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$450+ Cheap flights from Tyler to Knoxville (TYR - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYR — TYS
Oct 25 — Nov 11
Sat 10/25
Sat 11/1
1 adult, Economy
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Cheap flight deals from Tyler to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Tyler (TYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$450
(American Airlines)
Provider with most accurate pricing for Tyler Pounds Field-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Tyler Pounds Field-Knoxville McGhee Tyson flights.
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From Tyler Pounds Field to Knoxville McGhee Tyson
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Find flight deals from Tyler to Knoxville

Cheapest flights from Tyler to Knoxville
Explore the most affordable flight options available from Tyler to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:00 pmTYR - TYS
1 stop6h 23mAmerican Airlines
Mon 10/276:00 amTYS - TYR
1 stop4h 41mAmerican Airlines
Deal found 9/24$450
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/254:58 pmTYR - TYS
1 stop4h 10mAmerican Airlines
Wed 10/16:00 amTYS - TYR
1 stop4h 49mAmerican Airlines
Deal found 9/23$455
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amTYR - TYS
1 stop6h 24mAmerican Airlines
Sun 10/126:00 amTYS - TYR
1 stop4h 41mAmerican Airlines
Deal found 9/23$536
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amTYR - TYS
1 stop4h 45mAmerican Airlines
Sat 10/186:00 amTYS - TYR
1 stop4h 36mAmerican Airlines
Deal found 9/24$645
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:00 amTYR - TYS
1 stop4h 45mAmerican Airlines
Fri 10/2412:35 pmTYS - TYR
1 stop4h 55mAmerican Airlines
Deal found 9/25$756

Cheapflights Fare Finder

 
Customize your flight search to find flights from Tyler to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Tyler to Knoxville that are best for you.

Fly from

Tyler

Fly to

Knoxville

Route

Depart

Return

Price

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Fri 10/24

5:00 pm-12:23 am

1 stop6h 23m

Knoxville McGhee Tyson

Mon 10/27

6:00 am-9:41 am

1 stop4h 41m

$450

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Sat 10/11

6:00 am-11:45 am

1 stop4h 45m

Knoxville McGhee Tyson

Sat 10/18

6:00 am-9:36 am

1 stop4h 36m

$645

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Tue 10/21

6:00 am-11:45 am

1 stop4h 45m

Knoxville McGhee Tyson

Fri 10/24

12:35 pm-4:30 pm

1 stop4h 55m

$756

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Sun 1/4

10:20 am-3:39 pm

1 stop4h 19m

Knoxville McGhee Tyson

Fri 1/9

6:30 pm-9:47 pm

1 stop4h 17m

$822

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Thu 10/9

5:00 pm-11:51 pm

1 stop5h 51m

Knoxville McGhee Tyson

Mon 10/13

6:00 am-9:41 am

1 stop4h 41m

$829

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Compare providers for flights from Tyler to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Tyler to Knoxville in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Tyler-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Tyler-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Tyler-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Tyler-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Tyler-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Tyler to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Tyler with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Tyler to Knoxville

What is the cheapest month to book a flight from Tyler to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Tyler to Knoxville (average of $294). Flying from Tyler to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 25, 2025.
Peruse reviews from past customers who have flown with American Airlines from Tyler to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Overall

7.2

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Overall

7.2

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from Tyler to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Tyler to Knoxville?

    For as low as $450, American Airlines can have you in Knoxville from Tyler in 6h 23m. Tyler and Knoxville are separated by a distance of 694 mi.

  • Can I find deals for flights from Tyler to Knoxville that include hotel bookings?

    Yes. In addition to deals on Tyler to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Tyler to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Tyler to Knoxville.

  • Can I find deals for business class flights from Tyler to Knoxville?

    Yes. Cheapflights offers flight deals from Tyler to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Tyler to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Tyler to Knoxville (average of $294). Flying from Tyler to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top airline flying from Tyler to Knoxville

Discover the top airline that operate flights from Tyler to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$403Average$428FlexibilityNo cancel feeOn-time71%

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