$128+ Cheap flights from San Francisco to Knoxville (SFO - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Jul 20 — Jul 271
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Francisco to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Francisco to KnoxvilleExplore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Wed 8/128:19 pm
TYS
- SFO
1 stop6h 59m
Frontier
Deal found 6/18![Frontier logo]()
$244
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Wed 7/228:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/18![Frontier logo]()
$252
This Frontier deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Wed 7/158:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/17![Frontier logo]()
$260
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:38 pm
SFO
- TYS
1 stop27h 46m
Frontier
Wed 7/228:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/16![Frontier logo]()
$262
This CheapOair deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:38 pm
SFO
- TYS
1 stop27h 46m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop18h 24m
Frontier
Deal found 6/18![Frontier logo]()
$289
This Frontier deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Fri 7/108:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/17![Frontier logo]()
$308
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/18![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:30 am
SFO
- TYS
1 stop8h 43m
Multiple Airlines
Sun 9/137:00 am
TYS
- SFO
1 stop7h 36m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:25 am
SFO
- TYS
1 stop11h 14m
Multiple Airlines
Thu 11/56:30 am
TYS
- SFO
1 stop20h 45m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$328
This CheapOair deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:39 pm
SFO
- TYS
1 stop18h 45m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/19![Frontier logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:56 pm
SFO
- TYS
1 stop21h 50m
Multiple Airlines
Sun 8/307:00 am
TYS
- SFO
2 stops55h 52m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$338
Best flights from San Francisco to KnoxvilleDiscover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
Discover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:40 am
SFO
- TYS
1 stop6h 39m
Delta
Tue 7/146:40 am
TYS
- SFO
1 stop7h 52m
Delta
Deal found 6/15![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:59 pm
SFO
- TYS
1 stop8h 18m
United Airlines
Thu 9/176:00 am
TYS
- SFO
1 stop7h 26m
United Airlines
Deal found 6/16![United Airlines logo]()
$367
This CheapOair deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
SFO
- TYS
1 stop10h 37m
Frontier
Fri 7/38:32 pm
TYS
- SFO
1 stop27h 26m
Frontier
Deal found 6/20![Frontier logo]()
$383
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:40 pm
SFO
- TYS
2 stops9h 25m
Southwest
Thu 9/177:10 am
TYS
- SFO
2 stops10h 00m
Southwest
Deal found 6/16![Southwest logo]()
$498
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/910:38 pm
SFO
- TYS
1 stop8h 05m
United Airlines
Tue 8/117:15 am
TYS
- SFO
1 stop7h 59m
United Airlines
Deal found 6/17![United Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:05 pm
SFO
- TYS
2 stops16h 20m
Southwest
Sun 8/307:35 am
TYS
- SFO
2 stops10h 30m
Southwest
Deal found 6/19![Southwest logo]()
$500
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
SFO
- TYS
1 stop7h 58m
United Airlines
Wed 8/269:45 am
TYS
- SFO
1 stop10h 50m
United Airlines
Deal found 6/19![United Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:20 am
SFO
- TYS
2 stops10h 50m
Delta
Sun 8/305:40 am
TYS
- SFO
1 stop7h 37m
Delta
Deal found 6/18![Delta logo]()
$569
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:40 am
SFO
- TYS
2 stops10h 15m
Southwest
Sat 8/86:50 am
TYS
- SFO
2 stops10h 55m
Southwest
Deal found 6/19![Southwest logo]()
$527
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:50 pm
SFO
- TYS
2 stops14h 35m
Southwest
Sun 8/307:35 am
TYS
- SFO
2 stops10h 30m
Southwest
Deal found 6/19![Southwest logo]()
$533
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
SFO
- TYS
2 stops11h 55m
Southwest
Tue 7/217:10 am
TYS
- SFO
2 stops9h 30m
Southwest
Deal found 6/16![Southwest logo]()
$565
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:30 am
SFO
- TYS
2 stops12h 45m
Southwest
Mon 7/137:45 pm
TYS
- SFO
2 stops7h 50m
Southwest
Deal found 6/15![Southwest logo]()
$588
Last-minute flights from San Francisco to KnoxvilleDiscover last-minute flight deals from San Francisco to Knoxville. Data last updated June 20, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Knoxville. Data last updated June 20, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:40 am
SFO
- TYS
1 stop6h 39m
Delta
Tue 7/146:40 am
TYS
- SFO
1 stop7h 52m
Delta
Deal found 6/16![Delta logo]()
$355
This Frontier deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Wed 7/158:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/17![Frontier logo]()
$260
This Frontier deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Fri 7/108:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/17![Frontier logo]()
$308
This Frontier deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Mon 7/138:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/16![Frontier logo]()
$356
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/18![Frontier logo]()
$359
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:38 pm
SFO
- TYS
1 stop27h 46m
Frontier
