HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$139+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Apr 5 — Apr 121
Sun 4/5
Sun 4/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Buffalo to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.

This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/314:15 pm
BUF
-
TYS
1 stop3h 50m
Southwest
Tue 4/78:15 am
TYS
-
BUF
1 stop6h 20m
Southwest
Deal found 3/3$277
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:30 am
BUF
-
TYS
2 stops12h 04m
United Airlines
Sat 5/27:00 am
TYS
-
BUF
2 stops7h 10m
United Airlines
Deal found 3/2$288
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
BUF
-
TYS
1 stop5h 31m
American Airlines
Wed 4/296:38 pm
TYS
-
BUF
1 stop4h 41m
American Airlines
Deal found 3/2$298
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:30 pm
BUF
-
TYS
1 stop5h 10m
Southwest
Thu 3/263:45 pm
TYS
-
BUF
2 stops8h 25m
Southwest
Deal found 3/3$303
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:49 pm
BUF
-
TYS
1 stop4h 40m
United Airlines
Thu 3/267:00 am
TYS
-
BUF
1 stop6h 17m
United Airlines
Deal found 3/3$309
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:55 pm
BUF
-
TYS
1 stop6h 15m
Southwest
Tue 4/78:15 am
TYS
-
BUF
1 stop4h 00m
Southwest
Deal found 3/3$317
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:29 am
BUF
-
TYS
1 stop5h 42m
American Airlines
Wed 4/86:00 am
TYS
-
BUF
1 stop5h 58m
American Airlines
Deal found 3/4$318
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:15 pm
BUF
-
TYS
1 stop3h 50m
Southwest
Fri 3/277:50 am
TYS
-
BUF
1 stop3h 50m
Southwest
Deal found 3/2$327

Find flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$277
(Southwest)

One-way from

$139
(Southwest)

Popular in

January

Cheapest in

March

Average price

$286
Provider with most accurate pricing for Buffalo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Knoxville McGhee Tyson flights.
Search Deals
From Buffalo to Knoxville McGhee Tyson
Search Deals
One-way flight from Buffalo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($125 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 4/28

10:30 am-10:34 pm

2 stops12h 04m

Knoxville McGhee Tyson

Sat 5/2

7:00 am-2:10 pm

2 stops7h 10m

$288
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 3/25

4:15 pm-8:05 pm

1 stop3h 50m

Knoxville McGhee Tyson

Fri 3/27

7:50 am-11:40 am

1 stop3h 50m

$327

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 5/27

6:05 am-5:10 pm

2 stops11h 05m

Knoxville McGhee Tyson

Wed 6/3

8:15 am-12:15 pm

1 stop4h 00m

$342

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 5/8

5:20 pm-9:15 pm

1 stop3h 55m

Knoxville McGhee Tyson

Mon 5/11

12:15 pm-6:35 pm

1 stop6h 20m

$377

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 5/7

9:20 am-6:10 pm

2 stops8h 50m

Knoxville McGhee Tyson

Sun 5/10

12:15 pm-6:55 pm

1 stop6h 40m

$442

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 4/3

5:55 pm-10:10 pm

1 stop4h 15m

Knoxville McGhee Tyson

Tue 4/7

8:15 am-12:15 pm

1 stop4h 00m

$452

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 3/20

7:30 pm-7:29 pm

1 stop23h 59m

Knoxville McGhee Tyson

Thu 3/26

7:00 am-2:14 pm

2 stops7h 14m

$468

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 4/24

11:25 am-8:20 pm

2 stops8h 55m

Knoxville McGhee Tyson

Mon 4/27

6:35 am-3:25 pm

2 stops8h 50m

$527

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 4/2

3:55 pm-10:10 pm

1 stop6h 15m

Knoxville McGhee Tyson

Thu 4/9

8:05 am-12:00 pm

1 stop3h 55m

$532
Cheapest one-way

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 4/15

11:55 am-5:10 pm

1 stop5h 15m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Buffalo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on February 27, 2026.

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 6, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,258 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,258 reviews
Delta
7.9
Good
8,258 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,403 reviews
Delta
7.9
Good
8,258 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.1
Good
11,392 reviews
Delta
7.9
Good
8,258 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    United Airlines and Southwest can get you from Buffalo to Knoxville in just under 3h 50m. Your travel time can differ by up to 8h 14m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $232 and $248 round-trip. United Airlines is 41% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$416FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights