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$190+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/31. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Buffalo to Knoxville McGhee Tyson are usually found in September or February, booked 60 days in advance, depart on a Tuesday or Sunday and return on a Wednesday

Cheap flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$225
(United Airlines)

One-way from

$190
(Mytrip)

Popular in

June

Cheapest in

September

Average price

$408
From Buffalo to Knoxville McGhee Tyson
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One-way flight from Buffalo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/275:54 pmBUF - TYS
1 stop4h 41mUnited Airlines
dom. 8/315:45 amTYS - BUF
1 stop4h 00mUnited Airlines
Deal found 6/11$225
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/96:30 amBUF - TYS
1 stop3h 44mDelta
mié. 7/165:30 amTYS - BUF
1 stop5h 32mDelta
Deal found 6/11$249
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/96:00 amBUF - TYS
1 stop5h 23mAmerican Airlines
mié. 7/165:05 amTYS - BUF
1 stop3h 52mAmerican Airlines
Deal found 6/11$250
This Frontier deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/99:45 pmBUF - TYS
2 stops21h 52mFrontier
jue. 10/168:22 pmTYS - BUF
2 stops15h 37mFrontier
Deal found 6/10$449
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/2811:41 amBUF - TYS
3 stops28h 24mMultiple Airlines
mié. 7/307:10 amTYS - BUF
2 stops27h 34mMultiple Airlines
Deal found 6/10$461

Cheapflights Fare Finder

Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Buffalo

Fly to

Knoxville

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mié. 8/27

5:54 pm-10:35 pm

1 stop4h 41m

Knoxville McGhee Tyson

dom. 8/31

5:45 am-9:45 am

1 stop4h 00m

$225

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mié. 7/9

6:30 am-10:14 am

1 stop3h 44m

Knoxville McGhee Tyson

mié. 7/16

5:30 am-11:02 am

1 stop5h 32m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mié. 7/9

6:00 am-11:23 am

1 stop5h 23m

Knoxville McGhee Tyson

mié. 7/16

5:05 am-8:57 am

1 stop3h 52m

$250

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

jue. 10/9

9:45 pm-7:37 pm

2 stops21h 52m

Knoxville McGhee Tyson

jue. 10/16

8:22 pm-11:59 am

2 stops15h 37m

$449

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

lun. 7/28

11:41 am-4:05 pm

3 stops28h 24m

Knoxville McGhee Tyson

mié. 7/30

7:10 am-10:44 am

2 stops27h 34m

$461

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

jue. 7/31

11:41 am-5:12 pm

2 stops29h 31m

$190

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sáb. 7/5

6:30 am-10:09 am

1 stop3h 39m

$200

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mar. 12/2

5:23 pm-11:50 pm

2 stops6h 27m

$244

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mar. 12/2

10:20 am-2:42 pm

1 stop4h 22m

$274

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sáb. 7/5

9:37 pm-4:29 pm

2 stops18h 52m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on June 9, 2025.

Booking 42 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $296). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to TYS?

Find hourly flight availability from Buffalo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

It’s typically best to fly out from Buffalo to Knoxville in the evening. Doing so could potentially save you 29% on the flight price compared to flying at noon, which is usually more expensive.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated junio 12, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Frontier
6.0
Okay
3,295 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $225 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $249 and $250 round-trip. United Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Buffalo to Knoxville one-way?

    One-way options have recently been found by users for as low as $200 on Delta. Other airlines that offer cheap prices include American Airlines from $239 and Frontier from $350 one-way.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $296). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Buffalo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$203Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$310FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$224Average$408FlexibilityNo cancel feeOn-time69%

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