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$80+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/12. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated May 1, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$235
(Mytrip)

One-way from

$80
(Mytrip)

Popular in

June

Cheapest in

May

Average price

$461
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
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From Spartanburg to Knoxville McGhee Tyson
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One-way flight from Spartanburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/34:46 pmCLT - TYS
1 stop22h 39mMultiple Airlines
Fri 6/207:15 amTYS - CLT
1 stop7h 13mMultiple Airlines
Deal found 4/30$235
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/319:26 amCLT - TYS
1 stop7h 45mAmerican Airlines
Sat 6/77:24 amTYS - CLT
1 stop24h 32mAmerican Airlines
Deal found 5/1$357
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/256:00 amCLT - TYS
1 stop17h 59mUnited Airlines
Mon 6/307:35 pmTYS - CLT
2 stops14h 37mUnited Airlines
Deal found 4/30$483
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/27:37 pmCLT - TYS
1 stop4h 11mDelta
Sun 5/49:30 amTYS - CLT
1 stop5h 24mDelta
Deal found 4/29$589

Cheapflights Fare Finder

Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 6/3

4:46 pm-3:25 pm

1 stop22h 39m

Knoxville McGhee Tyson

Fri 6/20

7:15 am-2:28 pm

1 stop7h 13m

$235

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 5/31

9:26 am-5:11 pm

1 stop7h 45m

Knoxville McGhee Tyson

Sat 6/7

7:24 am-7:56 am

1 stop24h 32m

$357

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 6/25

6:00 am-11:59 pm

1 stop17h 59m

Knoxville McGhee Tyson

Mon 6/30

7:35 pm-10:12 am

2 stops14h 37m

$483

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 6/12

2:26 pm-4:47 pm

1 stop26h 21m

$80

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 5/30

11:15 am-9:55 pm

1 stop10h 40m

$179

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 7/3

7:59 pm-10:46 am

1 stop14h 47m

$195

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 6/30

6:08 pm-2:58 pm

2 stops20h 50m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $296). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Knoxville as you normally would.

What is the cheapest day to fly from Spartanburg to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Spartanburg to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Spartanburg to Knoxville flight should consider departing on Saturday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Spartanburg to Knoxville have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 3 inbound flights from Spartanburg per day.

  • What are the cheapest airlines to fly from Spartanburg to Knoxville one-way?

    One-way options have recently been found by users for as low as $179 on American Airlines. Other airlines that offer cheap prices include Delta from $195 and United Airlines from $344 one-way.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Envoy Air (84%), Piedmont Airlines (75%) and American Airlines (74%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $352 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $320 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $235.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $296). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Spartanburg?

Book flights to Spartanburg if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$447Average$582FlexibilityNo cancel feeOn-time71%

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