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Knoxville

$88+ Cheap flights from North Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from North Carolina to Knoxville

Cheapest flights from North Carolina to Knoxville
Explore the most affordable flight options available from North Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3011:26 amORF - TYS
1 stop6h 34mAmerican Airlines
Fri 1/25:42 amTYS - ORF
1 stop4h 00mAmerican Airlines
Deal found 12/17$317
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:00 amCLT - TYS
1 stop8h 17mMultiple Airlines
Sun 1/47:15 amTYS - CLT
1 stop27h 48mMultiple Airlines
Deal found 12/15$345
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:23 amRDU - TYS
1 stop5h 53mMultiple Airlines
Mon 12/295:46 pmTYS - RDU
1 stop14h 28mMultiple Airlines
Deal found 12/17$357
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:20 amORF - TYS
1 stop4h 36mUnited Airlines
Sun 12/215:45 amTYS - ORF
1 stop4h 10mUnited Airlines
Deal found 12/17$369
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:48 pmMYR - TYS
1 stop3h 19mAmerican Airlines
Sun 1/45:00 amTYS - MYR
1 stop4h 20mAmerican Airlines
Deal found 12/16$372
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:54 amMYR - TYS
2 stops11h 59mMultiple Airlines
Wed 12/2411:08 amTYS - MYR
1 stop7h 00mMultiple Airlines
Deal found 12/17$387
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:20 amORF - TYS
1 stop4h 36mUnited Airlines
Tue 12/305:45 amTYS - ORF
1 stop4h 10mUnited Airlines
Deal found 12/16$389
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/289:49 pmRDU - TYS
1 stop12h 26mMultiple Airlines
Tue 12/306:33 pmTYS - RDU
1 stop22h 22mMultiple Airlines
Deal found 12/16$395
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:21 pmILM - TYS
1 stop4h 39mAmerican Airlines
Sun 1/45:00 amTYS - ILM
1 stop3h 36mAmerican Airlines
Deal found 12/15$404
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/231:21 pmILM - TYS
1 stop4h 39mAmerican Airlines
Thu 12/252:46 pmTYS - ILM
1 stop3h 02mAmerican Airlines
Deal found 12/17$419
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:55 pmORF - TYS
1 stop4h 04mUnited Airlines
Sat 1/35:45 amTYS - ORF
1 stop3h 54mUnited Airlines
Deal found 12/17$420
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:38 pmCLT - TYS
1 stop21h 21mMultiple Airlines
Wed 12/316:07 pmTYS - CLT
1 stop15h 32mMultiple Airlines
Deal found 12/17$425

Find flight deals from North Carolina to Knoxville

Keep the following information in mind while searching for North Carolina to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$181
(Kiwi.com)

One-way from

$88
(Mytrip)

Popular in

May

Cheapest in

August

Average price

$457

Good one-way deal

$320 or less
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
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From North Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from North Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
Search Deals
Price to beat on a one-way flight from North Carolina to Knoxville McGhee Tyson.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from North Carolina to Knoxville that are best for you.

Fly from

North Carolina

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 1/30

11:12 am-10:28 pm

1 stop11h 16m

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-12:40 am

1 stop6h 41m

$184

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 2/6

2:34 pm-8:36 pm

1 stop6h 02m

Knoxville McGhee Tyson

Mon 2/9

6:18 pm-1:58 pm

1 stop19h 40m

$185

NorfolkKnoxville

ORF - TYS

ORFTYS

Norfolk

Thu 2/5

7:33 pm-1:40 pm

1 stop18h 07m

Knoxville McGhee Tyson

Mon 2/9

12:55 pm-12:05 pm

1 stop23h 10m

$202

WilmingtonKnoxville

ILM - TYS

ILMTYS

Wilmington New Hanover County

Mon 1/12

6:00 am-11:45 am

1 stop5h 45m

Knoxville McGhee Tyson

Sat 1/17

5:14 pm-11:25 pm

1 stop6h 11m

$221

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 1/22

3:08 pm-12:05 pm

2 stops20h 57m

Knoxville McGhee Tyson

Mon 1/26

7:15 am-6:01 pm

1 stop10h 46m

$221

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 1/15

9:09 am-11:05 pm

1 stop13h 56m

Knoxville McGhee Tyson

Thu 1/22

7:26 pm-12:11 am

2 stops28h 45m

$224

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 1/22

9:09 am-11:05 pm

1 stop13h 56m

Knoxville McGhee Tyson

Sun 1/25

7:26 pm-12:11 am

2 stops28h 45m

$224

NorfolkKnoxville

ORF - TYS

ORFTYS

Norfolk

Thu 1/15

6:05 am-11:12 am

1 stop5h 07m

Knoxville McGhee Tyson

Sun 1/18

5:40 am-10:59 am

1 stop5h 19m

$244

WilmingtonKnoxville

ILM - TYS

ILMTYS

Wilmington New Hanover County

Thu 1/1

5:05 am-8:56 am

1 stop3h 51m

Knoxville McGhee Tyson

Mon 1/5

5:40 pm-9:56 pm

1 stop4h 16m

$244

NorfolkKnoxville

ORF - TYS

ORFTYS

Norfolk

Fri 2/27

7:31 pm-1:02 pm

1 stop17h 31m

Knoxville McGhee Tyson

Sun 3/1

11:50 am-10:04 pm

1 stop10h 14m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 60 results
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Best time to book a flight from North Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Knoxville

What is the cheapest month to book a flight from North Carolina to Knoxville?

Currently, November is the cheapest month in which you can book a flight from North Carolina to Knoxville (average of $113). Flying from North Carolina to Knoxville in June is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to TYS?

Find hourly flight availability from North Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from North Carolina to Knoxville in the afternoon. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from North Carolina to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from North Carolina to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their North Carolina to Knoxville flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from North Carolina?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from North Carolina. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from North Carolina to Knoxville?

    For as low as $244, American Airlines can have you in Knoxville from North Carolina in 5h 07m. There are 440 mi between North Carolina and Knoxville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from North Carolina to Knoxville?

    The most popular flight routes from North Carolina to Knoxville are Raleigh-Durham - Knoxville McGhee Tyson, Wilmington New Hanover County - Knoxville McGhee Tyson and Norfolk - Knoxville McGhee Tyson.

  • Can I find deals for flights from North Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on North Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Knoxville.

  • Can I find deals for business class flights from North Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from North Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from North Carolina to Knoxville (average of $113). Flying from North Carolina to Knoxville in June is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from North Carolina to Knoxville

Discover the top 2 airlines that operate flights from North Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$448FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$352FlexibilityNo cancel feeOn-timeN/A

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