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$334+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
Jul 23 — Jul 301
Wed 7/23
Wed 7/30
1 adult, Economy
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Cheap flight deals from South America to Knoxville

Keep the following information in mind while searching for South America to Knoxville flight deals. Data was last updated July 18, 2025.

Round-trip from

$596
(United Airlines)

One-way from

$334
(Kiwi.com)
From South America to Knoxville McGhee Tyson
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One-way flight from South America to Knoxville McGhee Tyson
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Find flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2025.

This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:14 pmGYE - TYS
2 stops30h 38mUnited Airlines
Mon 11/104:25 pmTYS - GYE
2 stops31h 16mUnited Airlines
Deal found 7/17$596
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/208:15 amGYE - TYS
1 stop14h 20mAmerican Airlines
Mon 11/105:01 pmTYS - GYE
1 stop28h 59mAmerican Airlines
Deal found 7/17$809
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/49:50 pmSCL - TYS
1 stop26h 09mAmerican Airlines
Tue 12/234:25 pmTYS - SCL
1 stop13h 25mAmerican Airlines
Deal found 7/16$968
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/411:05 pmSCL - TYS
2 stops21h 00mDelta
Tue 12/2311:55 amTYS - SCL
2 stops17h 05mDelta
Deal found 7/17$1,030
This eDestinos deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/312:40 amSCL - TYS
2 stops21h 22mLATAM Airlines
Tue 12/232:32 pmTYS - SCL
1 stop14h 28mLATAM Airlines
Deal found 7/16$1,548
This Copa Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/221:49 amTUC - TYS
2 stops33h 40mCopa Airlines
Mon 10/277:20 pmTYS - TUC
2 stops52h 20mCopa Airlines
Deal found 7/17$3,033

Cheapflights Fare Finder

Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

South America

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

12:14 pm-7:52 pm

2 stops30h 38m

Knoxville McGhee Tyson

Mon 11/10

4:25 pm-11:41 pm

2 stops31h 16m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

8:15 am-11:35 pm

1 stop14h 20m

Knoxville McGhee Tyson

Mon 11/10

5:01 pm-10:00 pm

1 stop28h 59m

$809

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 8/4

9:50 pm-11:59 pm

1 stop26h 09m

Knoxville McGhee Tyson

Tue 12/23

4:25 pm-7:50 am

1 stop13h 25m

$968

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 8/4

11:05 pm-8:05 pm

2 stops21h 00m

Knoxville McGhee Tyson

Tue 12/23

11:55 am-7:00 am

2 stops17h 05m

$1,030

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 8/3

12:40 am-10:02 pm

2 stops21h 22m

Knoxville McGhee Tyson

Tue 12/23

2:32 pm-7:00 am

1 stop14h 28m

$1,548

San Miguel de TucumánKnoxville

TUC - TYS

TUCTYS

San Miguel de Tucumán Benj Matienzo

Wed 10/22

1:49 am-10:29 am

2 stops33h 40m

Knoxville McGhee Tyson

Mon 10/27

7:20 pm-12:40 am

2 stops52h 20m

$3,033

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Thu 8/14

4:20 am-8:02 pm

2 stops14h 42m

$334

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 10/10

10:50 pm-5:17 pm

2 stops19h 27m

$592

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 10/9

12:25 am-11:46 pm

2 stops24h 21m

$596

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Thu 8/14

11:15 pm-9:30 am

1 stop9h 15m

$636

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/17

Showing 1-10 of 12 results
1
2

Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South America to Knoxville

What is the cheapest month to book a flight from South America to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $294). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 18, 2025.

When flying from South America to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 18, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from South America to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,958 reviews
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
LATAM Airlines
7.5
Good
1,810 reviews
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Copa Airlines
7.5
Good
1,483 reviews
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
United Airlines
7.4
Good
8,864 reviews
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,958 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • What are the cheapest airlines to fly from South America to Knoxville one-way?

    $592 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on LATAM Airlines and United Airlines, with prices starting from $596 and $806, respectively.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Santiago Arturo Merino Benitez - Knoxville McGhee Tyson, Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson or San Miguel de Tucumán Benj Matienzo - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $294). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

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