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Knoxville

$92+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
feb. 28 — mar. 71
sáb. 2/28
sáb. 3/7
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/265:55 am
CLT
-
TYS
1 stop8h 40m
Multiple Airlines
vie. 2/279:36 pm
TYS
-
CLT
1 stop10h 50m
Multiple Airlines
Deal found 1/28$250
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:40 am
CLT
-
TYS
1 stop5h 20m
Southwest
mié. 4/155:50 pm
TYS
-
CLT
1 stop3h 50m
Southwest
Deal found 1/27$261
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/246:25 am
SAV
-
TYS
1 stop3h 28m
American Airlines
mar. 3/34:04 pm
TYS
-
SAV
1 stop5h 19m
American Airlines
Deal found 1/27$263
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/198:56 am
CLT
-
TYS
1 stop13h 30m
Multiple Airlines
dom. 3/225:24 pm
TYS
-
CLT
1 stop14h 57m
Multiple Airlines
Deal found 1/28$269
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/66:35 pm
CHS
-
TYS
1 stop15h 05m
Multiple Airlines
lun. 3/99:36 pm
TYS
-
CHS
2 stops18h 29m
Multiple Airlines
Deal found 1/26$270
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/37:43 pm
CLT
-
TYS
1 stop20h 14m
Multiple Airlines
mar. 2/101:00 pm
TYS
-
CLT
1 stop24h 51m
Multiple Airlines
Deal found 1/27$270
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/256:54 pm
MYR
-
TYS
1 stop5h 03m
Delta
sáb. 3/285:40 am
TYS
-
MYR
1 stop3h 53m
Delta
Deal found 1/28$272
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/67:13 pm
CLT
-
TYS
1 stop14h 27m
Multiple Airlines
dom. 3/89:42 pm
TYS
-
CLT
1 stop10h 44m
Multiple Airlines
Deal found 1/27$273
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/195:30 am
SAV
-
TYS
1 stop3h 34m
Delta
lun. 2/236:41 pm
TYS
-
SAV
1 stop5h 16m
Delta
Deal found 1/29$281
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/1912:27 pm
SAV
-
TYS
1 stop23h 33m
Multiple Airlines
lun. 2/236:30 am
TYS
-
SAV
2 stops16h 49m
Multiple Airlines
Deal found 1/29$284
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/206:35 pm
CHS
-
TYS
1 stop18h 29m
Multiple Airlines
dom. 2/229:00 am
TYS
-
CHS
1 stop12h 59m
Multiple Airlines
Deal found 1/27$288
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/67:43 pm
CLT
-
TYS
1 stop15h 26m
Multiple Airlines
dom. 2/88:00 am
TYS
-
CLT
1 stop16h 40m
Multiple Airlines
Deal found 1/27$288

Find flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated enero 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$250
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$461
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
Search Deals
From South Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from South Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($68 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

jue. 2/26

5:55 am-2:35 pm

1 stop8h 40m

Knoxville McGhee Tyson

vie. 2/27

9:36 pm-8:26 am

1 stop10h 50m

$250

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

mar. 4/14

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

mié. 4/15

5:50 pm-9:40 pm

1 stop3h 50m

$261

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

mar. 2/24

6:25 am-9:53 am

1 stop3h 28m

Knoxville McGhee Tyson

mar. 3/3

4:04 pm-9:23 pm

1 stop5h 19m

$263

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

jue. 3/19

8:56 am-10:26 pm

1 stop13h 30m

Knoxville McGhee Tyson

dom. 3/22

5:24 pm-8:21 am

1 stop14h 57m

$269

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 3/6

6:35 pm-9:40 am

1 stop15h 05m

Knoxville McGhee Tyson

lun. 3/9

9:36 pm-4:05 pm

2 stops18h 29m

$270

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

mié. 3/25

6:54 pm-11:57 pm

1 stop5h 03m

Knoxville McGhee Tyson

sáb. 3/28

5:40 am-9:33 am

1 stop3h 53m

$272

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

vie. 3/6

7:13 pm-9:40 am

1 stop14h 27m

Knoxville McGhee Tyson

dom. 3/8

9:42 pm-8:26 am

1 stop10h 44m

$273

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

jue. 2/19

5:30 am-9:04 am

1 stop3h 34m

Knoxville McGhee Tyson

lun. 2/23

6:41 pm-11:57 pm

1 stop5h 16m

$281

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

jue. 2/19

12:27 pm-12:00 pm

1 stop23h 33m

Knoxville McGhee Tyson

lun. 2/23

6:30 am-11:19 pm

2 stops16h 49m

$284

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

mié. 3/25

3:40 pm-9:10 pm

1 stop5h 30m

Knoxville McGhee Tyson

sáb. 3/28

6:35 am-9:30 pm

2 stops14h 55m

$288

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 54 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from South Carolina to Knoxville?

    For as low as $263, Southwest can have you in Knoxville from South Carolina in 3h 28m. The distance from South Carolina to Knoxville is about 300 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are American Airlines ($280), Delta ($391), and Aeromexico ($435).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charlotte Douglas - Knoxville McGhee Tyson, Charleston - Knoxville McGhee Tyson or Myrtle Beach Intl - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $208). Flying from South Carolina to Knoxville in December is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for South Carolina to Knoxville

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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$350FlexibilityNo cancel feeOn-time71%
DeltaCheapest$254Average$478FlexibilityNo cancel feeOn-timeN/A

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