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Knoxville

$100+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated junio 12, 2025.

Round-trip from

$229
(Delta)

One-way from

$100
(Delta)

Popular in

December

Cheapest in

January

Average price

$351
From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/89:27 amSTL - TYS
1 stop4h 40mDelta
sáb. 7/125:30 amTYS - STL
1 stop4h 31mDelta
Deal found 6/10$229
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/85:27 pmSTL - TYS
1 stop5h 25mAmerican Airlines
sáb. 7/128:22 pmTYS - STL
1 stop4h 37mAmerican Airlines
Deal found 6/10$234
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/93:12 pmMCI - TYS
1 stop6h 11mMultiple Airlines
mié. 7/169:48 pmTYS - MCI
1 stop22h 21mMultiple Airlines
Deal found 6/10$237
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/288:21 pmSGF - TYS
1 stop15h 50mAllegiant Air
vie. 8/110:05 pmTYS - SGF
1 stop22h 20mAllegiant Air
Deal found 6/9$245
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/266:34 pmSGF - TYS
1 stop4h 47mAmerican Airlines
dom. 9/286:30 amTYS - SGF
1 stop4h 56mAmerican Airlines
Deal found 6/11$249
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/146:42 pmMCI - TYS
1 stop4h 04mDelta
sáb. 9/205:30 amTYS - MCI
1 stop6h 03mDelta
Deal found 6/9$249
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/275:06 amMCI - TYS
1 stop4h 10mAmerican Airlines
mar. 7/15:57 pmTYS - MCI
1 stop6h 53mAmerican Airlines
Deal found 6/12$259
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/175:26 pmSTL - TYS
1 stop13h 36mMultiple Airlines
lun. 7/216:00 amTYS - STL
2 stops35h 31mMultiple Airlines
Deal found 6/10$270
This FlightHub deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/147:48 pmMCI - TYS
1 stop22h 53mFrontier
dom. 9/218:26 pmTYS - MCI
1 stop23h 37mFrontier
Deal found 6/10$336
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/155:30 pmSTL - TYS
1 stop4h 07mUnited Airlines
vie. 8/227:25 pmTYS - STL
2 stops16h 15mUnited Airlines
Deal found 6/11$374
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/77:59 pmMCI - TYS
2 stops24h 11mAllegiant Air
dom. 8/105:59 pmTYS - MCI
2 stops20h 00mAllegiant Air
Deal found 6/11$378
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/178:00 amMCI - TYS
2 stops11h 42mUnited Airlines
sáb. 6/215:38 pmTYS - MCI
1 stop6h 37mUnited Airlines
Deal found 6/11$395

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 7/8

1:29 pm-7:01 pm

1 stop4h 32m

Knoxville McGhee Tyson

mar. 7/15

5:12 pm-8:36 pm

1 stop4h 24m

$229

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 7/8

5:27 pm-11:52 pm

1 stop5h 25m

Knoxville McGhee Tyson

sáb. 7/12

8:22 pm-11:59 pm

1 stop4h 37m

$234

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

mié. 7/9

3:12 pm-10:23 pm

1 stop6h 11m

Knoxville McGhee Tyson

mié. 7/16

9:48 pm-7:09 pm

1 stop22h 21m

$237

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

lun. 7/28

8:21 pm-1:11 pm

1 stop15h 50m

Knoxville McGhee Tyson

vie. 8/1

10:05 pm-7:25 pm

1 stop22h 20m

$245

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

vie. 9/26

6:34 pm-12:21 am

1 stop4h 47m

Knoxville McGhee Tyson

dom. 9/28

6:30 am-10:26 am

1 stop4h 56m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

vie. 8/22

5:50 am-1:08 pm

1 stop6h 18m

Knoxville McGhee Tyson

dom. 8/24

6:14 pm-10:26 pm

1 stop5h 12m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

vie. 6/27

5:06 am-10:16 am

1 stop4h 10m

Knoxville McGhee Tyson

dom. 6/29

5:15 am-9:56 am

1 stop5h 41m

$259

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

jue. 7/17

5:26 pm-8:02 am

1 stop13h 36m

Knoxville McGhee Tyson

lun. 7/21

6:00 am-4:31 pm

2 stops35h 31m

$270

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

jue. 6/26

8:01 pm-10:17 pm

1 stop25h 16m

Knoxville McGhee Tyson

sáb. 7/12

7:30 am-8:27 pm

1 stop13h 57m

$308

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

dom. 9/14

7:48 pm-7:41 pm

1 stop22h 53m

Knoxville McGhee Tyson

dom. 9/21

8:26 pm-7:03 pm

1 stop23h 37m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 27 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated junio 12, 2025.
To help decide which airline to fly from Missouri to Knoxville, see what other customers have to say about Delta, United Airlines and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
6.0
Okay
3,295 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $100. However, be on the lookout for offers from Allegiant Air and American Airlines, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$416FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$391FlexibilityNo cancel feeOn-time69%
DeltaCheapest$222Average$351FlexibilityNo cancel feeOn-timeN/A

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