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Knoxville

$96+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$194
(Kiwi.com)

One-way from

$96
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$338
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 14% potential increase in price ($61 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:40 pmCLT - TYS
1 stop19h 17mMultiple Airlines
Fri 11/219:35 pmTYS - CLT
1 stop10h 41mMultiple Airlines
Deal found 10/30$194
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:51 pmCLT - TYS
1 stop7h 02mMultiple Airlines
Wed 12/245:31 pmTYS - CLT
1 stop5h 58mMultiple Airlines
Deal found 10/30$228
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/13:51 pmCLT - TYS
1 stop6h 49mMultiple Airlines
Thu 12/412:43 pmTYS - CLT
1 stop11h 16mMultiple Airlines
Deal found 10/30$231
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:44 pmCLT - TYS
1 stop15h 50mMultiple Airlines
Wed 11/198:15 amTYS - CLT
1 stop11h 43mMultiple Airlines
Deal found 10/29$241
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:09 pmCLT - TYS
1 stop25h 10mMultiple Airlines
Thu 12/412:43 pmTYS - CLT
1 stop11h 16mMultiple Airlines
Deal found 10/29$248
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:49 pmCHS - TYS
1 stop10h 44mMultiple Airlines
Sun 12/145:23 pmTYS - CHS
2 stops27h 31mMultiple Airlines
Deal found 10/29$257
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:44 pmCLT - TYS
1 stop15h 20mMultiple Airlines
Tue 11/1811:24 amTYS - CLT
1 stop21h 38mMultiple Airlines
Deal found 10/30$263
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:11 pmCHS - TYS
2 stops43h 01mMultiple Airlines
Wed 11/198:15 amTYS - CHS
1 stop8h 51mMultiple Airlines
Deal found 10/27$268
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:00 amCHS - TYS
1 stop27h 04mMultiple Airlines
Sun 11/169:54 amTYS - CHS
1 stop12h 48mMultiple Airlines
Deal found 10/29$274
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:46 pmSAV - TYS
1 stop20h 18mMultiple Airlines
Tue 11/1811:24 amTYS - SAV
2 stops20h 09mMultiple Airlines
Deal found 10/30$301
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:00 amCHS - TYS
2 stops15h 26mMultiple Airlines
Sun 11/239:26 pmTYS - CHS
1 stop24h 39mMultiple Airlines
Deal found 10/28$302
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:10 amCHS - TYS
1 stop3h 26mAmerican Airlines
Sun 12/144:31 pmTYS - CHS
1 stop5h 29mAmerican Airlines
Deal found 10/30$327

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 11/18

5:40 pm-12:57 pm

1 stop19h 17m

Knoxville McGhee Tyson

Fri 11/21

9:35 pm-8:16 am

1 stop10h 41m

$194

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 11/17

6:44 pm-10:34 am

1 stop15h 50m

Knoxville McGhee Tyson

Wed 11/19

8:15 am-6:54 pm

2 stops10h 39m

$252

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 11/27

6:09 pm-7:19 pm

1 stop25h 10m

Knoxville McGhee Tyson

Thu 12/4

6:30 am-4:54 pm

1 stop10h 24m

$262

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 11/12

6:11 pm-1:12 pm

2 stops43h 01m

Knoxville McGhee Tyson

Wed 11/19

8:15 am-5:06 pm

1 stop8h 51m

$268

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

9:49 pm-8:33 am

1 stop10h 44m

Knoxville McGhee Tyson

Sun 12/14

7:11 pm-8:54 pm

1 stop25h 43m

$273

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

7:00 am-10:04 am

1 stop27h 04m

Knoxville McGhee Tyson

Sun 11/16

9:54 am-10:42 pm

1 stop12h 48m

$274

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 12/22

9:00 am-9:53 pm

2 stops12h 53m

Knoxville McGhee Tyson

Wed 12/24

5:31 pm-11:29 pm

1 stop5h 58m

$275

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 1/7

9:54 am-8:39 am

1 stop22h 45m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-10:41 am

1 stop16h 42m

$276

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 11/14

8:39 pm-1:01 pm

2 stops16h 22m

Knoxville McGhee Tyson

Tue 11/18

11:24 am-9:02 am

1 stop21h 38m

$281

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 11/20

7:00 am-10:26 pm

2 stops15h 26m

Knoxville McGhee Tyson

Sun 11/23

9:26 pm-10:05 pm

1 stop24h 39m

$302

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 56 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from South Carolina to Knoxville is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 16% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from South Carolina to Knoxville?

    For as low as $337, American Airlines can have you in Knoxville from South Carolina in 3h 13m. The distance from South Carolina to Knoxville is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charleston - Knoxville McGhee Tyson, Myrtle Beach Intl - Knoxville McGhee Tyson or Charlotte Douglas - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for South Carolina to Knoxville

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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$501FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$457FlexibilityNo cancel feeOn-time71%

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