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Knoxville

$100+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$199
(Delta)

One-way from

$100
(United Airlines)

Popular in

December

Cheapest in

January

Average price

$429
Provider with most accurate pricing for Kansas City-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Knoxville McGhee Tyson flights.
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From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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High demand for flights, 2% potential price rise
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/255:40 pmSTL - TYS
1 stop5h 11mDelta
Fri 5/307:50 amTYS - STL
1 stop6h 29mDelta
Deal found 4/29$199
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/285:45 amMCI - TYS
1 stop6h 34mDelta
Fri 5/305:45 amTYS - MCI
1 stop4h 40mDelta
Deal found 4/29$217
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/274:01 pmSTL - TYS
1 stop4h 54mAmerican Airlines
Sat 5/315:20 amTYS - STL
1 stop5h 34mAmerican Airlines
Deal found 4/29$225
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3111:26 amMCI - TYS
2 stops26h 36mMultiple Airlines
Sat 6/78:30 amTYS - MCI
1 stop12h 57mMultiple Airlines
Deal found 4/30$276
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/163:20 pmSGF - TYS
1 stop6h 25mUnited Airlines
Tue 5/205:35 pmTYS - SGF
1 stop5h 26mUnited Airlines
Deal found 4/30$281
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/257:11 amMCI - TYS
1 stop5h 54mAmerican Airlines
Tue 6/38:00 amTYS - MCI
1 stop6h 08mAmerican Airlines
Deal found 4/29$319
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/275:30 pmSTL - TYS
1 stop4h 05mUnited Airlines
Sun 6/297:00 amTYS - STL
1 stop4h 40mUnited Airlines
Deal found 4/29$319
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1311:14 amSGF - TYS
1 stop5h 17mAmerican Airlines
Sat 5/175:20 amTYS - SGF
1 stop6h 24mAmerican Airlines
Deal found 4/29$327
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/261:00 pmSTL - TYS
3 stops26h 12mMultiple Airlines
Wed 5/2811:24 amTYS - STL
1 stop22h 51mMultiple Airlines
Deal found 4/29$337
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/46:14 pmMCI - TYS
1 stop13h 15mAllegiant Air
Sun 5/187:00 amTYS - MCI
1 stop11h 33mAllegiant Air
Deal found 4/30$381
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/283:21 pmMCI - TYS
2 stops7h 38mUnited Airlines
Fri 5/307:00 amTYS - MCI
1 stop4h 34mUnited Airlines
Deal found 4/29$384
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:27 amSGF - TYS
1 stop27h 44mAllegiant Air
Mon 5/192:01 pmTYS - SGF
1 stop25h 24mAllegiant Air
Deal found 4/30$394

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 5/25

5:40 pm-11:51 pm

1 stop5h 11m

Knoxville McGhee Tyson

Fri 5/30

7:50 am-1:19 pm

1 stop6h 29m

$199

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Wed 5/28

5:45 am-1:19 pm

1 stop6h 34m

Knoxville McGhee Tyson

Fri 5/30

5:45 am-9:25 am

1 stop4h 40m

$217

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 5/27

4:01 pm-9:55 pm

1 stop4h 54m

Knoxville McGhee Tyson

Sat 5/31

5:20 am-9:54 am

1 stop5h 34m

$225

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sat 5/31

11:26 am-3:02 pm

2 stops26h 36m

Knoxville McGhee Tyson

Sat 6/7

8:30 am-8:27 pm

1 stop12h 57m

$276

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Fri 5/16

3:20 pm-10:45 pm

1 stop6h 25m

Knoxville McGhee Tyson

Tue 5/20

5:35 pm-10:01 pm

1 stop5h 26m

$281

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sun 5/25

5:15 am-11:41 am

1 stop5h 26m

Knoxville McGhee Tyson

Sat 5/31

5:20 am-9:50 am

1 stop5h 30m

$319

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 6/27

5:30 pm-10:35 pm

1 stop4h 05m

Knoxville McGhee Tyson

Sun 6/29

7:00 am-10:40 am

1 stop4h 40m

$319

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Tue 5/13

11:14 am-5:31 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 5/17

5:20 am-10:44 am

1 stop6h 24m

$327

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 5/26

1:00 pm-4:12 pm

3 stops26h 12m

Knoxville McGhee Tyson

Wed 5/28

11:24 am-9:15 am

1 stop22h 51m

$337

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Wed 5/28

3:21 pm-11:59 pm

2 stops7h 38m

Knoxville McGhee Tyson

Fri 5/30

7:00 am-10:34 am

1 stop4h 34m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 22 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
To help decide which airline to fly from Missouri to Knoxville, see what other customers have to say about Delta, United Airlines and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $100. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Kansas City - Knoxville McGhee Tyson. You may also consider Lambert-St Louis - Knoxville McGhee Tyson or Columbia Regional - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$415FlexibilityNo cancel feeOn-time71%
DeltaCheapest$208Average$309FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$213Average$391FlexibilityNo cancel feeOn-time69%

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