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Knoxville

$116+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:49 pmMCI - TYS
1 stop22h 33mFrontier
Sun 11/167:07 pmTYS - MCI
1 stop25h 26mFrontier
Deal found 10/27$198
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/233:02 pmCOU - TYS
1 stop6h 53mUnited Airlines
Sat 12/135:54 pmTYS - COU
1 stop4h 28mUnited Airlines
Deal found 10/30$218
This Flightnetwork deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:49 pmMCI - TYS
1 stop22h 33mFrontier
Sun 11/97:17 pmTYS - MCI
1 stop25h 16mFrontier
Deal found 10/29$234
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:57 pmSTL - TYS
1 stop18h 56mFrontier
Thu 12/44:52 pmTYS - STL
1 stop18h 22mFrontier
Deal found 10/30$239
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:47 pmSTL - TYS
1 stop16h 46mMultiple Airlines
Wed 12/172:53 pmTYS - STL
1 stop21h 03mMultiple Airlines
Deal found 10/28$240
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:30 amMCI - TYS
1 stop9h 32mMultiple Airlines
Sun 12/146:30 amTYS - MCI
1 stop14h 20mMultiple Airlines
Deal found 10/28$242
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:49 pmMCI - TYS
1 stop17h 55mMultiple Airlines
Fri 11/149:38 pmTYS - MCI
1 stop15h 50mMultiple Airlines
Deal found 10/29$246
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:49 pmMCI - TYS
1 stop17h 55mMultiple Airlines
Mon 11/179:29 pmTYS - MCI
1 stop15h 59mMultiple Airlines
Deal found 10/29$248
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:00 amSGF - TYS
1 stop6h 27mAmerican Airlines
Sat 12/61:14 pmTYS - SGF
1 stop6h 45mAmerican Airlines
Deal found 10/30$249
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/139:30 amSTL - TYS
1 stop5h 02mAmerican Airlines
Tue 12/161:14 pmTYS - STL
1 stop4h 36mAmerican Airlines
Deal found 10/28$251
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:26 amMCI - TYS
2 stops28h 27mMultiple Airlines
Thu 12/46:30 amTYS - MCI
1 stop13h 44mMultiple Airlines
Deal found 10/29$254
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:28 pmMCI - TYS
1 stop20h 54mMultiple Airlines
Mon 11/179:29 pmTYS - MCI
1 stop15h 59mMultiple Airlines
Deal found 10/29$255

Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$198
(Mytrip)

One-way from

$116
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$381
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
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From Missouri to Knoxville McGhee Tyson
Search Deals
One-way flight from Missouri to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sun 11/23

3:02 pm-10:55 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 12/13

5:54 pm-9:22 pm

1 stop4h 28m

$218

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 11/27

7:57 pm-3:53 pm

1 stop18h 56m

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-10:14 am

1 stop18h 22m

$239

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 12/14

2:47 pm-8:33 am

1 stop16h 46m

Knoxville McGhee Tyson

Wed 12/17

2:53 pm-10:56 am

1 stop21h 03m

$240

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 12/4

7:00 am-2:27 pm

1 stop6h 27m

Knoxville McGhee Tyson

Sat 12/6

1:14 pm-6:59 pm

1 stop6h 45m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

6:00 am-11:07 am

1 stop4h 07m

Knoxville McGhee Tyson

Sat 2/21

12:30 pm-4:55 pm

1 stop5h 25m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 12/13

9:30 am-3:32 pm

1 stop5h 02m

Knoxville McGhee Tyson

Tue 12/16

1:14 pm-4:50 pm

1 stop4h 36m

$251

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 11/14

10:22 am-10:17 pm

1 stop10h 55m

Knoxville McGhee Tyson

Sat 11/22

7:27 pm-8:05 am

1 stop13h 38m

$272

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 11/16

2:12 pm-1:57 pm

1 stop22h 45m

Knoxville McGhee Tyson

Fri 11/21

4:48 pm-10:02 am

1 stop18h 14m

$274

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 11/13

8:00 am-1:17 pm

1 stop4h 17m

Knoxville McGhee Tyson

Mon 11/17

6:45 am-10:51 am

1 stop5h 06m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/4

11:40 am-6:52 pm

1 stop6h 12m

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-11:42 pm

1 stop4h 43m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 46 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $149). Flying from Missouri to Knoxville in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 31% on flights from Missouri to Knoxville by exploring options for tickets in the evening.

What is the cheapest day to fly from Missouri to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Knoxville flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Missouri to Knoxville?

    United Airlines, Frontier, and American Airlines can get you from Missouri to Knoxville in just under 6h 27m. Your travel time can differ by up to 12h 29m. The distance from Missouri to Knoxville is about 530 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $131. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $149). Flying from Missouri to Knoxville in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$382FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$318FlexibilityNo cancel feeOn-timeN/A

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