Knoxville

$85+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Feb 14 — Feb 211
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 88 days in advance, depart on a Wednesday or Friday and return on a Friday

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated January 15, 2026.

Round-trip from

$167
(Mytrip)

One-way from

$85
(Super.com)

Popular in

March

Cheapest in

February

Average price

$240
From Mesa to Knoxville McGhee Tyson
One-way flight from Mesa to Knoxville McGhee Tyson
High demand for flights, 1% potential price rise
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Average for round-trip flights in January 2026

Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Mytrip deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1212:25 pm
PHX
-
TYS
Nonstop3h 27m
Allegiant Air
Sun 2/228:30 am
TYS
-
PHX
Nonstop4h 35m
Allegiant Air
Deal found 1/14$167
This Booking.com deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:54 am
PHX
-
TYS
Nonstop3h 23m
Allegiant Air
Sun 3/18:30 am
TYS
-
PHX
Nonstop4h 34m
Allegiant Air
Deal found 1/15$174
This Gotogate deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/51:21 pm
PHX
-
TYS
Nonstop3h 23m
Allegiant Air
Sun 2/228:30 am
TYS
-
PHX
Nonstop4h 35m
Allegiant Air
Deal found 1/13$182
This Booking.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:56 am
PHX
-
TYS
Nonstop3h 24m
Allegiant Air
Sun 4/198:00 am
TYS
-
PHX
Nonstop4h 06m
Allegiant Air
Deal found 1/13$183
This Mytrip deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:51 pm
PHX
-
TYS
1 stop17h 15m
Frontier
Mon 3/28:13 pm
TYS
-
PHX
1 stop14h 29m
Frontier
Deal found 1/13$189
This Gotogate deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:54 am
PHX
-
TYS
Nonstop3h 23m
Multiple Airlines
Mon 3/28:13 pm
TYS
-
PHX
1 stop6h 28m
Multiple Airlines
Deal found 1/13$197
This Gotogate deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/59:22 am
PHX
-
TYS
1 stop28h 08m
Multiple Airlines
Sun 2/228:30 am
TYS
-
PHX
Nonstop4h 35m
Multiple Airlines
Deal found 1/13$202
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/24:16 pm
PHX
-
TYS
Nonstop3h 36m
Allegiant Air
Thu 8/62:51 pm
TYS
-
PHX
Nonstop4h 10m
Allegiant Air
Deal found 1/12$209
This Mytrip deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/291:16 pm
PHX
-
TYS
Nonstop3h 23m
Allegiant Air
Sun 2/110:00 am
TYS
-
PHX
Nonstop4h 26m
Allegiant Air
Deal found 1/13$210
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:52 am
PHX
-
TYS
1 stop7h 14m
Frontier
Mon 3/28:13 pm
TYS
-
PHX
1 stop14h 29m
Frontier
Deal found 1/13$214
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1212:25 pm
PHX
-
TYS
Nonstop3h 27m
Multiple Airlines
Sun 2/225:56 pm
TYS
-
PHX
2 stops32h 59m
Multiple Airlines
Deal found 1/14$222

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 2/12

12:25 pm-5:52 pm

Nonstop3h 27m

Knoxville McGhee Tyson

Sun 2/22

8:30 am-11:05 am

Nonstop4h 35m

$167

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 2/26

10:51 pm-6:06 pm

1 stop17h 15m

Knoxville McGhee Tyson

Mon 3/2

8:13 pm-8:42 am

1 stop14h 29m

$189

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 2/26

1:22 pm-6:06 pm

1 stop26h 44m

Knoxville McGhee Tyson

Sun 3/1

8:30 am-11:04 am

Nonstop4h 34m

$202

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 2/13

6:00 am-7:27 pm

1 stop11h 27m

Knoxville McGhee Tyson

Sun 2/22

8:30 am-11:05 am

Nonstop4h 35m

$238

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 2/13

6:00 am-7:27 pm

1 stop11h 27m

Knoxville McGhee Tyson

Fri 2/20

8:12 pm-6:11 pm

1 stop23h 59m

$239

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 2/19

11:55 am-5:22 pm

Nonstop3h 27m

Knoxville McGhee Tyson

Sat 2/21

9:24 pm-3:27 pm

2 stops20h 03m

$275

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 3/12

1:00 pm-7:28 pm

Nonstop3h 28m

Knoxville McGhee Tyson

Sun 3/15

10:54 am-12:10 pm

Nonstop4h 16m

$276

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 2/10

2:33 pm-11:59 pm

1 stop7h 26m

Knoxville McGhee Tyson

Tue 2/17

5:47 pm-11:51 pm

1 stop8h 04m

$289

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 2/6

7:00 am-3:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Fri 2/13

8:12 pm-12:41 am

1 stop6h 29m

$295

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 4/7

10:29 pm-9:16 am

1 stop7h 47m

Knoxville McGhee Tyson

Sat 4/11

5:20 pm-9:14 pm

1 stop6h 54m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 21 results
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Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on January 9, 2026.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 88 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in December is currently the most expensive (average of $162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 15, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Boarding

8.1

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • How long is the flight from Mesa to Knoxville?

    For as low as $167, Allegiant Air can have you in Knoxville from Mesa in 3h 27m. Mesa and Knoxville are separated by a distance of 1594 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Mesa to Knoxville are Allegiant Air ($65), Frontier ($92), and United Airlines ($114).

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $66. On average you can expect to pay $181. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $167.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in December is currently the most expensive (average of $162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$96Average$255FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$108Average$223FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$170Average$416FlexibilityNo cancel feeOn-time69%
DeltaCheapest$209Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$403FlexibilityNo cancel feeOn-time71%

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