What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

American Airlines, at $329, was found to be the cheapest airline from Panama City, Florida to Key West.Alternate airlines to your destination round-trip include Delta and United Airlines. You may be able to fly from Panama City, Florida to Key West for 36% less than the average price by searching for these airlines.

What is the cheapest day to fly from Panama City, Florida to Key West?

Travelers seeking maximum savings on their Panama City, Florida to Key West flight should consider departing on Sunday mornings when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Panama City, Florida to Key West?

Leaving on a Saturday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 51% on the overall cost on flights from Panama City, Florida to Key West.

What is the cheapest month to fly from Panama City, Florida to Key West?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, September can be a great choice for travel to Key West. Flights to Key West from Panama City, Florida in September are about $520 on average during September, but can be found for as low as $321.

What is the cheapest time of day to fly from ECP to EYW?

It’s typically best to fly out from Panama City, Florida to Key West in the morning. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Most accurate provider : When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to Key West that include hotel bookings?

Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Key West?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

Can I find deals for business class flights from Panama City to Key West?

Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$259+ Flights from Panama City, FL to Key West

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Key West with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Key West

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$329 (American Airlines)
One-way from	$259 (Delta)
Popular in	March
Cheapest in	September
Average price	$576

Provider with most accurate pricing for Panama City NW Florida Beaches-Key West flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Key West flights.

Search Deals

From Panama City NW Florida Beaches to Key West

Search Deals

One-way flight from Panama City NW Florida Beaches to Key West

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($79 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

Sat 8/235:30 amECP - EYW

1 stop5h 29mAmerican Airlines

Sat 8/3012:50 pmEYW - ECP

1 stop6h 25mAmerican Airlines

Deal found 4/29

$329

Wed 6/116:00 amECP - EYW

1 stop3h 53mDelta

Tue 6/176:29 pmEYW - ECP

1 stop5h 52mDelta

Deal found 4/29

$347

Tue 5/62:15 pmECP - EYW

2 stops22h 45mUnited Airlines

Sat 5/108:45 amEYW - ECP

2 stops29h 28mUnited Airlines

Deal found 4/29

$878

Best flights from Panama City to Key West
Discover carefully curated flight deals from Panama City to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2025.

Sat 8/235:30 amECP - EYW

1 stop5h 29mAmerican Airlines

Sat 8/3012:50 pmEYW - ECP

1 stop6h 25mAmerican Airlines

Deal found 4/29

$329

Wed 6/116:00 amECP - EYW

1 stop3h 53mDelta

Tue 6/176:29 pmEYW - ECP

1 stop5h 52mDelta

Deal found 4/29

$347

Wed 5/142:15 pmECP - EYW

2 stops26h 50mUnited Airlines

Sun 5/188:45 amEYW - ECP

2 stops53h 28mUnited Airlines

Deal found 4/29

$890

Last-minute flights from Panama City to Key West
Discover last-minute flight deals from Panama City to Key West. Data last updated April 29, 2025 and is based on user searches.

Tue 5/67:30 amECP - EYW

1 stop5h 35mDelta

Sat 5/106:25 pmEYW - ECP

1 stop3h 54mDelta

Deal found 4/29

$573

Tue 5/610:22 amECP - EYW

1 stop5h 18mAmerican Airlines

Sat 5/107:29 pmEYW - ECP

2 stops15h 19mAmerican Airlines

Deal found 4/29

$857

Tue 5/62:15 pmECP - EYW

2 stops22h 45mUnited Airlines

Sat 5/108:45 amEYW - ECP

2 stops29h 28mUnited Airlines

Deal found 4/29

$878

Wed 5/146:00 amECP - EYW

1 stop3h 51mDelta

Sun 5/187:00 amEYW - ECP

1 stop3h 49mDelta

Deal found 4/29

$459

Wed 5/1410:22 amECP - EYW

1 stop5h 18mAmerican Airlines

Sun 5/187:29 pmEYW - ECP

2 stops19h 20mAmerican Airlines

Deal found 4/29

$749

One-way flights from Panama City to Key West
Search for one-way flight options from Panama City to Key West. Find affordable one-way fares based on user searches. Data last updated April 29, 2025.

