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Knoxville

$79+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(Delta)

One-way from

$103
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$348
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 28% potential increase in price ($144 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:55 pmMYR - TYS
1 stop3h 56mDelta
Wed 6/115:45 amTYS - MYR
1 stop4h 30mDelta
Deal found 4/30$229
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:00 amMYR - TYS
1 stop3h 24mAmerican Airlines
Mon 7/286:00 pmTYS - MYR
1 stop6h 02mAmerican Airlines
Deal found 4/30$234
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/34:46 pmCLT - TYS
1 stop22h 39mMultiple Airlines
Fri 6/207:15 amTYS - CLT
1 stop7h 13mMultiple Airlines
Deal found 4/30$235
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/152:29 pmMYR - TYS
1 stop6h 38mMultiple Airlines
Thu 6/199:04 pmTYS - MYR
1 stop13h 29mMultiple Airlines
Deal found 4/30$253
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/149:42 amCHS - TYS
1 stop22h 37mMultiple Airlines
Sat 6/218:10 amTYS - CHS
1 stop14h 19mMultiple Airlines
Deal found 4/30$285
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2910:53 amCHS - TYS
1 stop8h 21mAmerican Airlines
Sat 5/316:00 amTYS - CHS
1 stop8h 09mAmerican Airlines
Deal found 4/30$347
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/42:13 pmCLT - TYS
1 stop31h 39mAmerican Airlines
Thu 7/106:34 amTYS - CLT
1 stop8h 35mAmerican Airlines
Deal found 4/30$357
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/288:30 amSAV - TYS
1 stop2h 53mDelta
Wed 6/45:45 amTYS - SAV
1 stop5h 38mDelta
Deal found 4/29$362
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:25 pmCHS - TYS
1 stop3h 48mDelta
Mon 11/177:15 pmTYS - CHS
1 stop4h 26mDelta
Deal found 4/30$367
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:41 pmSAV - TYS
1 stop21h 29mMultiple Airlines
Mon 5/199:00 amTYS - SAV
2 stops10h 56mMultiple Airlines
Deal found 4/30$373
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/152:10 pmSAV - TYS
2 stops31h 29mAllegiant Air
Mon 5/199:00 amTYS - SAV
2 stops10h 56mAllegiant Air
Deal found 4/30$391
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:16 pmMYR - TYS
2 stops17h 12mUnited Airlines
Sun 8/247:00 amTYS - MYR
2 stops9h 19mUnited Airlines
Deal found 4/30$418

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 6/1

7:55 pm-11:51 pm

1 stop3h 56m

Knoxville McGhee Tyson

Wed 6/11

5:45 am-10:15 am

1 stop4h 30m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 5/14

5:00 am-8:24 am

1 stop3h 24m

Knoxville McGhee Tyson

Mon 7/28

6:00 pm-12:02 am

1 stop6h 02m

$234

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 6/3

4:46 pm-3:25 pm

1 stop22h 39m

Knoxville McGhee Tyson

Fri 6/20

7:15 am-2:28 pm

1 stop7h 13m

$235

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 6/15

2:29 pm-9:07 pm

1 stop6h 38m

Knoxville McGhee Tyson

Thu 6/19

9:04 pm-10:33 am

1 stop13h 29m

$253

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 6/14

9:42 am-8:19 am

1 stop22h 37m

Knoxville McGhee Tyson

Sat 6/21

8:10 am-10:29 pm

1 stop14h 19m

$285

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/29

10:53 am-7:14 pm

1 stop8h 21m

Knoxville McGhee Tyson

Sat 5/31

6:00 am-2:09 pm

1 stop8h 09m

$347

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 7/5

11:12 am-9:52 pm

1 stop10h 40m

Knoxville McGhee Tyson

Sat 7/12

7:29 am-7:05 pm

1 stop11h 36m

$357

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 5/28

8:30 am-11:23 am

1 stop2h 53m

Knoxville McGhee Tyson

Wed 6/4

5:45 am-11:23 am

1 stop5h 38m

$362

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/15

6:41 pm-4:10 pm

1 stop21h 29m

Knoxville McGhee Tyson

Mon 5/19

9:00 am-7:56 pm

2 stops10h 56m

$373

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/15

2:10 pm-9:39 pm

2 stops31h 29m

Knoxville McGhee Tyson

Mon 5/19

9:00 am-7:56 pm

2 stops10h 56m

$391

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 34 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are Allegiant Air ($170), American Airlines ($179), and Delta ($195).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Myrtle Beach Intl - Knoxville McGhee Tyson, Charlotte Douglas - Knoxville McGhee Tyson or Charleston - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$481FlexibilityNo cancel feeOn-time71%

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