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$114+ Cheap flights from Columbus to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$235
(Kiwi.com)

One-way from

$114
(Kiwi.com)

Popular in

November

Cheapest in

December

Average price

$315
From Columbus to Knoxville McGhee Tyson
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One-way flight from Columbus to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/26:21 pmCMH - TYS
1 stop18h 12mMultiple Airlines
Fri 11/79:09 pmTYS - CMH
1 stop24h 03mMultiple Airlines
Deal found 9/14$235
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1410:02 amCMH - TYS
1 stop4h 41mDelta
Tue 10/215:44 amTYS - CMH
1 stop3h 13mDelta
Deal found 9/16$239
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amCMH - TYS
1 stop4h 51mAmerican Airlines
Tue 10/77:00 amTYS - CMH
1 stop5h 05mAmerican Airlines
Deal found 9/14$244
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/265:00 amCMH - TYS
1 stop15h 25mMultiple Airlines
Thu 10/307:17 pmTYS - CMH
1 stop23h 51mMultiple Airlines
Deal found 9/15$262
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/275:00 amCMH - TYS
1 stop12h 37mMultiple Airlines
Thu 10/307:17 pmTYS - CMH
1 stop23h 51mMultiple Airlines
Deal found 9/15$263
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amCMH - TYS
1 stop4h 13mUnited Airlines
Sat 12/67:25 pmTYS - CMH
1 stop4h 16mUnited Airlines
Deal found 9/16$266
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:50 amCMH - TYS
1 stop6h 06mAmerican Airlines
Sat 11/86:30 amTYS - CMH
1 stop3h 53mAmerican Airlines
Deal found 9/15$278
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/207:14 pmCMH - TYS
1 stop3h 49mAmerican Airlines
Mon 9/227:45 pmTYS - CMH
1 stop3h 22mAmerican Airlines
Deal found 9/16$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:28 pmCMH - TYS
2 stops22h 05mMultiple Airlines
Sat 11/810:54 amTYS - CMH
1 stop10h 18mMultiple Airlines
Deal found 9/15$287
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amCMH - TYS
1 stop4h 29mUnited Airlines
Sun 10/127:00 amTYS - CMH
1 stop6h 17mUnited Airlines
Deal found 9/16$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Columbus to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 10/20

7:59 pm-11:46 pm

1 stop3h 47m

Knoxville McGhee Tyson

Sat 11/8

2:41 pm-8:37 pm

1 stop5h 56m

$239

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 10/3

6:00 am-10:51 am

1 stop4h 51m

Knoxville McGhee Tyson

Tue 10/7

7:00 am-12:05 pm

1 stop5h 05m

$244

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 10/27

5:00 am-5:37 pm

1 stop12h 37m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-7:08 pm

1 stop23h 51m

$263

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 11/2

6:21 pm-12:33 pm

1 stop18h 12m

Knoxville McGhee Tyson

Fri 11/7

12:50 pm-1:43 pm

2 stops24h 53m

$272

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 10/20

12:28 pm-10:33 am

2 stops22h 05m

Knoxville McGhee Tyson

Sat 11/8

10:54 am-9:12 pm

1 stop10h 18m

$287

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 10/26

5:00 am-8:25 pm

1 stop15h 25m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-11:23 am

2 stops16h 06m

$302

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 10/13

4:08 pm-8:44 pm

1 stop4h 36m

Knoxville McGhee Tyson

Mon 10/20

8:37 pm-11:59 pm

1 stop3h 22m

$317

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 9/29

8:34 am-5:34 pm

1 stop9h 00m

Knoxville McGhee Tyson

Fri 10/3

8:54 pm-11:41 am

1 stop14h 47m

$344

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 10/24

5:00 am-2:36 pm

1 stop9h 36m

Knoxville McGhee Tyson

Sun 10/26

7:00 am-6:13 pm

1 stop11h 13m

$347

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 9/19

3:46 pm-9:41 pm

1 stop5h 55m

Knoxville McGhee Tyson

Fri 9/26

2:08 pm-6:17 pm

1 stop4h 09m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 16 results
1
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Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Knoxville

What is the cheapest month to book a flight from Columbus to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $295). Flying from Columbus to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to TYS?

Find hourly flight availability from Columbus to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

One of the essential ways to save on airfare from Columbus to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 16, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Columbus to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Columbus to Knoxville. You should not have trouble finding flights to McGhee Tyson from Columbus; the airport handles an average of 0 inbound flights from Columbus per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Knoxville airport from Columbus. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Columbus to Knoxville?

    A quick flight from Columbus to Knoxville can take about 3h 47m. Delta provides one of the quickest options available for as low as $239. Airlines will cover a distance of 296 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Columbus to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $218 and $258, respectively. American Airlines is currently priced 27% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $295). Flying from Columbus to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Columbus to Knoxville

Discover the top 3 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$317FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$316FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$243Average$358FlexibilityNo cancel feeOn-time69%

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