$128+ Cheap flights from Missouri to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Apr 16 — Apr 231
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to KnoxvilleExplore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:24 pm
STL
- TYS
1 stop5h 02m
American Airlines
Tue 5/127:53 am
TYS
- STL
1 stop4h 54m
American Airlines
Deal found 3/12![American Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:21 am
STL
- TYS
2 stops22h 15m
Multiple Airlines
Fri 4/104:20 pm
TYS
- STL
1 stop18h 28m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:57 pm
STL
- TYS
1 stop3h 53m
American Airlines
Thu 4/96:54 pm
TYS
- STL
1 stop5h 05m
American Airlines
Deal found 3/12![American Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:45 am
STL
- TYS
1 stop7h 25m
Southwest
Thu 5/146:35 am
TYS
- STL
2 stops9h 20m
Southwest
Deal found 3/11![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:25 am
STL
- TYS
1 stop4h 55m
Southwest
Tue 4/215:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/15![Southwest logo]()
$271
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:50 am
STL
- TYS
2 stops8h 30m
Southwest
Thu 4/1612:15 pm
TYS
- STL
1 stop6h 55m
Southwest
Deal found 3/12![Southwest logo]()
$272
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/112:33 pm
STL
- TYS
1 stop4h 45m
American Airlines
Tue 4/145:11 pm
TYS
- STL
1 stop5h 56m
American Airlines
Deal found 3/13![American Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:27 pm
STL
- TYS
1 stop6h 51m
American Airlines
Sun 4/197:00 am
TYS
- STL
1 stop6h 48m
American Airlines
Deal found 3/12![American Airlines logo]()
$278
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:18 am
MCI
- TYS
1 stop6h 57m
United Airlines
Wed 4/157:00 am
TYS
- MCI
1 stop4h 27m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:45 am
STL
- TYS
1 stop5h 35m
Southwest
Tue 4/1412:50 pm
TYS
- STL
2 stops7h 25m
Southwest
Deal found 3/13![Southwest logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:41 am
STL
- TYS
1 stop8h 40m
Multiple Airlines
Fri 4/104:20 pm
TYS
- STL
1 stop18h 28m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:58 am
COU
- TYS
1 stop5h 33m
American Airlines
Sat 4/46:21 pm
TYS
- COU
1 stop5h 15m
American Airlines
Deal found 3/15![American Airlines logo]()
$288
Best flights from Missouri to KnoxvilleDiscover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
Discover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/119:21 am
STL
- TYS
1 stop6h 33m
United Airlines
Thu 5/146:01 pm
TYS
- STL
1 stop4h 12m
United Airlines
Deal found 3/11![United Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:45 am
STL
- TYS
1 stop7h 25m
Southwest
Thu 5/146:35 am
TYS
- STL
2 stops9h 20m
Southwest
Deal found 3/11![Southwest logo]()
$268
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:29 am
STL
- TYS
1 stop7h 57m
American Airlines
Mon 4/135:11 pm
TYS
- STL
1 stop5h 56m
American Airlines
Deal found 3/16![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:13 pm
MCI
- TYS
1 stop5h 43m
Delta
Tue 6/25:40 am
TYS
- MCI
1 stop6h 36m
Delta
Deal found 3/14![Delta logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:56 am
SGF
- TYS
1 stop13h 16m
Allegiant Air
Mon 6/226:34 pm
TYS
- SGF
1 stop16h 22m
Allegiant Air
Deal found 3/14![Allegiant Air logo]()
$405
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:55 am
STL
- TYS
1 stop9h 25m
Southwest
Thu 4/1612:15 pm
TYS
- STL
1 stop6h 55m
Southwest
Deal found 3/12![Southwest logo]()
$272
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:18 am
MCI
- TYS
1 stop6h 57m
United Airlines
Wed 4/157:00 am
TYS
- MCI
1 stop4h 27m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:25 am
MCI
- TYS
2 stops8h 15m
Southwest
Wed 4/157:05 am
TYS
- MCI
2 stops9h 00m
Southwest
Deal found 3/11![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:39 am
SGF
- TYS
1 stop5h 52m
American Airlines
Sat 4/45:00 am
TYS
- SGF
1 stop7h 18m
American Airlines
Deal found 3/16![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:09 am
STL
- TYS
1 stop7h 06m
United Airlines
Sat 4/115:15 pm
TYS
- STL
1 stop6h 13m
United Airlines
Deal found 3/12![United Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:05 am
STL
- TYS
1 stop10h 05m
Southwest
Tue 5/128:15 am
TYS
- STL
1 stop8h 00m
Southwest
Deal found 3/16![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:50 am
STL
- TYS
2 stops8h 30m
Southwest
Mon 4/136:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 3/16![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:05 pm
COU
- TYS
1 stop4h 43m
United Airlines
Wed 8/196:30 am
TYS
- COU
1 stop5h 25m
United Airlines
