HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$106+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated July 30, 2025.

Round-trip from

$175
(Mytrip)

One-way from

$106
(Mytrip)

Popular in

June

Cheapest in

March

Average price

$298
From South Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from South Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($46 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/142:31 pmMYR - TYS
1 stop7h 44mMultiple Airlines
Mon 8/186:00 amTYS - MYR
1 stop5h 01mMultiple Airlines
Deal found 7/30$175
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:00 amCLT - TYS
1 stop5h 18mMultiple Airlines
Thu 9/1812:08 pmTYS - CLT
1 stop8h 19mMultiple Airlines
Deal found 7/29$218
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/295:23 amMYR - TYS
1 stop3h 46mAmerican Airlines
Fri 9/58:23 amTYS - MYR
1 stop3h 09mAmerican Airlines
Deal found 7/30$229
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/57:50 pmMYR - TYS
1 stop4h 09mDelta
Sun 8/105:30 amTYS - MYR
1 stop4h 40mDelta
Deal found 7/28$269
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:10 amCHS - TYS
1 stop5h 15mDelta
Tue 10/75:44 amTYS - CHS
1 stop4h 37mDelta
Deal found 7/27$297
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:50 amSAV - TYS
1 stop3h 52mDelta
Sat 9/66:14 pmTYS - SAV
1 stop5h 45mDelta
Deal found 7/29$297
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/288:17 pmCHS - TYS
2 stops24h 53mMultiple Airlines
Thu 9/412:08 pmTYS - CHS
2 stops20h 07mMultiple Airlines
Deal found 7/29$304
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:12 pmCHS - TYS
1 stop3h 39mAmerican Airlines
Mon 11/177:20 pmTYS - CHS
1 stop3h 50mAmerican Airlines
Deal found 7/30$307
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/213:05 pmSAV - TYS
2 stops19h 29mMultiple Airlines
Sun 8/247:30 amTYS - SAV
1 stop6h 46mMultiple Airlines
Deal found 7/28$309
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/215:00 amSAV - TYS
1 stop4h 10mAmerican Airlines
Sun 8/248:25 pmTYS - SAV
1 stop3h 29mAmerican Airlines
Deal found 7/28$327
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:34 pmCLT - TYS
1 stop13h 03mAmerican Airlines
Tue 9/235:20 pmTYS - CLT
1 stop14h 15mAmerican Airlines
Deal found 7/28$355
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/89:47 pmMYR - TYS
2 stops18h 34mAllegiant Air
Sun 8/108:54 pmTYS - MYR
2 stops18h 20mAllegiant Air
Deal found 7/29$358

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 8/14

2:31 pm-10:15 pm

1 stop7h 44m

Knoxville McGhee Tyson

Mon 8/18

6:00 am-11:01 am

1 stop5h 01m

$175

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 9/11

6:00 am-11:18 am

1 stop5h 18m

Knoxville McGhee Tyson

Thu 9/18

12:08 pm-8:27 pm

1 stop8h 19m

$218

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 8/29

5:23 am-9:09 am

1 stop3h 46m

Knoxville McGhee Tyson

Fri 9/5

8:23 am-11:32 am

1 stop3h 09m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 8/29

2:20 pm-8:06 pm

1 stop5h 46m

Knoxville McGhee Tyson

Sun 8/31

5:45 am-10:11 am

1 stop4h 26m

$294

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 10/4

5:10 am-10:25 am

1 stop5h 15m

Knoxville McGhee Tyson

Tue 10/7

5:44 am-10:21 am

1 stop4h 37m

$297

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 9/3

6:50 am-10:42 am

1 stop3h 52m

Knoxville McGhee Tyson

Sat 9/6

6:14 pm-11:59 pm

1 stop5h 45m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/28

8:17 pm-9:10 pm

2 stops24h 53m

Knoxville McGhee Tyson

Thu 9/4

12:08 pm-8:15 am

2 stops20h 07m

$304

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/28

6:00 am-9:10 am

1 stop3h 10m

Knoxville McGhee Tyson

Thu 9/4

5:19 pm-11:01 pm

1 stop5h 42m

$307

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 8/21

3:05 pm-10:34 am

2 stops19h 29m

Knoxville McGhee Tyson

Sun 8/24

7:30 am-2:16 pm

1 stop6h 46m

$309

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 8/21

5:00 am-9:10 am

1 stop4h 10m

Knoxville McGhee Tyson

Sun 8/24

8:25 pm-11:54 pm

1 stop3h 29m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 31 results
1
2
3
4

Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $294). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 30, 2025.
Read through reviews of airlines operating flights from South Carolina to Knoxville, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are Allegiant Air ($146), American Airlines ($189), and Delta ($220).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charleston - Knoxville McGhee Tyson, Charlotte Douglas - Knoxville McGhee Tyson or Savannah/Hilton Head - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $294). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
LaGuardia to Nashville flights
Newark to Nashville flights
John F Kennedy Intl to Nashville flights
Boston to Nashville flights
Los Angeles to Nashville flights
O'Hare Intl to Nashville flights
Reagan-National to Nashville flights
Seattle to Nashville flights
San Francisco to Nashville flights
Dallas/Fort Worth to Nashville flights
Ontario to Nashville flights
Denver to Nashville flights
Hobby to Nashville flights
Santa Ana to Nashville flights
LaGuardia to Knoxville flights
Minneapolis to Nashville flights
Philadelphia to Nashville flights
O'Hare Intl to Knoxville flights
Fort Lauderdale to Nashville flights
Burbank to Nashville flights
Dulles Intl to Nashville flights
Baltimore to Nashville flights
George Bush Intcntl to Nashville flights
Raleigh to Nashville flights
Hobby to Knoxville flights
LaGuardia to Memphis flights
Sky Harbor Intl to Nashville flights
George Bush Intcntl to Knoxville flights
Newark to Memphis flights
Detroit to Nashville flights
Portland to Nashville flights
Sacramento to Nashville flights
Orlando to Nashville flights
John F Kennedy Intl to Knoxville flights
Providence to Nashville flights
Cleveland to Nashville flights
San Antonio to Nashville flights
Dallas/Fort Worth to Knoxville flights
Midway to Nashville flights
Miami to Nashville flights
Charlotte to Nashville flights
West Palm Beach to Nashville flights
San Diego to Nashville flights
Tampa to Nashville flights
Salt Lake City to Nashville flights
O'Hare Intl to Memphis flights
Love Field to Nashville flights
Austin to Knoxville flights
New Orleans to Nashville flights
Omaha to Nashville flights

Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$473FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$489FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.