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$419+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Best flights from Medford to Knoxville
Discover carefully curated flight deals from Medford to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:00 amMFR - TYS
2 stops12h 52mUnited Airlines
Sat 1/319:30 amTYS - MFR
2 stops11h 22mUnited Airlines
Deal found 12/8$419
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:32 amMFR - TYS
2 stops12h 24mAmerican Airlines
Fri 2/135:00 amTYS - MFR
2 stops11h 34mAmerican Airlines
Deal found 12/10$507
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/75:00 amMFR - TYS
2 stops12h 52mUnited Airlines
Sun 2/159:40 amTYS - MFR
2 stops14h 42mUnited Airlines
Deal found 12/9$459
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:25 pmMFR - TYS
2 stops13h 07mUnited Airlines
Fri 2/134:15 pmTYS - MFR
1 stop8h 03mUnited Airlines
Deal found 12/10$655

Find flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$419
(United Airlines)

Popular in

March

Cheapest in

November

Average price

$941
Provider with most accurate pricing for Medford-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Medford-Knoxville McGhee Tyson flights.
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From Medford to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($37 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Medford

Fly to

Knoxville

Route

Depart

Return

Price

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 1/28

5:00 am-8:52 pm

2 stops12h 52m

Knoxville McGhee Tyson

Sat 1/31

9:30 am-5:52 pm

2 stops11h 22m

$419

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 2/7

5:00 am-8:52 pm

2 stops12h 52m

Knoxville McGhee Tyson

Sun 2/15

9:40 am-9:22 pm

2 stops14h 42m

$459

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 2/6

5:32 am-8:56 pm

2 stops12h 24m

Knoxville McGhee Tyson

Fri 2/13

5:00 am-1:34 pm

2 stops11h 34m

$507

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 2/6

6:25 pm-10:32 am

2 stops13h 07m

Knoxville McGhee Tyson

Fri 2/13

4:15 pm-9:18 pm

1 stop8h 03m

$655

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 12/19

5:00 am-3:00 pm

1 stop7h 00m

$775

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 12/19

6:00 am-8:18 am

3 stops47h 18m

$1,265

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Compare providers for flights from Medford to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Knoxville

What is the cheapest month to book a flight from Medford to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Medford to Knoxville (average of $313). Flying from Medford to Knoxville in March is currently the most expensive (average of $1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,095 reviews

Comfort

7.3

Boarding

7.7

Food

6.6

Crew

8.1

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.
United Airlines
7.4
Good
9,095 reviews
United Airlines
7.4
Good
9,095 reviews

Comfort

7.3

Boarding

7.7

Food

6.6

Crew

8.1

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 12h 52m. There are 2113 mi between Medford and Knoxville.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $348, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 47% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Medford to Knoxville (average of $313). Flying from Medford to Knoxville in March is currently the most expensive (average of $1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$348Average$584FlexibilityNo cancel feeOn-time69%

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