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Knoxville

$71+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 47 days in advance, depart on a Wednesday or Friday and return on a Friday

Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This Booking.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 1/1110:00 amTYS - PHX
Nonstop4h 26mAllegiant Air
Deal found 11/24$142
This Booking.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Thu 12/112:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Deal found 11/24$164
This Cheapflightsfares deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 12/72:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Deal found 11/25$166
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:56 pmPHX - TYS
Nonstop3h 26mMultiple Airlines
Mon 12/154:52 pmTYS - PHX
1 stop9h 52mMultiple Airlines
Deal found 11/26$176
This Priceline deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:00 amPHX - TYS
1 stop6h 57mFrontier
Thu 12/114:52 pmTYS - PHX
1 stop6h 29mFrontier
Deal found 11/24$182

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated November 26, 2025.

Round-trip from

$142
(Booking.com)

One-way from

$71
(Cheapflightsfares)

Popular in

March

Cheapest in

February

Average price

$313
From Mesa to Knoxville McGhee Tyson
Search Deals
One-way flight from Mesa to Knoxville McGhee Tyson
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 1/18

1:16 pm-6:39 pm

Nonstop3h 23m

Knoxville McGhee Tyson

Thu 1/22

10:00 am-12:26 pm

Nonstop4h 26m

$168

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 12/18

4:56 pm-10:22 pm

Nonstop3h 26m

Knoxville McGhee Tyson

Tue 12/23

12:21 pm-2:26 pm

Nonstop4h 05m

$231

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 1/4

4:56 pm-10:22 pm

Nonstop3h 26m

Knoxville McGhee Tyson

Fri 1/9

7:35 am-5:01 pm

1 stop11h 26m

$253

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 12/12

7:00 am-7:14 pm

2 stops10h 14m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-8:06 am

1 stop27h 36m

$283

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 1/7

3:05 pm-11:09 pm

1 stop6h 04m

Knoxville McGhee Tyson

Fri 1/9

6:09 pm-11:40 pm

1 stop7h 31m

$301

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 1/6

1:01 pm-11:09 pm

1 stop8h 08m

Knoxville McGhee Tyson

Sun 1/11

5:40 am-10:30 am

1 stop6h 50m

$320

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 2/11

7:15 am-11:45 pm

2 stops14h 30m

Knoxville McGhee Tyson

Sun 2/15

6:55 am-12:24 pm

1 stop7h 29m

$328

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 2/11

9:30 am-7:50 pm

1 stop8h 20m

Knoxville McGhee Tyson

Mon 2/16

6:45 am-2:30 pm

1 stop9h 45m

$344

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 1/5

11:53 pm-10:15 am

1 stop8h 22m

Knoxville McGhee Tyson

Sun 1/11

6:09 pm-11:40 pm

1 stop7h 31m

$399

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 1/4

12:45 am-10:15 am

1 stop7h 30m

Knoxville McGhee Tyson

Mon 1/12

11:07 am-7:45 pm

2 stops10h 38m

$474

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 18 results
1
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Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on November 21, 2025.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in September is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

It’s typically best to fly out from Mesa to Knoxville at noon. Doing so could potentially save you 69% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mesa to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to Knoxville flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 26, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
700 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Frontier
5.8
Fair
3,099 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • How long is the flight from Mesa to Knoxville?

    For as low as $168, Allegiant Air can have you in Knoxville from Mesa in 3h 23m. Mesa and Knoxville are separated by a distance of 1594 mi. Most flights are nonstop.

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $103. On average you can expect to pay $219. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $168.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in September is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$114Average$223FlexibilityNo cancel feeOn-time88%
FrontierCheapest$119Average$260FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$250Average$460FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$250Average$418FlexibilityNo cancel feeOn-time71%
DeltaCheapest$269Average$338FlexibilityNo cancel feeOn-timeN/A

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