$120+ Cheap flights from San Francisco to Knoxville (SFO - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Apr 21 — Apr 281
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Knoxville
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Best
Last-minute
One-way
Cheapest flights from San Francisco to KnoxvilleExplore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
This CheapOair deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2712:33 pm
SFO
- TYS
1 stop28h 04m
Frontier
Mon 8/318:32 pm
TYS
- SFO
1 stop18h 06m
Frontier
Deal found 3/22![Frontier logo]()
$261
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Mon 5/188:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Deal found 3/20![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:47 pm
SFO
- TYS
1 stop29h 04m
Multiple Airlines
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$302
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Sun 4/264:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Deal found 3/20![Frontier logo]()
$322
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/259:35 pm
SFO
- TYS
1 stop19h 02m
Frontier
Mon 6/298:32 pm
TYS
- SFO
1 stop18h 06m
Frontier
Deal found 3/20![Frontier logo]()
$366
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:20 am
SFO
- TYS
1 stop9h 44m
American Airlines
Tue 5/124:09 pm
TYS
- SFO
1 stop8h 51m
American Airlines
Deal found 3/18![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:00 am
SFO
- TYS
1 stop30h 33m
Multiple Airlines
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:28 pm
SFO
- TYS
1 stop7h 04m
American Airlines
Tue 4/284:09 pm
TYS
- SFO
1 stop8h 55m
American Airlines
Deal found 3/19![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
SFO
- TYS
1 stop10h 00m
American Airlines
Sat 5/25:57 pm
TYS
- SFO
1 stop8h 07m
American Airlines
Deal found 3/17![American Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:25 pm
SFO
- TYS
2 stops23h 08m
Multiple Airlines
Mon 6/810:03 pm
TYS
- SFO
1 stop15h 26m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$395
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2711:49 pm
SFO
- TYS
1 stop7h 49m
American Airlines
Fri 8/77:30 am
TYS
- SFO
1 stop8h 39m
American Airlines
Deal found 3/17![American Airlines logo]()
$396
Best flights from San Francisco to KnoxvilleDiscover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
Discover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:30 pm
SFO
- TYS
1 stop8h 52m
Delta
Tue 6/163:54 pm
TYS
- SFO
1 stop7h 23m
Delta
Deal found 3/21![Delta logo]()
$474
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:00 am
SFO
- TYS
1 stop8h 15m
United Airlines
Wed 4/227:05 am
TYS
- SFO
1 stop10h 48m
United Airlines
Deal found 3/17![United Airlines logo]()
$479
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:20 am
SFO
- TYS
2 stops12h 45m
Southwest
Mon 6/87:45 pm
TYS
- SFO
2 stops7h 45m
Southwest
Deal found 3/17![Southwest logo]()
$518
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:30 pm
SFO
- TYS
1 stop10h 20m
United Airlines
Tue 4/285:53 pm
TYS
- SFO
2 stops16h 55m
United Airlines
Deal found 3/17![United Airlines logo]()
$523
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:10 am
SFO
- TYS
1 stop6h 25m
Southwest
Mon 4/202:45 pm
TYS
- SFO
2 stops11h 20m
Southwest
Deal found 3/21![Southwest logo]()
$638
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:45 pm
SFO
- TYS
2 stops13h 21m
United Airlines
Sat 5/97:00 am
TYS
- SFO
1 stop9h 23m
United Airlines
Deal found 3/20![United Airlines logo]()
$602
Last-minute flights from San Francisco to KnoxvilleDiscover last-minute flight deals from San Francisco to Knoxville. Data last updated March 22, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Knoxville. Data last updated March 22, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Mon 4/134:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Deal found 3/20![Frontier logo]()
$460
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:00 am
SFO
- TYS
1 stop6h 28m
Multiple Airlines
Mon 4/131:43 pm
TYS
- SFO
2 stops36h 42m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:47 pm
SFO
- TYS
1 stop29h 04m
Multiple Airlines
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:16 pm
SFO
- TYS
1 stop7h 39m
American Airlines
Wed 4/226:00 am
TYS
- SFO
1 stop10h 15m
American Airlines
Deal found 3/18![American Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:38 pm
SFO
- TYS
2 stops16h 25m
Multiple Airlines
Sun 4/194:28 pm
TYS
- SFO
1 stop19h 45m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:00 am
SFO
- TYS
1 stop30h 33m
Multiple Airlines
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$371
