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Knoxville

$113+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:40 pmMCI - TYS
1 stop6h 02mUnited Airlines
Wed 12/312:00 pmTYS - MCI
1 stop7h 31mUnited Airlines
Deal found 12/17$302
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:12 amMCI - TYS
1 stop4h 38mAmerican Airlines
Sun 1/45:00 amTYS - MCI
1 stop7h 26mAmerican Airlines
Deal found 12/15$381
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:04 pmSGF - TYS
1 stop22h 48mAllegiant Air
Mon 12/2212:50 pmTYS - SGF
1 stop20h 22mAllegiant Air
Deal found 12/16$385
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:45 amMCI - TYS
1 stop8h 15mUnited Airlines
Tue 12/239:50 amTYS - MCI
1 stop6h 10mUnited Airlines
Deal found 12/15$433
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:04 pmSGF - TYS
1 stop22h 48mMultiple Airlines
Mon 12/229:15 pmTYS - SGF
2 stops44h 11mMultiple Airlines
Deal found 12/16$443
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:15 pmMCI - TYS
1 stop28h 17mMultiple Airlines
Fri 1/26:00 amTYS - MCI
1 stop17h 59mMultiple Airlines
Deal found 12/16$469
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSTL - TYS
1 stop7h 39mAmerican Airlines
Sun 12/285:08 pmTYS - STL
1 stop7h 36mAmerican Airlines
Deal found 12/15$473
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:00 pmSGF - TYS
1 stop7h 42mUnited Airlines
Sun 12/2111:58 amTYS - SGF
1 stop7h 29mUnited Airlines
Deal found 12/17$476
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:35 amCOU - TYS
1 stop7h 21mAmerican Airlines
Sun 1/47:48 amTYS - COU
1 stop12h 24mAmerican Airlines
Deal found 12/16$477
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - TYS
2 stops20h 01mMultiple Airlines
Sun 1/44:26 pmTYS - MCI
1 stop28h 24mMultiple Airlines
Deal found 12/15$477
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amSTL - TYS
1 stop3h 50mAmerican Airlines
Wed 12/247:00 amTYS - STL
1 stop7h 14mAmerican Airlines
Deal found 12/17$523
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2412:47 pmMCI - TYS
1 stop6h 04mUnited Airlines
Fri 12/2611:00 amTYS - MCI
1 stop7h 41mUnited Airlines
Deal found 12/16$524

Find flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$230
(American Airlines)

One-way from

$113
(Kiwi.com)

Popular in

January

Cheapest in

July

Average price

$337
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
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From Missouri to Knoxville McGhee Tyson
Search Deals
One-way flight from Missouri to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

5:14 am-11:27 am

1 stop5h 13m

Knoxville McGhee Tyson

Sun 2/22

5:00 am-8:32 am

1 stop4h 32m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

5:11 pm-10:10 am

1 stop15h 59m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$252

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 1/26

9:42 am-10:21 pm

1 stop11h 39m

Knoxville McGhee Tyson

Wed 1/28

4:47 pm-10:31 am

1 stop18h 44m

$264

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/28

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Fri 1/30

5:40 am-8:53 am

1 stop4h 13m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 2/6

9:54 am-3:56 pm

1 stop5h 02m

Knoxville McGhee Tyson

Mon 2/9

5:14 pm-11:12 pm

1 stop6h 58m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 2/8

5:04 pm-11:45 pm

1 stop5h 41m

Knoxville McGhee Tyson

Thu 2/12

12:00 pm-5:42 pm

1 stop6h 42m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 2/9

9:59 am-3:19 pm

1 stop4h 20m

Knoxville McGhee Tyson

Thu 2/12

12:00 pm-5:42 pm

1 stop6h 42m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/22

9:34 am-3:46 pm

1 stop5h 12m

Knoxville McGhee Tyson

Sun 1/25

4:41 pm-10:59 pm

1 stop7h 18m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 2/1

6:57 pm-11:45 pm

1 stop3h 48m

Knoxville McGhee Tyson

Fri 2/6

6:41 pm-11:37 pm

1 stop5h 56m

$279

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 1/15

11:26 am-7:56 pm

2 stops31h 30m

Knoxville McGhee Tyson

Thu 1/22

9:29 am-10:31 am

1 stop26h 02m

$288

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 40 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $149). Flying from Missouri to Knoxville in September is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 31% on flights from Missouri to Knoxville by exploring options for tickets in the evening.

What is the cheapest day to fly from Missouri to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Knoxville flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Missouri to Knoxville?

    American Airlines, Delta, and United Airlines can get you from Missouri to Knoxville in just under 4h 08m. Your travel time can differ by up to 1h 05m. The distance from Missouri to Knoxville is about 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $99. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $149). Flying from Missouri to Knoxville in September is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$338FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$391FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$322FlexibilityNo cancel feeOn-timeN/A

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