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$319+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$319
(American Airlines)

Popular in

March

Cheapest in

December

Average price

$458
Provider with most accurate pricing for Medford-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Medford-Knoxville McGhee Tyson flights.
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From Medford to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 15% potential increase in price ($115 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Medford to Knoxville

Cheapest flights from Medford to Knoxville
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:36 pmMFR - TYS
2 stops13h 12mUnited Airlines
Wed 11/124:55 pmTYS - MFR
1 stop7h 19mUnited Airlines
Deal found 10/26$422
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:00 amMFR - TYS
1 stop7h 51mUnited Airlines
Mon 11/176:45 amTYS - MFR
3 stops18h 45mUnited Airlines
Deal found 10/26$479
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:20 amMFR - TYS
2 stops12h 43mAmerican Airlines
Mon 11/175:10 amTYS - MFR
2 stops11h 49mAmerican Airlines
Deal found 10/27$507
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:36 pmMFR - TYS
2 stops13h 12mUnited Airlines
Wed 11/124:55 pmTYS - MFR
1 stop7h 19mUnited Airlines
Deal found 10/26$540

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Medford

Fly to

Knoxville

Route

Depart

Return

Price

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Thu 1/8

6:00 pm-9:45 am

2 stops12h 45m

Knoxville McGhee Tyson

Sat 1/17

7:54 am-7:38 pm

2 stops14h 44m

$319

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 2/24

6:05 am-9:32 pm

2 stops12h 27m

Knoxville McGhee Tyson

Sat 2/28

6:45 am-1:03 pm

2 stops9h 18m

$364

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 11/10

5:00 am-3:51 pm

1 stop7h 51m

Knoxville McGhee Tyson

Mon 11/17

6:45 am-10:30 pm

3 stops18h 45m

$479

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Thu 1/8

5:00 am-3:14 pm

1 stop7h 14m

Knoxville McGhee Tyson

Sat 1/17

1:59 pm-9:02 pm

2 stops10h 03m

$485

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 11/10

5:20 am-9:03 pm

2 stops12h 43m

Knoxville McGhee Tyson

Mon 11/17

5:10 am-1:59 pm

2 stops11h 49m

$507

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 2/24

5:02 am-3:05 pm

1 stop7h 03m

Knoxville McGhee Tyson

Sat 2/28

9:40 am-9:18 pm

2 stops14h 38m

$515

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Compare providers for flights from Medford to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Knoxville

What is the cheapest month to book a flight from Medford to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Medford to Knoxville (average of $280). Flying from Medford to Knoxville in March is currently the most expensive (average of $799). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Medford to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 28, 2025.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,997 reviews

Comfort

7.3

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,997 reviews
United Airlines
7.4
Good
8,997 reviews

Comfort

7.3

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 7h 51m. There are 2113 mi between Medford and Knoxville. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $373, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Medford to Knoxville (average of $280). Flying from Medford to Knoxville in March is currently the most expensive (average of $799). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$373Average$558FlexibilityNo cancel feeOn-time69%

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