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Knoxville

$116+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated septiembre 15, 2025.

Round-trip from

$223
(Delta)

One-way from

$116
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$360
From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/29:30 amSTL - TYS
1 stop4h 21mDelta
dom. 12/77:59 pmTYS - STL
1 stop4h 42mDelta
Deal found 9/13$223
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:23 pmSTL - TYS
1 stop6h 27mUnited Airlines
jue. 10/27:00 amTYS - STL
1 stop4h 49mUnited Airlines
Deal found 9/12$226
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/612:20 pmSTL - TYS
1 stop9h 13mMultiple Airlines
dom. 11/97:00 amTYS - STL
1 stop27h 07mMultiple Airlines
Deal found 9/14$237
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/2811:21 amSTL - TYS
1 stop4h 10mDelta
mar. 11/410:25 amTYS - STL
1 stop6h 45mDelta
Deal found 9/12$238
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/166:40 amSTL - TYS
1 stop4h 05mDelta
mar. 1/66:10 pmTYS - STL
1 stop6h 30mDelta
Deal found 9/14$249
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/221:57 pmSTL - TYS
1 stop19h 38mMultiple Airlines
jue. 9/255:55 pmTYS - STL
2 stops20h 07mMultiple Airlines
Deal found 9/13$254
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/611:12 amMCI - TYS
2 stops34h 14mMultiple Airlines
lun. 11/109:27 pmTYS - MCI
1 stop12h 37mMultiple Airlines
Deal found 9/14$258
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/111:55 pmSTL - TYS
1 stop4h 05mDelta
vie. 11/143:51 pmTYS - STL
1 stop6h 13mDelta
Deal found 9/15$265
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/227:00 amMCI - TYS
1 stop6h 43mDelta
mar. 10/282:27 pmTYS - MCI
1 stop5h 35mDelta
Deal found 9/14$267
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/256:01 amSTL - TYS
1 stop3h 41mDelta
lun. 9/296:08 pmTYS - STL
1 stop6h 16mDelta
Deal found 9/14$274
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/135:11 pmMCI - TYS
1 stop16h 22mMultiple Airlines
vie. 10/178:17 pmTYS - MCI
1 stop22h 38mMultiple Airlines
Deal found 9/14$275
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/2410:15 amMCI - TYS
1 stop12h 11mMultiple Airlines
dom. 10/265:34 pmTYS - MCI
2 stops27h 19mMultiple Airlines
Deal found 9/14$278

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

sáb. 2/21

10:00 am-3:06 pm

1 stop4h 06m

Knoxville McGhee Tyson

mié. 2/25

7:20 pm-11:40 pm

1 stop5h 20m

$197

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 12/2

9:30 am-2:51 pm

1 stop4h 21m

Knoxville McGhee Tyson

dom. 12/7

7:59 pm-11:41 pm

1 stop4h 42m

$223

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

jue. 11/6

12:20 pm-10:33 pm

1 stop9h 13m

Knoxville McGhee Tyson

dom. 11/9

7:00 am-9:07 am

1 stop27h 07m

$237

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mié. 2/18

10:00 am-3:06 pm

1 stop4h 06m

Knoxville McGhee Tyson

sáb. 2/21

10:05 am-3:01 pm

1 stop5h 56m

$237

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 10/28

11:21 am-4:31 pm

1 stop4h 10m

Knoxville McGhee Tyson

mar. 11/4

10:25 am-4:10 pm

1 stop6h 45m

$238

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 12/16

11:35 am-5:27 pm

1 stop4h 52m

Knoxville McGhee Tyson

mar. 1/6

7:17 pm-11:49 pm

1 stop5h 32m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 10/14

7:00 am-1:24 pm

1 stop5h 24m

Knoxville McGhee Tyson

sáb. 10/18

2:13 pm-6:42 pm

1 stop5h 29m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

sáb. 10/25

3:59 pm-11:07 pm

1 stop6h 08m

Knoxville McGhee Tyson

lun. 10/27

8:10 pm-11:41 pm

1 stop4h 31m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

mar. 12/16

6:40 am-11:45 am

1 stop4h 05m

Knoxville McGhee Tyson

mar. 1/6

6:10 pm-11:40 pm

1 stop6h 30m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

jue. 11/6

11:12 am-10:26 pm

2 stops34h 14m

Knoxville McGhee Tyson

lun. 11/10

9:27 pm-9:04 am

1 stop12h 37m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 38 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $295). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Missouri to Knoxville?

    Delta and American Airlines can get you from Missouri to Knoxville in just under 4h 06m. Your travel time can differ by up to 15m. The distance from Missouri to Knoxville is about 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Kansas City - Knoxville McGhee Tyson. You may also consider Lambert-St Louis - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $295). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Missouri to Knoxville

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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$391FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$410FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$315FlexibilityNo cancel feeOn-timeN/A

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