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$386+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Cheapest flights from Medford to Knoxville
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This United Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:02 am
MFR
-
TYS
1 stop7h 03m
United Airlines
Sat 2/289:40 am
TYS
-
MFR
2 stops14h 38m
United Airlines
Deal found 1/24$386
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:28 pm
MFR
-
TYS
2 stops17h 56m
Delta
Fri 5/15:24 pm
TYS
-
MFR
2 stops9h 28m
Delta
Deal found 1/25$388
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:28 pm
MFR
-
TYS
2 stops17h 56m
Delta
Tue 4/285:26 pm
TYS
-
MFR
2 stops9h 26m
Delta
Deal found 1/25$413
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:28 pm
MFR
-
TYS
2 stops17h 56m
Delta
Wed 4/2911:02 am
TYS
-
MFR
2 stops15h 28m
Delta
Deal found 1/25$443
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:34 pm
MFR
-
TYS
2 stops12h 34m
United Airlines
Thu 4/307:00 am
TYS
-
MFR
2 stops13h 55m
United Airlines
Deal found 1/25$445
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:28 pm
MFR
-
TYS
2 stops14h 49m
Delta
Fri 5/15:24 pm
TYS
-
MFR
2 stops9h 28m
Delta
Deal found 1/25$449
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:28 pm
MFR
-
TYS
2 stops17h 56m
Delta
Sat 5/211:02 am
TYS
-
MFR
2 stops15h 28m
Delta
Deal found 1/25$468
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:31 pm
MFR
-
TYS
2 stops12h 37m
United Airlines
Sat 5/27:05 am
TYS
-
MFR
2 stops13h 50m
United Airlines
Deal found 1/25$470
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:31 pm
MFR
-
TYS
2 stops13h 19m
United Airlines
Sat 5/27:05 am
TYS
-
MFR
2 stops13h 50m
United Airlines
Deal found 1/25$500

Find flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$386
(United Airlines)

Popular in

March

Cheapest in

November

Average price

$721
Provider with most accurate pricing for Medford-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Knoxville McGhee Tyson flights.
Search Deals
From Medford to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($84 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Medford

Fly to

Knoxville

Route

Depart

Return

Price

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 2/21

5:02 am-3:05 pm

1 stop7h 03m

Knoxville McGhee Tyson

Sat 2/28

9:40 am-9:18 pm

2 stops14h 38m

$386

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 4/25

12:28 pm-9:24 am

2 stops17h 56m

Knoxville McGhee Tyson

Fri 5/1

5:24 pm-11:52 pm

2 stops9h 28m

$388

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 4/25

12:28 pm-9:24 am

2 stops17h 56m

Knoxville McGhee Tyson

Tue 4/28

5:26 pm-11:52 pm

2 stops9h 26m

$413

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 4/24

5:28 pm-11:17 am

2 stops14h 49m

Knoxville McGhee Tyson

Fri 5/1

5:24 pm-11:52 pm

2 stops9h 28m

$449

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 4/24

6:31 pm-10:50 am

2 stops13h 19m

Knoxville McGhee Tyson

Tue 4/28

7:05 am-5:50 pm

2 stops13h 45m

$464

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 4/24

6:31 pm-10:50 am

2 stops13h 19m

Knoxville McGhee Tyson

Wed 4/29

10:49 am-9:37 pm

2 stops13h 48m

$500

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 4/25

2:12 pm-10:50 am

3 stops17h 38m

Knoxville McGhee Tyson

Tue 4/28

7:05 am-5:50 pm

2 stops13h 45m

$517

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 4/27

6:31 pm-10:08 am

2 stops12h 37m

Knoxville McGhee Tyson

Fri 5/1

9:00 am-11:47 am

2 stops29h 47m

$524

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sun 4/26

11:14 am-10:21 am

2 stops20h 07m

Knoxville McGhee Tyson

Sat 5/2

11:02 am-11:30 pm

2 stops15h 28m

$547

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 4/25

2:12 pm-10:50 am

3 stops17h 38m

Knoxville McGhee Tyson

Wed 4/29

10:49 am-9:37 pm

2 stops13h 48m

$553

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Compare providers for flights from Medford to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Knoxville

What is the cheapest month to book a flight from Medford to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Medford to Knoxville (average of $314). Flying from Medford to Knoxville in March is currently the most expensive (average of $1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 26, 2026.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,199 reviews

Crew

8.1

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,199 reviews
United Airlines
7.4
Good
9,199 reviews

Crew

8.1

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 7h 03m. There are 2113 mi between Medford and Knoxville. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $348, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 45% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Medford to Knoxville (average of $314). Flying from Medford to Knoxville in March is currently the most expensive (average of $1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$348Average$574FlexibilityNo cancel feeOn-time69%

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