$113+ Cheap flights from Knoxville to Detroit Metropolitan Wayne County Airport (TYS - DTW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DTW
Oct 9 — Oct 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Detroit with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Detroit
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to DetroitExplore the most affordable flight options available from Knoxville to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Knoxville to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop28h 25m
Tue 10/204:29 pm -
1 stop17h 36m
Deal found 9/8![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:55 am -
1 stop14h 42m
Mon 11/94:29 pm -
1 stop24h 49m
Deal found 9/8![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop14h 24m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/7![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
1 stop25h 54m
Tue 10/134:29 pm -
1 stop17h 36m
Deal found 9/4![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:14 pm -
1 stop27h 13m
Mon 10/124:29 pm -
1 stop25h 45m
Deal found 9/5![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:41 pm -
1 stop6h 48m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/4![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
2 stops11h 42m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/6![Multiple Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:05 am -
1 stop6h 15m
Fri 11/135:50 am -
1 stop6h 20m
Deal found 9/8![Southwest logo]()
$308
Best flights from Knoxville to DetroitDiscover carefully curated flight deals from Knoxville to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Knoxville to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:50 pm -
2 stops11h 05m
Mon 11/95:00 am -
2 stops7h 10m
Deal found 9/8![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:45 am -
Nonstop1h 44m
Mon 11/97:49 pm -
Nonstop1h 40m
Deal found 9/8![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:50 pm -
2 stops11h 05m
Fri 11/135:00 am -
2 stops7h 10m
Deal found 9/7![Southwest logo]()
$368
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:25 am -
Nonstop1h 49m
Thu 12/317:50 pm -
Nonstop1h 35m
Deal found 9/8![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:05 am -
1 stop6h 15m
Thu 11/193:55 pm -
1 stop4h 50m
Deal found 9/8![Southwest logo]()
$377
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:26 am -
Nonstop1h 44m
Sun 10/257:55 pm -
Nonstop1h 42m
Deal found 9/7![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:45 am -
Nonstop1h 44m
Sun 10/254:44 pm -
Nonstop1h 40m
Deal found 9/4![Delta logo]()
$379
Last-minute flights from Knoxville to DetroitDiscover last-minute flight deals from Knoxville to Detroit. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Detroit. Data last updated September 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:14 pm -
1 stop27h 13m
Mon 10/124:29 pm -
1 stop25h 45m
Deal found 9/5![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:08 pm -
2 stops9h 31m
Mon 10/124:29 pm -
1 stop25h 45m
Deal found 9/5![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
1 stop25h 54m
Tue 10/134:29 pm -
1 stop17h 36m
Deal found 9/4![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:55 pm -
2 stops20h 35m
Mon 10/124:29 pm -
1 stop25h 45m
Deal found 9/4![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop28h 25m
Tue 10/204:29 pm -
1 stop17h 36m
Deal found 9/8![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop14h 24m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/7![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
2 stops11h 42m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/6![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:41 pm -
1 stop6h 48m
Sun 10/258:59 pm -
1 stop14h 15m
Deal found 9/4![Multiple Airlines logo]()
$298
One-way flights from Knoxville to DetroitSearch for one-way flight options from Knoxville to Detroit. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Knoxville to Detroit. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop28h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop12h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:28 am -
1 stop7h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:37 pm -
1 stop30h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:00 pm -
1 stop12h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
1 stop28h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$135
Find flight deals from Knoxville to Detroit
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Detroit (DTW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (Kiwi.com) |
One-way from | $113 (Kiwi.com) |
Popular in | November |
Cheapest in | May |
Average price | $415 |
Good round-trip deal | $373 or less |
Good one-way deal | $243 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Knoxville to Detroit Metropolitan Wayne County Airport that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Tue 11/3
7:05 am-1:20 pm
1 stop6h 15m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$175
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Sun 12/6
12:50 pm-8:05 pm
1 stop7h 15m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Tue 9/22
12:45 pm-8:35 pm
2 stops7h 50m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$200
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Fri 12/18
12:40 pm-7:20 pm
1 stop6h 40m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$214
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Sat 11/7
3:57 pm-9:19 am
3 stops41h 22m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$246
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Fri 3/5
7:20 pm-7:52 am
2 stops12h 32m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$320
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Thu 11/5
12:50 pm-11:55 pm
2 stops11h 05m
Detroit Metropolitan Wayne County
Mon 11/9
5:00 am-12:10 pm
2 stops7h 10m
$337
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Fri 11/6
11:45 am-1:29 pm
Nonstop1h 44m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Mon 11/9
7:06 am-8:56 am
Nonstop1h 50m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Quickest round-trip
KnoxvilleDetroit
TYS Knoxville McGhee Tyson - DTW Detroit Metropolitan Wayne County
TYSDTW
Knoxville McGhee Tyson
Sun 11/8
5:18 pm-7:01 pm
Nonstop1h 43m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Detroit
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Detroit in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Detroit Metropolitan Wayne County Airport flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Detroit Metropolitan Wayne County Airport flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Detroit Metropolitan Wayne County Airport flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Detroit Metropolitan Wayne County Airport flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Detroit Metropolitan Wayne County Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Detroit
Have a flexible travel schedule? Discover the best time to fly to Detroit from Knoxville with our price prediction graph.
TYS-DTW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Detroit Metropolitan Wayne County Airport
Prices
Airlines
What is the cheapest month to book a flight from Knoxville to Detroit Metropolitan Wayne County Airport?
Currently, May is the cheapest month in which you can book a flight from Knoxville to Detroit Metropolitan Wayne County Airport (average of $339). Flying from Knoxville to Detroit Metropolitan Wayne County Airport in November is currently the most expensive (average of $728). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to DTW?
Find hourly flight availability from Knoxville to Detroit. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 9, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Detroit Metropolitan Wayne County Airport as you normally would.
Reviews of airlines servicing Detroit
Get insights into the airlines that provide service to Detroit. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Detroit. Reviews last updated September 9, 2026.
Read reviews from past customers who have flown Delta from Knoxville to Detroit Metropolitan Wayne County Airport. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentSalvador,Aug 2026
PHL - DTW
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Detroit Metropolitan Wayne County Airport?
Book flights to Detroit Metropolitan Wayne County Airport if you plan to visit one of these locationsDearborn
Southfield
Sterling Heights
Troy
Auburn Hills
Pontiac
Warren
Rochester Hills
Livonia
Southgate
Romulus
Roseville
Allen Park
Ypsilanti
Plymouth
Fremont
Port Huron
Waterford
Utica
Madison Heights
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Detroit flight routes
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Detroit
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Detroit by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Detroit
Explore flights to Detroit departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Search flights from Knoxville to Detroit by cabin class
Find flights from Knoxville to Detroit, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Detroit flights
Browse other Knoxville and Detroit flight options. Last updated on September 9, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Detroit
Discover the top airline that operate flights from Knoxville to Detroit. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$425 | FlexibilityNo cancel fee | On-timeN/A |