What are the cheapest airlines to fly from Mexico to Knoxville one-way?

The cheapest airlines for a one-way flight from Mexico to Knoxville are American Airlines ($280), Delta ($391), and Aeromexico ($435).

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from MX to TYS?

When flying from Mexico to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What airport do you fly into for flights to Knoxville from Mexico?

If you book a flight to Knoxville from Mexico, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

Can I find deals for flights from Mexico to Knoxville that include hotel bookings?

Yes. In addition to deals on Mexico to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mexico to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico to Knoxville.

Can I find deals for business class flights from Mexico to Knoxville?

Yes. Cheapflights offers flight deals from Mexico to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$316+ Flights from Mexico to Knoxville

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Cheap flight deals from Mexico to Knoxville

Cheapest flights from Mexico to Knoxville
Explore the most affordable flight options available from Mexico to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

vie. 2/612:49 pm

SLP

TYS

2 stops23h 35m

United Airlines

lun. 2/96:45 am

TYS

SLP

2 stops30h 04m

United Airlines

Deal found 1/26

$647

vie. 2/68:00 am

MLM

TYS

2 stops25h 32m

United Airlines

dom. 2/811:07 am

TYS

MLM

2 stops33h 15m

United Airlines

Deal found 1/28

$714

Last-minute flights from Mexico to Knoxville
Discover last-minute flight deals from Mexico to Knoxville. Data last updated enero 29, 2026 and is based on user searches.

vie. 2/612:49 pm

SLP

TYS

2 stops23h 35m

United Airlines

lun. 2/96:45 am

TYS

SLP

2 stops30h 04m

United Airlines

Deal found 1/26

$647

vie. 2/68:00 am

MLM

TYS

1 stop10h 50m

United Airlines

dom. 2/82:25 pm

TYS

MLM

2 stops29h 57m

United Airlines

Deal found 1/28

$714

One-way flights from Mexico to Knoxville
Search for one-way flight options from Mexico to Knoxville. Find affordable one-way fares based on user searches. Data last updated enero 29, 2026.

mié. 5/136:10 am

SLP

TYS

2 stops10h 05m

Delta

Deal found 1/27

$316

jue. 5/147:12 am

SLP

TYS

2 stops49h 37m

United Airlines

Deal found 1/27

$322

mié. 5/133:10 pm

SLP

TYS

3 stops27h 40m

Multiple Airlines

Deal found 1/27

$421

jue. 5/143:10 pm

SLP

TYS

3 stops29h 41m

Multiple Airlines

Deal found 1/27

$529

Find flight deals from Mexico to Knoxville

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Popular in	December
Cheapest in	September
Average price	$542

Provider with most accurate pricing for Mexico City Benito Juarez-Knoxville McGhee Tyson flight deals.

Search Deals

Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Knoxville McGhee Tyson flights.

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($82 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($20 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in January 2026

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

San Luis PotosíKnoxville

SLP - TYS

SLPTYS

San Luis Potosi

mié. 5/13

9:40 am-6:15 pm

1 stop6h 35m

$316

San Luis PotosíKnoxville

SLP - TYS

SLPTYS

San Luis Potosi

jue. 5/14

9:40 am-6:15 pm

1 stop6h 35m

$316

San Luis PotosíKnoxville

SLP - TYS

SLPTYS

San Luis Potosi

jue. 5/14

7:12 am-10:49 am

2 stops49h 37m

$322

San Luis PotosíKnoxville

SLP - TYS

SLPTYS

San Luis Potosi

mié. 5/13

3:10 pm-8:50 pm

3 stops27h 40m

$421

San Luis PotosíKnoxville

SLP - TYS

SLPTYS

San Luis Potosi

jue. 5/14

3:10 pm-10:51 pm

3 stops29h 41m

$529

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Best time to book a flight from Mexico to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mexico with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico to Knoxville

What is the cheapest month to book a flight from Mexico to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Mexico to Knoxville (average of $446). Flying from Mexico to Knoxville in October is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

What airport do you fly into for flights to Knoxville from Mexico?
If you book a flight to Knoxville from Mexico, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.
What are the cheapest airlines to fly from Mexico to Knoxville one-way?
The cheapest airlines for a one-way flight from Mexico to Knoxville are American Airlines ($280), Delta ($391), and Aeromexico ($435).
Can I find deals for flights from Mexico to Knoxville that include hotel bookings?
Yes. In addition to deals on Mexico to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mexico to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico to Knoxville.
Can I find deals for business class flights from Mexico to Knoxville?
Yes. Cheapflights offers flight deals from Mexico to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mexico to Knoxville?
Currently, April is the cheapest month in which you can book a flight from Mexico to Knoxville (average of $446). Flying from Mexico to Knoxville in October is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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$316+ Cheap flights from Mexico to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mexico to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Mexico to Knoxville

Cheapest flights from Mexico to KnoxvilleExplore the most affordable flight options available from Mexico to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

Explore the most affordable flight options available from Mexico to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

Find flight deals from Mexico to Knoxville

Keep the following information in mind while searching for Mexico to Knoxville flight deals. Data was last updated enero 29, 2026.

Most accurate provider

Most trusted provider

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mexico to Knoxville that are best for you.

Best time to book a flight from Mexico to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mexico with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mexico to Knoxville

What is the cheapest month to book a flight from Mexico to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Mexico to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from Mexico?

What are the cheapest airlines to fly from Mexico to Knoxville one-way?

Can I find deals for flights from Mexico to Knoxville that include hotel bookings?

How can I find direct flights from Mexico to Knoxville?

Can I find deals for business class flights from Mexico to Knoxville?

What is the cheapest month to book a flight from Mexico to Knoxville?

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Cheapest flights from Mexico to Knoxville
Explore the most affordable flight options available from Mexico to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.