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$133+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This Frontier deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/26:15 am
SFO
-
TYS
1 stop6h 20m
Frontier
Fri 2/64:25 pm
TYS
-
SFO
1 stop11h 03m
Frontier
Deal found 1/17$235
This Frontier deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:15 am
SFO
-
TYS
1 stop8h 51m
Frontier
Mon 3/28:13 pm
TYS
-
SFO
1 stop7h 15m
Frontier
Deal found 1/20$236
This Priceline deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/266:15 am
SFO
-
TYS
1 stop6h 20m
Frontier
Fri 1/304:25 pm
TYS
-
SFO
1 stop11h 03m
Frontier
Deal found 1/19$296
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:15 am
SFO
-
TYS
1 stop10h 03m
Multiple Airlines
Thu 2/268:30 am
TYS
-
SFO
1 stop12h 28m
Multiple Airlines
Deal found 1/20$312
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:55 pm
SFO
-
TYS
1 stop8h 11m
Delta
Sat 5/26:16 am
TYS
-
SFO
1 stop10h 24m
Delta
Deal found 1/19$329
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/299:33 pm
SFO
-
TYS
1 stop22h 06m
Multiple Airlines
Sun 4/59:46 pm
TYS
-
SFO
2 stops49h 24m
Multiple Airlines
Deal found 1/18$334
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/299:33 pm
SFO
-
TYS
1 stop22h 06m
Multiple Airlines
Fri 4/32:19 pm
TYS
-
SFO
1 stop21h 57m
Multiple Airlines
Deal found 1/18$335
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/299:33 pm
SFO
-
TYS
1 stop22h 06m
Multiple Airlines
Mon 4/61:33 pm
TYS
-
SFO
2 stops34h 35m
Multiple Airlines
Deal found 1/18$343
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:50 pm
SFO
-
TYS
1 stop8h 18m
United Airlines
Sat 4/47:05 am
TYS
-
SFO
1 stop8h 13m
United Airlines
Deal found 1/18$344

Find flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$236
(Frontier)

One-way from

$133
(Kiwi.com)

Popular in

November

Cheapest in

August

Average price

$498
Provider with most accurate pricing for San Francisco-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Knoxville McGhee Tyson flights.
Search Deals
From San Francisco to Knoxville McGhee Tyson
Search Deals
One-way flight from San Francisco to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 2/27

6:15 am-6:06 pm

1 stop8h 51m

Knoxville McGhee Tyson

Mon 3/2

8:13 pm-9:39 pm

2 stops28h 26m

$284

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 2/27

10:45 pm-12:08 pm

1 stop10h 23m

Knoxville McGhee Tyson

Tue 3/3

6:35 am-11:32 am

1 stop7h 57m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 3/7

6:00 am-6:37 pm

1 stop9h 37m

Knoxville McGhee Tyson

Sat 3/14

2:54 pm-11:10 pm

1 stop11h 16m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 2/27

6:15 am-6:06 pm

1 stop8h 51m

Knoxville McGhee Tyson

Sun 3/1

8:30 am-8:17 am

1 stop26h 47m

$347

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 3/29

9:33 pm-10:39 pm

1 stop22h 06m

Knoxville McGhee Tyson

Sun 4/5

3:24 pm-8:16 am

1 stop19h 52m

$358

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 3/30

10:40 pm-10:31 am

1 stop8h 51m

Knoxville McGhee Tyson

Tue 3/31

5:24 pm-10:36 pm

1 stop8h 12m

$365

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 2/4

6:00 am-3:46 pm

1 stop6h 46m

Knoxville McGhee Tyson

Sun 2/8

6:00 am-11:04 am

1 stop8h 04m

$369

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 2/15

6:15 am-10:25 pm

2 stops13h 10m

Knoxville McGhee Tyson

Sun 2/22

8:30 am-8:17 am

1 stop26h 47m

$389

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 4/1

6:00 am-4:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Fri 4/3

5:24 pm-10:36 pm

1 stop8h 12m

$401

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 4/1

6:00 am-4:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Thu 4/2

5:24 pm-10:36 pm

1 stop8h 12m

$401

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/18

Showing 1-10 of 18 results
1
2

Compare providers for flights from San Francisco to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on January 16, 2026.

Booking 28 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, May is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $138). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 20, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,080 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
8,080 reviews
Delta
7.9
Good
8,080 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
9,183 reviews
Delta
7.9
Good
8,080 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,163 reviews
Delta
7.9
Good
8,080 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Frontier
5.7
Fair
3,056 reviews
Delta
7.9
Good
8,080 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Knoxville?

    A quick flight from San Francisco to Knoxville can take about 8h 51m. Frontier provides one of the quickest options available for as low as $284. Airlines will cover a distance of 2114 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $151. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $308 and $308, respectively. Users have found that Frontier is 68% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

    One-way options have recently been found by users for as low as $96 on Frontier. Other airlines that offer cheap prices include United Airlines from $162 and American Airlines from $174 one-way.

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $138). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$151Average$276FlexibilityNo cancel feeOn-time62%
DeltaCheapest$308Average$427FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$487FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$328Average$549FlexibilityNo cancel feeOn-time69%

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