providers for flights from Des Moines to Lexington

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Lexington in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Lexington flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Lexington flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Lexington flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Lexington flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Lexington flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Lexington

Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lexington

What is the cheapest month to book a flight from Des Moines to Lexington?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $118). Flying from Des Moines to Lexington in January is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Lexington

Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated diciembre 12, 2025.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,095 reviews

Entertainment

7.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.
United Airlines
7.4
Good
9,095 reviews
United Airlines
7.4
Good
9,095 reviews

Entertainment

7.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.
American Airlines
7.2
Good
11,050 reviews
United Airlines
7.4
Good
9,095 reviews

Entertainment

7.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Lexington?

    Delta, American Airlines, and United Airlines can get you from Des Moines to Lexington in just under 4h 35m. Your travel time can differ by up to 41m. The distance between Des Moines and Lexington is about 537 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Lexington round-trip?

    United Airlines, at $225, was found to be the cheapest airline from Des Moines to Lexington. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Des Moines to Lexington for 43% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Lexington that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lexington flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lexington?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lexington.

  • Can I find deals for business class flights from Des Moines to Lexington?

    Yes. Cheapflights offers flight deals from Des Moines to Lexington by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Lexington?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $118). Flying from Des Moines to Lexington in January is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Somerset
Berea
Georgetown
Frankfort

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Lexington

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Nashville flights
Cedar Rapids to Nashville flights
Des Moines to Nashville flights
Des Moines to Knoxville flights
Moline to Nashville flights
Cedar Rapids to Knoxville flights
Omaha to Louisville flights
Cedar Rapids to Lexington flights
Cedar Rapids to Cincinnati flights
Cedar Rapids to Louisville flights
Omaha to Cincinnati flights
Des Moines to Louisville flights
Des Moines to Cincinnati flights
Moline to Knoxville flights
Omaha to Lexington flights
Moline to Cincinnati flights
Omaha to Knoxville flights
Moline to Louisville flights
Moline to Lexington flights
Sioux City to Nashville flights
Waterloo to Nashville flights
Des Moines to Blountville flights
Sioux City to Louisville flights
Cedar Rapids to Blountville flights
Sioux City to Knoxville flights
La Crosse to Nashville flights
La Crosse to Louisville flights
Omaha to Evansville flights
Dubuque to Nashville flights
La Crosse to Cincinnati flights
Omaha to Huntington flights
Dubuque to Knoxville flights
Dubuque to Louisville flights
Omaha to Blountville flights
Dubuque to Lexington flights
Dubuque to Cincinnati flights

Top 2 airlines flying from Des Moines to Lexington

Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$225Average$385FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$378FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.