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$126+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Buffalo to Knoxville McGhee Tyson are usually found in February or May, booked 42 days in advance, depart on a Tuesday or Sunday and return on a Wednesday

Cheap flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$251
(Delta)

One-way from

$126
(Delta)

Popular in

June

Cheapest in

February

Average price

$363
From Buffalo to Knoxville McGhee Tyson
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One-way flight from Buffalo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($10 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:55 pmBUF - TYS
1 stop4h 55mUnited Airlines
Wed 10/2210:51 amTYS - BUF
1 stop6h 02mUnited Airlines
Deal found 9/15$251
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:20 amBUF - TYS
1 stop5h 32mAmerican Airlines
Sat 11/155:35 pmTYS - BUF
1 stop6h 01mAmerican Airlines
Deal found 9/17$260
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:20 amBUF - TYS
1 stop5h 32mAmerican Airlines
Mon 11/176:16 pmTYS - BUF
1 stop5h 20mAmerican Airlines
Deal found 9/15$269
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/211:50 amBUF - TYS
1 stop4h 13mAmerican Airlines
Mon 10/68:37 pmTYS - BUF
1 stop3h 38mAmerican Airlines
Deal found 9/16$279
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/83:04 pmBUF - TYS
1 stop6h 20mAmerican Airlines
Mon 11/106:16 pmTYS - BUF
1 stop5h 20mAmerican Airlines
Deal found 9/16$285
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/137:38 pmBUF - TYS
1 stop4h 12mAmerican Airlines
Wed 10/1511:15 amTYS - BUF
1 stop6h 37mAmerican Airlines
Deal found 9/15$314
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:40 amBUF - TYS
1 stop4h 50mAmerican Airlines
Mon 11/106:16 pmTYS - BUF
1 stop5h 20mAmerican Airlines
Deal found 9/15$319
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/177:40 amBUF - TYS
1 stop6h 49mAmerican Airlines
Sat 11/225:52 pmTYS - BUF
1 stop5h 44mAmerican Airlines
Deal found 9/16$334
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:30 pmBUF - TYS
1 stop4h 16mDelta
Mon 10/205:44 amTYS - BUF
1 stop5h 17mDelta
Deal found 9/15$337
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1611:35 amBUF - TYS
1 stop6h 13mAmerican Airlines
Mon 10/208:37 pmTYS - BUF
1 stop3h 38mAmerican Airlines
Deal found 9/17$339

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Buffalo

Fly to

Knoxville

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 10/15

5:55 pm-10:50 pm

1 stop4h 55m

Knoxville McGhee Tyson

Wed 10/22

10:51 am-4:53 pm

1 stop6h 02m

$251

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 11/14

4:26 pm-9:24 pm

1 stop4h 58m

Knoxville McGhee Tyson

Mon 11/17

6:16 pm-11:36 pm

1 stop5h 20m

$314

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 11/6

7:40 am-12:30 pm

1 stop4h 50m

Knoxville McGhee Tyson

Mon 11/10

6:16 pm-11:36 pm

1 stop5h 20m

$319

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/16

7:30 pm-11:46 pm

1 stop4h 16m

Knoxville McGhee Tyson

Mon 10/20

5:44 am-11:01 am

1 stop5h 17m

$337

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/16

7:30 pm-11:46 pm

1 stop4h 16m

Knoxville McGhee Tyson

Sun 10/19

5:16 pm-11:39 pm

1 stop6h 23m

$357

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/16

11:35 am-5:48 pm

1 stop6h 13m

Knoxville McGhee Tyson

Sun 10/19

8:37 pm-12:15 am

1 stop3h 38m

$359

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 11/14

4:26 pm-9:24 pm

1 stop4h 58m

Knoxville McGhee Tyson

Sun 11/16

8:04 pm-12:08 am

1 stop4h 04m

$359

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/16

11:35 am-5:48 pm

1 stop6h 13m

Knoxville McGhee Tyson

Mon 10/20

8:37 pm-12:15 am

1 stop3h 38m

$368

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 10/17

7:38 pm-11:53 pm

1 stop4h 15m

Knoxville McGhee Tyson

Sun 10/19

8:37 pm-12:15 am

1 stop3h 38m

$388

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 12/13

1:16 pm-8:00 pm

1 stop6h 44m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 15 results
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Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on September 12, 2025.

Booking 42 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $295). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to TYS?

Find hourly flight availability from Buffalo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s typically best to fly out from Buffalo to Knoxville in the evening. Doing so could potentially save you 29% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    United Airlines and American Airlines can get you from Buffalo to Knoxville in just under 4h 55m. Your travel time can differ by up to 03m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $232 and $248 round-trip. United Airlines is 33% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $295). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$415FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$336FlexibilityNo cancel feeOn-time71%

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