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$88+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:00 amCLT - TYS
1 stop8h 17mMultiple Airlines
Sun 1/47:15 amTYS - CLT
1 stop27h 48mMultiple Airlines
Deal found 12/15$345
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:38 pmCLT - TYS
1 stop21h 21mMultiple Airlines
Wed 12/316:07 pmTYS - CLT
1 stop15h 32mMultiple Airlines
Deal found 12/17$425
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:34 pmCLT - TYS
1 stop24h 19mMultiple Airlines
Wed 12/241:58 pmTYS - CLT
1 stop21h 24mMultiple Airlines
Deal found 12/17$428
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:38 pmCLT - TYS
2 stops24h 15mMultiple Airlines
Tue 12/239:08 amTYS - CLT
1 stop11h 25mMultiple Airlines
Deal found 12/17$430
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:38 pmCLT - TYS
1 stop10h 40mMultiple Airlines
Mon 12/296:00 amTYS - CLT
1 stop14h 39mMultiple Airlines
Deal found 12/17$442
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:54 amCLT - TYS
1 stop6h 40mMultiple Airlines
Fri 12/195:51 pmTYS - CLT
1 stop21h 10mMultiple Airlines
Deal found 12/17$474

Find flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$184
(Mytrip)

One-way from

$88
(Mytrip)
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
Search Deals
From Spartanburg to Knoxville McGhee Tyson
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One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 1/30

11:12 am-10:28 pm

1 stop11h 16m

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-12:40 am

1 stop6h 41m

$184

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 1/1

9:34 pm-10:15 am

1 stop12h 41m

Knoxville McGhee Tyson

Mon 1/5

7:15 am-11:03 am

1 stop27h 48m

$271

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/20

9:07 pm-6:58 pm

2 stops21h 51m

Knoxville McGhee Tyson

Sun 2/22

5:56 pm-6:02 pm

2 stops24h 06m

$279

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/20

9:07 pm-6:58 pm

2 stops21h 51m

Knoxville McGhee Tyson

Sat 2/21

9:24 pm-8:26 am

1 stop11h 02m

$279

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 1/5

9:38 pm-6:32 pm

1 stop20h 54m

Knoxville McGhee Tyson

Mon 1/12

8:30 am-6:32 pm

1 stop10h 02m

$298

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 3/25

6:10 am-11:50 am

1 stop5h 40m

Knoxville McGhee Tyson

Wed 4/8

7:05 am-12:55 pm

1 stop5h 50m

$317

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 4/7

1:45 pm-8:50 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 4/14

7:05 am-12:55 pm

1 stop5h 50m

$317

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 1/16

1:24 pm-11:09 am

1 stop21h 45m

$98

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 1/14

7:43 pm-8:39 am

1 stop12h 56m

$106

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 2/17

7:05 pm-10:08 am

1 stop15h 03m

$109

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Showing 1-10 of 13 results
1
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Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from Spartanburg to Knoxville in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,055 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Comfort

7.2

Food

6.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,055 reviews
American Airlines
7.2
Good
11,055 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Comfort

7.2

Food

6.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 8 inbound flights from Spartanburg per day.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Envoy Air (100%), PSA Airlines (89%) and American Airlines (84%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $388 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $305 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $184.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$366Average$556FlexibilityNo cancel feeOn-time71%

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