Knoxville

$111+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Jun 1 — Jun 81
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 73 days in advance, depart on a Wednesday or Monday and return on a Friday

Cheap flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:01 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Sun 8/162:51 pm
TYS
-
PHX
Nonstop4h 10m
Allegiant Air
Deal found 4/29$123
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:22 pm
PHX
-
TYS
Nonstop3h 31m
Allegiant Air
Sun 9/132:34 pm
TYS
-
PHX
Nonstop3h 58m
Allegiant Air
Deal found 4/28$217
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:15 am
PHX
-
TYS
1 stop11h 09m
Frontier
Fri 5/298:19 pm
TYS
-
PHX
1 stop6h 10m
Frontier
Deal found 5/1$230
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:20 pm
PHX
-
TYS
Nonstop3h 36m
Multiple Airlines
Fri 8/148:32 pm
TYS
-
PHX
1 stop30h 00m
Multiple Airlines
Deal found 4/28$234
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:43 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Sun 10/251:52 pm
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Deal found 4/29$245
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:51 am
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Sun 10/46:00 am
TYS
-
PHX
Nonstop4h 01m
Allegiant Air
Deal found 4/30$254
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:20 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Sun 7/192:41 pm
TYS
-
PHX
Nonstop3h 49m
Allegiant Air
Deal found 4/30$264
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:20 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Thu 7/92:41 pm
TYS
-
PHX
Nonstop3h 49m
Allegiant Air
Deal found 4/28$267
This Expedia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:15 am
PHX
-
TYS
1 stop11h 09m
Frontier
Mon 5/258:19 pm
TYS
-
PHX
1 stop22h 04m
Frontier
Deal found 4/30$270

Find flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated May 2, 2026.

Round-trip from

$123
(Cheapflightsfares)

One-way from

$111
(Expedia)

Popular in

April

Cheapest in

February

Average price

$356
From Mesa to Knoxville McGhee Tyson
One-way flight from Mesa to Knoxville McGhee Tyson
Highest demand for flights based on searches. 17% potential increase in price ($64 potential increase over avg. RT price).
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 8/20

2:05 pm-10:56 pm

1 stop5h 51m

Knoxville McGhee Tyson

Mon 8/24

7:20 pm-10:47 pm

1 stop6h 27m

$399

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 9/13

9:10 pm-1:25 pm

2 stops13h 15m

Knoxville McGhee Tyson

Sat 9/19

6:50 am-11:30 am

2 stops7h 40m

$430

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 9/18

8:00 am-6:35 pm

2 stops7h 35m

Knoxville McGhee Tyson

Mon 9/21

2:05 pm-6:55 pm

1 stop7h 50m

$433

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 8/26

6:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Wed 9/2

6:30 am-2:54 pm

2 stops11h 24m

$434

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 8/11

6:40 pm-10:08 am

2 stops12h 28m

Knoxville McGhee Tyson

Tue 8/18

7:15 am-2:23 pm

2 stops10h 08m

$439

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 6/2

7:05 am-8:50 pm

2 stops10h 45m

Knoxville McGhee Tyson

Tue 6/9

7:10 am-1:30 pm

2 stops9h 20m

$478

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 6/2

10:06 am-12:30 am

2 stops11h 24m

Knoxville McGhee Tyson

Tue 6/9

5:57 pm-11:22 pm

1 stop8h 25m

$479

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 7/3

10:55 am-9:10 pm

2 stops7h 15m

Knoxville McGhee Tyson

Thu 7/9

6:40 am-12:35 pm

2 stops8h 55m

$497

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 7/1

9:05 am-9:15 pm

2 stops9h 10m

Knoxville McGhee Tyson

Wed 7/8

2:45 pm-9:55 pm

2 stops10h 10m

$503
Cheapest one-way

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 6/24

10:27 pm-11:59 am

2 stops34h 32m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How much does it cost to fly round-trip from Mesa to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 2, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 6 different airlines.

  • How long is the flight from Mesa to Knoxville?

    For as low as $399, Delta can have you in Knoxville from Mesa in 5h 51m. Mesa and Knoxville are separated by a distance of 1594 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Mesa to Knoxville are Allegiant Air ($65), Frontier ($92), and American Airlines ($125).

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $79. On average you can expect to pay $171. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $236.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top 6 airlines flying from Mesa to Knoxville

Discover the top 6 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$90Average$230FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$108Average$240FlexibilityNo cancel feeOn-time88%
DeltaCheapest$209Average$338FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$239Average$403FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$250Average$402FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$350Average$470FlexibilityNo cancel feeOn-time63%

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