$148+ Cheap flights from Buffalo to Knoxville (BUF - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Knoxville
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Best
Last-minute
One-way
Cheapest flights from Buffalo to KnoxvilleExplore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:07 pm
BUF
- TYS
1 stop25h 23m
Multiple Airlines
Sun 5/1011:27 am
TYS
- BUF
2 stops47h 14m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:02 am
BUF
- TYS
1 stop6h 28m
Multiple Airlines
Mon 5/46:20 pm
TYS
- BUF
2 stops43h 34m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:49 pm
BUF
- TYS
1 stop25h 35m
Multiple Airlines
Thu 5/141:14 pm
TYS
- BUF
2 stops46h 19m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:50 pm
BUF
- TYS
1 stop3h 52m
Delta
Tue 5/57:50 am
TYS
- BUF
1 stop3h 49m
Delta
Deal found 4/4![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:55 pm
BUF
- TYS
2 stops7h 01m
American Airlines
Tue 5/56:00 am
TYS
- BUF
1 stop5h 58m
American Airlines
Deal found 4/4![American Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Tue 5/128:15 am
TYS
- BUF
1 stop6h 20m
Southwest
Deal found 4/6![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 am
BUF
- TYS
2 stops11h 05m
Southwest
Wed 5/1312:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Deal found 4/8![Southwest logo]()
$305
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:36 am
BUF
- TYS
1 stop5h 11m
American Airlines
Sat 6/64:43 pm
TYS
- BUF
1 stop5h 19m
American Airlines
Deal found 4/8![American Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:02 am
BUF
- TYS
1 stop6h 28m
Multiple Airlines
Thu 4/309:25 pm
TYS
- BUF
2 stops13h 58m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$312
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
BUF
- TYS
2 stops8h 27m
United Airlines
Sat 6/65:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Deal found 4/8![United Airlines logo]()
$316
Best flights from Buffalo to KnoxvilleDiscover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:50 pm
BUF
- TYS
1 stop3h 52m
Delta
Tue 5/57:50 am
TYS
- BUF
1 stop3h 49m
Delta
Deal found 4/4![Delta logo]()
$295
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:55 am
BUF
- TYS
1 stop5h 15m
Southwest
Wed 5/1312:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Deal found 4/5![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
BUF
- TYS
2 stops11h 01m
United Airlines
Tue 5/57:00 am
TYS
- BUF
2 stops11h 10m
United Airlines
Deal found 4/7![United Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 am
BUF
- TYS
2 stops11h 05m
Southwest
Wed 5/1312:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Deal found 4/8![Southwest logo]()
$305
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:19 pm
BUF
- TYS
1 stop4h 33m
Delta
Sun 8/27:43 pm
TYS
- BUF
1 stop4h 16m
Delta
Deal found 4/6![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:52 pm
BUF
- TYS
1 stop4h 02m
United Airlines
Wed 6/36:30 am
TYS
- BUF
2 stops7h 55m
United Airlines
Deal found 4/5![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:45 am
BUF
- TYS
2 stops10h 05m
Southwest
Sat 9/127:50 am
TYS
- BUF
2 stops8h 55m
Southwest
Deal found 4/6![Southwest logo]()
$367
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:40 pm
BUF
- TYS
1 stop4h 07m
Delta
Mon 9/77:20 pm
TYS
- BUF
1 stop4h 38m
Delta
Deal found 4/5![Delta logo]()
$377
Last-minute flights from Buffalo to KnoxvilleDiscover last-minute flight deals from Buffalo to Knoxville. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Knoxville. Data last updated April 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:02 am
BUF
- TYS
1 stop6h 28m
Multiple Airlines
Thu 4/309:25 pm
TYS
- BUF
2 stops13h 58m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:50 pm
BUF
- TYS
1 stop3h 52m
Delta
Tue 5/57:50 am
TYS
- BUF
1 stop3h 49m
Delta
Deal found 4/4![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:55 pm
BUF
- TYS
2 stops7h 01m
American Airlines
Tue 5/56:00 am
TYS
- BUF
1 stop5h 58m
American Airlines
Deal found 4/4![American Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:02 am
BUF
- TYS
1 stop6h 28m
Multiple Airlines
Mon 5/46:20 pm
TYS
- BUF
2 stops43h 34m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:07 pm
BUF
- TYS
1 stop25h 23m
Multiple Airlines
Sun 5/1011:27 am
TYS
- BUF
2 stops47h 14m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 am
BUF
- TYS
2 stops11h 05m
Southwest
