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$93+ Cheap flights from Buffalo to Knoxville (BUF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
ago. 23 — ago. 301
sáb. 8/23
sáb. 8/30
1 adult, Economy
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Cheapflights Tip: The best prices from Buffalo to Knoxville McGhee Tyson are usually found in February or October, booked 42 days in advance, depart on a Tuesday or Sunday and return on a Wednesday

Cheap flight deals from Buffalo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 18, 2025.

Round-trip from

$234
(American Airlines)

One-way from

$93
(FlightHub)

Popular in

June

Cheapest in

February

Average price

$293
From Buffalo to Knoxville McGhee Tyson
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One-way flight from Buffalo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($28 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Buffalo to Knoxville

Cheapest flights from Buffalo to Knoxville
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 18, 2025.

This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/308:00 amBUF - TYS
2 stops7h 35mAmerican Airlines
mar. 9/210:36 amTYS - BUF
1 stop6h 45mAmerican Airlines
Deal found 8/16$234
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/266:49 pmBUF - TYS
1 stop4h 14mAmerican Airlines
dom. 9/288:36 pmTYS - BUF
1 stop3h 36mAmerican Airlines
Deal found 8/17$249
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/58:00 amBUF - TYS
1 stop6h 09mAmerican Airlines
dom. 9/78:36 pmTYS - BUF
1 stop3h 36mAmerican Airlines
Deal found 8/17$254
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/305:10 pmBUF - TYS
1 stop6h 38mDelta
mar. 9/26:14 pmTYS - BUF
1 stop5h 43mDelta
Deal found 8/16$258
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/257:08 pmBUF - TYS
1 stop4h 36mDelta
dom. 9/285:45 amTYS - BUF
1 stop5h 16mDelta
Deal found 8/16$274
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/2910:12 amBUF - TYS
1 stop10h 29mMultiple Airlines
vie. 9/58:49 pmTYS - BUF
2 stops21h 25mMultiple Airlines
Deal found 8/16$279
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/147:41 pmBUF - TYS
1 stop26h 53mMultiple Airlines
dom. 9/218:30 amTYS - BUF
1 stop8h 57mMultiple Airlines
Deal found 8/17$286
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/247:30 pmBUF - TYS
1 stop4h 29mUnited Airlines
lun. 12/110:50 amTYS - BUF
1 stop5h 58mUnited Airlines
Deal found 8/18$294
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/257:41 pmBUF - TYS
1 stop21h 53mMultiple Airlines
dom. 9/287:00 amTYS - BUF
1 stop9h 02mMultiple Airlines
Deal found 8/16$298
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/247:30 pmBUF - TYS
1 stop4h 29mUnited Airlines
dom. 11/309:50 amTYS - BUF
2 stops8h 45mUnited Airlines
Deal found 8/18$299
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/276:00 amBUF - TYS
2 stops8h 43mUnited Airlines
sáb. 11/298:26 amTYS - BUF
2 stops10h 20mUnited Airlines
Deal found 8/18$304

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Buffalo

Fly to

Knoxville

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sáb. 8/30

8:00 am-3:35 pm

2 stops7h 35m

Knoxville McGhee Tyson

mar. 9/2

6:12 pm-11:00 pm

1 stop4h 48m

$234

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mié. 9/17

6:03 am-11:11 am

1 stop5h 08m

Knoxville McGhee Tyson

mar. 9/23

5:45 am-11:01 am

1 stop5h 16m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mar. 9/30

6:45 pm-11:03 pm

1 stop4h 18m

Knoxville McGhee Tyson

mar. 10/7

2:00 pm-6:18 pm

1 stop4h 18m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

lun. 11/24

6:00 am-11:05 am

1 stop5h 05m

Knoxville McGhee Tyson

mar. 12/2

6:10 pm-11:55 pm

1 stop5h 45m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

vie. 9/26

6:49 pm-11:03 pm

1 stop4h 14m

Knoxville McGhee Tyson

dom. 9/28

7:18 am-1:03 pm

1 stop5h 45m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

jue. 11/27

6:30 am-10:13 am

1 stop3h 43m

Knoxville McGhee Tyson

mar. 12/2

6:10 pm-11:55 pm

1 stop5h 45m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mié. 9/10

6:04 am-10:45 am

1 stop4h 41m

Knoxville McGhee Tyson

mié. 9/17

5:40 pm-11:14 pm

1 stop5h 34m

$249

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

dom. 9/21

4:57 pm-7:45 pm

1 stop26h 48m

$93

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

mar. 10/7

5:14 am-10:13 am

1 stop4h 59m

$126

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

sáb. 12/13

12:09 pm-6:13 pm

1 stop6h 04m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 13 results
1
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Best time to book a flight from Buffalo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Knoxville

How far ahead should I book a flight from Buffalo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Knoxville. Price data was last updated on August 8, 2025.

Booking 42 days in advance of your planned departure date is, on average, the best time to get cheap flights from Buffalo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Buffalo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $294). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to TYS?

Find hourly flight availability from Buffalo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 18, 2025.

It’s typically best to fly out from Buffalo to Knoxville in the evening. Doing so could potentially save you 29% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated agosto 18, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Knoxville?

    American Airlines and Delta can get you from Buffalo to Knoxville in just under 5h 08m. Your travel time can differ by up to 2h 27m. Airlines will cover a distance of 567 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Knoxville round-trip?

    Our cheapest airline available from Buffalo to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $224 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $232 and $238 round-trip. United Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Buffalo to Knoxville one-way?

    One-way options have recently been found by users for as low as $93 on Frontier. Other airlines that offer cheap prices include American Airlines from $126 and Delta from $126 one-way.

  • Can I find deals for flights from Buffalo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Buffalo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Knoxville.

  • Can I find deals for business class flights from Buffalo to Knoxville?

    Yes. Cheapflights offers flight deals from Buffalo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $294). Flying from Buffalo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Buffalo to Knoxville

Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$224Average$413FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$316FlexibilityNo cancel feeOn-time71%

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