$112+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Jun 9 — Jun 161
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:49 pm
TYS
- CMH
2 stops28h 16m
Multiple Airlines
Mon 6/1512:16 pm
CMH
- TYS
1 stop9h 34m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$252
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:50 pm
TYS
- CMH
1 stop3h 40m
Southwest
Wed 6/34:10 pm
CMH
- TYS
1 stop4h 40m
Southwest
Deal found 5/8![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/155:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/9![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2411:29 am
TYS
- CMH
1 stop5h 54m
American Airlines
Thu 5/286:00 am
CMH
- TYS
1 stop7h 10m
American Airlines
Deal found 5/9![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/85:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/7![Southwest logo]()
$344
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Sun 6/215:35 am
CMH
- TYS
2 stops10h 10m
Southwest
Deal found 5/5![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:15 am
TYS
- CMH
1 stop8h 46m
United Airlines
Wed 9/22:12 pm
CMH
- TYS
1 stop6h 41m
United Airlines
Deal found 5/7![United Airlines logo]()
$369
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:15 am
TYS
- CMH
2 stops10h 05m
Southwest
Wed 6/38:50 am
CMH
- TYS
2 stops8h 20m
Southwest
Deal found 5/8![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:00 am
TYS
- CMH
1 stop7h 17m
United Airlines
Sun 6/216:00 am
CMH
- TYS
1 stop4h 42m
United Airlines
Deal found 5/5![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/155:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/9![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:15 am
TYS
- CMH
1 stop8h 46m
United Airlines
Wed 9/22:12 pm
CMH
- TYS
1 stop6h 41m
United Airlines
Deal found 5/7![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/85:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/7![Southwest logo]()
$344
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Sun 6/215:35 am
CMH
- TYS
2 stops10h 10m
Southwest
Deal found 5/5![Southwest logo]()
$352
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated May 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated May 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
TYS
- CMH
1 stop6h 14m
United Airlines
Sun 5/246:00 am
CMH
- TYS
1 stop4h 42m
United Airlines
Deal found 5/5![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2411:29 am
TYS
- CMH
1 stop5h 54m
American Airlines
Thu 5/286:00 am
CMH
- TYS
1 stop7h 10m
American Airlines
Deal found 5/9![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:50 pm
TYS
- CMH
1 stop3h 40m
Southwest
Wed 6/34:10 pm
CMH
- TYS
1 stop4h 40m
Southwest
Deal found 5/8![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/85:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/7![Southwest logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:49 pm
TYS
- CMH
2 stops28h 16m
Multiple Airlines
Mon 6/1512:16 pm
CMH
- TYS
1 stop9h 34m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$252
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Mon 6/155:35 pm
CMH
- TYS
1 stop4h 55m
Southwest
Deal found 5/9![Southwest logo]()
$324
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- CMH
1 stop5h 45m
Southwest
Sun 6/215:35 am
CMH
- TYS
2 stops10h 10m
Southwest
Deal found 5/5![Southwest logo]()
$352
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1512:40 pm
TYS
- CMH
2 stops28h 25m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:05 pm
TYS
- CMH
2 stops28h 00m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$121
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- CMH
1 stop3h 40m
Southwest
Deal found 5/5![Southwest logo]()
$150
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:59 pm
TYS
- CMH
1 stop3h 53m
American Airlines
Deal found 5/7![American Airlines logo]()
$156
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:30 am
TYS
- CMH
2 stops11h 30m
Southwest
Deal found 5/7![Southwest logo]()
$161
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:40 am
TYS
- CMH
1 stop6h 11m
Delta
Deal found 5/9![Delta logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/218:15 am
TYS
- CMH
2 stops33h 33m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$215
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:45 am
TYS
- CMH
1 stop4h 04m
United Airlines
Deal found 5/9![United Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:24 pm
TYS
- CMH
2 stops18h 10m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$228
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:45 pm
TYS
- CMH
1 stop5h 40m
Southwest
Deal found 5/7![Southwest logo]()
$229
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 10, 2026.
Round-trip from | $252 (Kiwi.com) |
|---|---|
One-way from | $112 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 6/2
8:15 am-6:20 pm
2 stops10h 05m
Columbus
Wed 6/3
8:50 am-5:10 pm
2 stops8h 20m
$309
Quickest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 6/8
6:40 am-12:25 pm
1 stop5h 45m
Columbus
Mon 6/15
5:35 pm-10:30 pm
1 stop4h 55m
$324
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Thu 6/18
6:00 am-1:17 pm
1 stop7h 17m
Columbus
Sun 6/21
6:00 am-10:42 am
1 stop4h 42m
$337
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 6/5
6:40 am-12:25 pm
1 stop5h 45m
Columbus
Mon 6/8
5:35 pm-10:30 pm
1 stop4h 55m
$344
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Thu 6/18
6:40 am-12:25 pm
1 stop5h 45m
Columbus
Sun 6/21
5:35 am-3:45 pm
2 stops10h 10m
$352
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 9/1
7:15 am-4:01 pm
1 stop8h 46m
Columbus
Wed 9/2
2:12 pm-8:53 pm
1 stop6h 41m
$369
Cheapest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 6/15
12:40 pm-5:05 pm
2 stops28h 25m
$112
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 7/1
6:12 am-12:21 pm
1 stop6h 09m
$150
Quickest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 5/26
5:50 pm-9:30 pm
1 stop3h 40m
$150
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Thu 6/4
7:59 pm-11:52 pm
1 stop3h 53m
$156
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated May 10, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on May 10, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Columbus
Discover the top 3 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$218 | Average$377 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$258 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$361 | FlexibilityNo cancel fee | On-time69% |