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Knoxville

$107+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated junio 12, 2025.

Round-trip from

$229
(American Airlines)

One-way from

$107
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$276
From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 26% potential increase in price ($134 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/42:44 pmMYR - TYS
1 stop3h 16mAmerican Airlines
mar. 7/87:52 pmTYS - MYR
1 stop4h 10mAmerican Airlines
Deal found 6/11$229
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/126:20 amCLT - TYS
1 stop15h 57mMultiple Airlines
lun. 7/1412:45 pmTYS - CLT
2 stops33h 31mMultiple Airlines
Deal found 6/11$240
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/217:56 pmMYR - TYS
2 stops17h 15mMultiple Airlines
lun. 7/286:00 amTYS - MYR
1 stop16h 17mMultiple Airlines
Deal found 6/10$244
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/231:10 pmCHS - TYS
2 stops18h 40mMultiple Airlines
vie. 6/277:15 amTYS - CHS
1 stop15h 14mMultiple Airlines
Deal found 6/12$246
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/106:36 pmSAV - TYS
1 stop22h 11mAllegiant Air
dom. 7/138:00 amTYS - SAV
2 stops38h 45mAllegiant Air
Deal found 6/11$258
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/266:41 pmSAV - TYS
1 stop22h 06mMultiple Airlines
lun. 6/306:00 amTYS - SAV
2 stops15h 50mMultiple Airlines
Deal found 6/10$276
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/116:00 amMYR - TYS
1 stop5h 08mDelta
lun. 6/167:44 pmTYS - MYR
1 stop4h 23mDelta
Deal found 6/9$279
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/73:26 pmCHS - TYS
2 stops30h 49mAllegiant Air
sáb. 8/99:00 amTYS - CHS
2 stops29h 36mAllegiant Air
Deal found 6/11$307
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/138:00 amCLT - TYS
1 stop7h 41mAmerican Airlines
mar. 9/166:00 amTYS - CLT
1 stop11h 05mAmerican Airlines
Deal found 6/11$317
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/194:55 pmMYR - TYS
1 stop5h 45mUnited Airlines
dom. 6/227:00 amTYS - MYR
1 stop7h 35mUnited Airlines
Deal found 6/10$329
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/256:00 amCHS - TYS
1 stop10h 57mAmerican Airlines
dom. 8/316:49 amTYS - CHS
1 stop12h 14mAmerican Airlines
Deal found 6/11$354
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/137:59 pmCHS - TYS
1 stop4h 00mDelta
mié. 7/236:19 pmTYS - CHS
1 stop5h 40mDelta
Deal found 6/12$357

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

vie. 7/4

2:44 pm-6:00 pm

1 stop3h 16m

Knoxville McGhee Tyson

mar. 7/8

7:52 pm-12:02 am

1 stop4h 10m

$229

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

sáb. 7/12

6:20 am-10:17 pm

1 stop15h 57m

Knoxville McGhee Tyson

lun. 7/14

12:45 pm-10:16 pm

2 stops33h 31m

$240

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

lun. 7/21

7:56 pm-1:11 pm

2 stops17h 15m

Knoxville McGhee Tyson

lun. 7/28

6:00 am-10:17 pm

1 stop16h 17m

$244

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

lun. 6/23

1:10 pm-7:50 am

2 stops18h 40m

Knoxville McGhee Tyson

vie. 6/27

7:15 am-10:29 pm

1 stop15h 14m

$246

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

jue. 7/10

6:36 pm-4:47 pm

1 stop22h 11m

Knoxville McGhee Tyson

dom. 7/13

8:00 am-10:45 pm

2 stops38h 45m

$258

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

jue. 6/26

6:41 pm-4:47 pm

1 stop22h 06m

Knoxville McGhee Tyson

lun. 6/30

6:00 am-9:50 pm

2 stops15h 50m

$276

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 8/7

3:26 pm-10:15 pm

2 stops30h 49m

Knoxville McGhee Tyson

sáb. 8/9

9:00 am-2:36 pm

2 stops29h 36m

$307

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

jue. 6/19

4:55 pm-10:40 pm

1 stop5h 45m

Knoxville McGhee Tyson

dom. 6/22

7:00 am-2:35 pm

1 stop7h 35m

$329

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

lun. 8/25

6:00 am-4:57 pm

1 stop10h 57m

Knoxville McGhee Tyson

dom. 8/31

6:49 am-7:03 pm

1 stop12h 14m

$354

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

dom. 7/13

7:59 pm-11:59 pm

1 stop4h 00m

Knoxville McGhee Tyson

mié. 7/23

6:19 pm-11:59 pm

1 stop5h 40m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 36 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated junio 12, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are Allegiant Air ($108), American Airlines ($202), and Delta ($226).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charlotte Douglas - Knoxville McGhee Tyson, Savannah/Hilton Head - Knoxville McGhee Tyson or Myrtle Beach Intl - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$490FlexibilityNo cancel feeOn-time71%

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