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$249+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Panama City to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(Delta)

One-way from

$249
(American Airlines)

Popular in

March

Cheapest in

October

Average price

$306
Provider with most accurate pricing for Panama City NW Florida Beaches-Key West flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Key West flights.
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From Panama City NW Florida Beaches to Key West
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One-way flight from Panama City NW Florida Beaches to Key West
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Highest demand for flights based on searches. 19% potential increase in price ($122 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:32 pmECP - EYW
1 stop5h 34mDelta
Tue 12/166:10 pmEYW - ECP
1 stop5h 27mDelta
Deal found 10/30$317
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:43 pmECP - EYW
2 stops7h 24mAmerican Airlines
Tue 12/167:30 amEYW - ECP
1 stop5h 08mAmerican Airlines
Deal found 10/30$322
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:15 amECP - EYW
1 stop5h 26mAmerican Airlines
Thu 12/117:00 amEYW - ECP
2 stops8h 13mAmerican Airlines
Deal found 10/30$332
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:00 amECP - EYW
1 stop4h 31mDelta
Tue 11/186:18 pmEYW - ECP
1 stop5h 19mDelta
Deal found 10/30$359
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:00 pmECP - EYW
1 stop4h 51mAmerican Airlines
Tue 11/181:33 pmEYW - ECP
2 stops10h 42mAmerican Airlines
Deal found 10/30$364
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:15 amECP - EYW
2 stops8h 46mAmerican Airlines
Wed 11/194:10 pmEYW - ECP
2 stops8h 05mAmerican Airlines
Deal found 10/30$369
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1012:00 pmECP - EYW
1 stop4h 51mAmerican Airlines
Mon 12/14:53 pmEYW - ECP
1 stop7h 56mAmerican Airlines
Deal found 10/29$373
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amECP - EYW
1 stop7h 03mDelta
Sat 11/157:40 amEYW - ECP
1 stop6h 07mDelta
Deal found 10/29$389

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Panama City

Fly to

Key West

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Tue 12/16

6:10 pm-10:37 pm

1 stop5h 27m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

2:43 pm-9:45 pm

1 stop6h 02m

Key West

Tue 12/16

6:33 pm-11:10 pm

1 stop5h 37m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 12/12

12:08 pm-5:52 pm

1 stop4h 44m

Key West

Wed 12/17

4:10 pm-11:10 pm

2 stops8h 00m

$322

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 1/5

6:00 am-11:31 am

1 stop4h 31m

Key West

Mon 1/12

6:08 pm-10:55 pm

1 stop5h 47m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 2/20

7:19 am-7:24 pm

2 stops11h 05m

Key West

Wed 2/25

11:47 am-10:25 pm

2 stops11h 38m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 12/6

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Thu 12/11

7:40 am-12:47 pm

1 stop6h 07m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 1/9

12:03 pm-6:01 pm

1 stop4h 58m

Key West

Mon 1/12

7:08 am-11:33 am

1 stop5h 25m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 12/6

7:15 am-1:41 pm

1 stop5h 26m

Key West

Thu 12/11

7:00 am-2:13 pm

2 stops8h 13m

$332

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/14

6:00 am-11:31 am

1 stop4h 31m

Key West

Tue 11/18

6:18 pm-10:37 pm

1 stop5h 19m

$359

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 1/10

12:03 pm-6:06 pm

1 stop5h 03m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Compare providers for flights from Panama City to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $140). Flying from Panama City, Florida to Key West in October is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City, Florida to Key West?

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Panama City to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Key West?

    Airlines like Delta and American Airlines fly from Panama City, Florida to Key West in about 5h 34m. The time it takes to get you to your destination can typically vary by up to 28m. Panama City, Florida and Key West are separated by a distance of 471 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

    American Airlines, at $296, was found to be the cheapest airline from Panama City, Florida to Key West. An alternate airline flying to your destination would be Delta. You may be able to fly from Panama City, Florida to Key West for 40% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Key West that include hotel bookings?

    Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

  • Can I find deals for business class flights from Panama City to Key West?

    Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Key West?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $140). Flying from Panama City, Florida to Key West in October is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to Key West

Discover the top 2 airlines that operate flights from Panama City to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$468FlexibilityNo cancel feeOn-time71%
DeltaCheapest$306Average$527FlexibilityNo cancel feeOn-timeN/A

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