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Knoxville

$128+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
fev 21 — fev 281
sáb 2/21
sáb 2/28
1 adult, Economy
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Cheap flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on janeiro 22, 2026.

This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 4/216:10 am
BUF
-
TYS
1 stop3h 56m
Delta
sáb 4/257:46 am
TYS
-
BUF
1 stop3h 59m
Delta
Deal found 1/20$289
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 4/213:41 pm
BUF
-
TYS
2 stops7h 15m
American Airlines
sáb 4/254:15 pm
TYS
-
BUF
1 stop5h 09m
American Airlines
Deal found 1/20$294
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 3/287:51 pm
BUF
-
TYS
1 stop3h 59m
American Airlines
sáb 4/46:05 am
TYS
-
BUF
1 stop5h 21m
American Airlines
Deal found 1/21$299
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 2/2311:17 am
BUF
-
TYS
1 stop7h 15m
Multiple Airlines
qui 2/263:25 pm
TYS
-
BUF
2 stops24h 45m
Multiple Airlines
Deal found 1/19$305
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 4/146:59 pm
BUF
-
TYS
1 stop3h 57m
American Airlines
seg 4/207:50 am
TYS
-
BUF
1 stop6h 29m
American Airlines
Deal found 1/21$308
This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 3/205:29 pm
BUF
-
TYS
1 stop4h 09m
American Airlines
qui 3/265:02 pm
TYS
-
BUF
1 stop6h 29m
American Airlines
Deal found 1/22$318
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 5/96:00 am
BUF
-
TYS
2 stops9h 20m
Southwest
seg 5/1112:15 pm
TYS
-
BUF
1 stop6h 20m
Southwest
Deal found 1/21$323
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 5/285:20 pm
BUF
-
TYS
1 stop3h 55m
Southwest
seg 6/112:15 pm
TYS
-
BUF
1 stop6h 20m
Southwest
Deal found 1/21$337
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 3/66:19 am
BUF
-
TYS
1 stop5h 01m
American Airlines
sex 3/136:10 am
TYS
-
BUF
1 stop4h 48m
American Airlines
Deal found 1/20$338
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 3/201:00 pm
BUF
-
TYS
1 stop3h 43m
Delta
qui 3/265:24 pm
TYS
-
BUF
1 stop5h 31m
Delta
Deal found 1/21$343

Find flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated janeiro 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$289
(American Airlines)

One-way from

$128
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$588
Provider with most accurate pricing for Buffalo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Knoxville McGhee Tyson flights.
Search Deals
From Buffalo to Knoxville McGhee Tyson
Search Deals
One-way flight from Buffalo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($99 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janeiro 22, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Buffalo

Fly to

Knoxville

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

seg 2/23

6:07 am-10:49 am

1 stop4h 42m

Knoxville McGhee Tyson

qui 2/26

6:45 am-1:12 pm

1 stop6h 27m

$299

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

seg 2/23

11:17 am-6:32 pm

1 stop7h 15m

Knoxville McGhee Tyson

qui 2/26

3:25 pm-4:10 pm

2 stops24h 45m

$305

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

ter 4/14

6:59 pm-10:56 pm

1 stop3h 57m

Knoxville McGhee Tyson

seg 4/20

7:50 am-2:19 pm

1 stop6h 29m

$308

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sáb 5/9

9:30 am-1:20 pm

1 stop3h 50m

Knoxville McGhee Tyson

seg 5/11

8:05 am-12:00 pm

1 stop3h 55m

$318

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sex 3/20

5:29 pm-9:38 pm

1 stop4h 09m

Knoxville McGhee Tyson

qui 3/26

5:02 pm-11:31 pm

1 stop6h 29m

$318

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

seg 6/1

7:00 am-1:18 pm

1 stop6h 18m

Knoxville McGhee Tyson

sáb 6/6

2:00 pm-8:31 pm

1 stop6h 31m

$337

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

qui 5/28

10:55 am-6:10 pm

1 stop7h 15m

Knoxville McGhee Tyson

seg 6/1

8:05 am-6:00 pm

2 stops9h 55m

$342

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sex 3/20

1:00 pm-4:43 pm

1 stop3h 43m

Knoxville McGhee Tyson

qui 3/26

5:24 pm-10:55 pm

1 stop5h 31m

$343

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

ter 3/3

7:00 am-3:32 pm

2 stops8h 32m

Knoxville McGhee Tyson

sáb 3/7

6:38 pm-10:49 pm

1 stop4h 11m

$352

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

qui 3/12

12:05 pm-9:15 pm

2 stops9h 10m

Knoxville McGhee Tyson

seg 3/16

3:45 pm-12:10 am

2 stops8h 25m

$358

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 12 results
1
2

Compare providers for flights from Buffalo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on January 16, 2026.

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in October is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated janeiro 22, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,087 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,087 reviews
Delta
7.9
Good
8,087 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,190 reviews
Delta
7.9
Good
8,087 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,087 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    United Airlines, American Airlines, and Southwest can get you from Buffalo to Knoxville in just under 3h 50m. Your travel time can differ by up to 52m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $232 and $248 round-trip. United Airlines is 39% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $137). Flying from Buffalo to Knoxville in October is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Buffalo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janeiro 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$416FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$337FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$339FlexibilityNo cancel feeOn-time71%

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