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Knoxville

$64+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in January or February, booked 47 days in advance, depart on a Monday or Sunday and return on a Tuesday

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated August 16, 2025.

Round-trip from

$102
(Mytrip)

One-way from

$64
(Cheapflightsfares)

Popular in

December

Cheapest in

January

Average price

$288
From Mesa to Knoxville McGhee Tyson
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One-way flight from Mesa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 5% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/44:19 pmPHX - TYS
Nonstop3h 31mAllegiant Air
Thu 9/112:33 pmTYS - PHX
Nonstop3h 56mAllegiant Air
Deal found 8/15$102
This Booking.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/44:19 pmPHX - TYS
Nonstop3h 31mAllegiant Air
Sun 9/72:33 pmTYS - PHX
Nonstop3h 56mAllegiant Air
Deal found 8/15$141
This Cheapflightsfares deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/214:19 pmPHX - TYS
Nonstop3h 31mAllegiant Air
Thu 9/252:33 pmTYS - PHX
Nonstop3h 56mAllegiant Air
Deal found 8/15$144
This Priceline deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/118:37 amPHX - TYS
1 stop8h 13mFrontier
Mon 9/158:35 pmTYS - PHX
1 stop6h 22mFrontier
Deal found 8/14$152
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/213:57 pmPHX - TYS
Nonstop3h 27mAllegiant Air
Thu 8/281:52 pmTYS - PHX
Nonstop4h 15mAllegiant Air
Deal found 8/14$157
This Cheapflightsfares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:49 amPHX - TYS
Nonstop3h 30mAllegiant Air
Sat 10/1812:45 pmTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 8/14$159
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/159:02 amPHX - TYS
1 stop7h 43mFrontier
Thu 9/188:40 pmTYS - PHX
1 stop5h 47mFrontier
Deal found 8/14$168
This Priceline deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/229:05 amPHX - TYS
1 stop7h 40mFrontier
Mon 9/298:35 pmTYS - PHX
1 stop6h 22mFrontier
Deal found 8/16$172
This Booking.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:02 amPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 10/192:23 pmTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 8/15$181
This Cheapflightsfares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:02 amPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 10/262:23 pmTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 8/14$182
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/254:19 pmPHX - TYS
Nonstop3h 31mAllegiant Air
Sun 9/282:33 pmTYS - PHX
Nonstop3h 56mAllegiant Air
Deal found 8/14$196

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 9/4

4:19 pm-10:50 pm

Nonstop3h 31m

Knoxville McGhee Tyson

Thu 9/11

2:33 pm-3:29 pm

Nonstop3h 56m

$102

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 9/4

4:19 pm-10:50 pm

Nonstop3h 31m

Knoxville McGhee Tyson

Sun 9/7

2:33 pm-3:29 pm

Nonstop3h 56m

$141

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 9/21

4:19 pm-10:50 pm

Nonstop3h 31m

Knoxville McGhee Tyson

Thu 9/25

2:33 pm-3:29 pm

Nonstop3h 56m

$144

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 9/11

8:37 am-7:50 pm

1 stop8h 13m

Knoxville McGhee Tyson

Mon 9/15

8:35 pm-11:57 pm

1 stop6h 22m

$152

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 9/11

8:37 am-7:50 pm

1 stop8h 13m

Knoxville McGhee Tyson

Thu 9/18

8:40 pm-11:27 pm

1 stop5h 47m

$152

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 9/4

11:09 am-7:50 pm

1 stop5h 41m

Knoxville McGhee Tyson

Thu 9/11

8:40 pm-11:27 pm

1 stop5h 47m

$152

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 10/13

11:49 am-6:19 pm

Nonstop3h 30m

Knoxville McGhee Tyson

Sat 10/18

12:45 pm-1:44 pm

Nonstop3h 59m

$159

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 9/15

9:02 am-7:45 pm

1 stop7h 43m

Knoxville McGhee Tyson

Thu 9/18

8:40 pm-11:27 pm

1 stop5h 47m

$168

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 10/17

8:02 am-2:28 pm

Nonstop3h 26m

Knoxville McGhee Tyson

Sun 10/19

2:23 pm-3:22 pm

Nonstop3h 59m

$181

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 10/17

8:02 am-2:28 pm

Nonstop3h 26m

Knoxville McGhee Tyson

Sun 10/26

2:23 pm-3:22 pm

Nonstop3h 59m

$182

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 19 results
1
2

Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on August 8, 2025.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $294). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

When flying from Mesa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to Knoxville flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,985 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
701 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.8
Fair
3,211 reviews
Delta
8.0
Very good
7,985 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $64. On average you can expect to pay $131. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $102.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $294). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$96Average$260FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$113Average$216FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$261Average$454FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$263Average$465FlexibilityNo cancel feeOn-time69%
DeltaCheapest$269Average$355FlexibilityNo cancel feeOn-timeN/A

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