What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

Flying on United Airlines is currently your cheapest option to Knoxville, with prices starting at $309. Additional round-trip tickets that might be worth considering are offered by American Airlines and Frontier, with the lowest prices starting at $311 and $316, respectively. Users have found that United Airlines is 35% cheaper than the other options available to this destination.

What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

One-way options have recently been found by users for as low as $155 on United Airlines. Other airlines that offer cheap prices include Frontier from $220 and American Airlines from $230 one-way.

What is the cheapest day to fly from San Francisco to Knoxville?

Travelers seeking maximum savings on their San Francisco to Knoxville flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from San Francisco to Knoxville?

The most popular airlines flying from San Francisco to Knoxville are American Airlines, Delta and Frontier. Something to consider prior to booking your flight.

Where are the most common layover locations when flying from San Francisco to Knoxville?

San Francisco to Knoxville flights have a layover in Dallas most often.

Where are the least popular layover locations for San Francisco to Knoxville flights?

Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.

What are some popular things to do or see while on a layover in Dallas?

Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $61 per day.

What is the cheapest day to fly round-trip from San Francisco to Knoxville?

Leaving on a Monday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 30% on the overall cost on flights from San Francisco to Knoxville.

How far in advance should I book a flight from San Francisco to Knoxville?

To save on the cost of your flight from San Francisco to Knoxville, book at least 35 days before your planned departure. Booking around this time can save you about 75% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $458 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $550.

What is the cheapest month to fly from San Francisco to Knoxville?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, August can be a great choice for travel to Knoxville. Flights to Knoxville from San Francisco in August are about $482 on average during August, but can be found for as low as $256.

Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

Can I find deals for business class flights from San Francisco to Knoxville?

Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$155+ Flights from San Francisco to Knoxville

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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Round-trip from	$309 (United Airlines)
One-way from	$155 (United Airlines)
Popular in	December
Cheapest in	August
Average price	$553

From San Francisco to Knoxville McGhee Tyson

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One-way flight from San Francisco to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 7% potential increase in price ($40 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Mon 8/411:55 pmSFO - TYS

1 stop7h 22mUnited Airlines

Fri 8/87:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/9

$309

Thu 7/2412:55 amSFO - TYS

1 stop7h 46mAmerican Airlines

Fri 8/16:22 pmTYS - SFO

1 stop7h 38mAmerican Airlines

Deal found 6/10

$311

Sun 9/76:00 amSFO - TYS

1 stop10h 41mFrontier

Mon 9/158:26 pmTYS - SFO

1 stop6h 48mFrontier

Deal found 6/10

$316

Fri 9/57:29 amSFO - TYS

1 stop6h 50mDelta

Thu 9/116:05 pmTYS - SFO

1 stop8h 44mDelta

Deal found 6/10

$334

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Mon 8/411:01 amTYS - SFO

1 stop28h 06mMultiple Airlines

Deal found 6/10

$354

Best flights from San Francisco to Knoxville
Discover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Mon 8/411:55 pmSFO - TYS

1 stop7h 22mUnited Airlines

Fri 8/87:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/9

$309

Thu 7/2412:55 amSFO - TYS

1 stop7h 46mAmerican Airlines

Fri 8/16:22 pmTYS - SFO

1 stop7h 38mAmerican Airlines

Deal found 6/10

$311

Sun 9/76:00 amSFO - TYS

1 stop10h 41mFrontier

Mon 9/158:26 pmTYS - SFO

1 stop6h 48mFrontier

Deal found 6/10

$316

Fri 9/57:29 amSFO - TYS

1 stop6h 50mDelta

Thu 9/116:05 pmTYS - SFO

1 stop8h 44mDelta

Deal found 6/10

$334

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Mon 8/411:01 amTYS - SFO

1 stop28h 06mMultiple Airlines

Deal found 6/10

$354

Last-minute flights from San Francisco to Knoxville
Discover last-minute flight deals from San Francisco to Knoxville. Data last updated June 12, 2025 and is based on user searches.

