What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

Delta, at $287, was found to be the cheapest airline from Panama City, Florida to Key West. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Panama City, Florida to Key West for 46% less than the average price by searching for these airlines.

What is the cheapest day to fly from Panama City, Florida to Key West?

Travelers seeking maximum savings on their Panama City, Florida to Key West flight should consider departing on Sunday mornings when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

What is the cheapest day to fly round-trip from Panama City, Florida to Key West?

Leaving on a Saturday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 51% on the overall cost on flights from Panama City, Florida to Key West.

What is the cheapest month to fly from Panama City, Florida to Key West?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, July can be a great choice for travel to Key West. Flights to Key West from Panama City, Florida in July are about $534 on average during July, but can be found for as low as $354.

What is the cheapest time of day to fly from ECP to EYW?

It’s typically best to fly out from Panama City, Florida to Key West in the morning. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Can I find deals for flights from Panama City to Key West that include hotel bookings?

Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Key West?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

Can I find deals for business class flights from Panama City to Key West?

Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$165+ Flights from Panama City, FL to Key West

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Cheap flight deals from Panama City to Key West

Round-trip from	$287 (Delta)
One-way from	$165 (Delta)
Popular in	March
Cheapest in	July
Average price	$407

From Panama City NW Florida Beaches to Key West

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One-way flight from Panama City NW Florida Beaches to Key West

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Highest demand for flights based on searches. 11% potential increase in price ($71 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Tue 9/26:00 amECP - EYW

1 stop3h 56mDelta

Wed 9/102:00 pmEYW - ECP

1 stop6h 48mDelta

Deal found 7/30

$287

Thu 12/1111:18 amECP - EYW

2 stops6h 20mAmerican Airlines

Tue 12/168:10 amEYW - ECP

1 stop6h 37mAmerican Airlines

Deal found 7/30

$302

Best flights from Panama City to Key West
Discover carefully curated flight deals from Panama City to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2025.

Tue 9/26:00 amECP - EYW

1 stop3h 56mDelta

Wed 9/102:00 pmEYW - ECP

1 stop6h 48mDelta

Deal found 7/30

$287

Wed 8/2710:18 amECP - EYW

1 stop5h 28mAmerican Airlines

Sun 8/3112:50 pmEYW - ECP

1 stop6h 24mAmerican Airlines

Deal found 7/28

$357

Last-minute flights from Panama City to Key West
Discover last-minute flight deals from Panama City to Key West. Data last updated July 30, 2025 and is based on user searches.

Wed 8/66:00 amECP - EYW

1 stop3h 51mDelta

Wed 8/66:27 pmEYW - ECP

1 stop4h 06mDelta

Deal found 7/29

$659

Wed 8/610:13 amECP - EYW

1 stop5h 33mAmerican Airlines

Wed 8/67:40 pmEYW - ECP

2 stops14h 58mAmerican Airlines

Deal found 7/29

$935

Tue 8/269:24 amECP - EYW

1 stop6h 48mDelta

Wed 9/36:20 pmEYW - ECP

1 stop5h 46mDelta

Deal found 7/29

$307

Fri 8/295:30 amECP - EYW

1 stop5h 16mAmerican Airlines

Sat 8/301:58 pmEYW - ECP

1 stop5h 16mAmerican Airlines

Deal found 7/29

$367

One-way flights from Panama City to Key West
Search for one-way flight options from Panama City to Key West. Find affordable one-way fares based on user searches. Data last updated July 30, 2025.

Fri 8/221:53 pmECP - EYW

1 stop5h 19mDelta

Deal found 7/29

$165

Mon 8/1810:18 amECP - EYW

2 stops7h 49mAmerican Airlines

Deal found 7/30

$284

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 9/2

6:00 am-10:56 am

1 stop3h 56m

Key West

Wed 9/10

2:00 pm-7:48 pm

1 stop6h 48m

$287

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 8/27

10:18 am-4:46 pm

1 stop5h 28m

Key West

Sun 8/31

12:50 pm-6:14 pm

1 stop6h 24m

$357

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 8/22

1:53 pm-8:12 pm

1 stop5h 19m

$165

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 8/18

10:18 am-7:07 pm

2 stops7h 49m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Read through reviews of airlines operating flights from Panama City to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

pilar,May 2025

RSW - ATL

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?
Delta, at $287, was found to be the cheapest airline from Panama City, Florida to Key West. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Panama City, Florida to Key West for 46% less than the average price by searching for these airlines.
Can I find deals for flights from Panama City to Key West that include hotel bookings?
Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Key West?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.
Can I find deals for business class flights from Panama City to Key West?
Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to Key West?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to Key West

Top 2 airlines flying from Panama City to Key West

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$322	Average$558	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$358	Average$468	FlexibilityNo cancel fee	On-time71%

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$165+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Key West with Cheapflights

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Cheap flight deals from Panama City to Key West

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key WestExplore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Reviews of airlines servicing Key West

Read through reviews of airlines operating flights from Panama City to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

Can I find deals for flights from Panama City to Key West that include hotel bookings?

How can I find direct flights from Panama City to Key West?

Can I find deals for business class flights from Panama City to Key West?

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Key West

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Key West

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Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.