How long is the flight from South Carolina to Knoxville?

For as low as $236, American Airlines can have you in Knoxville from South Carolina in 3h 26m. The distance from South Carolina to Knoxville is about 302 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular routes from South Carolina to Knoxville?

Most travelers choose Charleston - Knoxville McGhee Tyson, Savannah/Hilton Head - Knoxville McGhee Tyson or Myrtle Beach Intl - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

What is the cheapest month to fly from South Carolina to Knoxville?

Flights from South Carolina to Knoxville lean towards being more expensive in December. Prices are generally better when you fly from South Carolina to Knoxville in September, with the cheapest ticket starting at $232.

What airport do you fly into for flights to Knoxville from South Carolina?

For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

Can I find deals for business class flights from South Carolina to Knoxville?

Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$104+ Flights from South Carolina to Knoxville

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Cheap flight deals from South Carolina to Knoxville

Round-trip from	$236 (American Airlines)
One-way from	$104 (Kiwi.com)
Popular in	December
Cheapest in	September
Average price	$268

From South Carolina to Knoxville McGhee Tyson

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One-way flight from South Carolina to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 23% potential increase in price ($117 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Fri 10/247:41 pmCHS - TYS

1 stop3h 26mAmerican Airlines

Sat 10/255:00 amTYS - CHS

1 stop3h 16mAmerican Airlines

Deal found 9/12

$236

Fri 10/310:10 amCHS - TYS

1 stop24h 08mMultiple Airlines

Wed 10/87:15 amTYS - CHS

1 stop11h 26mMultiple Airlines

Deal found 9/13

$239

Fri 11/75:40 pmCHS - TYS

1 stop16h 24mMultiple Airlines

Mon 11/107:20 amTYS - CHS

1 stop9h 25mMultiple Airlines

Deal found 9/15

$241

Fri 10/1710:06 pmCLT - TYS

1 stop9h 44mMultiple Airlines

Sat 10/184:26 pmTYS - CLT

1 stop7h 02mMultiple Airlines

Deal found 9/14

$241

Mon 10/610:11 amCHS - TYS

1 stop6h 30mMultiple Airlines

Wed 10/87:15 amTYS - CHS

1 stop11h 26mMultiple Airlines

Deal found 9/13

$247

Fri 10/1710:06 pmCLT - TYS

1 stop9h 44mMultiple Airlines

Sun 10/199:50 pmTYS - CLT

1 stop9h 57mMultiple Airlines

Deal found 9/15

$249

Thu 10/26:08 pmCHS - TYS

1 stop17h 47mMultiple Airlines

Wed 10/87:15 amTYS - CHS

1 stop11h 26mMultiple Airlines

Deal found 9/13

$253

Fri 11/141:46 pmSAV - TYS

1 stop20h 18mMultiple Airlines

Wed 11/198:15 amTYS - SAV

1 stop28h 33mMultiple Airlines

Deal found 9/13

$253

Sun 10/510:11 amCHS - TYS

1 stop10h 14mMultiple Airlines

Wed 10/87:15 amTYS - CHS

1 stop11h 26mMultiple Airlines

Deal found 9/13

$257

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Wed 10/17:15 amTYS - CLT

1 stop7h 14mMultiple Airlines

Deal found 9/14

$276

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Thu 10/25:44 pmTYS - CLT

2 stops17h 59mMultiple Airlines

Deal found 9/13

$279

Fri 10/310:10 amCHS - TYS

1 stop6h 56mMultiple Airlines

Mon 10/68:10 pmTYS - CHS

2 stops22h 31mMultiple Airlines

Deal found 9/13

$282

Best flights from South Carolina to Knoxville
Discover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Fri 10/247:41 pmCHS - TYS

