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$254+ Cheap flights from Myrtle Beach to Key West (MYR - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Myrtle Beach Intl to Key West are usually found in November or September, booked 13 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Cheap flight deals from Myrtle Beach to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$254
(American Airlines)

Popular in

March

Cheapest in

November

Average price

$366
From Myrtle Beach Intl to Key West
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Key West

Cheapest flights from Myrtle Beach to Key West
Explore the most affordable flight options available from Myrtle Beach to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:29 pmMYR - EYW
1 stop6h 17mAmerican Airlines
Sat 12/134:20 pmEYW - MYR
2 stops7h 34mAmerican Airlines
Deal found 9/15$254
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:45 pmMYR - EYW
1 stop7h 02mAmerican Airlines
Thu 11/277:00 amEYW - MYR
2 stops6h 59mAmerican Airlines
Deal found 9/17$284
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/172:14 pmMYR - EYW
1 stop19h 53mMultiple Airlines
Fri 10/248:55 amEYW - MYR
1 stop8h 49mMultiple Airlines
Deal found 9/17$286
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:30 pmMYR - EYW
1 stop11h 45mMultiple Airlines
Sun 12/78:50 pmEYW - MYR
1 stop11h 54mMultiple Airlines
Deal found 9/15$288
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/11:31 pmMYR - EYW
2 stops18h 44mMultiple Airlines
Sat 10/410:47 amEYW - MYR
1 stop22h 02mMultiple Airlines
Deal found 9/17$300
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3010:45 amMYR - EYW
2 stops45h 30mBreeze Airways
Sat 10/410:47 amEYW - MYR
1 stop22h 02mBreeze Airways
Deal found 9/15$301
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/51:53 pmMYR - EYW
1 stop27h 53mMultiple Airlines
Thu 10/98:55 amEYW - MYR
2 stops29h 59mMultiple Airlines
Deal found 9/15$304
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:01 pmMYR - EYW
2 stops17h 39mMultiple Airlines
Sat 10/189:52 amEYW - MYR
1 stop22h 57mMultiple Airlines
Deal found 9/15$310

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Myrtle Beach

Fly to

Key West

Route

Depart

Return

Price

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

11:35 am-7:24 pm

2 stops7h 49m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 10/17

2:14 pm-10:07 am

1 stop19h 53m

Key West

Fri 10/24

8:55 am-5:44 pm

1 stop8h 49m

$286

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 12/2

1:54 pm-11:50 pm

2 stops9h 56m

Key West

Tue 12/9

7:00 am-2:44 pm

2 stops7h 44m

$289

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 9/30

10:45 am-8:15 am

2 stops45h 30m

Key West

Sat 10/4

10:47 am-8:49 am

1 stop22h 02m

$301

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 10/5

1:53 pm-5:46 pm

1 stop27h 53m

Key West

Thu 10/9

8:55 am-2:54 pm

2 stops29h 59m

$304

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 10/11

9:01 pm-2:40 pm

2 stops17h 39m

Key West

Sat 10/18

9:52 am-8:49 am

1 stop22h 57m

$310

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 10/1

4:15 pm-8:15 am

1 stop16h 00m

Key West

Sat 10/4

10:47 am-8:49 am

1 stop22h 02m

$313

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 10/11

9:01 pm-2:40 pm

2 stops17h 39m

Key West

Wed 10/15

10:02 am-8:49 am

1 stop22h 47m

$315

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Myrtle Beach to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Key West

How far ahead should I book a flight from Myrtle Beach to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Myrtle Beach to Key West. Price data was last updated on September 12, 2025.

The best time to book flights from Myrtle Beach to Key West is 12 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Myrtle Beach to Key West?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $328). Flying from Myrtle Beach to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to EYW?

Find hourly flight availability from Myrtle Beach to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Key West is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 9% on airfare.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta and American Airlines from Myrtle Beach to Key West have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

CAE - ATL

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

CAE - ATL

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

CAE - ATL

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Key West?

    There are many flights that can get you from Myrtle Beach to Key West in 6h 17m. Fly via American Airlines to get the fastest option. There are 653 mi between Myrtle Beach and Key West.

  • What are the cheapest airlines flying from Myrtle Beach to Key West round-trip?

    According to our current data, Delta ($223), and American Airlines ($283) offers the cheapest pricing from Myrtle Beach to Key West. Users have found that Delta is 50% cheaper than the other options available to this destination.

  • Can I find deals for flights from Myrtle Beach to Key West that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Key West.

  • Can I find deals for business class flights from Myrtle Beach to Key West?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Key West?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $328). Flying from Myrtle Beach to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Myrtle Beach to Key West

Discover the top 2 airlines that operate flights from Myrtle Beach to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$487FlexibilityNo cancel feeOn-time71%

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