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Key West

$307+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Panama City to Key West

Best flights from Panama City to Key West
Discover carefully curated flight deals from Panama City to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:56 amECP - EYW
1 stop7h 27mAmerican Airlines
Wed 4/158:08 amEYW - ECP
1 stop6h 22mAmerican Airlines
Deal found 12/17$307
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/86:00 amECP - EYW
1 stop4h 29mDelta
Sun 1/116:06 pmEYW - ECP
1 stop5h 45mDelta
Deal found 12/17$473
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/54:09 pmECP - EYW
1 stop5h 35mAmerican Airlines
Mon 1/127:08 amEYW - ECP
1 stop5h 25mAmerican Airlines
Deal found 12/16$353
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:30 pmECP - EYW
1 stop5h 13mAmerican Airlines
Wed 2/186:20 pmEYW - ECP
1 stop5h 17mAmerican Airlines
Deal found 12/16$387
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/144:30 pmECP - EYW
1 stop5h 13mAmerican Airlines
Wed 2/186:20 pmEYW - ECP
1 stop5h 17mAmerican Airlines
Deal found 12/16$387
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2012:03 pmECP - EYW
1 stop4h 58mAmerican Airlines
Tue 1/277:08 amEYW - ECP
1 stop5h 25mAmerican Airlines
Deal found 12/17$398
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/144:30 pmECP - EYW
1 stop5h 13mAmerican Airlines
Tue 2/176:20 pmEYW - ECP
1 stop5h 17mAmerican Airlines
Deal found 12/16$407
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/134:30 pmECP - EYW
1 stop5h 13mAmerican Airlines
Tue 2/176:20 pmEYW - ECP
1 stop5h 17mAmerican Airlines
Deal found 12/16$499
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:30 pmECP - EYW
1 stop5h 13mAmerican Airlines
Mon 2/164:40 pmEYW - ECP
1 stop8h 12mAmerican Airlines
Deal found 12/16$545

Find flight deals from Panama City to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$307
(American Airlines)

Popular in

March

Cheapest in

October

Average price

$452
Provider with most accurate pricing for Panama City NW Florida Beaches-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Key West flights.
Search Deals
From Panama City NW Florida Beaches to Key West
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($136 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Panama City

Fly to

Key West

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/8

9:56 am-6:23 pm

1 stop7h 27m

Key West

Wed 4/15

8:08 am-1:30 pm

1 stop6h 22m

$307

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 1/5

4:09 pm-10:44 pm

1 stop5h 35m

Key West

Mon 1/12

7:08 am-11:33 am

1 stop5h 25m

$353

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 2/12

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Wed 2/18

6:20 pm-10:37 pm

1 stop5h 17m

$387

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 2/14

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Wed 2/18

6:20 pm-10:37 pm

1 stop5h 17m

$387

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 1/20

12:03 pm-6:01 pm

1 stop4h 58m

Key West

Tue 1/27

7:08 am-11:33 am

1 stop5h 25m

$398

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 2/14

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Tue 2/17

6:20 pm-10:37 pm

1 stop5h 17m

$407

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 1/8

6:00 am-11:29 am

1 stop4h 29m

Key West

Sun 1/11

6:06 pm-10:51 pm

1 stop5h 45m

$473

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 2/13

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Tue 2/17

6:20 pm-10:37 pm

1 stop5h 17m

$499

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 2/12

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Mon 2/16

4:40 pm-11:52 pm

1 stop8h 12m

$545

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 3/21

7:19 am-3:57 pm

1 stop7h 38m

$360

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $161). Flying from Panama City, Florida to Key West in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City, Florida to Key West?

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Panama City to Key West, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Key West?

    Airlines like American Airlines fly from Panama City, Florida to Key West in about 7h 27m. The time it takes to get you to your destination can typically vary by up to . Panama City, Florida and Key West are separated by a distance of 471 mi.

  • What is the cheapest airline to fly from Panama City, Florida to Key West round-trip?

    Delta, at $306, was found to be the cheapest airline from Panama City, Florida to Key West.. You may be able to fly from Panama City, Florida to Key West for 35% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Key West that include hotel bookings?

    Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

  • Can I find deals for business class flights from Panama City to Key West?

    Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Key West?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $161). Flying from Panama City, Florida to Key West in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Panama City to Key West

Discover the top airline that operate flights from Panama City to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$306Average$522FlexibilityNo cancel feeOn-timeN/A

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