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$265+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheap flight deals from South America to Knoxville

Keep the following information in mind while searching for South America to Knoxville flight deals. Data was last updated agosto 14, 2025.

Round-trip from

$596
(United Airlines)

One-way from

$265
(eDestinos)
From South America to Knoxville McGhee Tyson
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One-way flight from South America to Knoxville McGhee Tyson
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Find flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:44 pmGYE - TYS
2 stops31h 59mUnited Airlines
lun. 11/109:10 amTYS - GYE
2 stops28h 24mUnited Airlines
Deal found 8/13$596
This United deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/212:21 pmGYE - TYS
2 stops35h 23mMultiple Airlines
vie. 12/511:42 amTYS - GYE
2 stops21h 23mMultiple Airlines
Deal found 8/14$683
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/208:15 amGYE - TYS
2 stops24h 37mAmerican Airlines
lun. 11/107:20 pmTYS - GYE
2 stops27h 20mAmerican Airlines
Deal found 8/14$708
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/98:32 amGYE - TYS
2 stops34h 21mUnited Airlines
mar. 10/287:00 amTYS - GYE
2 stops31h 32mUnited Airlines
Deal found 8/13$713
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/268:20 amGYE - TYS
2 stops25h 17mAmerican Airlines
vie. 10/36:10 pmTYS - GYE
2 stops26h 38mAmerican Airlines
Deal found 8/12$721
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/208:15 amSCL - TYS
2 stops16h 31mDelta
lun. 10/2711:35 amTYS - SCL
2 stops17h 25mDelta
Deal found 8/14$725
This LATAM Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/1912:25 amSCL - TYS
2 stops24h 21mLATAM Airlines
lun. 10/275:16 pmTYS - SCL
1 stop13h 24mLATAM Airlines
Deal found 8/13$738
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:55 pmSCL - TYS
2 stops20h 47mDelta
dom. 10/263:48 pmTYS - SCL
1 stop14h 52mDelta
Deal found 8/14$765
This LATAM Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/2012:25 amSCL - TYS
2 stops23h 42mLATAM Airlines
dom. 10/265:28 pmTYS - SCL
1 stop13h 12mLATAM Airlines
Deal found 8/13$778
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/98:20 amGYE - TYS
1 stop14h 30mAmerican Airlines
mar. 10/286:15 amTYS - GYE
1 stop13h 55mAmerican Airlines
Deal found 8/13$790
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/25:00 amGYE - TYS
1 stop10h 37mAmerican Airlines
vie. 12/57:48 amTYS - GYE
2 stops14h 17mAmerican Airlines
Deal found 8/14$807
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/2910:45 pmSCL - TYS
1 stop23h 24mUnited Airlines
vie. 12/57:25 pmTYS - SCL
2 stops35h 25mUnited Airlines
Deal found 8/13$809

Cheapflights Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

South America

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

lun. 10/20

2:44 pm-11:43 pm

2 stops31h 59m

Knoxville McGhee Tyson

lun. 11/10

9:10 am-1:34 pm

2 stops28h 24m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

dom. 11/2

12:21 pm-11:44 pm

2 stops35h 23m

Knoxville McGhee Tyson

vie. 12/5

11:42 am-9:05 am

2 stops21h 23m

$683

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

lun. 10/20

8:15 am-9:52 am

2 stops24h 37m

Knoxville McGhee Tyson

lun. 11/10

7:20 pm-10:40 pm

2 stops27h 20m

$708

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

mar. 9/9

8:32 am-7:53 pm

2 stops34h 21m

Knoxville McGhee Tyson

mar. 10/28

7:00 am-1:32 pm

2 stops31h 32m

$713

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

vie. 9/26

8:20 am-10:37 am

2 stops25h 17m

Knoxville McGhee Tyson

vie. 10/3

6:10 pm-7:48 pm

2 stops26h 38m

$721

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

lun. 10/20

9:40 pm-4:31 pm

1 stop19h 51m

Knoxville McGhee Tyson

lun. 10/27

3:48 pm-7:40 am

1 stop14h 52m

$725

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

lun. 10/20

8:50 am-11:46 pm

2 stops15h 56m

Knoxville McGhee Tyson

lun. 10/27

11:35 am-11:05 am

3 stops22h 30m

$738

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

jue. 11/27

11:25 pm-1:25 pm

2 stops16h 00m

Knoxville McGhee Tyson

vie. 12/5

10:05 am-4:30 am

2 stops16h 25m

$765

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

mar. 9/9

8:20 am-11:50 pm

1 stop14h 30m

Knoxville McGhee Tyson

mar. 10/28

6:15 am-7:10 pm

1 stop13h 55m

$790

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

mié. 9/3

11:15 pm-10:42 am

1 stop10h 27m

Knoxville McGhee Tyson

vie. 9/19

12:01 pm-7:30 pm

1 stop8h 29m

$1,344

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 32 results
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Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South America to Knoxville

What is the cheapest month to book a flight from South America to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $294). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

When flying from South America to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated agosto 14, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from South America to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • What are the cheapest airlines to fly from South America to Knoxville one-way?

    $517 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $522 and $592, respectively.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson, Santiago Arturo Merino Benitez - Knoxville McGhee Tyson or San Miguel de Tucumán Benj Matienzo - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $294). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for South America to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South America to Knoxville

Discover the top airline that operate flights from South America to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$568Average$835FlexibilityNo cancel feeOn-timeN/A

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