HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$248+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South America to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/204:15 amGYE - TYS
2 stops12h 25mMultiple Airlines
Wed 10/227:26 pmTYS - GYE
2 stops31h 39mMultiple Airlines
Deal found 10/16$645
This Trip.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/194:15 amGYE - TYS
2 stops14h 56mMultiple Airlines
Tue 10/2111:23 amTYS - GYE
2 stops34h 02mMultiple Airlines
Deal found 10/15$692
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:45 pmSCL - TYS
2 stops27h 14mUnited Airlines
Thu 11/2011:45 amTYS - SCL
1 stop19h 05mUnited Airlines
Deal found 10/15$703
This Mytrip deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:20 pmUIO - TYS
2 stops26h 13mMultiple Airlines
Fri 11/145:45 amTYS - UIO
2 stops21h 05mMultiple Airlines
Deal found 10/14$705
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/219:55 pmSCL - TYS
1 stop26h 44mAmerican Airlines
Sun 10/262:21 pmTYS - SCL
1 stop16h 44mAmerican Airlines
Deal found 10/14$716
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/271:35 amUIO - TYS
1 stop22h 09mUnited Airlines
Fri 12/52:30 pmTYS - UIO
2 stops34h 00mUnited Airlines
Deal found 10/14$724
This eDestinos deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:35 amSCL - TYS
2 stops34h 37mMultiple Airlines
Thu 11/206:00 amTYS - SCL
2 stops40h 06mMultiple Airlines
Deal found 10/14$740
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1410:45 pmSCL - TYS
1 stop21h 24mUnited Airlines
Sun 1/45:35 pmTYS - SCL
2 stops37h 15mUnited Airlines
Deal found 10/14$747
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/288:27 amUIO - TYS
1 stop15h 32mAmerican Airlines
Fri 12/56:00 amTYS - UIO
1 stop13h 45mAmerican Airlines
Deal found 10/14$747
This Mytrip deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:15 pmUIO - TYS
2 stops39h 14mAvianca
Mon 10/207:26 pmTYS - UIO
2 stops38h 09mAvianca
Deal found 10/14$754
This LATAM Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:05 amSCL - TYS
2 stops24h 02mLATAM Airlines
Sun 10/2611:40 amTYS - SCL
1 stop19h 00mLATAM Airlines
Deal found 10/14$756
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1410:30 pmSCL - TYS
1 stop27h 27mAmerican Airlines
Sun 1/412:18 pmTYS - SCL
1 stop17h 27mAmerican Airlines
Deal found 10/14$806

Cheap flight deals from South America to Knoxville

Keep the following information in mind while searching for South America to Knoxville flight deals. Data was last updated October 16, 2025.

Round-trip from

$637
(Mytrip)

One-way from

$248
(eDestinos)
From South America to Knoxville McGhee Tyson
Search Deals
One-way flight from South America to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

South America

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

1:45 pm-8:34 pm

2 stops30h 49m

Knoxville McGhee Tyson

Sun 5/3

11:27 am-8:35 am

3 stops22h 08m

$655

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

2:33 pm-2:13 pm

2 stops23h 40m

Knoxville McGhee Tyson

Sun 5/3

8:44 pm-1:33 pm

2 stops17h 49m

$693

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

7:35 am-9:39 pm

1 stop14h 04m

Knoxville McGhee Tyson

Wed 4/1

7:04 am-1:33 pm

1 stop7h 29m

$699

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

2:33 pm-5:35 pm

1 stop27h 02m

Knoxville McGhee Tyson

Thu 5/7

7:15 am-1:33 pm

1 stop7h 18m

$699

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

2:33 pm-5:35 pm

1 stop27h 02m

Knoxville McGhee Tyson

Mon 5/4

7:15 am-1:33 pm

1 stop7h 18m

$700

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 11/13

10:45 pm-11:59 pm

2 stops27h 14m

Knoxville McGhee Tyson

Thu 11/20

8:26 am-8:50 am

2 stops22h 24m

$703

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Thu 10/30

2:20 pm-5:33 pm

2 stops26h 13m

Knoxville McGhee Tyson

Fri 11/14

5:45 am-2:50 am

2 stops21h 05m

$705

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Thu 11/27

1:35 am-11:44 pm

1 stop22h 09m

Knoxville McGhee Tyson

Fri 12/5

2:30 pm-12:30 am

2 stops34h 00m

$724

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/12

4:35 am-1:12 pm

2 stops34h 37m

Knoxville McGhee Tyson

Thu 11/20

6:00 am-12:06 am

2 stops40h 06m

$740

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 12/14

10:45 pm-6:09 pm

1 stop21h 24m

Knoxville McGhee Tyson

Sun 1/4

5:35 pm-8:50 am

2 stops37h 15m

$747

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 26 results
1
2
3

Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South America to Knoxville

What is the cheapest month to book a flight from South America to Knoxville?

Currently, August is the cheapest month in which you can book a flight from South America to Knoxville (average of $120). Flying from South America to Knoxville in December is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

When flying from South America to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 43% versus a flight in the evening.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from South America to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,979 reviews
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,041 reviews
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • How long is the flight from South America to Knoxville?

    Airlines like American Airlines and United Airlines fly from South America to Knoxville in about 23h 40m. The time it takes to get you to your destination can typically vary by up to 3h 34m. The distance between South America and Knoxville is about 2635 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson, Quito Mariscal Sucr - Knoxville McGhee Tyson or Santiago Arturo Merino Benitez - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from South America to Knoxville (average of $120). Flying from South America to Knoxville in December is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South America to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Boston to Nashville flights
John F Kennedy Intl to Nashville flights
Newark to Nashville flights
LaGuardia to Nashville flights
Los Angeles to Nashville flights
Reagan-National to Nashville flights
Dulles Intl to Nashville flights
O'Hare Intl to Nashville flights
Baltimore to Nashville flights
Hobby to Nashville flights
Seattle to Nashville flights
Dallas/Fort Worth to Nashville flights
Philadelphia to Nashville flights
San Francisco to Nashville flights
Denver to Nashville flights
George Bush Intcntl to Nashville flights
Raleigh to Nashville flights
Minneapolis to Nashville flights
Fort Lauderdale to Nashville flights
Detroit to Nashville flights
Ontario to Nashville flights
Newark to Memphis flights
Orlando to Nashville flights
Providence to Nashville flights
Midway to Nashville flights
Burbank to Nashville flights
LaGuardia to Memphis flights
John F Kennedy Intl to Memphis flights
LaGuardia to Knoxville flights
Santa Ana to Nashville flights
Austin to Nashville flights
Tampa to Nashville flights
Hartford to Nashville flights
Sky Harbor Intl to Nashville flights
Charlotte to Nashville flights
John F Kennedy Intl to Knoxville flights
Dallas/Fort Worth to Knoxville flights
Dallas/Fort Worth to Memphis flights
O'Hare Intl to Knoxville flights
Miami to Nashville flights
Love Field to Nashville flights
Cleveland to Nashville flights
San Diego to Nashville flights
Los Angeles to Memphis flights
Reagan-National to Memphis flights
Pittsburgh to Nashville flights
George Bush Intcntl to Knoxville flights
Grand Rapids to Nashville flights
Atlanta to Nashville flights
Los Angeles to Knoxville flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Cookie settings©2025 Cheapflights