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Knoxville

$158+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Aug 21 — Aug 281
Fri 8/21
Fri 8/28
1 adult, Economy
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Cheap flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:20 pm
BUF
-
TYS
2 stops23h 15m
Multiple Airlines
Mon 8/312:49 pm
TYS
-
BUF
1 stop18h 34m
Multiple Airlines
Deal found 7/18$255
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1510:30 am
BUF
-
TYS
1 stop6h 28m
United Airlines
Sat 8/227:20 pm
TYS
-
BUF
1 stop4h 24m
United Airlines
Deal found 7/21$279
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:16 pm
BUF
-
TYS
2 stops23h 25m
Multiple Airlines
Mon 9/214:18 pm
TYS
-
BUF
1 stop25h 16m
Multiple Airlines
Deal found 7/21$284
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:13 pm
BUF
-
TYS
1 stop6h 39m
Delta
Wed 9/97:33 am
TYS
-
BUF
1 stop3h 49m
Delta
Deal found 7/19$319
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/208:54 pm
BUF
-
TYS
1 stop23h 45m
Multiple Airlines
Fri 9/258:55 pm
TYS
-
BUF
2 stops39h 26m
Multiple Airlines
Deal found 7/20$322
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:35 pm
BUF
-
TYS
2 stops6h 20m
Southwest
Wed 9/98:05 am
TYS
-
BUF
1 stop6h 15m
Southwest
Deal found 7/19$324
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:40 am
BUF
-
TYS
2 stops7h 30m
Southwest
Tue 9/228:05 am
TYS
-
BUF
1 stop6h 15m
Southwest
Deal found 7/20$333
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am
BUF
-
TYS
1 stop7h 07m
American Airlines
Sun 9/206:30 am
TYS
-
BUF
1 stop6h 12m
American Airlines
Deal found 7/19$338

Find flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$255
(Kiwi.com)

One-way from

$158
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$606
Provider with most accurate pricing for Buffalo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Knoxville McGhee Tyson flights.
Search Deals
From Buffalo to Knoxville McGhee Tyson
Search Deals
One-way flight from Buffalo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($152 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 8/27

6:27 am-10:20 am

1 stop3h 53m

Knoxville McGhee Tyson

Mon 8/31

6:12 pm-11:59 pm

1 stop5h 47m

$319

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 8/24

10:30 am-4:58 pm

1 stop6h 28m

Knoxville McGhee Tyson

Mon 8/31

7:00 am-2:18 pm

2 stops7h 18m

$324

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 8/20

7:19 pm-11:52 pm

1 stop4h 33m

Knoxville McGhee Tyson

Mon 8/24

7:41 pm-11:59 pm

1 stop4h 18m

$338
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 8/27

6:27 am-10:20 am

1 stop3h 53m

Knoxville McGhee Tyson

Sun 8/30

7:15 am-11:22 am

1 stop4h 07m

$338

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 8/25

8:40 am-6:55 pm

2 stops10h 15m

Knoxville McGhee Tyson

Sat 8/29

12:30 pm-9:05 pm

2 stops8h 35m

$348

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 8/24

5:40 am-1:25 pm

2 stops7h 45m

Knoxville McGhee Tyson

Mon 8/31

7:10 am-3:15 pm

2 stops8h 05m

$348

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 9/4

12:16 pm-5:19 pm

1 stop5h 03m

Knoxville McGhee Tyson

Mon 9/7

7:15 am-11:22 am

1 stop4h 07m

$357

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 8/27

7:59 pm-11:59 pm

1 stop4h 00m

Knoxville McGhee Tyson

Mon 8/31

7:00 am-2:18 pm

2 stops7h 18m

$364

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 8/11

6:00 am-4:58 pm

2 stops10h 58m

Knoxville McGhee Tyson

Sun 8/16

5:45 am-9:48 am

1 stop4h 03m

$364

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 9/20

6:20 am-10:18 am

1 stop3h 58m

Knoxville McGhee Tyson

Fri 9/25

5:20 pm-11:52 pm

1 stop6h 32m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/18

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Buffalo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $343). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 22, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,476 reviews

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work
Delta
7.8
Good
8,476 reviews
Delta
7.8
Good
8,476 reviews

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work
United Airlines
7.4
Good
10,020 reviews
Delta
7.8
Good
8,476 reviews

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work
American Airlines
7.1
Good
11,834 reviews
Delta
7.8
Good
8,476 reviews

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    Delta, United Airlines, and Southwest can get you from Buffalo to Knoxville in just under 3h 53m. Your travel time can differ by up to 6h 22m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $250 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $255 and $346 round-trip. Delta is 46% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $343). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$396FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$255Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$346Average$411FlexibilityNo cancel feeOn-time69%

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