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Knoxville

$109+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 73 days in advance, depart on a Wednesday or Friday and return on a Friday

Cheap flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Mytrip deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:15 pm
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Sun 4/128:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Deal found 3/8$190
This Booking.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Sun 4/128:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Deal found 3/7$192
This Booking.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:20 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Thu 7/162:41 pm
TYS
-
PHX
Nonstop3h 49m
Allegiant Air
Deal found 3/9$193
This CheapOair deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:58 pm
PHX
-
TYS
1 stop19h 15m
Frontier
Mon 6/18:08 pm
TYS
-
PHX
1 stop16h 52m
Frontier
Deal found 3/8$201
This Booking.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Sun 4/198:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Deal found 3/6$209
This Booking.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Thu 5/282:49 pm
TYS
-
PHX
Nonstop4h 10m
Allegiant Air
Deal found 3/7$211
This Booking.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:20 pm
PHX
-
TYS
Nonstop3h 32m
Allegiant Air
Sun 6/142:42 pm
TYS
-
PHX
Nonstop3h 48m
Allegiant Air
Deal found 3/6$215
This Cheapflightsfares deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Sun 4/268:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Deal found 3/5$217

Find flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated March 10, 2026.

Round-trip from

$190
(Mytrip)

One-way from

$109
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$346
From Mesa to Knoxville McGhee Tyson
Search Deals
One-way flight from Mesa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 4/25

6:40 am-6:30 pm

2 stops8h 50m

Knoxville McGhee Tyson

Sat 5/2

5:40 pm-10:30 pm

1 stop7h 50m

$334

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 4/19

6:00 am-3:06 pm

1 stop6h 06m

Knoxville McGhee Tyson

Wed 4/22

9:00 am-2:17 pm

1 stop8h 17m

$354

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 4/18

5:30 am-6:30 pm

2 stops10h 00m

Knoxville McGhee Tyson

Wed 4/22

8:15 am-3:15 pm

2 stops10h 00m

$358

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 4/11

10:05 am-7:35 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 4/14

7:05 am-12:25 pm

2 stops8h 20m

$359
Quickest round-trip

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 5/20

8:00 am-6:11 pm

1 stop7h 11m

Knoxville McGhee Tyson

Sun 5/24

7:15 am-10:34 am

1 stop6h 19m

$380

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 4/15

10:30 am-7:56 pm

1 stop6h 26m

Knoxville McGhee Tyson

Sat 4/18

2:25 pm-7:49 pm

1 stop8h 24m

$419

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 5/4

6:44 pm-10:49 am

2 stops13h 05m

Knoxville McGhee Tyson

Tue 5/12

7:00 am-2:28 pm

2 stops10h 28m

$428

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 4/15

12:48 pm-11:08 pm

1 stop7h 20m

Knoxville McGhee Tyson

Sun 4/19

7:00 am-4:54 pm

2 stops12h 54m

$449

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 5/7

7:00 am-4:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 5/12

9:50 am-8:19 pm

2 stops13h 29m

$473

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 5/7

11:47 pm-10:49 am

1 stop8h 02m

Knoxville McGhee Tyson

Sat 5/9

7:00 am-5:08 pm

2 stops13h 08m

$473

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Showing 1-10 of 22 resultsSorted by cheapest first
1
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3

Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on March 6, 2026.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 73 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in December is currently the most expensive (average of $162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 10, 2026.

When flying from Mesa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 10, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,409 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.3
Good
714 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,415 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Frontier
5.7
Fair
3,033 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • How long is the flight from Mesa to Knoxville?

    For as low as $354, Southwest can have you in Knoxville from Mesa in 6h 06m. Mesa and Knoxville are separated by a distance of 1594 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Mesa to Knoxville are Allegiant Air ($65), Frontier ($92), and American Airlines ($125).

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $109. On average you can expect to pay $274. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $193.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in December is currently the most expensive (average of $162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$96Average$240FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$108Average$227FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$170Average$413FlexibilityNo cancel feeOn-time69%
DeltaCheapest$209Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$378FlexibilityNo cancel feeOn-time71%

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