$115+ Cheap flights from Mesa, AZ to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 81 days in advance, depart on a Wednesday or Saturday and return on a Friday
Cheap flight deals from Mesa to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to KnoxvilleExplore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Booking.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:30 pm -
Nonstop3h 36m
Sun 11/1512:29 pm -
Nonstop4h 01m
Deal found 9/18![Allegiant Air logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:30 pm -
Nonstop3h 36m
Sun 11/158:43 pm -
2 stops21h 29m
Deal found 9/20![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:50 pm -
2 stops25h 16m
Thu 11/126:30 am -
1 stop20h 12m
Deal found 9/21![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:43 pm -
Nonstop3h 27m
Fri 11/68:25 am -
2 stops31h 20m
Deal found 9/22![Multiple Airlines logo]()
$255
This Booking.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:03 pm -
Nonstop3h 29m
Sun 12/131:58 pm -
Nonstop4h 15m
Deal found 9/19![Allegiant Air logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:30 am -
1 stop10h 09m
Sun 11/19:29 pm -
1 stop22h 58m
Deal found 9/21![Multiple Airlines logo]()
$267
This Booking.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/244:51 pm -
Nonstop3h 23m
Fri 12/2512:54 pm -
Nonstop4h 11m
Deal found 9/22![Allegiant Air logo]()
$268
Best flights from Mesa to KnoxvilleDiscover carefully curated flight deals from Mesa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Mesa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:52 pm -
1 stop6h 53m
Fri 10/233:45 pm -
1 stop6h 43m
Deal found 9/18![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:00 am -
1 stop13h 35m
Mon 10/267:25 pm -
1 stop7h 50m
Deal found 9/20![Southwest logo]()
$394
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/61:40 pm -
1 stop5h 57m
Sat 3/134:00 pm -
1 stop6h 17m
Deal found 9/22![Delta logo]()
$501
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:50 pm -
2 stops13h 30m
Sun 11/157:05 am -
2 stops8h 40m
Deal found 9/18![Southwest logo]()
$419
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:21 am -
2 stops9h 11m
Tue 11/106:45 am -
2 stops10h 43m
Deal found 9/21![United Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
2 stops11h 49m
Tue 10/2010:42 am -
2 stops9h 32m
Deal found 9/21![United Airlines logo]()
$470
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:00 am -
1 stop7h 49m
Sat 10/3110:51 am -
2 stops12h 34m
Deal found 9/19![United Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:37 pm -
2 stops12h 16m
Fri 11/69:00 am -
2 stops14h 25m
Deal found 9/19![United Airlines logo]()
$554
Last-minute flights from Mesa to KnoxvilleDiscover last-minute flight deals from Mesa to Knoxville. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Knoxville. Data last updated September 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:51 am -
Nonstop3h 27m
Sun 10/259:29 pm -
1 stop24h 04m
Deal found 9/19![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:10 pm -
1 stop7h 22m
Fri 10/167:58 pm -
1 stop7h 01m
Deal found 9/17![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:10 pm -
1 stop7h 22m
Tue 10/201:58 pm -
1 stop8h 44m
Deal found 9/17![American Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:24 am -
1 stop6h 25m
Sat 10/2410:42 am -
1 stop7h 55m
Deal found 9/19![United Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:11 am -
Nonstop3h 27m
Mon 10/269:42 pm -
1 stop17h 48m
Deal found 9/21![Multiple Airlines logo]()
$280
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:25 pm -
1 stop9h 14m
Sat 10/315:40 am -
1 stop6h 29m
Deal found 9/17![Delta logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:01 am -
1 stop10h 54m
Thu 10/296:30 am -
1 stop20h 12m
Deal found 9/21![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:30 am -
1 stop10h 09m
Sun 11/19:29 pm -
1 stop22h 58m
Deal found 9/21![Multiple Airlines logo]()
$267
One-way flights from Mesa to KnoxvilleSearch for one-way flight options from Mesa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Mesa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This CheapOair deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:11 am -
Nonstop3h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Allegiant Air logo]()
$115
This CheapOair deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:03 pm -
Nonstop3h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Allegiant Air logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/253:43 pm -
Nonstop3h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Allegiant Air logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:15 am -
3 stops49h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:30 am -
1 stop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$131
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:10 pm -
1 stop7h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$146
Find flight deals from Mesa to Knoxville
Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated September 22, 2026.
Round-trip from | $215 (Travelocity) |
|---|---|
One-way from | $115 (CheapOair) |
Popular in | April |
Cheapest in | February |
Average price | $318 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Wed 10/28
7:05 am-3:26 pm
1 stop5h 21m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$146
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Mon 10/19
11:09 pm-9:38 am
1 stop7h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$160
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Wed 10/14
10:25 am-9:55 pm
1 stop8h 30m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$160
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Tue 10/20
6:00 am-5:28 pm
1 stop8h 28m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$160
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Mon 10/19
8:51 pm-11:29 am
3 stops59h 38m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$168
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Tue 1/19
8:10 pm-11:02 am
2 stops12h 52m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$201
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Sun 10/18
11:52 pm-9:45 am
1 stop6h 53m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$205
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Fri 12/11
12:51 pm-11:59 pm
2 stops9h 08m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$206
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Wed 10/28
12:00 pm-11:59 pm
2 stops8h 59m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$225
PhoenixKnoxville
PHX Phoenix Sky Harbor Intl - TYS Knoxville McGhee Tyson
PHXTYS
Phoenix Sky Harbor Intl
Fri 10/16
11:52 pm-9:45 am
1 stop6h 53m
Knoxville McGhee Tyson
Fri 10/23
3:45 pm-7:28 pm
1 stop6h 43m
$389
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Mesa to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
PHX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Knoxville
MS9-TYS
PHX-TYS
How much does it cost to fly round-trip from Mesa to Knoxville?
Airfare is typical for this route at the moment.
Mesa to Knoxville flights typically cost between $213 and $430 in February.The cheapest round-trip price found within the last 5 days was $215 on Allegiant Air (Feb 18-Feb 21).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 22, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
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Popular flight searches
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Consider these flights traveling from Mesa to Knoxville.
Top 6 airlines flying from Mesa to Knoxville
Discover the top 6 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$90 | Average$240 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$133 | Average$252 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$199 | Average$462 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$234 | Average$458 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$469 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$470 | FlexibilityNo cancel fee | On-time63% |