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Knoxville

$324+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South America to Knoxville

Keep the following information in mind while searching for South America to Knoxville flight deals. Data was last updated May 1, 2025.

Round-trip from

$683
(United Airlines)

One-way from

$324
(Kiwi.com)
From South America to Knoxville McGhee Tyson
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One-way flight from South America to Knoxville McGhee Tyson
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Find flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/201:15 amUIO - TYS
2 stops44h 25mUnited Airlines
Fri 10/32:20 pmTYS - UIO
2 stops34h 05mUnited Airlines
Deal found 4/30$683
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:15 pmUIO - TYS
2 stops27h 40mMultiple Airlines
Sat 8/234:41 pmTYS - UIO
3 stops30h 44mMultiple Airlines
Deal found 4/30$706
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/208:28 amGYE - TYS
2 stops27h 52mUnited Airlines
Mon 11/105:20 pmTYS - GYE
2 stops30h 21mUnited Airlines
Deal found 4/30$740
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/207:30 amGYE - TYS
1 stop14h 42mAmerican Airlines
Mon 11/108:24 pmTYS - GYE
2 stops25h 36mAmerican Airlines
Deal found 4/30$815
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:00 amUIO - TYS
1 stop15h 20mAmerican Airlines
Sat 8/237:00 amTYS - UIO
1 stop18h 05mAmerican Airlines
Deal found 4/30$832
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/165:30 amSCL - TYS
3 stops30h 58mMultiple Airlines
Mon 7/1412:45 pmTYS - SCL
3 stops24h 40mMultiple Airlines
Deal found 4/30$893
This Priceline deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/113:15 amUIO - TYS
2 stops29h 50mAvianca
Thu 8/75:45 amTYS - UIO
2 stops21h 20mAvianca
Deal found 4/29$920
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/411:05 pmSCL - TYS
2 stops21h 00mLATAM Airlines
Tue 12/232:32 pmTYS - SCL
2 stops13h 28mLATAM Airlines
Deal found 4/30$971
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/49:50 pmSCL - TYS
1 stop26h 09mAmerican Airlines
Tue 12/235:28 amTYS - SCL
1 stop24h 22mAmerican Airlines
Deal found 4/30$972
This Atrapalo deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Atrapalo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/149:45 amGYE - TYS
2 stops35h 55mAvianca
Sat 6/219:55 amTYS - GYE
2 stops17h 10mAvianca
Deal found 4/30$1,186
This Ovago deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/193:35 amGYE - TYS
2 stops18h 00mMultiple Airlines
Mon 11/107:10 pmTYS - GYE
2 stops25h 25mMultiple Airlines
Deal found 4/30$1,586

Cheapflights Fare Finder

Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

South America

Fly to

Knoxville

Route

Depart

Return

Price

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Fri 6/20

1:15 am-10:40 pm

2 stops44h 25m

Knoxville McGhee Tyson

Fri 10/3

2:20 pm-11:25 pm

2 stops34h 05m

$683

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Fri 5/23

6:15 pm-10:55 pm

2 stops27h 40m

Knoxville McGhee Tyson

Sat 8/23

4:41 pm-10:25 pm

3 stops30h 44m

$706

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

8:28 am-1:20 pm

2 stops27h 52m

Knoxville McGhee Tyson

Mon 11/10

5:20 pm-11:41 pm

2 stops30h 21m

$740

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

7:30 am-11:12 pm

1 stop14h 42m

Knoxville McGhee Tyson

Mon 11/10

8:24 pm-10:00 pm

2 stops25h 36m

$815

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Fri 5/23

6:00 am-10:20 pm

1 stop15h 20m

Knoxville McGhee Tyson

Sat 8/23

7:00 am-12:05 am

1 stop18h 05m

$832

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 6/16

5:30 am-12:28 pm

3 stops30h 58m

Knoxville McGhee Tyson

Mon 7/14

12:45 pm-1:25 pm

3 stops24h 40m

$893

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 5/11

3:15 am-10:05 am

2 stops29h 50m

Knoxville McGhee Tyson

Thu 8/7

5:45 am-2:05 am

2 stops21h 20m

$920

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 8/4

11:05 pm-8:05 pm

2 stops21h 00m

Knoxville McGhee Tyson

Tue 12/23

2:32 pm-6:00 am

2 stops13h 28m

$971

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 8/4

9:50 pm-11:59 pm

1 stop26h 09m

Knoxville McGhee Tyson

Tue 12/23

5:28 am-7:50 am

1 stop24h 22m

$972

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 6/14

9:45 am-10:40 pm

2 stops35h 55m

Knoxville McGhee Tyson

Sat 6/21

9:55 am-2:05 am

2 stops17h 10m

$1,186

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 25 results
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Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South America to Knoxville

What is the cheapest month to book a flight from South America to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $296). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South America to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.5
Good
1,415 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • What are the cheapest airlines to fly from South America to Knoxville one-way?

    $437 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $583 and $596, respectively.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Quito Mariscal Sucr - Knoxville McGhee Tyson, Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson or Santiago Arturo Merino Benitez - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $296). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South America?

Book flights to South America if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South America to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South America to Knoxville

Discover the top airline that operate flights from South America to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$447Average$834FlexibilityNo cancel feeOn-timeN/A

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