1 stop3h 26mAmerican Airlines

Sat 10/255:00 amTYS - CHS

1 stop3h 16mAmerican Airlines

Deal found 9/12

$236

Fri 11/75:40 pmCHS - TYS

1 stop16h 24mMultiple Airlines

Mon 11/107:20 amTYS - CHS

1 stop9h 25mMultiple Airlines

Deal found 9/15

$241

Tue 10/146:58 pmMYR - TYS

1 stop4h 09mDelta

Tue 10/215:44 amTYS - MYR

1 stop4h 07mDelta

Deal found 9/14

$307

Thu 10/237:30 amSAV - TYS

2 stops24h 25mAllegiant Air

Sun 10/269:15 pmTYS - SAV

1 stop12h 57mAllegiant Air

Deal found 9/15

$403

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Wed 10/17:15 amTYS - CLT

1 stop7h 14mMultiple Airlines

Deal found 9/14

$276

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Thu 10/25:44 pmTYS - CLT

2 stops17h 59mMultiple Airlines

Deal found 9/13

$279

Mon 10/138:20 pmMYR - TYS

1 stop3h 30mAmerican Airlines

Mon 10/208:37 pmTYS - MYR

1 stop3h 22mAmerican Airlines

Deal found 9/13

$317

Fri 10/2410:11 amCHS - TYS

1 stop23h 52mMultiple Airlines

Sun 10/269:15 pmTYS - CHS

1 stop11h 46mMultiple Airlines

Deal found 9/15

$282

Wed 10/85:40 amSAV - TYS

1 stop3h 20mDelta

Sat 10/116:15 amTYS - SAV

1 stop3h 02mDelta

Deal found 9/15

$347

Mon 10/205:21 amMYR - TYS

1 stop4h 11mAmerican Airlines

Wed 10/228:15 amTYS - MYR

1 stop3h 13mAmerican Airlines

Deal found 9/13

$317

Thu 12/115:40 pmCHS - TYS

1 stop14h 53mMultiple Airlines

Mon 12/225:38 pmTYS - CHS

1 stop14h 59mMultiple Airlines

Deal found 9/15

$283

Tue 3/106:00 amMYR - TYS

1 stop3h 13mDelta

Wed 3/115:30 amTYS - MYR

1 stop4h 38mDelta

Deal found 9/13

$357

Last-minute flights from South Carolina to Knoxville
Discover last-minute flight deals from South Carolina to Knoxville. Data last updated September 15, 2025 and is based on user searches.

Tue 9/2310:46 amCLT - TYS

1 stop28h 55mMultiple Airlines

Thu 9/2512:08 pmTYS - CLT

1 stop10h 51mMultiple Airlines

Deal found 9/13

$318

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Wed 10/17:15 amTYS - CLT

1 stop7h 14mMultiple Airlines

Deal found 9/14

$276

Sun 9/287:16 pmCLT - TYS

1 stop22h 18mMultiple Airlines

Thu 10/25:44 pmTYS - CLT

2 stops17h 59mMultiple Airlines

Deal found 9/13

$279

Tue 9/3012:02 pmSAV - TYS

1 stop23h 53mMultiple Airlines

Sat 10/411:10 pmTYS - SAV

2 stops34h 59mMultiple Airlines

Deal found 9/15

$287

Fri 10/36:00 amSAV - TYS

1 stop8h 50mMultiple Airlines

Mon 10/68:10 pmTYS - SAV

2 stops37h 46mMultiple Airlines

Deal found 9/15

$311

Tue 10/146:58 pmMYR - TYS

1 stop4h 09mDelta

Tue 10/215:44 amTYS - MYR

1 stop4h 07mDelta

Deal found 9/14

$307

Tue 10/147:55 pmCHS - TYS

1 stop16h 00mMultiple Airlines

Fri 10/177:15 amTYS - CHS

1 stop13h 00mMultiple Airlines

Deal found 9/15

$316

Fri 10/1710:06 pmCLT - TYS

1 stop9h 44mMultiple Airlines

Sat 10/184:26 pmTYS - CLT

1 stop7h 02mMultiple Airlines

Deal found 9/14

$241

Fri 10/1710:06 pmCLT - TYS

1 stop9h 44mMultiple Airlines

Sun 10/199:50 pmTYS - CLT

1 stop9h 57mMultiple Airlines

Deal found 9/15

$249

Mon 10/208:20 pmMYR - TYS

1 stop3h 30mAmerican Airlines

Wed 10/223:49 pmTYS - MYR

1 stop4h 58mAmerican Airlines

Deal found 9/14

$317

Thu 10/235:45 amCLT - TYS

1 stop14h 40mMultiple Airlines

Sun 10/267:00 amTYS - CLT

1 stop9h 39mMultiple Airlines

Deal found 9/13

$297

Fri 10/2410:11 amCHS - TYS

1 stop23h 52mMultiple Airlines

Sun 10/269:15 pmTYS - CHS

1 stop11h 46mMultiple Airlines

Deal found 9/15

$282

One-way flights from South Carolina to Knoxville
Search for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Mon 9/292:01 pmCLT - TYS

