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$126+ Cheap flights from Columbus to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/13. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:14 pmCMH - TYS
1 stop24h 12mMultiple Airlines
Fri 11/149:38 pmTYS - CMH
1 stop17h 45mMultiple Airlines
Deal found 10/29$228
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1211:14 amCMH - TYS
1 stop10h 58mMultiple Airlines
Sun 12/145:23 pmTYS - CMH
2 stops18h 18mMultiple Airlines
Deal found 10/30$260
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:01 amCMH - TYS
1 stop7h 46mAmerican Airlines
Wed 12/247:00 amTYS - CMH
1 stop6h 05mAmerican Airlines
Deal found 10/29$293
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:35 pmCMH - TYS
2 stops18h 56mMultiple Airlines
Wed 12/245:31 pmTYS - CMH
1 stop24h 02mMultiple Airlines
Deal found 10/29$311
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:12 pmCMH - TYS
1 stop4h 41mAmerican Airlines
Sun 12/144:59 pmTYS - CMH
1 stop4h 17mAmerican Airlines
Deal found 10/28$317
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:08 amCMH - TYS
2 stops13h 25mMultiple Airlines
Mon 11/179:09 pmTYS - CMH
1 stop26h 01mMultiple Airlines
Deal found 10/29$330
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:42 amCMH - TYS
1 stop13h 32mMultiple Airlines
Sun 11/167:07 pmTYS - CMH
2 stops20h 28mMultiple Airlines
Deal found 10/28$331
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:00 amCMH - TYS
1 stop4h 19mAmerican Airlines
Fri 11/286:12 amTYS - CMH
1 stop5h 32mAmerican Airlines
Deal found 10/29$332

Cheap flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Round-trip from

$228
(Kiwi.com)

One-way from

$126
(Delta)

Popular in

November

Cheapest in

December

Average price

$293
From Columbus to Knoxville McGhee Tyson
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One-way flight from Columbus to Knoxville McGhee Tyson
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Columbus to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 12/12

11:14 am-10:12 pm

1 stop10h 58m

Knoxville McGhee Tyson

Sun 12/14

5:23 pm-11:41 am

2 stops18h 18m

$260

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 11/12

9:42 am-10:14 pm

1 stop12h 32m

Knoxville McGhee Tyson

Fri 11/14

2:02 pm-8:47 am

2 stops18h 45m

$290

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 12/19

8:01 am-3:47 pm

1 stop7h 46m

Knoxville McGhee Tyson

Wed 12/24

7:00 am-1:05 pm

1 stop6h 05m

$293

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 12/12

4:12 pm-8:53 pm

1 stop4h 41m

Knoxville McGhee Tyson

Sun 12/14

4:59 pm-9:16 pm

1 stop4h 17m

$317

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 11/13

9:08 am-10:33 pm

2 stops13h 25m

Knoxville McGhee Tyson

Mon 11/17

9:09 pm-11:10 pm

1 stop26h 01m

$330

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 11/14

9:42 am-11:14 pm

1 stop13h 32m

Knoxville McGhee Tyson

Sun 11/16

7:07 pm-3:35 pm

2 stops20h 28m

$331

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 11/23

6:00 am-10:19 am

1 stop4h 19m

Knoxville McGhee Tyson

Fri 11/28

6:12 am-11:44 am

1 stop5h 32m

$332

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 12/19

5:35 pm-9:34 pm

2 stops27h 59m

Knoxville McGhee Tyson

Tue 12/23

9:08 am-5:33 pm

1 stop8h 25m

$332

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 12/13

1:46 pm-6:58 pm

1 stop5h 12m

$126

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 11/25

6:00 am-10:19 am

1 stop4h 19m

$160

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 17 results
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Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Knoxville

What is the cheapest month to book a flight from Columbus to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $193). Flying from Columbus to Knoxville in November is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to TYS?

Find hourly flight availability from Columbus to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Columbus to Knoxville is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 28% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 30, 2025.
See what other customers who have flown with Delta and American Airlines from Columbus to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Columbus to Knoxville. You should not have trouble finding flights to McGhee Tyson from Columbus; the airport handles an average of 0 inbound flights from Columbus per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Knoxville airport from Columbus. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Columbus to Knoxville?

    A quick flight from Columbus to Knoxville can take about 7h 46m. American Airlines provides one of the quickest options available for as low as $293. Airlines will cover a distance of 296 mi.

  • What are the cheapest airlines flying from Columbus to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $218. American Airlines is currently priced 27% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Columbus to Knoxville one-way?

    One-way options have recently been found by users for as low as $126 on Delta. Other airlines that offer cheap prices include American Airlines from $160 and United Airlines from $239 one-way.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $193). Flying from Columbus to Knoxville in November is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Columbus to Knoxville

Discover the top 3 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$323FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$316FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$243Average$294FlexibilityNo cancel feeOn-time69%

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