HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$136+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Dec 18 — Dec 251
Thu 12/18
Thu 12/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Buffalo to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Buffalo to Knoxville McGhee Tyson are usually found in March or May, booked 89 days in advance, depart on a Tuesday or Sunday and return on a Wednesday

Find flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 18, 2025.

This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/211:35 amBUF - TYS
1 stop4h 14mAmerican Airlines
Sat 12/68:13 pmTYS - BUF
1 stop3h 54mAmerican Airlines
Deal found 11/17$277
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:24 amBUF - TYS
1 stop5h 00mAmerican Airlines
Mon 12/226:25 pmTYS - BUF
1 stop4h 44mAmerican Airlines
Deal found 11/18$337
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:14 amBUF - TYS
1 stop7h 44mAmerican Airlines
Tue 12/237:00 amTYS - BUF
1 stop5h 57mAmerican Airlines
Deal found 11/17$396
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:11 amBUF - TYS
1 stop4h 41mAmerican Airlines
Tue 12/210:54 amTYS - BUF
1 stop4h 06mAmerican Airlines
Deal found 11/18$457
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:52 amBUF - TYS
1 stop9h 38mMultiple Airlines
Sun 11/235:49 pmTYS - BUF
2 stops22h 31mMultiple Airlines
Deal found 11/16$472
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:35 amBUF - TYS
2 stops9h 29mUnited Airlines
Tue 12/232:00 pmTYS - BUF
1 stop19h 46mUnited Airlines
Deal found 11/17$487
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:58 pmBUF - TYS
1 stop3h 40mAmerican Airlines
Sun 12/285:08 pmTYS - BUF
1 stop5h 36mAmerican Airlines
Deal found 11/16$522

Cheap flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$277
(American Airlines)

One-way from

$136
(Kiwi.com)

Popular in

October

Cheapest in

March

Average price

$388
Provider with most accurate pricing for Buffalo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Knoxville McGhee Tyson flights.
Search Deals
From Buffalo to Knoxville McGhee Tyson
Search Deals
One-way flight from Buffalo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Buffalo

Fly to

Knoxville

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 12/2

11:35 am-3:49 pm

1 stop4h 14m

Knoxville McGhee Tyson

Sat 12/6

8:13 pm-12:07 am

1 stop3h 54m

$277

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 1/7

9:55 am-2:49 pm

1 stop4h 54m

Knoxville McGhee Tyson

Mon 1/12

9:30 am-2:14 pm

1 stop4h 44m

$307

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 12/19

5:24 am-10:24 am

1 stop5h 00m

Knoxville McGhee Tyson

Mon 12/22

6:25 pm-11:09 pm

1 stop4h 44m

$337

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 1/25

6:05 am-11:03 am

1 stop4h 58m

Knoxville McGhee Tyson

Thu 1/29

5:14 pm-11:41 pm

1 stop6h 27m

$407

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 1/25

11:24 am-8:52 pm

2 stops9h 28m

Knoxville McGhee Tyson

Thu 1/29

6:45 am-2:14 pm

2 stops7h 29m

$417

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 11/29

6:11 am-10:52 am

1 stop4h 41m

Knoxville McGhee Tyson

Tue 12/2

10:54 am-3:00 pm

1 stop4h 06m

$457

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 11/21

11:52 am-9:30 pm

1 stop9h 38m

Knoxville McGhee Tyson

Sun 11/23

5:49 pm-4:20 pm

2 stops22h 31m

$472

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 12/16

11:35 am-9:04 pm

2 stops9h 29m

Knoxville McGhee Tyson

Tue 12/23

2:00 pm-9:46 am

1 stop19h 46m

$487

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 1/4

6:32 pm-10:07 pm

2 stops27h 35m

$136

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 12/2

6:12 am-11:47 am

1 stop5h 35m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 15 results
1
2

Compare providers for flights from Buffalo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on November 14, 2025.

Booking 86 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in October is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to TYS?

Find hourly flight availability from Buffalo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 18, 2025.

It’s typically best to fly out from Buffalo to Knoxville in the evening. Doing so could potentially save you 28% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 18, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,019 reviews
Delta
7.9
Good
8,003 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,003 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    American Airlines and United Airlines can get you from Buffalo to Knoxville in just under 4h 14m. Your travel time can differ by up to 40m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $232 and $248 round-trip. United Airlines is 35% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in October is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Nashville flights
Newark to Nashville flights
LaGuardia to Nashville flights
LaGuardia to Knoxville flights
John F Kennedy Intl to Knoxville flights
John F Kennedy Intl to Memphis flights
Newark to Memphis flights
LaGuardia to Memphis flights
Newark to Knoxville flights
Buffalo to Nashville flights
Stewart to Nashville flights
Albany to Nashville flights
Rochester to Nashville flights
LaGuardia to Chattanooga flights
Syracuse to Nashville flights
Newark to Chattanooga flights
John F Kennedy Intl to Chattanooga flights
White Plains to Nashville flights
John F Kennedy Intl to Blountville flights
Newark to Blountville flights
LaGuardia to Blountville flights
Syracuse to Knoxville flights
Rochester to Knoxville flights
Buffalo to Memphis flights
Stewart to Knoxville flights
Albany to Knoxville flights
Stewart to Memphis flights
Buffalo to Chattanooga flights
White Plains to Knoxville flights
Islip to Nashville flights
Plattsburgh to Nashville flights
White Plains to Memphis flights
Albany to Memphis flights
Syracuse to Chattanooga flights
Syracuse to Memphis flights
Rochester to Memphis flights
Islip to Knoxville flights
Ithaca to Nashville flights
Rochester to Chattanooga flights
Syracuse to Blountville flights
Albany to Chattanooga flights
Binghamton to Nashville flights
Ithaca to Knoxville flights
White Plains to Chattanooga flights
Buffalo to Blountville flights
Elmira to Nashville flights
Rutland to Nashville flights
Saranac Lake to Nashville flights
Albany to Blountville flights

Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$415FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$323FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$344FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.