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$80+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or July, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$159
(Priceline)

One-way from

$80
(Priceline)

Popular in

December

Cheapest in

August

Average price

$383
From San Francisco to Knoxville McGhee Tyson
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One-way flight from San Francisco to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 10% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:49 amSFO - TYS
1 stop26h 29mFrontier
Thu 10/98:17 pmTYS - SFO
1 stop6h 57mFrontier
Deal found 8/14$225
This Priceline deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/86:29 amSFO - TYS
1 stop10h 16mFrontier
Mon 9/158:35 pmTYS - SFO
1 stop6h 41mFrontier
Deal found 8/13$247
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:29 amSFO - TYS
1 stop10h 16mFrontier
Mon 9/228:35 pmTYS - SFO
1 stop6h 41mFrontier
Deal found 8/12$255
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:29 amSFO - TYS
1 stop10h 16mFrontier
Mon 10/68:35 pmTYS - SFO
1 stop6h 41mFrontier
Deal found 8/12$261
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1110:37 pmSFO - TYS
1 stop20h 53mMultiple Airlines
Thu 9/187:00 amTYS - SFO
1 stop20h 16mMultiple Airlines
Deal found 8/13$273
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/233:25 pmSFO - TYS
1 stop25h 07mFrontier
Sun 10/268:17 pmTYS - SFO
1 stop6h 57mFrontier
Deal found 8/14$277
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1110:37 pmSFO - TYS
1 stop20h 53mMultiple Airlines
Sun 9/147:35 pmTYS - SFO
2 stops28h 46mMultiple Airlines
Deal found 8/12$292
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:29 amSFO - TYS
1 stop10h 21mFrontier
Mon 9/158:35 pmTYS - SFO
1 stop6h 41mFrontier
Deal found 8/12$293
This Priceline deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:34 amSFO - TYS
1 stop9h 58mFrontier
Mon 10/278:17 pmTYS - SFO
1 stop6h 57mFrontier
Deal found 8/13$297
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:25 pmSFO - TYS
1 stop12h 54mMultiple Airlines
Mon 10/274:43 pmTYS - SFO
1 stop8h 10mMultiple Airlines
Deal found 8/13$300

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 10/4

10:49 am-4:18 pm

1 stop26h 29m

Knoxville McGhee Tyson

Thu 10/9

8:17 pm-12:14 am

1 stop6h 57m

$225

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 9/15

6:29 am-7:45 pm

1 stop10h 16m

Knoxville McGhee Tyson

Thu 9/18

8:40 pm-12:16 am

1 stop6h 36m

$247

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 9/8

6:29 am-7:45 pm

1 stop10h 16m

Knoxville McGhee Tyson

Mon 9/15

8:35 pm-12:16 am

1 stop6h 41m

$247

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 9/15

6:29 am-7:45 pm

1 stop10h 16m

Knoxville McGhee Tyson

Mon 9/22

8:35 pm-12:16 am

1 stop6h 41m

$255

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 9/29

6:29 am-7:45 pm

1 stop10h 16m

Knoxville McGhee Tyson

Mon 10/6

8:35 pm-12:16 am

1 stop6h 41m

$261

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/11

10:37 pm-10:30 pm

1 stop20h 53m

Knoxville McGhee Tyson

Thu 9/18

7:00 am-12:16 am

1 stop20h 16m

$273

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 10/23

3:25 pm-7:32 pm

1 stop25h 07m

Knoxville McGhee Tyson

Sun 10/26

8:17 pm-12:14 am

1 stop6h 57m

$277

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/11

10:37 pm-10:30 pm

1 stop20h 53m

Knoxville McGhee Tyson

Sun 9/14

7:35 pm-9:21 pm

2 stops28h 46m

$292

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/11

6:29 am-7:50 pm

1 stop10h 21m

Knoxville McGhee Tyson

Mon 9/15

8:35 pm-12:16 am

1 stop6h 41m

$293

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 10/24

6:34 am-7:32 pm

1 stop9h 58m

Knoxville McGhee Tyson

Mon 10/27

8:17 pm-12:14 am

1 stop6h 57m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 19 results
1
2

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on August 8, 2025.

Booking 28 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $294). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

It’s optimal to fly from San Francisco to Knoxville at noon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 14, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Frontier
5.8
Fair
3,217 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $149. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $308 and $308, respectively. Users have found that Frontier is 68% cheaper than the other options available to this destination.

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $294). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$149Average$278FlexibilityNo cancel feeOn-time62%
DeltaCheapest$308Average$426FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$492FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$315Average$565FlexibilityNo cancel feeOn-time69%

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