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$109+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:54 amCLT - TYS
1 stop27h 09mMultiple Airlines
Mon 12/85:34 pmTYS - CLT
2 stops30h 25mMultiple Airlines
Deal found 10/31$215
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:58 pmCLT - TYS
1 stop17h 35mMultiple Airlines
Thu 12/114:52 pmTYS - CLT
1 stop23h 57mMultiple Airlines
Deal found 10/31$226
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:51 pmCLT - TYS
1 stop7h 02mMultiple Airlines
Wed 12/245:31 pmTYS - CLT
1 stop5h 58mMultiple Airlines
Deal found 10/30$228
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:58 pmCLT - TYS
1 stop17h 35mMultiple Airlines
Mon 12/85:34 pmTYS - CLT
1 stop16h 16mMultiple Airlines
Deal found 11/2$231
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/169:20 pmCLT - TYS
1 stop16h 37mMultiple Airlines
Thu 11/206:00 amTYS - CLT
2 stops12h 59mMultiple Airlines
Deal found 11/1$251
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:44 pmCLT - TYS
1 stop15h 20mMultiple Airlines
Mon 11/179:09 pmTYS - CLT
2 stops22h 49mMultiple Airlines
Deal found 10/31$260
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:55 pmCLT - TYS
2 stops15h 08mMultiple Airlines
Sun 12/77:11 pmTYS - CLT
1 stop14h 28mMultiple Airlines
Deal found 10/30$273

Cheap flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated November 3, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$215
(Kiwi.com)

One-way from

$109
(Kiwi.com)
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
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From Spartanburg to Knoxville McGhee Tyson
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One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 12/5

8:54 am-12:03 pm

1 stop27h 09m

Knoxville McGhee Tyson

Mon 12/8

5:34 pm-11:59 pm

2 stops30h 25m

$215

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 12/4

2:58 pm-8:33 am

1 stop17h 35m

Knoxville McGhee Tyson

Mon 12/8

5:34 pm-9:50 am

1 stop16h 16m

$231

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 11/16

9:20 pm-1:57 pm

1 stop16h 37m

Knoxville McGhee Tyson

Thu 11/20

6:00 am-6:59 pm

2 stops12h 59m

$251

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 12/4

10:38 pm-12:03 pm

2 stops37h 25m

Knoxville McGhee Tyson

Thu 12/11

4:52 pm-4:49 pm

1 stop23h 57m

$251

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 12/5

8:55 pm-12:03 pm

2 stops15h 08m

Knoxville McGhee Tyson

Sun 12/7

7:11 pm-9:39 am

1 stop14h 28m

$273

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 12/20

8:54 am-8:33 pm

1 stop11h 39m

Knoxville McGhee Tyson

Mon 12/22

9:15 pm-9:39 am

1 stop12h 24m

$330

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 12/20

8:54 am-8:33 pm

1 stop11h 39m

Knoxville McGhee Tyson

Tue 12/23

9:27 pm-8:33 pm

1 stop23h 06m

$333

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 12/22

9:00 am-9:53 pm

2 stops12h 53m

Knoxville McGhee Tyson

Wed 12/24

11:08 am-8:39 pm

2 stops9h 31m

$348

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 12/2

3:11 pm-12:03 pm

1 stop20h 52m

$109

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 2/4

5:06 pm-8:39 am

1 stop15h 33m

$118

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 19 results
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Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s typically best to fly out from Spartanburg to Knoxville in the afternoon. Doing so could potentially save you 29% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 3, 2025.

The most flights from SB1 to TYS are scheduled on a Thursday (12 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 3, 2025.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,037 reviews

Boarding

7.5

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,037 reviews
American Airlines
7.2
Good
11,037 reviews

Boarding

7.5

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 9 inbound flights from Spartanburg per day.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Envoy Air (96%), Piedmont Airlines (94%) and American Airlines (91%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $453 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $320 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $231.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $216). Flying from Spartanburg to Knoxville in August is currently the most expensive (average of $551). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$366Average$555FlexibilityNo cancel feeOn-time71%

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