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$160+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:10 am
BUF
-
TYS
1 stop4h 39m
United Airlines
Tue 5/127:18 pm
TYS
-
BUF
1 stop4h 37m
United Airlines
Deal found 3/11$298
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:59 pm
BUF
-
TYS
1 stop4h 03m
American Airlines
Tue 4/146:38 pm
TYS
-
BUF
1 stop5h 11m
American Airlines
Deal found 3/10$299
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:00 am
BUF
-
TYS
2 stops9h 20m
Southwest
Tue 5/128:15 am
TYS
-
BUF
1 stop4h 00m
Southwest
Deal found 3/11$303
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:42 pm
BUF
-
TYS
1 stop26h 50m
Multiple Airlines
Thu 3/266:30 pm
TYS
-
BUF
1 stop24h 16m
Multiple Airlines
Deal found 3/11$316
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:30 am
BUF
-
TYS
1 stop5h 31m
American Airlines
Sun 5/106:00 am
TYS
-
BUF
1 stop6h 13m
American Airlines
Deal found 3/10$328
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:02 pm
BUF
-
TYS
1 stop4h 32m
United Airlines
Tue 4/147:00 am
TYS
-
BUF
2 stops7h 17m
United Airlines
Deal found 3/10$329
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:52 pm
BUF
-
TYS
1 stop6h 38m
United Airlines
Tue 6/307:19 pm
TYS
-
BUF
1 stop4h 40m
United Airlines
Deal found 3/8$337
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:05 am
BUF
-
TYS
1 stop4h 38m
American Airlines
Mon 9/285:09 pm
TYS
-
BUF
1 stop6h 08m
American Airlines
Deal found 3/9$339
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:00 am
BUF
-
TYS
1 stop5h 48m
American Airlines
Tue 6/306:07 pm
TYS
-
BUF
2 stops5h 49m
American Airlines
Deal found 3/8$342
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:28 pm
BUF
-
TYS
1 stop4h 27m
American Airlines
Mon 4/205:57 pm
TYS
-
BUF
1 stop5h 50m
American Airlines
Deal found 3/12$348
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:42 pm
BUF
-
TYS
2 stops45h 54m
Multiple Airlines
Mon 4/201:15 pm
TYS
-
BUF
1 stop6h 11m
Multiple Airlines
Deal found 3/12$354

Find flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$298
(United Airlines)

One-way from

$160
(American Airlines)

Popular in

January

Cheapest in

May

Average price

$283
Provider with most accurate pricing for Buffalo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Knoxville McGhee Tyson flights.
Search Deals
From Buffalo to Knoxville McGhee Tyson
Search Deals
One-way flight from Buffalo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($132 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 4/7

6:02 pm-10:34 pm

1 stop4h 32m

Knoxville McGhee Tyson

Tue 4/14

7:00 am-2:17 pm

2 stops7h 17m

$329

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 6/24

5:52 pm-12:30 am

1 stop6h 38m

Knoxville McGhee Tyson

Tue 6/30

7:19 pm-11:59 pm

1 stop4h 40m

$337

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 6/24

12:45 pm-8:20 pm

2 stops7h 35m

Knoxville McGhee Tyson

Tue 6/30

12:45 pm-9:25 pm

2 stops8h 40m

$367

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 4/25

10:35 am-3:09 pm

1 stop4h 34m

Knoxville McGhee Tyson

Sat 5/2

7:00 am-6:17 pm

2 stops11h 17m

$392

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 4/7

11:00 am-7:40 pm

2 stops8h 40m

Knoxville McGhee Tyson

Tue 4/14

7:05 am-6:15 pm

2 stops11h 10m

$393
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 8/22

6:00 am-10:36 am

1 stop4h 36m

Knoxville McGhee Tyson

Wed 8/26

5:45 am-9:40 am

1 stop3h 55m

$407

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 9/4

6:30 am-12:25 pm

1 stop5h 55m

Knoxville McGhee Tyson

Mon 9/7

6:21 am-11:58 am

1 stop5h 37m

$427
Cheapest one-way

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 3/30

5:29 am-11:11 am

1 stop5h 42m

$160

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 4/9

11:25 am-8:20 pm

2 stops8h 55m

$184
Quickest one-way

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 8/1

8:02 am-12:49 pm

1 stop4h 47m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Buffalo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 13, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,285 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,285 reviews
Delta
7.9
Good
8,285 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,418 reviews
Delta
7.9
Good
8,285 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.1
Good
11,446 reviews
Delta
7.9
Good
8,285 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    United Airlines and Southwest can get you from Buffalo to Knoxville in just under 4h 32m. Your travel time can differ by up to 3h 03m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $239 and $248 round-trip. United Airlines is 40% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$453FlexibilityNo cancel feeOn-time69%
DeltaCheapest$239Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%

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