$93+ Cheap flights from Mesa, AZ to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 73 days in advance, depart on a Wednesday or Friday and return on a Thursday
Cheap flight deals from Mesa to Knoxville
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Cheapest flights from Mesa to KnoxvilleExplore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:01 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Sun 8/162:51 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$153
This Booking.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$159
This Cheapflightsfares deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Sun 8/232:39 pm
TYS
- PHX
Nonstop3h 47m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$163
This CheapOair deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/24:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$183
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/304:16 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Sun 9/62:34 pm
TYS
- PHX
Nonstop3h 58m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$186
This Cheapflightsfares deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/33:38 pm
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Thu 10/86:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:01 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Sun 8/167:00 am
TYS
- PHX
1 stop27h 40m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$211
This Cheapflightsfares deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Sun 10/46:00 am
TYS
- PHX
Nonstop4h 01m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$213
This Booking.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$216
Best flights from Mesa to KnoxvilleDiscover carefully curated flight deals from Mesa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Mesa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:45 am
PHX
- TYS
2 stops7h 45m
Southwest
Tue 8/257:00 am
TYS
- PHX
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:55 pm
PHX
- TYS
2 stops12h 42m
United Airlines
Wed 9/27:00 am
TYS
- PHX
2 stops14h 00m
United Airlines
Deal found 6/11![United Airlines logo]()
$370
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:00 pm
PHX
- TYS
1 stop5h 52m
Delta
Sun 9/66:00 am
TYS
- PHX
1 stop6h 06m
Delta
Deal found 6/15![Delta logo]()
$374
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:05 am
PHX
- TYS
1 stop5h 20m
Southwest
Sat 8/296:50 am
TYS
- PHX
2 stops6h 45m
Southwest
Deal found 6/14![Southwest logo]()
$374
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2611:05 pm
PHX
- TYS
1 stop11h 40m
Southwest
Fri 7/316:40 am
TYS
- PHX
2 stops9h 35m
Southwest
Deal found 6/15![Southwest logo]()
$410
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:54 pm
PHX
- TYS
2 stops11h 49m
United Airlines
Sun 8/26:00 am
TYS
- PHX
1 stop9h 26m
United Airlines
Deal found 6/10![United Airlines logo]()
$544
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/298:10 am
PHX
- TYS
2 stops9h 15m
Southwest
Sun 8/27:00 pm
TYS
- PHX
2 stops8h 25m
Southwest
Deal found 6/15![Southwest logo]()
$488
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:55 pm
PHX
- TYS
2 stops12h 42m
United Airlines
Sun 8/237:00 am
TYS
- PHX
1 stop8h 56m
United Airlines
Deal found 6/10![United Airlines logo]()
$544
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:54 pm
PHX
- TYS
2 stops11h 49m
United Airlines
Sat 7/186:00 am
TYS
- PHX
1 stop8h 03m
United Airlines
Deal found 6/12![United Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:59 pm
PHX
- TYS
2 stops12h 43m
United Airlines
Wed 7/1512:10 pm
TYS
- PHX
1 stop8h 30m
United Airlines
Deal found 6/14![United Airlines logo]()
$564
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:00 am
PHX
- TYS
2 stops8h 15m
Southwest
Fri 7/177:30 am
TYS
- PHX
2 stops13h 55m
Southwest
Deal found 6/10![Southwest logo]()
$569
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:59 pm
PHX
- TYS
2 stops12h 43m
United Airlines
Mon 7/276:00 am
TYS
- PHX
1 stop8h 03m
United Airlines
Deal found 6/11![United Airlines logo]()
$569
Last-minute flights from Mesa to KnoxvilleDiscover last-minute flight deals from Mesa to Knoxville. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Knoxville. Data last updated June 15, 2026 and is based on user searches.
This Gotogate deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:20 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Mon 7/138:19 pm
TYS
- PHX
1 stop6h 13m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$306
This Priceline deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:40 am
PHX
- TYS
1 stop9h 44m
Frontier
Fri 7/178:19 pm
TYS
- PHX
1 stop6h 13m
Frontier
Deal found 6/11![Frontier logo]()
$305
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Sun 7/192:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$264
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/194:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Thu 7/302:41 pm
TYS
- PHX
Nonstop3h 49m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/194:20 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Thu 7/303:38 pm
TYS
- PHX
2 stops31h 06m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:48 pm
PHX
- TYS
1 stop18h 03m
Multiple Airlines
Mon 7/272:47 pm
TYS
- PHX
1 stop25h 12m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$292
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:53 pm
PHX
- TYS
1 stop21h 31m
Frontier
Mon 7/278:19 pm
TYS
- PHX
1 stop22h 24m
Frontier
Deal found 6/15![Frontier logo]()
$295
This Booking.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Thu 8/63:01 pm
TYS
- PHX
Nonstop4h 10m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Multiple Airlines
Thu 8/67:00 am
TYS
- PHX
1 stop19h 27m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$238
One-way flights from Mesa to KnoxvilleSearch for one-way flight options from Mesa to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Mesa to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$98
This Cheapflightsfares deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:22 pm
PHX
- TYS
Nonstop3h 31m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$130
This Priceline deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
PHX
- TYS
1 stop9h 44m
Frontier
Deal found 6/13![Frontier logo]()
$136
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:48 pm
PHX
- TYS
1 stop23h 36m
Frontier
Deal found 6/12![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:45 am
PHX
- TYS
2 stops28h 14m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:55 pm
PHX
- TYS
1 stop16h 18m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:20 pm
PHX
- TYS
Nonstop3h 36m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$152
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:00 am
PHX
- TYS
1 stop8h 55m
Delta
Deal found 6/12![Delta logo]()
$156
This Cheapflightsfares deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:51 am
PHX
- TYS
Nonstop3h 27m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$159
Find flight deals from Mesa to Knoxville
Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated June 15, 2026.
Round-trip from | $159 (Booking.com) |
|---|---|
One-way from | $93 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Tue 8/18
5:45 am-4:30 pm
2 stops7h 45m
Knoxville McGhee Tyson
Tue 8/25
7:00 am-12:20 pm
2 stops8h 20m
$270
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Wed 8/26
6:55 pm-10:37 am
2 stops12h 42m
Knoxville McGhee Tyson
Wed 9/2
7:00 am-6:00 pm
2 stops14h 00m
$370
Quickest round-trip
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Fri 9/4
3:00 pm-11:52 pm
1 stop5h 52m
Knoxville McGhee Tyson
Sun 9/6
6:00 am-9:06 am
1 stop6h 06m
$374
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Fri 8/28
5:05 am-1:25 pm
1 stop5h 20m
Knoxville McGhee Tyson
Sat 8/29
6:50 am-10:35 am
2 stops6h 45m
$374
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Sun 7/26
11:05 pm-1:45 pm
1 stop11h 40m
Knoxville McGhee Tyson
Fri 7/31
6:40 am-1:15 pm
2 stops9h 35m
$410
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Wed 7/29
8:10 am-8:25 pm
2 stops9h 15m
Knoxville McGhee Tyson
Sun 8/2
7:00 pm-12:25 am
2 stops8h 25m
$488
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Fri 7/31
6:54 pm-9:43 am
2 stops11h 49m
Knoxville McGhee Tyson
Sun 8/2
6:00 am-12:26 pm
1 stop9h 26m
$544
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Thu 8/20
6:55 pm-10:37 am
2 stops12h 42m
Knoxville McGhee Tyson
Sun 8/23
7:00 am-12:56 pm
1 stop8h 56m
$544
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Thu 7/9
6:54 pm-9:43 am
2 stops11h 49m
Knoxville McGhee Tyson
Sat 7/18
6:00 am-11:03 am
1 stop8h 03m
$563
PhoenixKnoxville
PHX - TYS
PHXTYS
Phoenix Sky Harbor Intl
Wed 7/8
6:59 pm-10:42 am
2 stops12h 43m
Knoxville McGhee Tyson
Wed 7/15
12:10 pm-5:40 pm
1 stop8h 30m
$564
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Mesa to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
PHX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Knoxville
MS9-TYS
PHX-TYS
How much does it cost to fly round-trip from Mesa to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 15, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Overall
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Alternative routes for Mesa to Knoxville
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Complete your trip
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Search flights from Mesa to Knoxville by cabin class
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Mesa and Knoxville flights
Browse other Mesa and Knoxville flight options. Last updated on June 15, 2026.
Popular flight searches
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Mesa to Knoxville flights
Consider these flights traveling from Mesa to Knoxville.
Top 6 airlines flying from Mesa to Knoxville
Discover the top 6 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$90 | Average$240 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$117 | Average$243 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$199 | Average$453 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$234 | Average$458 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$261 | Average$438 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$350 | Average$481 | FlexibilityNo cancel fee | On-time63% |