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Knoxville

$117+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated July 31, 2025.

Round-trip from

$194
(United Airlines)

One-way from

$117
(FlightHub)

Popular in

December

Cheapest in

January

Average price

$318
From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 3% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/271:26 pmSTL - TYS
1 stop4h 37mDelta
Sun 8/316:14 pmTYS - STL
1 stop4h 48mDelta
Deal found 7/31$214
This FlightHub deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/237:54 pmSTL - TYS
1 stop22h 47mFrontier
Mon 9/17:10 pmTYS - STL
1 stop15h 01mFrontier
Deal found 7/30$215
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:00 amMCI - TYS
1 stop10h 38mMultiple Airlines
Sun 8/249:12 pmTYS - MCI
1 stop14h 27mMultiple Airlines
Deal found 7/30$226
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/285:15 amSTL - TYS
1 stop5h 15mAmerican Airlines
Sun 9/77:18 amTYS - STL
1 stop6h 05mAmerican Airlines
Deal found 7/30$229
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/285:00 amSGF - TYS
1 stop5h 30mAmerican Airlines
Sun 8/315:30 amTYS - SGF
1 stop6h 57mAmerican Airlines
Deal found 7/30$249
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:42 pmMCI - TYS
1 stop5h 06mDelta
Mon 8/256:14 pmTYS - MCI
1 stop4h 04mDelta
Deal found 7/31$249
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/86:56 pmSGF - TYS
1 stop4h 03mDelta
Tue 8/196:14 pmTYS - SGF
1 stop4h 51mDelta
Deal found 7/29$279
This FlightHub deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:51 pmMCI - TYS
1 stop22h 46mFrontier
Sun 10/128:22 pmTYS - MCI
1 stop23h 40mFrontier
Deal found 7/30$295
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/64:10 pmMCI - TYS
1 stop4h 51mAmerican Airlines
Tue 8/1210:36 amTYS - MCI
1 stop6h 04mAmerican Airlines
Deal found 7/30$309
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/316:00 amMCI - TYS
1 stop7h 50mUnited Airlines
Sat 9/62:30 pmTYS - MCI
2 stops8h 12mUnited Airlines
Deal found 7/30$324
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:11 pmSTL - TYS
1 stop5h 32mUnited Airlines
Tue 10/147:00 amTYS - STL
1 stop4h 49mUnited Airlines
Deal found 7/31$328
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1812:05 pmSTL - TYS
3 stops30h 54mMultiple Airlines
Sat 9/204:31 pmTYS - STL
2 stops19h 19mMultiple Airlines
Deal found 7/29$347

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 8/27

1:26 pm-7:03 pm

1 stop4h 37m

Knoxville McGhee Tyson

Sun 8/31

6:14 pm-10:02 pm

1 stop4h 48m

$214

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/23

7:54 pm-7:41 pm

1 stop22h 47m

Knoxville McGhee Tyson

Mon 9/1

7:10 pm-9:11 am

1 stop15h 01m

$215

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Wed 8/13

7:20 pm-4:29 pm

1 stop20h 09m

Knoxville McGhee Tyson

Sun 8/17

5:25 pm-7:04 pm

1 stop26h 39m

$218

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 8/22

6:00 am-5:38 pm

1 stop10h 38m

Knoxville McGhee Tyson

Sun 8/24

9:12 pm-10:39 am

1 stop14h 27m

$226

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 8/28

5:15 am-11:30 am

1 stop5h 15m

Knoxville McGhee Tyson

Sun 9/7

7:18 am-12:23 pm

1 stop6h 05m

$229

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 8/28

5:00 am-11:30 am

1 stop5h 30m

Knoxville McGhee Tyson

Sun 8/31

5:30 am-11:27 am

1 stop6h 57m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 8/22

5:42 pm-11:48 pm

1 stop5h 06m

Knoxville McGhee Tyson

Mon 8/25

6:14 pm-9:18 pm

1 stop4h 04m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Wed 8/6

4:10 pm-10:01 pm

1 stop4h 51m

Knoxville McGhee Tyson

Tue 8/12

10:36 am-3:40 pm

1 stop6h 04m

$309

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sun 8/3

8:25 am-3:18 pm

1 stop5h 53m

Knoxville McGhee Tyson

Sat 8/9

7:00 am-10:29 am

1 stop4h 29m

$324

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 10/9

5:11 pm-11:43 pm

1 stop5h 32m

Knoxville McGhee Tyson

Tue 10/14

7:00 am-10:49 am

1 stop4h 49m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 25 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $294). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Missouri to Knoxville. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,239 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $117. However, be on the lookout for offers from United Airlines and Allegiant Air, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $294). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$391FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$403FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$347FlexibilityNo cancel feeOn-timeN/A

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