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Knoxville

$95+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Apr 28 — May 51
Tue 4/28
Tue 5/5
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:54 pm
CLT
-
TYS
1 stop14h 12m
Multiple Airlines
Fri 5/11:15 pm
TYS
-
CLT
1 stop18h 54m
Multiple Airlines
Deal found 3/27$209
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:33 pm
CLT
-
TYS
1 stop24h 57m
Multiple Airlines
Thu 4/169:32 pm
TYS
-
CLT
1 stop11h 38m
Multiple Airlines
Deal found 3/28$211
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:04 am
CLT
-
TYS
1 stop5h 46m
Multiple Airlines
Thu 4/309:25 pm
TYS
-
CLT
1 stop11h 45m
Multiple Airlines
Deal found 3/27$213
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
-
TYS
1 stop16h 56m
Multiple Airlines
Thu 4/309:25 pm
TYS
-
CLT
1 stop11h 45m
Multiple Airlines
Deal found 3/27$217
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:25 am
CHS
-
TYS
1 stop4h 52m
Delta
Tue 4/284:38 pm
TYS
-
CHS
1 stop4h 03m
Delta
Deal found 3/23$221
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:00 am
MYR
-
TYS
1 stop3h 32m
American Airlines
Wed 4/295:00 am
TYS
-
MYR
1 stop3h 23m
American Airlines
Deal found 3/25$221
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:36 pm
CLT
-
TYS
1 stop28h 06m
Multiple Airlines
Sat 5/211:56 am
TYS
-
CLT
1 stop26h 16m
Multiple Airlines
Deal found 3/26$222
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:00 pm
CHS
-
TYS
2 stops8h 50m
Southwest
Tue 5/128:15 am
TYS
-
CHS
1 stop5h 20m
Southwest
Deal found 3/25$226
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:20 am
CHS
-
TYS
1 stop5h 57m
Delta
Sat 4/255:15 pm
TYS
-
CHS
1 stop4h 40m
Delta
Deal found 3/23$243
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:52 am
MYR
-
TYS
1 stop24h 14m
Multiple Airlines
Fri 5/17:30 am
TYS
-
MYR
1 stop15h 59m
Multiple Airlines
Deal found 3/27$250
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:32 pm
CLT
-
TYS
1 stop19h 58m
Multiple Airlines
Sun 5/39:25 pm
TYS
-
CLT
1 stop22h 37m
Multiple Airlines
Deal found 3/27$252
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:07 am
CHS
-
TYS
1 stop13h 58m
Multiple Airlines
Mon 4/131:15 pm
TYS
-
CHS
1 stop19h 23m
Multiple Airlines
Deal found 3/25$253

Find flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated March 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$190
(Kiwi.com)

One-way from

$95
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$646
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
Search Deals
From South Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from South Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 4/22

5:00 am-8:32 am

1 stop3h 32m

Knoxville McGhee Tyson

Wed 4/29

5:00 am-8:23 am

1 stop3h 23m

$221

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 4/25

5:20 am-11:17 am

1 stop5h 57m

Knoxville McGhee Tyson

Tue 4/28

4:38 pm-8:41 pm

1 stop4h 03m

$243

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 4/24

11:52 am-12:06 pm

1 stop24h 14m

Knoxville McGhee Tyson

Fri 5/1

7:30 am-11:29 pm

1 stop15h 59m

$250

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 5/9

6:41 pm-8:50 pm

1 stop26h 09m

Knoxville McGhee Tyson

Sat 5/16

11:56 am-12:05 pm

1 stop24h 09m

$260

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 5/29

8:31 pm-12:04 pm

1 stop15h 33m

Knoxville McGhee Tyson

Mon 6/1

1:36 pm-8:58 pm

1 stop7h 22m

$280

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/28

8:12 am-1:10 pm

1 stop4h 58m

Knoxville McGhee Tyson

Mon 6/1

7:33 pm-10:29 pm

1 stop2h 56m

$297

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 5/12

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

Tue 5/19

7:05 am-5:45 pm

2 stops10h 40m

$304

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 4/25

6:10 am-3:20 pm

1 stop9h 10m

Knoxville McGhee Tyson

Sun 4/26

6:40 am-2:30 pm

2 stops7h 50m

$312

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 4/10

6:00 am-12:25 pm

1 stop6h 25m

Knoxville McGhee Tyson

Sun 4/12

11:27 am-9:37 am

2 stops22h 10m

$313

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Mon 5/25

7:59 pm-11:56 pm

1 stop3h 57m

Knoxville McGhee Tyson

Wed 5/27

5:40 am-9:31 am

1 stop3h 51m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, May is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $214). Flying from South Carolina to Knoxville in February is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from South Carolina to Knoxville?

    For as low as $221, American Airlines can have you in Knoxville from South Carolina in 3h 32m. The distance from South Carolina to Knoxville is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charleston - Knoxville McGhee Tyson, Charlotte Douglas - Knoxville McGhee Tyson or Hilton Head Island - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $214). Flying from South Carolina to Knoxville in February is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$254Average$498FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$340FlexibilityNo cancel feeOn-time71%

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