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Knoxville

$92+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:55 am
CLT
-
TYS
1 stop8h 40m
Multiple Airlines
Fri 2/279:36 pm
TYS
-
CLT
1 stop10h 50m
Multiple Airlines
Deal found 1/28$250
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:40 am
CLT
-
TYS
1 stop5h 20m
Southwest
Wed 4/155:50 pm
TYS
-
CLT
1 stop3h 50m
Southwest
Deal found 1/27$261
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:56 am
CLT
-
TYS
1 stop13h 30m
Multiple Airlines
Sun 3/225:24 pm
TYS
-
CLT
1 stop14h 57m
Multiple Airlines
Deal found 1/28$269
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:43 pm
CLT
-
TYS
1 stop20h 14m
Multiple Airlines
Tue 2/101:00 pm
TYS
-
CLT
1 stop24h 51m
Multiple Airlines
Deal found 1/27$270
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:13 pm
CLT
-
TYS
1 stop14h 27m
Multiple Airlines
Sun 3/89:42 pm
TYS
-
CLT
1 stop10h 44m
Multiple Airlines
Deal found 1/27$273
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/67:43 pm
CLT
-
TYS
1 stop15h 26m
Multiple Airlines
Sun 2/88:00 am
TYS
-
CLT
1 stop16h 40m
Multiple Airlines
Deal found 1/27$288
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:10 am
CLT
-
TYS
1 stop6h 35m
Southwest
Sun 3/227:25 pm
TYS
-
CLT
1 stop3h 35m
Southwest
Deal found 1/28$290
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:10 am
CLT
-
TYS
1 stop6h 35m
Southwest
Sun 3/86:35 am
TYS
-
CLT
2 stops9h 20m
Southwest
Deal found 1/27$295

Find flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$250
(Kiwi.com)

One-way from

$92
(Kiwi.com)
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
Search Deals
From Spartanburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 2/26

5:55 am-2:35 pm

1 stop8h 40m

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:26 am

1 stop10h 50m

$250

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 4/14

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

Wed 4/15

5:50 pm-9:40 pm

1 stop3h 50m

$261

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 3/19

8:56 am-10:26 pm

1 stop13h 30m

Knoxville McGhee Tyson

Sun 3/22

5:24 pm-8:21 am

1 stop14h 57m

$269

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 3/6

7:13 pm-9:40 am

1 stop14h 27m

Knoxville McGhee Tyson

Sun 3/8

9:42 pm-8:26 am

1 stop10h 44m

$273

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/6

7:43 pm-11:09 am

1 stop15h 26m

Knoxville McGhee Tyson

Sun 2/8

8:00 am-12:40 am

1 stop16h 40m

$288

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 3/19

6:10 am-12:45 pm

1 stop6h 35m

Knoxville McGhee Tyson

Sun 3/22

7:25 pm-11:00 pm

1 stop3h 35m

$290

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 3/6

6:10 am-12:45 pm

1 stop6h 35m

Knoxville McGhee Tyson

Sun 3/8

6:35 am-3:55 pm

2 stops9h 20m

$295

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 2/3

11:35 am-3:57 pm

2 stops28h 22m

Knoxville McGhee Tyson

Tue 2/10

1:00 pm-1:51 pm

1 stop24h 51m

$310

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 2/5

6:00 am-6:28 pm

1 stop12h 28m

Knoxville McGhee Tyson

Sun 2/8

8:00 am-9:39 pm

1 stop13h 39m

$335

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 2/18

7:00 am-12:12 pm

2 stops29h 12m

Knoxville McGhee Tyson

Sun 2/22

9:32 pm-11:56 pm

1 stop26h 24m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 22 results
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Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

It’s typically best to fly out from Spartanburg to Knoxville in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 29, 2026.

The most flights from SB1 to TYS are scheduled on a Monday (11 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (7 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,205 reviews

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,205 reviews
American Airlines
7.2
Good
11,205 reviews

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 9 inbound flights from Spartanburg per day.

  • How long is the flight from Spartanburg to Knoxville?

    For as low as $261, Southwest can have you in Knoxville from Spartanburg in 5h 20m. There are 176 mi between Spartanburg and Knoxville.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Piedmont Airlines (81%), PSA Airlines (79%) and American Airlines (79%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $320 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $278 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $250.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$482Average$547FlexibilityNo cancel feeOn-time71%

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