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Knoxville

$88+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:15 pmCHS - TYS
1 stop21h 45mMultiple Airlines
Sun 1/47:15 amTYS - CHS
1 stop5h 55mMultiple Airlines
Deal found 12/16$338
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:00 amCLT - TYS
1 stop8h 17mMultiple Airlines
Sun 1/47:15 amTYS - CLT
1 stop27h 48mMultiple Airlines
Deal found 12/15$345
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:15 amSAV - TYS
1 stop8h 02mMultiple Airlines
Sun 1/47:15 amTYS - SAV
1 stop29h 13mMultiple Airlines
Deal found 12/16$349
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:14 amHHH - TYS
1 stop4h 53mAmerican Airlines
Sun 1/45:00 amTYS - HHH
1 stop5h 44mAmerican Airlines
Deal found 12/16$357
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:00 amSAV - TYS
1 stop24h 18mAllegiant Air
Mon 12/229:08 amTYS - SAV
1 stop14h 23mAllegiant Air
Deal found 12/16$364
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:48 pmMYR - TYS
1 stop3h 19mAmerican Airlines
Sun 1/45:00 amTYS - MYR
1 stop4h 20mAmerican Airlines
Deal found 12/16$372
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:30 amSAV - TYS
2 stops14h 23mMultiple Airlines
Tue 12/306:33 pmTYS - SAV
1 stop21h 24mMultiple Airlines
Deal found 12/17$384
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:54 amMYR - TYS
2 stops11h 59mMultiple Airlines
Wed 12/2411:08 amTYS - MYR
1 stop7h 00mMultiple Airlines
Deal found 12/17$387
This Mytrip deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:00 amSAV - TYS
1 stop12h 33mMultiple Airlines
Mon 12/225:38 pmTYS - SAV
2 stops20h 54mMultiple Airlines
Deal found 12/16$413
This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:18 pmCHS - TYS
2 stops18h 15mMultiple Airlines
Fri 1/27:15 amTYS - CHS
1 stop5h 55mMultiple Airlines
Deal found 12/17$414
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:54 amMYR - TYS
1 stop28h 09mMultiple Airlines
Mon 12/229:15 pmTYS - MYR
1 stop20h 53mMultiple Airlines
Deal found 12/15$417
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:38 pmCLT - TYS
1 stop21h 21mMultiple Airlines
Wed 12/316:07 pmTYS - CLT
1 stop15h 32mMultiple Airlines
Deal found 12/17$425

Find flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$184
(Mytrip)

One-way from

$88
(Mytrip)

Popular in

June

Cheapest in

September

Average price

$316
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From South Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from South Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 1/30

11:12 am-10:28 pm

1 stop11h 16m

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-12:40 am

1 stop6h 41m

$184

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 1/22

1:17 pm-12:05 pm

1 stop22h 48m

Knoxville McGhee Tyson

Thu 1/29

9:29 am-5:13 pm

1 stop7h 44m

$231

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 1/1

2:59 pm-10:15 am

1 stop19h 16m

Knoxville McGhee Tyson

Mon 1/5

6:00 am-8:37 am

1 stop26h 37m

$242

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 1/15

7:00 am-11:05 pm

2 stops16h 05m

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

$257

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 1/17

7:19 pm-11:21 pm

1 stop4h 02m

Knoxville McGhee Tyson

Sun 1/18

2:57 pm-6:49 pm

1 stop3h 52m

$264

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 1/1

9:34 pm-10:15 am

1 stop12h 41m

Knoxville McGhee Tyson

Mon 1/5

7:15 am-11:03 am

1 stop27h 48m

$271

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/20

9:07 pm-6:58 pm

2 stops21h 51m

Knoxville McGhee Tyson

Sun 2/22

5:56 pm-6:02 pm

2 stops24h 06m

$279

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/20

9:07 pm-6:58 pm

2 stops21h 51m

Knoxville McGhee Tyson

Sat 2/21

9:24 pm-8:26 am

1 stop11h 02m

$279

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 1/5

9:38 pm-6:32 pm

1 stop20h 54m

Knoxville McGhee Tyson

Mon 1/12

8:30 am-6:32 pm

1 stop10h 02m

$298

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 1/16

1:17 pm-11:09 am

2 stops21h 52m

Knoxville McGhee Tyson

Sun 1/18

9:29 am-5:05 pm

1 stop7h 36m

$306

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Showing 1-10 of 54 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $302). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from South Carolina to Knoxville is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 16% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from South Carolina to Knoxville?

    For as low as $264, American Airlines can have you in Knoxville from South Carolina in 4h 02m. The distance from South Carolina to Knoxville is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Savannah/Hilton Head - Knoxville McGhee Tyson, Charleston - Knoxville McGhee Tyson or Charlotte Douglas - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $302). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$427FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$522FlexibilityNo cancel feeOn-timeN/A

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