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$377+ Cheap flights from Panama City, FL to Key West (ECP - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Apr 16 — Apr 231
Thu 4/16
Thu 4/23
1 adult, Economy
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Cheap flight deals from Panama City to Key West

Cheapest flights from Panama City to Key West
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.

This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:50 pm
ECP
-
EYW
1 stop4h 59m
Delta
Tue 5/197:30 am
EYW
-
ECP
1 stop4h 23m
Delta
Deal found 3/14$377
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:40 pm
ECP
-
EYW
1 stop4h 56m
American Airlines
Sat 5/93:58 pm
EYW
-
ECP
2 stops8h 48m
American Airlines
Deal found 3/13$392
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:49 am
ECP
-
EYW
1 stop3h 57m
Delta
Wed 4/291:24 pm
EYW
-
ECP
1 stop5h 36m
Delta
Deal found 3/14$464
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:00 am
ECP
-
EYW
1 stop6h 47m
American Airlines
Sat 7/117:29 pm
EYW
-
ECP
1 stop5h 08m
American Airlines
Deal found 3/16$473
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:40 pm
ECP
-
EYW
1 stop4h 56m
American Airlines
Tue 5/198:20 am
EYW
-
ECP
1 stop8h 03m
American Airlines
Deal found 3/14$484
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:49 am
ECP
-
EYW
1 stop3h 57m
Delta
Sat 4/256:18 pm
EYW
-
ECP
1 stop5h 54m
Delta
Deal found 3/12$489
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:21 am
ECP
-
EYW
2 stops8h 09m
American Airlines
Sat 4/253:58 pm
EYW
-
ECP
2 stops8h 48m
American Airlines
Deal found 3/14$494
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:14 am
ECP
-
EYW
2 stops6h 13m
American Airlines
Sun 9/133:00 pm
EYW
-
ECP
1 stop4h 50m
American Airlines
Deal found 3/16$498
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:47 pm
ECP
-
EYW
1 stop3h 58m
Delta
Sun 8/22:35 pm
EYW
-
ECP
1 stop6h 01m
Delta
Deal found 3/12$503
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:00 am
ECP
-
EYW
1 stop3h 48m
Delta
Wed 4/16:25 pm
EYW
-
ECP
1 stop5h 39m
Delta
Deal found 3/13$513

Find flight deals from Panama City to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$377
(Delta)

Popular in

March

Cheapest in

October

Average price

$692
Provider with most accurate pricing for Panama City NW Florida Beaches-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Key West flights.
Search Deals
From Panama City NW Florida Beaches to Key West
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Panama City to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 5/15

1:50 pm-7:49 pm

1 stop4h 59m

Key West

Tue 5/19

7:30 am-10:53 am

1 stop4h 23m

$377

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/22

5:49 am-10:46 am

1 stop3h 57m

Key West

Sat 4/25

6:18 pm-11:12 pm

1 stop5h 54m

$464

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 3/31

6:00 am-10:48 am

1 stop3h 48m

Key West

Sat 4/4

6:25 pm-11:04 pm

1 stop5h 39m

$464
Quickest round-trip

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/22

5:49 am-10:46 am

1 stop3h 57m

Key West

Wed 4/29

2:40 pm-6:00 pm

1 stop4h 20m

$464

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 9/9

11:14 am-6:27 pm

2 stops6h 13m

Key West

Sun 9/13

1:28 pm-6:50 pm

1 stop6h 22m

$498

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sun 7/26

2:47 pm-7:45 pm

1 stop3h 58m

Key West

Sun 8/2

2:35 pm-7:36 pm

1 stop6h 01m

$503

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 3/28

6:00 am-10:48 am

1 stop3h 48m

Key West

Wed 4/1

6:25 pm-11:04 pm

1 stop5h 39m

$513

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 9/9

6:00 am-1:09 pm

1 stop6h 09m

Key West

Sun 9/13

2:35 pm-7:37 pm

1 stop6h 02m

$533

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 5/11

11:45 am-7:49 pm

1 stop7h 04m

Key West

Fri 5/15

7:30 am-12:50 pm

1 stop6h 20m

$555

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 6/20

6:00 am-12:23 pm

1 stop5h 23m

Key West

Fri 6/26

2:35 pm-7:36 pm

1 stop6h 01m

$624

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Key West

What is the cheapest month to book a flight from Panama City, Florida to Key West?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $161). Flying from Panama City, Florida to Key West in February is currently the most expensive (average of $332). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City, Florida to Key West?

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated March 17, 2026.
Read through reviews of airlines operating flights from Panama City to Key West, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,468 reviews
Delta
7.9
Good
8,288 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Key West?

    Airlines like Delta and American Airlines fly from Panama City, Florida to Key West in about 4h 59m. The time it takes to get you to your destination can typically vary by up to 1h 14m. Panama City, Florida and Key West are separated by a distance of 471 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Key West round-trip?

    American Airlines, at $296, was found to be the cheapest airline from Panama City, Florida to Key West. An alternate airline flying to your destination would be Delta. You may be able to fly from Panama City, Florida to Key West for 35% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Key West that include hotel bookings?

    Yes. In addition to deals on Panama City to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Key West.

  • Can I find deals for business class flights from Panama City to Key West?

    Yes. Cheapflights offers flight deals from Panama City to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Key West?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $161). Flying from Panama City, Florida to Key West in February is currently the most expensive (average of $332). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to Key West

Discover the top 2 airlines that operate flights from Panama City to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$332FlexibilityNo cancel feeOn-time71%
DeltaCheapest$306Average$488FlexibilityNo cancel feeOn-timeN/A

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