Deal found 3/12![United Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:52 pm
SGF
- TYS
1 stop4h 04m
Delta
Tue 5/123:30 pm
TYS
- SGF
1 stop3h 36m
Delta
Deal found 3/14![Delta logo]()
$424
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:00 am
STL
- TYS
1 stop12h 10m
Southwest
Fri 5/226:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 3/14![Southwest logo]()
$312
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:10 pm
SGF
- TYS
1 stop4h 38m
United Airlines
Wed 8/264:56 pm
TYS
- SGF
1 stop7h 46m
United Airlines
Deal found 3/11![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Tue 4/217:05 am
TYS
- STL
2 stops8h 45m
Southwest
Deal found 3/13![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/48:00 am
MCI
- TYS
2 stops10h 42m
United Airlines
Sat 4/118:30 am
TYS
- MCI
1 stop8h 42m
United Airlines
Deal found 3/13![United Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Mon 4/206:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 3/13![Southwest logo]()
$327
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:00 pm
MCI
- TYS
1 stop7h 41m
United Airlines
Tue 4/289:40 am
TYS
- MCI
2 stops11h 05m
United Airlines
Deal found 3/15![United Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:35 am
STL
- TYS
2 stops8h 15m
Southwest
Mon 5/252:45 pm
TYS
- STL
1 stop8h 55m
Southwest
Deal found 3/15![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Fri 4/172:45 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/13![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:30 am
MCI
- TYS
1 stop4h 10m
Southwest
Mon 4/206:35 am
TYS
- MCI
2 stops7h 45m
Southwest
Deal found 3/14![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 am
MCI
- TYS
2 stops6h 50m
Southwest
Thu 4/96:45 pm
TYS
- MCI
1 stop5h 50m
Southwest
Deal found 3/16![Southwest logo]()
$366
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:40 am
MCI
- TYS
1 stop9h 30m
Southwest
Thu 4/27:25 pm
TYS
- MCI
1 stop5h 50m
Southwest
Deal found 3/11![Southwest logo]()
$370
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:00 am
MCI
- TYS
2 stops9h 20m
Southwest
Tue 4/2112:50 pm
TYS
- MCI
2 stops9h 40m
Southwest
Deal found 3/11![Southwest logo]()
$388
Last-minute flights from Missouri to KnoxvilleDiscover last-minute flight deals from Missouri to Knoxville. Data last updated March 17, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Knoxville. Data last updated March 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:58 am
COU
- TYS
1 stop5h 33m
American Airlines
Sat 4/46:21 pm
TYS
- COU
1 stop5h 15m
American Airlines
Deal found 3/15![American Airlines logo]()
$288
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:57 pm
STL
- TYS
1 stop3h 53m
American Airlines
Thu 4/96:54 pm
TYS
- STL
1 stop5h 05m
American Airlines
Deal found 3/12![American Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:41 am
STL
- TYS
1 stop8h 40m
Multiple Airlines
Fri 4/104:20 pm
TYS
- STL
1 stop18h 28m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:21 am
STL
- TYS
2 stops22h 15m
Multiple Airlines
Fri 4/104:20 pm
TYS
- STL
1 stop18h 28m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:21 pm
STL
- TYS
1 stop5h 36m
Delta
Wed 4/85:40 am
TYS
- STL
1 stop4h 25m
Delta
Deal found 3/12![Delta logo]()
$283
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:18 am
MCI
- TYS
1 stop6h 57m
United Airlines
Wed 4/157:00 am
TYS
- MCI
1 stop4h 27m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:25 am
MCI
- TYS
2 stops8h 15m
Southwest
Wed 4/157:05 am
TYS
- MCI
2 stops9h 00m
Southwest
Deal found 3/11![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:55 am
STL
- TYS
1 stop9h 25m
Southwest
Thu 4/1612:15 pm
TYS
- STL
1 stop6h 55m
Southwest
Deal found 3/12![Southwest logo]()
$272
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/112:33 pm
STL
- TYS
1 stop4h 45m
American Airlines
Tue 4/145:11 pm
TYS
- STL
1 stop5h 56m
American Airlines
Deal found 3/13![American Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:45 am
STL
- TYS
1 stop5h 35m
Southwest
Tue 4/1412:50 pm
TYS
- STL
2 stops7h 25m
Southwest
Deal found 3/13![Southwest logo]()
$279
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:27 pm
STL
- TYS
1 stop6h 51m
American Airlines
Sun 4/197:00 am
TYS
- STL
1 stop6h 48m
American Airlines
Deal found 3/12![American Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:25 am
STL
- TYS
1 stop4h 55m
Southwest
Tue 4/215:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/15![Southwest logo]()
$271
One-way flights from Missouri to KnoxvilleSearch for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
Search for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:35 pm
