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$360+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
Jan 8 — Jan 151
Thu 1/8
Thu 1/15
1 adult, Economy
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Cheap flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 9, 2025.

This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:40 pmUIO - TYS
2 stops26h 19mMultiple Airlines
Sun 1/47:48 pmTYS - UIO
3 stops39h 32mMultiple Airlines
Deal found 12/9$970
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/231:35 amUIO - TYS
2 stops37h 13mUnited Airlines
Sun 1/49:50 amTYS - UIO
2 stops38h 40mUnited Airlines
Deal found 12/9$1,038

Find flight deals from South America to Knoxville

Keep the following information in mind while searching for South America to Knoxville flight deals. Data was last updated December 9, 2025.

Round-trip from

$596
(United Airlines)

One-way from

$360
(eDestinos)
From South America to Knoxville McGhee Tyson
Search Deals
One-way flight from South America to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

South America

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

8:34 am-7:55 pm

2 stops35h 21m

Knoxville McGhee Tyson

Thu 5/7

9:00 am-11:36 pm

2 stops15h 36m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

12:20 pm-6:05 pm

2 stops29h 45m

Knoxville McGhee Tyson

Fri 2/20

9:10 am-5:35 pm

2 stops32h 25m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

3:31 pm-10:43 am

2 stops19h 12m

Knoxville McGhee Tyson

Thu 5/7

7:15 am-8:55 pm

1 stop14h 40m

$693

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

8:50 am-11:52 pm

2 stops17h 02m

Knoxville McGhee Tyson

Mon 3/2

2:38 pm-2:05 pm

2 stops21h 27m

$714

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-7:55 pm

1 stop23h 10m

Knoxville McGhee Tyson

Mon 3/2

4:55 pm-8:50 am

1 stop13h 55m

$714

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Thu 1/22

1:35 am-8:52 pm

2 stops19h 17m

Knoxville McGhee Tyson

Mon 1/26

9:30 am-12:30 am

2 stops15h 00m

$836

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Fri 1/23

11:45 pm-9:21 am

1 stop9h 36m

Knoxville McGhee Tyson

Mon 1/26

2:37 pm-9:35 pm

1 stop6h 58m

$845

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Wed 2/18

7:00 pm-10:10 pm

3 stops27h 10m

$360

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

9:05 am-10:10 pm

3 stops37h 05m

$364

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/13

4:30 pm-12:12 pm

2 stops43h 42m

$441

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 20 results
1
2

Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South America to Knoxville

What is the cheapest month to book a flight from South America to Knoxville?

Currently, August is the cheapest month in which you can book a flight from South America to Knoxville (average of $120). Flying from South America to Knoxville in February is currently the most expensive (average of $676). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 9, 2025.

When flying from South America to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 35% versus a flight in the evening.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 9, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from South America to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,089 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • How long is the flight from South America to Knoxville?

    Airlines like United Airlines and LATAM Airlines fly from South America to Knoxville in about 17h 02m. The time it takes to get you to your destination can typically vary by up to 18h 19m. The distance between South America and Knoxville is about 4853 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson, Santiago Arturo Merino Benitez - Knoxville McGhee Tyson or San Miguel de Tucumán Benj Matienzo - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from South America to Knoxville (average of $120). Flying from South America to Knoxville in February is currently the most expensive (average of $676). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

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Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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