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Knoxville

$100+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in February or January, booked 47 days in advance, depart on a Friday or Monday and return on a Tuesday

Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 12/142:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Deal found 10/15$168
This Booking.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/234:12 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Fri 10/246:00 amTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 10/14$170
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:56 pmPHX - TYS
Nonstop3h 26mMultiple Airlines
Sun 12/76:30 amTYS - PHX
1 stop27h 36mMultiple Airlines
Deal found 10/14$172
This FlightHub deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:56 pmPHX - TYS
Nonstop3h 26mAllegiant Air
Sun 12/72:01 pmTYS - PHX
Nonstop4h 05mAllegiant Air
Deal found 10/16$179
This Booking.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/234:12 pmPHX - TYS
Nonstop3h 30mAllegiant Air
Mon 10/2710:00 amTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 10/14$182
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:36 pmPHX - TYS
Nonstop3h 22mAllegiant Air
Sun 11/162:34 pmTYS - PHX
Nonstop4h 12mAllegiant Air
Deal found 10/14$201
This Booking.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2011:49 amPHX - TYS
Nonstop3h 30mAllegiant Air
Mon 10/2710:00 amTYS - PHX
Nonstop3h 59mAllegiant Air
Deal found 10/14$204
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:11 pmPHX - TYS
1 stop21h 11mMultiple Airlines
Sun 11/27:00 amTYS - PHX
1 stop27h 24mMultiple Airlines
Deal found 10/14$210

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated October 16, 2025.

Round-trip from

$168
(Cheapflightsfares)

One-way from

$100
(Cheapflightsfares)

Popular in

March

Cheapest in

February

Average price

$298
From Mesa to Knoxville McGhee Tyson
Search Deals
One-way flight from Mesa to Knoxville McGhee Tyson
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High demand for flights, 2% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 11/12

3:12 pm-11:59 pm

1 stop6h 47m

Knoxville McGhee Tyson

Wed 11/19

8:26 am-2:10 pm

1 stop7h 44m

$251

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 11/8

11:59 pm-9:37 am

1 stop7h 38m

Knoxville McGhee Tyson

Tue 11/11

6:00 pm-12:08 am

1 stop8h 08m

$251

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 11/4

12:30 am-9:50 am

1 stop7h 20m

Knoxville McGhee Tyson

Sat 11/15

4:15 pm-11:26 pm

1 stop9h 11m

$251

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 12/4

4:35 pm-11:50 pm

1 stop5h 15m

Knoxville McGhee Tyson

Tue 12/9

5:25 am-12:13 pm

1 stop8h 48m

$280

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 10/27

11:49 am-6:19 pm

Nonstop3h 30m

Knoxville McGhee Tyson

Sat 11/1

6:12 pm-11:29 pm

3 stops56h 17m

$304

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 10/31

10:58 am-10:03 am

1 stop20h 05m

Knoxville McGhee Tyson

Sun 11/2

1:16 pm-11:29 pm

2 stops36h 13m

$316

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 11/4

8:30 am-5:08 pm

1 stop6h 38m

Knoxville McGhee Tyson

Wed 11/12

10:50 am-9:30 pm

2 stops12h 40m

$346

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 11/5

12:39 pm-10:55 pm

1 stop8h 16m

Knoxville McGhee Tyson

Sat 11/15

7:00 am-3:26 pm

2 stops10h 26m

$346

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 11/8

1:25 pm-11:44 pm

1 stop8h 19m

Knoxville McGhee Tyson

Tue 11/11

9:10 am-9:21 pm

2 stops14h 11m

$346

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 12/5

5:00 pm-1:11 pm

2 stops42h 11m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 16 results
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Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on October 10, 2025.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in September is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s typically best to fly out from Mesa to Knoxville at noon. Doing so could potentially save you 68% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mesa to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to Knoxville flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Mesa to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,041 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Allegiant Air
7.2
Good
693 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Frontier
5.8
Fair
3,137 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • How long is the flight from Mesa to Knoxville?

    For as low as $251, United Airlines can have you in Knoxville from Mesa in 6h 47m. Mesa and Knoxville are separated by a distance of 1594 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $78. On average you can expect to pay $201. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $168.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $88). Flying from Mesa to Knoxville in September is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$108Average$260FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$114Average$221FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$250Average$462FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$251Average$437FlexibilityNo cancel feeOn-time71%
DeltaCheapest$269Average$342FlexibilityNo cancel feeOn-timeN/A

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