MCI
- TYS
1 stop21h 23m
Allegiant Air
Deal found 3/13![Allegiant Air logo]()
$128
This Mytrip deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/242:34 pm
MCI
- TYS
1 stop27h 59m
Frontier
Deal found 3/12![Frontier logo]()
$135
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:57 pm
STL
- TYS
1 stop3h 53m
American Airlines
Deal found 3/16![American Airlines logo]()
$139
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:10 pm
STL
- TYS
2 stops6h 05m
Southwest
Deal found 3/14![Southwest logo]()
$144
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:41 pm
STL
- TYS
1 stop5h 49m
United Airlines
Deal found 3/15![United Airlines logo]()
$149
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
MCI
- TYS
1 stop5h 35m
Southwest
Deal found 3/15![Southwest logo]()
$154
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:15 am
MCI
- TYS
2 stops7h 54m
United Airlines
Deal found 3/13![United Airlines logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:51 pm
MCI
- TYS
1 stop23h 42m
Frontier
Deal found 3/13![Frontier logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/268:54 am
MCI
- TYS
1 stop12h 51m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$169
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:25 pm
MCI
- TYS
1 stop3h 43m
Delta
Deal found 3/13![Delta logo]()
$177
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:38 pm
MCI
- TYS
1 stop4h 18m
Delta
Deal found 3/14![Delta logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:14 pm
STL
- TYS
2 stops23h 37m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$182
Find flight deals from Missouri to Knoxville
Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated March 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (American Airlines) |
One-way from | $128 (Kiwi.com) |
Popular in | January |
Cheapest in | July |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/11
9:21 am-4:54 pm
1 stop6h 33m
Knoxville McGhee Tyson
Thu 5/14
6:01 pm-9:13 pm
1 stop4h 12m
$257
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/11
5:45 am-2:10 pm
1 stop7h 25m
Knoxville McGhee Tyson
Thu 5/14
6:35 am-2:55 pm
2 stops9h 20m
$268
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 4/9
9:55 am-8:20 pm
1 stop9h 25m
Knoxville McGhee Tyson
Thu 4/16
12:15 pm-6:10 pm
1 stop6h 55m
$272
Kansas CityKnoxville
MCI - TYS
MCITYS
Kansas City
Wed 4/8
10:18 am-6:15 pm
1 stop6h 57m
Knoxville McGhee Tyson
Wed 4/15
7:00 am-10:27 am
1 stop4h 27m
$279
Kansas CityKnoxville
MCI - TYS
MCITYS
Kansas City
Wed 4/8
10:25 am-7:40 pm
2 stops8h 15m
Knoxville McGhee Tyson
Wed 4/15
7:05 am-3:05 pm
2 stops9h 00m
$289
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 5/7
7:05 am-6:10 pm
1 stop10h 05m
Knoxville McGhee Tyson
Tue 5/12
8:15 am-3:15 pm
1 stop8h 00m
$289
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 4/9
10:50 am-8:20 pm
2 stops8h 30m
Knoxville McGhee Tyson
Mon 4/13
6:45 pm-8:55 pm
1 stop3h 10m
$292
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 4/7
10:09 am-6:15 pm
1 stop7h 06m
Knoxville McGhee Tyson
Sat 4/11
5:15 pm-10:28 pm
1 stop6h 13m
$305
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/18
5:00 am-6:10 pm
1 stop12h 10m
Knoxville McGhee Tyson
Fri 5/22
6:45 pm-8:55 pm
1 stop3h 10m
$312
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 4/9
6:29 am-3:26 pm
1 stop7h 57m
Knoxville McGhee Tyson
Mon 4/13
5:11 pm-10:07 pm
1 stop5h 56m
$317
Showing 1-10 of 47 resultsSorted by cheapest first
Best time to book a flight from Missouri to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Knoxville
USMO-TYS
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
What is the cheapest month to book a flight from Missouri to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $149). Flying from Missouri to Knoxville in February is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to Knoxville
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Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Knoxville by cabin class
Find flights from Missouri to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Missouri and Knoxville flights
Browse other Missouri and Knoxville flight options. Last updated on March 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Knoxville flights
Consider these flights traveling from Missouri to Knoxville.
Top 3 airlines flying from Missouri to Knoxville
Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$198 | Average$380 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$213 | Average$338 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$347 | FlexibilityNo cancel fee | On-timeN/A |