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$159+ Cheap flights from Columbus to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:45 am
CMH
-
TYS
1 stop7h 06m
Multiple Airlines
Mon 3/162:06 pm
TYS
-
CMH
1 stop19h 34m
Multiple Airlines
Deal found 1/27$206
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/244:12 pm
CMH
-
TYS
1 stop4h 25m
United Airlines
Tue 3/36:45 am
TYS
-
CMH
1 stop6h 30m
United Airlines
Deal found 1/27$251
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:35 pm
CMH
-
TYS
1 stop5h 40m
Southwest
Sat 3/77:10 pm
TYS
-
CMH
1 stop3h 35m
Southwest
Deal found 1/29$295
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/111:45 pm
CMH
-
TYS
2 stops6h 20m
Southwest
Mon 3/166:30 am
TYS
-
CMH
2 stops8h 25m
Southwest
Deal found 1/27$304
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/86:06 am
CMH
-
TYS
1 stop16h 47m
Multiple Airlines
Mon 3/27:21 pm
TYS
-
CMH
2 stops18h 20m
Multiple Airlines
Deal found 1/28$310
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:00 am
CMH
-
TYS
1 stop4h 06m
Delta
Sat 6/207:30 am
TYS
-
CMH
1 stop5h 57m
Delta
Deal found 1/27$317
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/96:06 am
CMH
-
TYS
1 stop11h 22m
Multiple Airlines
Mon 3/27:21 pm
TYS
-
CMH
2 stops18h 20m
Multiple Airlines
Deal found 1/27$326

Find flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Round-trip from

$206
(Kiwi.com)

One-way from

$159
(Delta)

Popular in

December

Cheapest in

July

Average price

$258
From Columbus to Knoxville McGhee Tyson
Search Deals
One-way flight from Columbus to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Columbus to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 3/11

5:45 am-12:51 pm

1 stop7h 06m

Knoxville McGhee Tyson

Mon 3/16

2:06 pm-9:40 am

1 stop19h 34m

$206

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 2/24

4:12 pm-8:37 pm

1 stop4h 25m

Knoxville McGhee Tyson

Tue 3/3

6:45 am-1:15 pm

1 stop6h 30m

$251

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 2/24

6:00 am-11:08 am

1 stop5h 08m

Knoxville McGhee Tyson

Tue 3/3

5:35 am-11:44 am

1 stop6h 09m

$251

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 3/5

3:35 pm-9:15 pm

1 stop5h 40m

Knoxville McGhee Tyson

Sat 3/7

7:10 pm-10:45 pm

1 stop3h 35m

$295

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 3/11

1:45 pm-8:05 pm

2 stops6h 20m

Knoxville McGhee Tyson

Mon 3/16

6:30 am-2:55 pm

2 stops8h 25m

$304

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 6/14

7:00 am-11:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Sat 6/20

7:30 am-1:27 pm

1 stop5h 57m

$317

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 2/9

6:06 am-5:28 pm

1 stop11h 22m

Knoxville McGhee Tyson

Mon 3/2

7:21 pm-1:41 pm

2 stops18h 20m

$326

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 3/12

12:20 pm-9:15 pm

2 stops8h 55m

Knoxville McGhee Tyson

Sun 3/15

7:40 am-11:55 am

1 stop4h 15m

$332

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 4/6

11:10 am-5:45 pm

1 stop6h 35m

$159

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 4/6

12:20 pm-9:15 pm

2 stops8h 55m

$164

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 18 results
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Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Knoxville

What is the cheapest month to book a flight from Columbus to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $194). Flying from Columbus to Knoxville in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Columbus to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 29, 2026.
See what other customers who have flown with Delta and American Airlines from Columbus to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Columbus to Knoxville. You should not have trouble finding flights to McGhee Tyson from Columbus; the airport handles an average of 0 inbound flights from Columbus per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Knoxville airport from Columbus. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Columbus to Knoxville?

    A quick flight from Columbus to Knoxville can take about 4h 25m. United Airlines provides one of the quickest options available for as low as $251. Airlines will cover a distance of 296 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Columbus to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $218. American Airlines is currently priced 31% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $194). Flying from Columbus to Knoxville in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Columbus to Knoxville

Discover the top 3 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$322FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$456FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$263Average$293FlexibilityNo cancel feeOn-time69%

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