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Lexington

$239+ Cheap flights from Des Moines to Lexington (DSM - LEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Lexington

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$249
(United Airlines)

One-way from

$239
(American Airlines)

Popular in

January

Cheapest in

April

Average price

$358
From Des Moines to Lexington Blue Grass
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One-way flight from Des Moines to Lexington Blue Grass
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Lexington

Cheapest flights from Des Moines to Lexington
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:39 pmDSM - LEX
1 stop4h 25mDelta
Tue 10/281:14 pmLEX - DSM
1 stop5h 30mDelta
Deal found 9/9$249
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:48 pmDSM - LEX
1 stop3h 42mAmerican Airlines
Tue 10/286:00 amLEX - DSM
2 stops9h 21mAmerican Airlines
Deal found 9/9$254
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/264:09 pmDSM - LEX
1 stop7h 17mAmerican Airlines
Tue 9/3012:30 pmLEX - DSM
1 stop6h 05mAmerican Airlines
Deal found 9/11$299
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:47 pmDSM - LEX
1 stop4h 18mDelta
Fri 1/3011:00 amLEX - DSM
1 stop6h 56mDelta
Deal found 9/10$314
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:36 pmDSM - LEX
1 stop4h 23mUnited Airlines
Sun 10/56:01 pmLEX - DSM
1 stop4h 49mUnited Airlines
Deal found 9/10$319
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:25 pmDSM - LEX
1 stop4h 36mUnited Airlines
Tue 9/307:05 amLEX - DSM
1 stop6h 14mUnited Airlines
Deal found 9/10$329
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:36 pmDSM - LEX
1 stop4h 23mUnited Airlines
Mon 10/206:01 pmLEX - DSM
1 stop4h 49mUnited Airlines
Deal found 9/9$388
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:27 pmDSM - LEX
1 stop6h 55mAmerican Airlines
Fri 1/3012:57 pmLEX - DSM
2 stops9h 55mAmerican Airlines
Deal found 9/10$408
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/241:10 pmDSM - LEX
1 stop6h 38mUnited Airlines
Sun 9/287:33 pmLEX - DSM
1 stop17h 46mUnited Airlines
Deal found 9/8$413

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Des Moines

Fly to

Lexington

Route

Depart

Return

Price

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 11/6

11:26 am-5:10 pm

1 stop4h 44m

Lexington Blue Grass

Sun 11/9

7:05 am-12:14 pm

1 stop6h 09m

$249

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/24

6:39 pm-12:04 am

1 stop4h 25m

Lexington Blue Grass

Tue 10/28

5:54 pm-8:35 pm

1 stop3h 41m

$249

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/24

1:48 pm-6:30 pm

1 stop3h 42m

Lexington Blue Grass

Tue 10/28

6:00 am-2:21 pm

2 stops9h 21m

$254

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 9/26

4:09 pm-12:26 am

1 stop7h 17m

Lexington Blue Grass

Tue 9/30

12:30 pm-5:35 pm

1 stop6h 05m

$299

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/17

6:36 pm-11:59 pm

1 stop4h 23m

Lexington Blue Grass

Sat 10/18

10:37 am-2:23 pm

1 stop4h 46m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/3

6:36 pm-11:59 pm

1 stop4h 23m

Lexington Blue Grass

Sun 10/5

6:01 pm-9:50 pm

1 stop4h 49m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/10

8:00 am-1:34 pm

1 stop4h 34m

Lexington Blue Grass

Sun 10/12

7:05 am-12:19 pm

1 stop6h 14m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 9/26

3:25 pm-9:01 pm

1 stop4h 36m

Lexington Blue Grass

Tue 9/30

7:05 am-12:19 pm

1 stop6h 14m

$329

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 10/16

6:36 pm-11:59 pm

1 stop4h 23m

Lexington Blue Grass

Mon 10/20

6:01 pm-9:50 pm

1 stop4h 49m

$388

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 10/2

4:04 pm-12:11 am

1 stop7h 07m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 13 results
1
2

Best time to book a flight from Des Moines to Lexington

Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lexington

What is the cheapest month to book a flight from Des Moines to Lexington?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $303). Flying from Des Moines to Lexington in April is currently the most expensive (average of $390). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Lexington

Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated September 11, 2025.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Boarding

7.7

Crew

8.1

Entertainment

7.1

Overall

7.4

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Boarding

7.7

Crew

8.1

Entertainment

7.1

Overall

7.4

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,937 reviews

Boarding

7.7

Crew

8.1

Entertainment

7.1

Overall

7.4

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Lexington?

    United Airlines, Delta, and American Airlines can get you from Des Moines to Lexington in just under 3h 42m. Your travel time can differ by up to 1h 02m. The distance between Des Moines and Lexington is about 537 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Lexington round-trip?

    American Airlines, at $198, was found to be the cheapest airline from Des Moines to Lexington. An alternate airline flying to your destination would be United Airlines. You may be able to fly from Des Moines to Lexington for 45% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Des Moines to Lexington one-way?

    One-way options have recently been found by users for as low as $239 on American Airlines. Other airlines that offer cheap prices include Delta from $239 and United Airlines from $274 one-way.

  • Can I find deals for flights from Des Moines to Lexington that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lexington flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lexington?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lexington.

  • Can I find deals for business class flights from Des Moines to Lexington?

    Yes. Cheapflights offers flight deals from Des Moines to Lexington by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Lexington?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Lexington (average of $303). Flying from Des Moines to Lexington in April is currently the most expensive (average of $390). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Georgetown
Berea
Frankfort

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Top 2 airlines flying from Des Moines to Lexington

Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$358FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$225Average$388FlexibilityNo cancel feeOn-time69%

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