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$305+ Cheap flights from Ithaca to Knoxville (ITH - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
ITH — TYS
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Ithaca to Knoxville

Cheapest flights from Ithaca to Knoxville
Explore the most affordable flight options available from Ithaca to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:00 am
ITH
-
TYS
1 stop4h 57m
United Airlines
Sat 2/147:25 pm
TYS
-
ITH
1 stop4h 17m
United Airlines
Deal found 2/7$424
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:00 am
ITH
-
TYS
2 stops16h 29m
United Airlines
Mon 4/137:00 am
TYS
-
ITH
2 stops16h 59m
United Airlines
Deal found 2/10$577
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:00 am
ITH
-
TYS
1 stop4h 49m
United Airlines
Sun 3/17:25 pm
TYS
-
ITH
1 stop23h 02m
United Airlines
Deal found 2/10$597
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:00 am
ITH
-
TYS
1 stop13h 29m
United Airlines
Fri 3/277:25 pm
TYS
-
ITH
1 stop4h 17m
United Airlines
Deal found 2/9$613
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 am
ITH
-
TYS
2 stops7h 15m
United Airlines
Fri 2/275:27 pm
TYS
-
ITH
2 stops30h 15m
United Airlines
Deal found 2/8$642

Find flight deals from Ithaca to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Ithaca (ITH) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$577
(United Airlines)

One-way from

$305
(United Airlines)
Provider with most accurate pricing for Ithaca Tompkins County-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Ithaca Tompkins County-Knoxville McGhee Tyson flights.
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From Ithaca Tompkins County to Knoxville McGhee Tyson
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One-way flight from Ithaca Tompkins County to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Ithaca to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Ithaca to Knoxville that are best for you.

Fly from

Ithaca

Fly to

Knoxville

Route

Depart

Return

Price

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 4/10

6:00 am-10:29 pm

2 stops16h 29m

Knoxville McGhee Tyson

Mon 4/13

7:00 am-11:59 pm

2 stops16h 59m

$577

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Wed 2/25

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Sun 3/1

7:25 pm-6:27 pm

1 stop23h 02m

$597

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 3/20

6:00 am-7:29 pm

1 stop13h 29m

Knoxville McGhee Tyson

Fri 3/27

7:25 pm-11:42 pm

1 stop4h 17m

$613

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Mon 2/23

6:00 am-1:15 pm

2 stops7h 15m

Knoxville McGhee Tyson

Fri 2/27

5:27 pm-11:42 pm

2 stops30h 15m

$642

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 4/17

6:00 am-10:29 pm

2 stops16h 29m

Knoxville McGhee Tyson

Sun 4/19

9:40 am-11:59 pm

1 stop14h 19m

$652

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 4/17

10:30 am-3:09 pm

1 stop4h 39m

$305

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 4/17

1:34 pm-11:54 pm

2 stops10h 20m

$410

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

Fri 2/27

6:00 am-8:37 pm

2 stops14h 37m

$839

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/8

  • Most accurate provider: When it comes to deals on Ithaca-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Ithaca-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Ithaca-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Ithaca-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Ithaca-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Ithaca to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Ithaca with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ithaca to Knoxville

What is the cheapest month to book a flight from Ithaca to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Ithaca to Knoxville (average of $137). Flying from Ithaca to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Ithaca to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Ithaca to Knoxville?

    Airlines like United Airlines fly from Ithaca to Knoxville in about 16h 29m. The time it takes to get you to your destination can typically vary by up to . Ithaca and Knoxville are separated by a distance of 612 mi.

  • Can I find deals for flights from Ithaca to Knoxville that include hotel bookings?

    Yes. In addition to deals on Ithaca to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ithaca to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ithaca to Knoxville.

  • Can I find deals for business class flights from Ithaca to Knoxville?

    Yes. Cheapflights offers flight deals from Ithaca to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ithaca to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Ithaca to Knoxville (average of $137). Flying from Ithaca to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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