Sat 7/52:47 pmECP - EYW

1 stop3h 52mDelta

Deal found 4/29

$259

Sat 7/56:30 amECP - EYW

2 stops30h 30mUnited Airlines

Deal found 4/29

$446

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 8/23

5:30 am-11:59 am

1 stop5h 29m

Key West

Sat 8/30

12:50 pm-6:15 pm

1 stop6h 25m

$329

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 6/11

6:00 am-10:53 am

1 stop3h 53m

Key West

Tue 6/17

6:29 pm-11:21 pm

1 stop5h 52m

$347

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 5/14

2:15 pm-6:05 pm

2 stops26h 50m

Key West

Sun 5/18

8:45 am-1:13 pm

2 stops53h 28m

$890

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 7/5

2:47 pm-7:39 pm

1 stop3h 52m

$259

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 7/5

6:30 am-2:00 pm

2 stops30h 30m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Compare providers for flights from Panama City to Key West

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Key West by month

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

Temperature in Key West by month

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

Reviews of airlines servicing Key West

Read reviews from past customers who have flown Delta, United Airlines and American Airlines from Panama City to Key West. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Delta

8.0

Very good

7,936 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

MCO - ATL

United Airlines

7.4

Good

8,696 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

MCO - ATL

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

MCO - ATL

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?
American Airlines, at $329, was found to be the cheapest airline from Panama City, Florida to Key West.Alternate airlines to your destination round-trip include Delta and United Airlines. You may be able to fly from Panama City, Florida to Key West for 36% less than the average price by searching for these airlines.
Can I find deals for flights from Panama City to Key West that include hotel bookings?
Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Key West?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.
Can I find deals for business class flights from Panama City to Key West?
Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to Key West?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Panama City to Key West

Miami to Tampa flights

Fort Lauderdale to Tampa flights

Tampa to Miami flights

Miami to Orlando flights

Tampa to Fort Lauderdale flights

Fort Lauderdale to Orlando flights

Tampa to Key West flights

Miami to Jacksonville flights

Orlando to Miami flights

Jacksonville to Miami flights

Fort Lauderdale to Jacksonville flights

Pensacola to Orlando flights

Orlando to Fort Lauderdale flights

Pensacola to Fort Lauderdale flights

Orlando to Key West flights

Jacksonville to Fort Lauderdale flights

Tampa to Pensacola flights

Fort Lauderdale to Pensacola flights

Pensacola to Tampa flights

Pensacola to Miami flights

Orlando to Pensacola flights

Fort Lauderdale to Tallahassee flights

West Palm Beach to Jacksonville flights

Miami to Tallahassee flights

Miami to Panama City flights

Pensacola to Fort Myers flights

Miami to Pensacola flights

Panama City to Miami flights

Tallahassee to Miami flights

West Palm Beach to Tampa flights

Fort Myers to Pensacola flights

Tampa to Panama City flights

Pensacola to Jacksonville flights

West Palm Beach to Tallahassee flights

Tallahassee to Fort Lauderdale flights

Orlando to Fort Myers flights

Jacksonville to Orlando flights

Fort Lauderdale to Key West flights

West Palm Beach to Pensacola flights

Pensacola to Key West flights

Orlando to Panama City flights

Fort Myers to Jacksonville flights

Jacksonville to Key West flights

Fort Lauderdale to Panama City flights

Fort Lauderdale to Miami flights

Key West to Tampa flights

Miami to Key West flights

Panama City to Orlando flights

Tampa to Jacksonville flights

Fort Myers to Orlando flights

Other flights to Key West

Top 2 airlines flying from Panama City to Key West

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$298	Average$540	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$358	Average$495	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$259+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Key West with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to Key West

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key WestExplore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Compare providers for flights from Panama City to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in April.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Rainfall in Key West by month

Plan your trip to Key West by taking into account the average rainfall totals by month.

Temperature in Key West by month

Plan your trip to Key West by taking into account the average temperature totals by month.

Reviews of airlines servicing Key West

Read reviews from past customers who have flown Delta, United Airlines and American Airlines from Panama City to Key West. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

Can I find deals for flights from Panama City to Key West that include hotel bookings?

How can I find direct flights from Panama City to Key West?

Can I find deals for business class flights from Panama City to Key West?

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Key West

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Key West

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.