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$112+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Aug 9 — Aug 161
Sat 8/9
Sat 8/16
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated August 4, 2025.

Round-trip from

$224
(Mytrip)

One-way from

$112
(Mytrip)

Popular in

January

Cheapest in

November

Average price

$593
From Spartanburg to Knoxville McGhee Tyson
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One-way flight from Spartanburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 0% potential increase in price ($0 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2025.

This Mytrip deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/115:45 amCLT - TYS
1 stop5h 33mMultiple Airlines
Thu 9/1812:08 pmTYS - CLT
1 stop10h 51mMultiple Airlines
Deal found 8/2$237
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2510:05 pmCLT - TYS
1 stop23h 56mAmerican Airlines
Mon 9/16:13 amTYS - CLT
1 stop26h 24mAmerican Airlines
Deal found 8/3$355

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2025.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 9/11

5:45 am-11:18 am

1 stop5h 33m

Knoxville McGhee Tyson

Thu 9/18

12:08 pm-10:59 pm

1 stop10h 51m

$237

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 8/25

10:05 pm-10:01 pm

1 stop23h 56m

Knoxville McGhee Tyson

Mon 9/1

6:13 am-8:37 am

1 stop26h 24m

$355

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 10/5

7:16 pm-9:56 am

1 stop14h 40m

$112

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 9/5

7:59 pm-11:43 am

1 stop15h 44m

$178

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 11/1

2:36 pm-11:52 am

1 stop21h 16m

$183

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 11/1

1:56 pm-11:48 am

2 stops21h 52m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/2

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $294). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 4, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,987 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,987 reviews
Delta
8.0
Very good
7,987 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,912 reviews
Delta
8.0
Very good
7,987 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,987 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 4 inbound flights from Spartanburg per day.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are PSA Airlines (83%), American Airlines (76%) and Piedmont Airlines (72%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $320 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $290 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $244.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $294). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$366Average$565FlexibilityNo cancel feeOn-time71%

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