$129+ Cheap flights from San Francisco to Knoxville (SFO - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Knoxville
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Cheapest flights from San Francisco to KnoxvilleExplore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am -
1 stop6h 28m
Sat 10/317:26 am -
1 stop9h 54m
Deal found 9/14![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:05 pm -
1 stop26h 34m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:05 pm -
1 stop27h 34m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$268
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:55 pm -
1 stop8h 39m
Wed 10/76:23 pm -
1 stop7h 36m
Deal found 9/14![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:14 pm -
1 stop22h 25m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:14 pm -
1 stop22h 25m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/13![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:05 pm -
1 stop27h 34m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/13![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:06 am -
1 stop7h 43m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:21 pm -
1 stop28h 28m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:23 pm -
1 stop20h 26m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/10![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:21 pm -
1 stop28h 28m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$317
Best flights from San Francisco to KnoxvilleDiscover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1210:25 pm -
1 stop9h 29m
Thu 10/156:23 pm -
1 stop7h 36m
Deal found 9/10![Delta logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:20 pm -
1 stop9h 10m
Thu 10/299:45 am -
1 stop11h 02m
Deal found 9/14![United Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:35 am -
1 stop6h 15m
Tue 11/37:05 am -
2 stops8h 45m
Deal found 9/11![Southwest logo]()
$416
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:10 pm -
1 stop8h 27m
Sat 9/263:45 pm -
1 stop7h 29m
Deal found 9/10![United Airlines logo]()
$457
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:25 pm -
1 stop9h 09m
Wed 10/146:23 pm -
1 stop7h 36m
Deal found 9/10![Delta logo]()
$461
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/196:45 am -
2 stops8h 55m
Sat 1/306:55 am -
2 stops10h 55m
Deal found 9/12![Southwest logo]()
$490
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:25 pm -
1 stop8h 09m
Fri 10/95:18 pm -
1 stop8h 20m
Deal found 9/12![Delta logo]()
$482
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop9h 45m
Thu 11/266:45 am -
2 stops12h 45m
Deal found 9/12![Southwest logo]()
$550
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:42 pm -
1 stop8h 03m
Sun 10/116:00 am -
1 stop7h 30m
Deal found 9/11![United Airlines logo]()
$554
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:30 pm -
1 stop7h 04m
Fri 10/95:40 am -
1 stop7h 54m
Deal found 9/10![Delta logo]()
$519
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:49 pm -
2 stops13h 45m
Sat 10/105:40 am -
2 stops10h 28m
Deal found 9/10![Delta logo]()
$527
Last-minute flights from San Francisco to KnoxvilleDiscover last-minute flight deals from San Francisco to Knoxville. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Knoxville. Data last updated September 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:55 pm -
1 stop8h 39m
Wed 10/76:23 pm -
1 stop7h 36m
Deal found 9/14![Delta logo]()
$270
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am -
1 stop6h 28m
Sat 10/317:26 am -
1 stop9h 54m
Deal found 9/14![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:05 pm -
1 stop26h 34m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:14 pm -
1 stop22h 25m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:14 pm -
1 stop22h 25m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/13![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:21 pm -
1 stop28h 28m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:23 pm -
1 stop20h 26m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/10![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:21 pm -
1 stop28h 28m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:06 am -
1 stop7h 43m
Sun 11/19:29 pm -
1 stop13h 50m
Deal found 9/13![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:05 pm -
1 stop27h 34m
Thu 11/59:33 pm -
1 stop18h 19m
Deal found 9/13![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:05 pm -
1 stop27h 34m
Mon 11/29:42 pm -
1 stop13h 37m
Deal found 9/13![Multiple Airlines logo]()
$287
One-way flights from San Francisco to KnoxvilleSearch for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop8h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$129
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:59 pm -
1 stop8h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$142
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:25 pm -
1 stop9h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/219:11 am -
2 stops23h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:17 pm -
3 stops40h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:19 pm -
3 stops56h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$174
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
1 stop6h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$182
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
1 stop8h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$192
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:10 am -
2 stops10h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:11 pm -
1 stop20h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:25 pm -
3 stops21h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$215
Find flight deals from San Francisco to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $257 (Delta) |
One-way from | $129 (Delta) |
Popular in | May |
Cheapest in | February |
Average price | $476 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Wed 11/18
6:00 am-4:20 pm
1 stop7h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$129
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Wed 10/21
6:00 am-5:28 pm
1 stop8h 28m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$129
Quickest round-trip
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Tue 11/17
11:59 pm-9:55 am
1 stop6h 56m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$129
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Mon 10/26
2:17 pm-10:05 am
3 stops40h 48m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$173
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Mon 10/26
10:45 pm-9:53 am
1 stop8h 08m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$182
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Wed 9/30
12:45 pm-11:59 pm
1 stop8h 14m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$192
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Tue 10/13
6:00 am-6:24 pm
1 stop9h 24m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$192
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Wed 11/18
6:10 am-7:50 pm
2 stops10h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$197
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Sun 10/25
10:14 pm-7:24 pm
2 stops18h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$219
San FranciscoKnoxville
SFO San Francisco - TYS Knoxville McGhee Tyson
SFOTYS
San Francisco
Sun 10/25
11:30 pm-9:53 am
1 stop7h 23m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$234
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
SFO-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Knoxville
How far ahead should I book a flight from San Francisco to Knoxville?
Booking 32 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Knoxville?
Currently, February is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $409). Flying from San Francisco to Knoxville in May is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Knoxville?
Airfare is below average for this route at the moment.
San Francisco to Knoxville flights typically cost between $388 and $585 in October.The cheapest round-trip price found within the last 5 days was $257 on Delta (Oct 28-Oct 31).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 15, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Top 4 airlines flying from San Francisco to Knoxville
Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$220 | Average$342 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$328 | Average$478 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$328 | Average$538 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$328 | Average$539 | FlexibilityNo cancel fee | On-time71% |