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$122+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or July, booked 83 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:30 amSFO - TYS
1 stop6h 27mFrontier
Sun 12/144:52 pmTYS - SFO
1 stop18h 01mFrontier
Deal found 12/3$288
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:24 amSFO - TYS
1 stop11h 15mMultiple Airlines
Tue 1/65:37 pmTYS - SFO
2 stops41h 26mMultiple Airlines
Deal found 12/4$367
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:13 pmSFO - TYS
1 stop23h 49mMultiple Airlines
Sun 12/144:52 pmTYS - SFO
2 stops26h 12mMultiple Airlines
Deal found 12/3$375
This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:00 amSFO - TYS
1 stop9h 41mAmerican Airlines
Tue 1/64:41 pmTYS - SFO
1 stop9h 31mAmerican Airlines
Deal found 12/4$412
This Frontier deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:24 amSFO - TYS
1 stop6h 07mFrontier
Mon 12/224:46 pmTYS - SFO
1 stop10h 38mFrontier
Deal found 12/1$413
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:30 amSFO - TYS
1 stop27h 41mMultiple Airlines
Sat 12/209:23 pmTYS - SFO
2 stops50h 07mMultiple Airlines
Deal found 12/2$419
This Expedia deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:24 amSFO - TYS
1 stop6h 07mFrontier
Tue 12/234:46 pmTYS - SFO
1 stop10h 38mFrontier
Deal found 12/1$437
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1311:20 pmSFO - TYS
1 stop8h 28mUnited Airlines
Sat 12/207:00 amTYS - SFO
1 stop8h 14mUnited Airlines
Deal found 12/2$452
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2611:05 pmSFO - TYS
1 stop8h 12mUnited Airlines
Wed 9/27:00 amTYS - SFO
1 stop8h 18mUnited Airlines
Deal found 12/2$455
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:24 amSFO - TYS
1 stop11h 15mMultiple Airlines
Sun 1/46:30 amTYS - SFO
2 stops28h 18mMultiple Airlines
Deal found 12/4$462
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amSFO - TYS
1 stop8h 02mMultiple Airlines
Tue 12/234:46 pmTYS - SFO
2 stops25h 25mMultiple Airlines
Deal found 12/4$465
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amSFO - TYS
2 stops36h 53mMultiple Airlines
Tue 12/234:46 pmTYS - SFO
1 stop10h 38mMultiple Airlines
Deal found 12/1$469

Find flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$259
(American Airlines)

One-way from

$122
(Trip.com)

Popular in

November

Cheapest in

August

Average price

$577
Provider with most accurate pricing for San Francisco-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Knoxville McGhee Tyson flights.
Search Deals
From San Francisco to Knoxville McGhee Tyson
Search Deals
One-way flight from San Francisco to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($44 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 2/4

8:00 am-5:42 pm

1 stop6h 42m

Knoxville McGhee Tyson

Sun 2/8

5:14 pm-10:28 pm

1 stop8h 14m

$259

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 3/30

11:59 pm-10:08 am

1 stop7h 09m

Knoxville McGhee Tyson

Sat 4/4

7:00 am-12:08 pm

1 stop8h 08m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 2/12

6:15 am-4:40 pm

1 stop7h 25m

Knoxville McGhee Tyson

Sun 2/15

5:35 pm-12:25 am

1 stop9h 50m

$330

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 1/25

2:05 pm-11:45 pm

1 stop6h 40m

Knoxville McGhee Tyson

Thu 1/29

2:37 pm-7:49 pm

1 stop8h 12m

$347

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 4/24

9:30 pm-9:11 am

1 stop8h 41m

Knoxville McGhee Tyson

Mon 4/27

7:20 pm-12:15 am

1 stop7h 55m

$354

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 2/4

6:00 am-11:09 pm

2 stops14h 09m

Knoxville McGhee Tyson

Sun 2/8

5:40 am-2:40 pm

2 stops12h 00m

$357

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 4/24

11:59 pm-11:18 am

1 stop8h 19m

Knoxville McGhee Tyson

Sat 5/9

12:18 pm-6:29 pm

1 stop9h 11m

$359

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 4/7

2:20 pm-11:51 pm

1 stop6h 31m

Knoxville McGhee Tyson

Mon 4/13

7:20 pm-12:15 am

1 stop7h 55m

$374

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/26

9:30 pm-9:11 am

1 stop8h 41m

Knoxville McGhee Tyson

Sat 5/2

6:45 am-1:20 pm

1 stop9h 35m

$374

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 5/16

10:45 pm-10:10 am

1 stop8h 25m

Knoxville McGhee Tyson

Thu 5/21

4:00 pm-10:49 pm

1 stop9h 49m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 19 results
1
2

Compare providers for flights from San Francisco to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on November 28, 2025.

Booking 28 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, May is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $138). Flying from San Francisco to Knoxville in December is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

It’s optimal to fly from San Francisco to Knoxville in the afternoon. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 4, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
9,066 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Frontier
5.8
Fair
3,091 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Knoxville?

    A quick flight from San Francisco to Knoxville can take about 6h 42m. American Airlines provides one of the quickest options available for as low as $259. Airlines will cover a distance of 2114 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $89. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $308 and $308, respectively. Users have found that Frontier is 81% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

    One-way options have recently been found by users for as low as $81 on Frontier. Other airlines that offer cheap prices include United Airlines from $162 and American Airlines from $174 one-way.

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $138). Flying from San Francisco to Knoxville in December is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$149Average$276FlexibilityNo cancel feeOn-time62%
DeltaCheapest$308Average$417FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$482FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$328Average$559FlexibilityNo cancel feeOn-time69%

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