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$202+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$367
(United Airlines)

One-way from

$202
(Kiwi.com)

Popular in

March

Cheapest in

December

Average price

$666
From Medford to Knoxville McGhee Tyson
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One-way flight from Medford to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 10% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Medford to Knoxville

Cheapest flights from Medford to Knoxville
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:00 amMFR - TYS
1 stop6h 42mUnited Airlines
Wed 11/194:55 pmTYS - MFR
1 stop7h 19mUnited Airlines
Deal found 9/11$367
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amMFR - TYS
2 stops9h 23mDelta
Sat 11/87:45 amTYS - MFR
2 stops11h 59mDelta
Deal found 9/9$414
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:36 pmMFR - TYS
2 stops13h 12mUnited Airlines
Mon 11/179:50 amTYS - MFR
2 stops15h 40mUnited Airlines
Deal found 9/9$419
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:00 amMFR - TYS
2 stops9h 23mDelta
Wed 11/195:25 amTYS - MFR
2 stops14h 18mDelta
Deal found 9/11$438
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/129:42 pmMFR - TYS
2 stops33h 51mMultiple Airlines
Sun 10/196:30 amTYS - MFR
1 stop11h 46mMultiple Airlines
Deal found 9/10$502
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amMFR - TYS
2 stops26h 05mUnited Airlines
Sat 11/84:50 pmTYS - MFR
1 stop7h 24mUnited Airlines
Deal found 9/9$558

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Medford

Fly to

Knoxville

Route

Depart

Return

Price

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 11/8

5:00 am-2:42 pm

1 stop6h 42m

Knoxville McGhee Tyson

Wed 11/19

4:55 pm-9:14 pm

1 stop7h 19m

$367

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 11/10

6:36 pm-10:48 am

2 stops13h 12m

Knoxville McGhee Tyson

Mon 11/17

4:55 pm-9:14 pm

1 stop7h 19m

$414

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 2/24

11:24 am-11:44 pm

2 stops9h 20m

Knoxville McGhee Tyson

Sat 2/28

7:30 am-4:44 pm

2 stops12h 14m

$418

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 2/24

5:05 am-5:31 pm

2 stops9h 26m

Knoxville McGhee Tyson

Sat 2/28

8:13 am-3:00 pm

2 stops9h 47m

$419

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 11/8

6:00 am-6:23 pm

2 stops9h 23m

Knoxville McGhee Tyson

Wed 11/19

5:25 am-4:43 pm

2 stops14h 18m

$438

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 2/24

5:10 am-2:39 pm

1 stop6h 29m

Knoxville McGhee Tyson

Sat 2/28

4:25 pm-9:10 pm

1 stop7h 45m

$472

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Thu 11/20

9:51 pm-5:32 pm

1 stop16h 41m

$202

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Thu 11/20

4:10 pm-11:55 am

2 stops16h 45m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Knoxville

What is the cheapest month to book a flight from Medford to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Medford to Knoxville (average of $294). Flying from Medford to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Medford to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 6h 42m. There are 2113 mi between Medford and Knoxville. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $379, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 43% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Medford to Knoxville (average of $294). Flying from Medford to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$379Average$577FlexibilityNo cancel feeOn-time69%

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