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Sun 4/264:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Deal found 3/20![Frontier logo]()
$322
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:28 pm
SFO
- TYS
1 stop7h 04m
American Airlines
Tue 4/284:09 pm
TYS
- SFO
1 stop8h 55m
American Airlines
Deal found 3/19![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
SFO
- TYS
1 stop10h 00m
American Airlines
Sat 5/25:57 pm
TYS
- SFO
1 stop8h 07m
American Airlines
Deal found 3/17![American Airlines logo]()
$389
One-way flights from San Francisco to KnoxvilleSearch for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
Search for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
SFO
- TYS
2 stops29h 41m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:00 am
SFO
- TYS
2 stops30h 41m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$136
This CheapOair deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:52 pm
SFO
- TYS
1 stop27h 41m
Frontier
Deal found 3/18![Frontier logo]()
$137
This Frontier deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:56 am
SFO
- TYS
1 stop7h 37m
Frontier
Deal found 3/18![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:29 pm
SFO
- TYS
3 stops42h 12m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:40 pm
SFO
- TYS
2 stops40h 42m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$176
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:38 pm
SFO
- TYS
3 stops32h 58m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:26 pm
SFO
- TYS
3 stops44h 24m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:04 pm
SFO
- TYS
3 stops56h 06m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:15 pm
SFO
- TYS
2 stops25h 24m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$185
Find flight deals from San Francisco to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $261 (CheapOair) |
One-way from | $120 (Kiwi.com) |
Popular in | November |
Cheapest in | August |
Average price | $517 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Thu 6/11
10:30 pm-10:22 am
1 stop8h 52m
Knoxville McGhee Tyson
Tue 6/16
3:54 pm-8:17 pm
1 stop7h 23m
$474
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sat 4/18
7:00 am-6:15 pm
1 stop8h 15m
Knoxville McGhee Tyson
Wed 4/22
7:05 am-2:53 pm
1 stop10h 48m
$479
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sun 5/31
5:20 am-9:05 pm
2 stops12h 45m
Knoxville McGhee Tyson
Mon 6/8
7:45 pm-12:30 am
2 stops7h 45m
$518
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Fri 4/24
9:30 pm-10:50 am
1 stop10h 20m
Knoxville McGhee Tyson
Tue 4/28
5:53 pm-7:48 am
2 stops16h 55m
$523
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Fri 4/24
10:45 pm-3:06 pm
2 stops13h 21m
Knoxville McGhee Tyson
Sat 5/9
7:00 am-1:23 pm
1 stop9h 23m
$602
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sat 4/18
10:10 am-7:35 pm
1 stop6h 25m
Knoxville McGhee Tyson
Mon 4/20
2:45 pm-11:05 pm
2 stops11h 20m
$638
Cheapest one-way
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 3/31
6:00 am-12:45 pm
2 stops27h 45m
$210
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Thu 6/4
12:52 pm-7:33 pm
1 stop27h 41m
$218
Quickest one-way
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 4/21
11:39 pm-9:18 am
1 stop6h 39m
$229
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sat 5/16
10:25 pm-10:21 am
1 stop8h 56m
$229
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
SFO-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Knoxville
How far ahead should I book a flight from San Francisco to Knoxville?
Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on March 13, 2026.
Booking 72 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Knoxville?
Currently, May is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $138). Flying from San Francisco to Knoxville in February is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 22, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Crew
8.5
Food
7.2
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Crew
8.5
Food
7.2
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Crew
8.5
Food
7.2
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Crew
8.5
Food
7.2
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Top 4 airlines flying from San Francisco to Knoxville
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$89 | Average$267 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$308 | Average$421 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$494 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$328 | Average$549 | FlexibilityNo cancel fee | On-time69% |