Wed 7/228:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/16![Frontier logo]()
$262
This CheapOair deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:38 pm
SFO
- TYS
1 stop27h 46m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop18h 24m
Frontier
Deal found 6/18![Frontier logo]()
$289
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Wed 7/228:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/18![Frontier logo]()
$252
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/18![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Multiple Airlines
Mon 7/2012:53 pm
TYS
- SFO
2 stops33h 59m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$360
This CheapOair deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:39 pm
SFO
- TYS
1 stop18h 45m
Frontier
Mon 7/208:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Deal found 6/19![Frontier logo]()
$337
One-way flights from San Francisco to KnoxvilleSearch for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
Search for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
This Priceline deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Deal found 6/19![Frontier logo]()
$128
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Deal found 6/18![Frontier logo]()
$136
This Trip.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Deal found 6/18![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:08 pm
SFO
- TYS
1 stop25h 19m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$151
This CheapOair deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/309:39 pm
SFO
- TYS
1 stop18h 45m
Frontier
Deal found 6/18![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:30 am
SFO
- TYS
1 stop8h 43m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:30 pm
SFO
- TYS
1 stop13h 27m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$176
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:30 pm
SFO
- TYS
2 stops24h 51m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$177
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:42 pm
SFO
- TYS
1 stop7h 19m
Delta
Deal found 6/15![Delta logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:00 pm
SFO
- TYS
2 stops44h 21m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$183
Find flight deals from San Francisco to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $244 (Frontier) |
One-way from | $128 (Priceline) |
Popular in | May |
Cheapest in | August |
Average price | $583 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 7/7
5:40 am-3:19 pm
1 stop6h 39m
Knoxville McGhee Tyson
Tue 7/14
6:40 am-11:32 am
1 stop7h 52m
$355
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 9/15
11:59 pm-11:17 am
1 stop8h 18m
Knoxville McGhee Tyson
Thu 9/17
6:00 am-10:26 am
1 stop7h 26m
$367
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Wed 6/24
6:00 am-7:37 pm
1 stop10h 37m
Knoxville McGhee Tyson
Fri 7/3
8:32 pm-8:58 pm
1 stop27h 26m
$383
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sun 8/9
10:38 pm-9:43 am
1 stop8h 05m
Knoxville McGhee Tyson
Tue 8/11
7:15 am-12:14 pm
1 stop7h 59m
$406
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 8/25
6:00 am-4:58 pm
1 stop7h 58m
Knoxville McGhee Tyson
Wed 8/26
9:45 am-5:35 pm
1 stop10h 50m
$465
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 9/15
11:40 pm-12:05 pm
2 stops9h 25m
Knoxville McGhee Tyson
Thu 9/17
7:10 am-2:10 pm
2 stops10h 00m
$498
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sat 8/22
5:05 pm-12:25 pm
2 stops16h 20m
Knoxville McGhee Tyson
Sun 8/30
7:35 am-3:05 pm
2 stops10h 30m
$500
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Wed 8/5
5:40 am-6:55 pm
2 stops10h 15m
Knoxville McGhee Tyson
Sat 8/8
6:50 am-2:45 pm
2 stops10h 55m
$527
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Sun 8/23
7:50 pm-1:25 pm
2 stops14h 35m
Knoxville McGhee Tyson
Sun 8/30
7:35 am-3:05 pm
2 stops10h 30m
$533
San FranciscoKnoxville
SFO - TYS
SFOTYS
San Francisco
Tue 7/14
5:30 am-8:25 pm
2 stops11h 55m
Knoxville McGhee Tyson
Tue 7/21
7:10 am-1:40 pm
2 stops9h 30m
$565
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
SFO-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Knoxville
How far ahead should I book a flight from San Francisco to Knoxville?
Booking 38 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Knoxville?
Currently, August is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $408). Flying from San Francisco to Knoxville in May is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 20, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from San Francisco
Popular flights
Alternative routes for San Francisco to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Francisco to Knoxville by cabin class
Find flights from San Francisco to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 20, 2026.
San Francisco and Knoxville flights
Browse other San Francisco and Knoxville flight options. Last updated on June 20, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on June 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from San Francisco to Knoxville
Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$89 | Average$267 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$308 | Average$471 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$514 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$328 | Average$537 | FlexibilityNo cancel fee | On-time69% |