What are the cheapest airlines to fly from Mesa to Knoxville one-way?

The cheapest airlines for a one-way flight from Mesa to Knoxville are Frontier ($88), Allegiant Air ($92), and Delta ($136).

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the cheapest flights from Mesa to Knoxville?

The cheapest flight price from Mesa to Knoxville is $86. On average you can expect to pay $320. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $179.

What are the most popular airlines that fly from Mesa to Knoxville?

When booking a flight from Mesa to Knoxville, you may want to consider flying on Allegiant Air, American Airlines or Delta as they are the most popular for this route.

What is the cheapest time of day to fly from MS9 to TYS?

When flying from Mesa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What airport do you fly into for flights to Knoxville from Mesa?

If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 6 different airlines.

Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mesa to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

Can I find deals for business class flights from Mesa to Knoxville?

Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Mesa to Knoxville

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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 32 days in advance, depart on a Wednesday or Saturday and return on a Friday

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Popular in	December
Cheapest in	February
Average price	$368

Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

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Average for round-trip flights in November 2026

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Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Southwest

8.0

Very good

4,222 reviews

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Delta

7.8

Good

8,722 reviews

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

United Airlines

7.3

Good

10,486 reviews

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Allegiant Air

7.3

Good

675 reviews

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

American Airlines

7.0

Good

12,234 reviews

Southwest

8.0

Very good

4,222 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

What airport do you fly into for flights to Knoxville from Mesa?
If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 6 different airlines.
What are the cheapest airlines to fly from Mesa to Knoxville one-way?
The cheapest airlines for a one-way flight from Mesa to Knoxville are Frontier ($88), Allegiant Air ($92), and Delta ($136).
What are the cheapest flights from Mesa to Knoxville?
The cheapest flight price from Mesa to Knoxville is $86. On average you can expect to pay $320. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $179.
Can I find deals for flights from Mesa to Knoxville that include hotel bookings?
Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mesa to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.
Can I find deals for business class flights from Mesa to Knoxville?
Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 6 airlines flying from Mesa to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$62	Average$240	FlexibilityNo cancel fee	On-time62%
Allegiant Air	Cheapest$129	Average$260	FlexibilityNo cancel fee	On-time88%
Delta	Cheapest$199	Average$453	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$234	Average$458	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$293	Average$484	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$297	Average$481	FlexibilityNo cancel fee	On-time63%

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Find cheap flights from Mesa to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Mesa to Knoxville

Popular in

Cheapest in

Average price

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Knoxville from Mesa?

What are the cheapest airlines to fly from Mesa to Knoxville one-way?

What are the cheapest flights from Mesa to Knoxville?

Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

How can I find direct flights from Mesa to Knoxville?

Can I find deals for business class flights from Mesa to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Mesa to Knoxville by cabin class

Find flights from Mesa to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Other flights to Knoxville

Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 13, 2026.

Mesa and Knoxville flights

Browse other Mesa and Knoxville flight options. Last updated on November 13, 2026.

Popular flight searches

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Mesa to Knoxville flights

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Top 6 airlines flying from Mesa to Knoxville

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Cheap flights from Mesa, AZ to Knoxville (TYS)

Find cheap flights from Mesa to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Mesa to Knoxville

Popular in

Cheapest in

Average price

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Knoxville from Mesa?

What are the cheapest airlines to fly from Mesa to Knoxville one-way?

What are the cheapest flights from Mesa to Knoxville?

Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

How can I find direct flights from Mesa to Knoxville?

Can I find deals for business class flights from Mesa to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Mesa to Knoxville by cabin class

Find flights from Mesa to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Other flights to Knoxville

Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 13, 2026.

Mesa and Knoxville flights

Browse other Mesa and Knoxville flight options. Last updated on November 13, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Mesa to Knoxville flights

Consider these flights traveling from Mesa to Knoxville.

Top 6 airlines flying from Mesa to Knoxville

100% Free

Book with Flexibility

Travel Smart