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Knoxville

$90+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
May 1 — May 81
Fri 5/1
Fri 5/8
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:09 pm
CLT
-
TYS
1 stop13h 31m
Multiple Airlines
Mon 5/46:20 pm
TYS
-
CLT
1 stop24h 32m
Multiple Airlines
Deal found 3/30$199
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:35 pm
CLT
-
TYS
1 stop22h 55m
Multiple Airlines
Sun 4/199:32 pm
TYS
-
CLT
1 stop11h 38m
Multiple Airlines
Deal found 3/31$202
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:54 pm
CLT
-
TYS
1 stop14h 12m
Multiple Airlines
Fri 5/11:15 pm
TYS
-
CLT
1 stop18h 54m
Multiple Airlines
Deal found 3/27$209
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:33 pm
CLT
-
TYS
1 stop24h 57m
Multiple Airlines
Thu 4/169:32 pm
TYS
-
CLT
1 stop11h 38m
Multiple Airlines
Deal found 3/28$211
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:04 am
CLT
-
TYS
1 stop5h 46m
Multiple Airlines
Thu 4/309:25 pm
TYS
-
CLT
1 stop11h 45m
Multiple Airlines
Deal found 3/27$213
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:19 pm
CLT
-
TYS
1 stop22h 11m
Multiple Airlines
Fri 5/11:15 pm
TYS
-
CLT
1 stop18h 54m
Multiple Airlines
Deal found 3/29$215
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
-
TYS
1 stop16h 56m
Multiple Airlines
Thu 4/309:25 pm
TYS
-
CLT
1 stop11h 45m
Multiple Airlines
Deal found 3/27$217
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:32 pm
CLT
-
TYS
2 stops18h 09m
Multiple Airlines
Sun 4/199:32 pm
TYS
-
CLT
1 stop16h 46m
Multiple Airlines
Deal found 3/31$231
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:17 pm
CLT
-
TYS
1 stop13h 19m
Multiple Airlines
Sat 4/1812:56 pm
TYS
-
CLT
1 stop7h 53m
Multiple Airlines
Deal found 3/31$237

Find flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated April 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(Kiwi.com)

One-way from

$90
(Kiwi.com)

Popular in

February

Cheapest in

April

Average price

$226
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
Search Deals
From Spartanburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 4/27

8:09 pm-9:40 am

1 stop13h 31m

Knoxville McGhee Tyson

Mon 5/4

6:20 pm-6:52 pm

1 stop24h 32m

$199

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 5/16

5:50 pm-8:50 pm

1 stop27h 00m

Knoxville McGhee Tyson

Sat 5/23

5:11 pm-11:40 pm

1 stop6h 29m

$293

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 5/12

1:45 pm-8:50 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 5/19

5:50 pm-9:50 pm

1 stop4h 00m

$299

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 4/26

10:07 pm-5:30 pm

2 stops19h 23m

Knoxville McGhee Tyson

Fri 5/1

1:15 pm-8:09 am

1 stop18h 54m

$326

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 5/28

4:20 pm-9:15 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sun 5/31

6:40 am-4:10 pm

2 stops9h 30m

$342

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 5/9

9:17 am-9:50 pm

1 stop12h 33m

Knoxville McGhee Tyson

Mon 5/11

6:00 am-3:24 pm

1 stop9h 24m

$411

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 6/19

11:35 am-9:10 pm

2 stops9h 35m

Knoxville McGhee Tyson

Sun 6/21

7:05 am-5:20 pm

2 stops10h 15m

$463

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 5/15

4:20 pm-9:15 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sun 5/17

6:40 am-4:10 pm

2 stops9h 30m

$502
Quickest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 4/27

4:49 pm-6:13 pm

Nonstop1h 24m

Knoxville McGhee Tyson

Mon 5/4

5:57 pm-7:22 pm

Nonstop1h 25m

$545
Cheapest one-way

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 4/30

7:05 pm-5:30 pm

2 stops22h 25m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $226). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $701). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2026.

It’s typically best to fly out from Spartanburg to Knoxville in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 1, 2026.

The most flights from SB1 to TYS are scheduled on a Monday (11 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 1, 2026.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,545 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Comfort

7.2

Overall

7.1

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,545 reviews
American Airlines
7.1
Good
11,545 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Comfort

7.2

Overall

7.1

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 6 inbound flights from Spartanburg per day.

  • How long is the flight from Spartanburg to Knoxville?

    For as low as $299, Southwest can have you in Knoxville from Spartanburg in 7h 05m. There are 176 mi between Spartanburg and Knoxville.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Piedmont Airlines (75%), British Airways (69%) and American Airlines (69%).

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $226). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $701). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$482Average$547FlexibilityNo cancel feeOn-time71%

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