1 stop20h 34mMultiple Airlines

Deal found 9/15

$104

Fri 9/268:51 pmCLT - TYS

1 stop23h 50mMultiple Airlines

Deal found 9/15

$109

Tue 9/302:32 pmCLT - TYS

1 stop21h 23mMultiple Airlines

Deal found 9/15

$116

Thu 12/119:49 amCLT - TYS

1 stop22h 44mMultiple Airlines

Deal found 9/13

$125

Fri 9/2610:10 amCHS - TYS

1 stop24h 08mMultiple Airlines

Deal found 9/14

$132

Sat 11/13:09 pmCLT - TYS

1 stop18h 54mMultiple Airlines

Deal found 9/15

$132

Sat 9/273:34 pmCLT - TYS

1 stop25h 55mMultiple Airlines

Deal found 9/15

$133

Sat 11/1511:00 amCLT - TYS

1 stop22h 04mMultiple Airlines

Deal found 9/13

$137

Fri 12/127:31 pmCLT - TYS

1 stop19h 24mMultiple Airlines

Deal found 9/13

$141

Sat 11/153:51 pmCLT - TYS

2 stops26h 31mFrontier

Deal found 9/13

$142

Sat 12/139:46 pmCLT - TYS

2 stops42h 06mMultiple Airlines

Deal found 9/13

$143

Tue 10/148:52 amCLT - TYS

1 stop27h 03mMultiple Airlines

Deal found 9/14

$145

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 10/24

7:41 pm-11:07 pm

1 stop3h 26m

Knoxville McGhee Tyson

Sat 10/25

5:00 am-8:16 am

1 stop3h 16m

$236

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/7

5:40 pm-10:04 am

1 stop16h 24m

Knoxville McGhee Tyson

Mon 11/10

7:20 am-4:45 pm

1 stop9h 25m

$241

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 9/28

7:16 pm-5:34 pm

1 stop22h 18m

Knoxville McGhee Tyson

Wed 10/1

7:15 am-2:29 pm

1 stop7h 14m

$276

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 9/28

7:16 pm-5:34 pm

1 stop22h 18m

Knoxville McGhee Tyson

Thu 10/2

5:44 pm-11:43 am

2 stops17h 59m

$279

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 10/24

10:11 am-10:03 am

1 stop23h 52m

Knoxville McGhee Tyson

Sun 10/26

9:15 pm-9:01 am

1 stop11h 46m

$282

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

5:40 pm-8:33 am

1 stop14h 53m

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:37 am

1 stop14h 59m

$283

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 12/2

2:16 pm-12:03 pm

2 stops21h 47m

Knoxville McGhee Tyson

Fri 12/5

6:30 am-2:48 pm

1 stop8h 18m

$288

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 10/17

7:20 am-11:16 pm

2 stops15h 56m

Knoxville McGhee Tyson

Sun 10/19

9:50 pm-7:47 am

1 stop9h 57m

$288

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 10/1

6:25 am-7:24 pm

2 stops12h 59m

Knoxville McGhee Tyson

Wed 10/8

7:15 am-6:41 pm

1 stop11h 26m

$297

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 10/14

6:58 pm-11:07 pm

1 stop4h 09m

Knoxville McGhee Tyson

Tue 10/21

5:44 am-9:51 am

1 stop4h 07m

$307

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 57 results

...

Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $294). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

What airport do you fly into for flights to Knoxville from South Carolina?
For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.
How long is the flight from South Carolina to Knoxville?
For as low as $236, American Airlines can have you in Knoxville from South Carolina in 3h 26m. The distance from South Carolina to Knoxville is about 302 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the most popular routes from South Carolina to Knoxville?
Most travelers choose Charleston - Knoxville McGhee Tyson, Savannah/Hilton Head - Knoxville McGhee Tyson or Myrtle Beach Intl - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.
Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?
Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.
Can I find deals for business class flights from South Carolina to Knoxville?
Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Knoxville?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $294). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Alcoa

Oak Ridge

Murphy

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from South Carolina to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$198	Average$459	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$228	Average$481	FlexibilityNo cancel fee	On-time71%

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$104+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Knoxville with Cheapflights

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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated September 15, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to KnoxvilleExplore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from South Carolina?

How long is the flight from South Carolina to Knoxville?

What are the most popular routes from South Carolina to Knoxville?

Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

How can I find direct flights from South Carolina to Knoxville?

Can I find deals for business class flights from South Carolina to Knoxville?

What is the cheapest month to book a flight from South Carolina to Knoxville?

Traveling to a place near Knoxville?

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from South Carolina to Knoxville

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Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.