Thu 6/196:37 amSFO - TYS

1 stop6h 52mFrontier

Sun 6/225:25 pmTYS - SFO

2 stops19h 54mFrontier

Deal found 6/11

$832

Thu 6/198:50 pmSFO - TYS

2 stops10h 03mDelta

Sun 6/225:45 amTYS - SFO

2 stops12h 07mDelta

Deal found 6/11

$1,781

Sat 6/216:00 amSFO - TYS

2 stops14h 05mUnited Airlines

Sat 6/285:15 pmTYS - SFO

1 stop9h 44mUnited Airlines

Deal found 6/11

$651

Sun 6/225:25 amSFO - TYS

1 stop9h 36mAmerican Airlines

Sat 6/286:25 pmTYS - SFO

1 stop8h 47mAmerican Airlines

Deal found 6/11

$449

Tue 6/245:05 amSFO - TYS

1 stop6h 44mUnited Airlines

Tue 7/17:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/10

$334

Thu 7/106:37 amSFO - TYS

1 stop6h 52mFrontier

Thu 7/175:25 pmTYS - SFO

1 stop9h 54mFrontier

Deal found 6/10

$324

Thu 7/2412:55 amSFO - TYS

1 stop7h 46mAmerican Airlines

Fri 8/16:22 pmTYS - SFO

1 stop7h 38mAmerican Airlines

Deal found 6/10

$311

Wed 7/3011:40 pmSFO - TYS

1 stop7h 34mDelta

Wed 8/66:42 amTYS - SFO

1 stop7h 09mDelta

Deal found 6/10

$309

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Mon 8/411:01 amTYS - SFO

1 stop28h 06mMultiple Airlines

Deal found 6/10

$354

One-way flights from San Francisco to Knoxville
Search for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Tue 7/229:10 pmSFO - TYS

1 stop10h 17mUnited Airlines

Deal found 6/10

$155

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Deal found 6/10

$178

Thu 7/316:37 amSFO - TYS

1 stop6h 52mFrontier

Deal found 6/11

$220

Fri 7/1812:13 pmSFO - TYS

1 stop8h 46mAmerican Airlines

Deal found 6/12

$230

Thu 7/1712:50 amSFO - TYS

2 stops11h 17mDelta

Deal found 6/10

$907

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/4

11:55 pm-10:17 am

1 stop7h 22m

Knoxville McGhee Tyson

Fri 8/8

7:35 pm-12:57 am

1 stop8h 22m

$309

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/24

12:55 am-11:41 am

1 stop7h 46m

Knoxville McGhee Tyson

Fri 8/1

6:22 pm-11:00 pm

1 stop7h 38m

$311

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 9/7

6:00 am-7:41 pm

1 stop10h 41m

Knoxville McGhee Tyson

Mon 9/15

8:26 pm-12:14 am

1 stop6h 48m

$316

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 9/5

7:29 am-5:19 pm

1 stop6h 50m

Knoxville McGhee Tyson

Thu 9/11

6:05 pm-11:49 pm

1 stop8h 44m

$334

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/31

11:59 pm-4:12 pm

1 stop13h 13m

Knoxville McGhee Tyson

Mon 8/4

11:01 am-12:07 pm

1 stop28h 06m

$354

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/25

11:00 pm-10:10 am

1 stop8h 10m

$155

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/31

11:59 pm-4:12 pm

1 stop13h 13m

$178

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/31

6:37 am-4:29 pm

1 stop6h 52m

$220

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 7/18

12:13 pm-11:59 pm

1 stop8h 46m

$230

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/17

12:50 am-3:07 pm

2 stops11h 17m

$907

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Booking 34 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

It’s optimal to fly from San Francisco to Knoxville at noon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight in the morning.

Rainfall in Knoxville by month

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from San Francisco to Knoxville, such as Delta, United Airlines and American Airlines. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Frontier

5.9

Fair

3,295 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

What are the cheapest airlines flying from San Francisco to Knoxville round-trip?
Flying on United Airlines is currently your cheapest option to Knoxville, with prices starting at $309. Additional round-trip tickets that might be worth considering are offered by American Airlines and Frontier, with the lowest prices starting at $311 and $316, respectively. Users have found that United Airlines is 35% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from San Francisco to Knoxville one-way?
One-way options have recently been found by users for as low as $155 on United Airlines. Other airlines that offer cheap prices include Frontier from $220 and American Airlines from $230 one-way.
Where are the most common layover locations when flying from San Francisco to Knoxville?
San Francisco to Knoxville flights have a layover in Dallas most often.
What are some popular things to do or see while on a layover in Dallas?
Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $61 per day.
Where are the least popular layover locations for San Francisco to Knoxville flights?
Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.
Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?
Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.
Can I find deals for business class flights from San Francisco to Knoxville?
Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Knoxville?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Maryville

Oak Ridge

Alcoa

Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$149	Average$276	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$298	Average$439	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$308	Average$491	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$338	Average$585	FlexibilityNo cancel fee	On-time69%

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$155+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to KnoxvilleExplore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from San Francisco to Knoxville?

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from San Francisco to Knoxville, such as Delta, United Airlines and American Airlines. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

Where are the most common layover locations when flying from San Francisco to Knoxville?

What are some popular things to do or see while on a layover in Dallas?

Where are the least popular layover locations for San Francisco to Knoxville flights?

Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

How can I find direct flights from San Francisco to Knoxville?

Can I find deals for business class flights from San Francisco to Knoxville?

What is the cheapest month to book a flight from San Francisco to Knoxville?

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Top 4 airlines flying from San Francisco to Knoxville

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Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.