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Key West

$307+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$317
(Delta)

Popular in

March

Cheapest in

July

Average price

$560
From Panama City NW Florida Beaches to Key West
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($70 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Panama City to Key West

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amECP - EYW
1 stop6h 02mDelta
Wed 11/126:18 pmEYW - ECP
1 stop5h 19mDelta
Deal found 9/8$307
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amECP - EYW
1 stop6h 02mDelta
Sat 11/86:17 pmEYW - ECP
1 stop5h 53mDelta
Deal found 9/8$317
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:35 pmECP - EYW
1 stop5h 31mDelta
Wed 10/296:17 pmEYW - ECP
2 stops21h 13mDelta
Deal found 9/10$320
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:15 amECP - EYW
1 stop7h 58mAmerican Airlines
Tue 12/164:10 pmEYW - ECP
2 stops8h 00mAmerican Airlines
Deal found 9/10$322
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/71:25 pmECP - EYW
1 stop5h 41mDelta
Fri 11/146:18 pmEYW - ECP
1 stop5h 39mDelta
Deal found 9/8$327
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/265:30 amECP - EYW
1 stop5h 40mAmerican Airlines
Mon 11/34:18 pmEYW - ECP
2 stops7h 57mAmerican Airlines
Deal found 9/9$332
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:35 pmECP - EYW
1 stop5h 31mDelta
Thu 10/306:17 pmEYW - ECP
1 stop5h 53mDelta
Deal found 9/10$333
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amECP - EYW
1 stop6h 02mDelta
Thu 11/136:18 pmEYW - ECP
2 stops19h 42mDelta
Deal found 9/8$341
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:00 amECP - EYW
1 stop4h 27mDelta
Sat 11/16:17 pmEYW - ECP
2 stops22h 13mDelta
Deal found 9/10$342
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:28 pmECP - EYW
2 stops21h 59mDelta
Fri 10/3112:22 pmEYW - ECP
1 stop3h 58mDelta
Deal found 9/10$351
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:35 pmECP - EYW
1 stop5h 31mDelta
Tue 10/286:17 pmEYW - ECP
2 stops21h 13mDelta
Deal found 9/10$352

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Panama City

Fly to

Key West

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 11/4

6:00 am-1:02 pm

1 stop6h 02m

Key West

Wed 11/12

6:18 pm-1:00 pm

2 stops19h 42m

$310

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 11/4

6:00 am-1:02 pm

1 stop6h 02m

Key West

Fri 11/14

6:18 pm-10:57 pm

1 stop5h 39m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 10/23

1:35 pm-8:06 pm

1 stop5h 31m

Key West

Wed 10/29

6:17 pm-11:10 pm

1 stop5h 53m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 11/8

9:24 am-5:12 pm

1 stop6h 48m

Key West

Wed 11/12

6:18 pm-10:37 pm

1 stop5h 19m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 10/29

7:10 am-1:02 pm

1 stop4h 52m

Key West

Sat 11/1

6:17 pm-11:10 pm

1 stop5h 53m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 11/4

6:00 am-1:02 pm

1 stop6h 02m

Key West

Thu 11/13

6:18 pm-10:57 pm

1 stop5h 39m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 10/28

6:00 am-11:27 am

1 stop4h 27m

Key West

Sat 11/1

6:17 pm-11:10 pm

1 stop5h 53m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/7

11:24 am-5:12 pm

1 stop4h 48m

Key West

Wed 11/12

6:18 pm-1:00 pm

2 stops19h 42m

$320

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 10/25

6:00 am-1:02 pm

1 stop6h 02m

Key West

Wed 10/29

6:17 pm-2:30 pm

2 stops21h 13m

$320

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 10/23

1:35 pm-8:06 pm

1 stop5h 31m

Key West

Fri 10/31

12:22 pm-3:20 pm

1 stop3h 58m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Panama City to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Key West?

    Airlines like Delta fly from Panama City, Florida to Key West in about 6h 02m. The time it takes to get you to your destination can typically vary by up to . Panama City, Florida and Key West are separated by a distance of 471 mi.

  • What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

    American Airlines, at $296, was found to be the cheapest airline from Panama City, Florida to Key West. An alternate airline flying to your destination would be Delta. You may be able to fly from Panama City, Florida to Key West for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Key West that include hotel bookings?

    Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

  • Can I find deals for business class flights from Panama City to Key West?

    Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Key West?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $328). Flying from Panama City, Florida to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to Key West

Discover the top 2 airlines that operate flights from Panama City to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$468FlexibilityNo cancel feeOn-time71%
DeltaCheapest$306Average$539FlexibilityNo cancel feeOn-timeN/A

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