Wed 5/1312:50 pm
TYS
- BUF
2 stops9h 25m
Southwest
Deal found 4/8![Southwest logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:49 pm
BUF
- TYS
1 stop25h 35m
Multiple Airlines
Thu 5/141:14 pm
TYS
- BUF
2 stops46h 19m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:00 pm
BUF
- TYS
1 stop5h 15m
Southwest
Tue 5/128:15 am
TYS
- BUF
1 stop6h 20m
Southwest
Deal found 4/6![Southwest logo]()
$303
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:36 am
BUF
- TYS
1 stop5h 11m
American Airlines
Sat 6/64:43 pm
TYS
- BUF
1 stop5h 19m
American Airlines
Deal found 4/8![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
BUF
- TYS
2 stops8h 27m
United Airlines
Sat 6/65:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Deal found 4/8![United Airlines logo]()
$316
One-way flights from Buffalo to KnoxvilleSearch for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:43 pm
BUF
- TYS
1 stop6h 02m
American Airlines
Deal found 4/6![American Airlines logo]()
$148
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:45 am
BUF
- TYS
2 stops10h 05m
Southwest
Deal found 4/6![Southwest logo]()
$153
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:39 pm
BUF
- TYS
1 stop4h 17m
Delta
Deal found 4/6![Delta logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:44 pm
BUF
- TYS
2 stops27h 53m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$163
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:44 am
BUF
- TYS
1 stop4h 14m
American Airlines
Deal found 4/6![American Airlines logo]()
$179
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:55 am
BUF
- TYS
2 stops10h 20m
Southwest
Deal found 4/6![Southwest logo]()
$194
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:09 am
BUF
- TYS
1 stop4h 59m
American Airlines
Deal found 4/6![American Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:35 am
BUF
- TYS
3 stops21h 01m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:57 pm
BUF
- TYS
3 stops41h 04m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$266
Find flight deals from Buffalo to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (Kiwi.com) |
One-way from | $148 (American Airlines) |
Popular in | January |
Cheapest in | August |
Average price | $409 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 4/28
12:50 pm-4:42 pm
1 stop3h 52m
Knoxville McGhee Tyson
Tue 5/5
7:50 am-11:39 am
1 stop3h 49m
$295
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 5/12
11:55 am-5:10 pm
1 stop5h 15m
Knoxville McGhee Tyson
Wed 5/13
12:50 pm-10:15 pm
2 stops9h 25m
$300
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Wed 5/6
6:05 am-5:10 pm
2 stops11h 05m
Knoxville McGhee Tyson
Wed 5/13
12:50 pm-10:15 pm
2 stops9h 25m
$305
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Wed 7/29
7:19 pm-11:52 pm
1 stop4h 33m
Knoxville McGhee Tyson
Sun 8/2
7:43 pm-11:59 pm
1 stop4h 16m
$357
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 9/8
9:45 am-7:50 pm
2 stops10h 05m
Knoxville McGhee Tyson
Sat 9/12
7:50 am-4:45 pm
2 stops8h 55m
$367
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Fri 9/4
7:40 pm-11:47 pm
1 stop4h 07m
Knoxville McGhee Tyson
Mon 9/7
7:20 pm-11:58 pm
1 stop4h 38m
$377
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 4/28
6:00 am-5:01 pm
2 stops11h 01m
Knoxville McGhee Tyson
Tue 5/5
7:00 am-6:10 pm
2 stops11h 10m
$386
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Sat 5/30
7:52 pm-11:54 pm
1 stop4h 02m
Knoxville McGhee Tyson
Wed 6/3
6:30 am-2:25 pm
2 stops7h 55m
$388
Cheapest one-way
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 8/11
9:45 am-7:50 pm
2 stops10h 05m
$153
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 5/21
7:44 pm-11:37 pm
2 stops27h 53m
$163
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
BUF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Knoxville
What is the cheapest month to book a flight from Buffalo to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 9, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
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Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Top 3 airlines flying from Buffalo to Knoxville
Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$239 | Average$337 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$343 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$283 | Average$411 | FlexibilityNo cancel fee | On-time69% |