HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Key West

$144+ Cheap flights from Myrtle Beach to Key West (MYR - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
Apr 5 — Apr 121
Sun 4/5
Sun 4/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Key West with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Key West

Cheapest flights from Myrtle Beach to Key West
Explore the most affordable flight options available from Myrtle Beach to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:27 am
MYR
-
EYW
1 stop25h 59m
Breeze Airways
Thu 4/304:22 pm
EYW
-
MYR
1 stop19h 58m
Breeze Airways
Deal found 3/1$254
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:20 am
MYR
-
EYW
2 stops24h 51m
Multiple Airlines
Thu 4/309:46 am
EYW
-
MYR
1 stop4h 36m
Multiple Airlines
Deal found 3/3$255
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:18 pm
MYR
-
EYW
1 stop18h 03m
Multiple Airlines
Mon 3/301:06 pm
EYW
-
MYR
1 stop21h 59m
Multiple Airlines
Deal found 3/4$260
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:28 am
MYR
-
EYW
2 stops22h 53m
Multiple Airlines
Mon 3/301:06 pm
EYW
-
MYR
1 stop21h 59m
Multiple Airlines
Deal found 3/1$266
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:28 pm
MYR
-
EYW
1 stop19h 09m
Multiple Airlines
Tue 3/3112:25 pm
EYW
-
MYR
1 stop27h 18m
Multiple Airlines
Deal found 3/3$272
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:18 pm
MYR
-
EYW
1 stop20h 20m
Multiple Airlines
Tue 4/71:01 pm
EYW
-
MYR
2 stops28h 32m
Multiple Airlines
Deal found 3/5$277
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:23 pm
MYR
-
EYW
2 stops22h 03m
Multiple Airlines
Thu 4/304:22 pm
EYW
-
MYR
1 stop19h 58m
Multiple Airlines
Deal found 3/1$279
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:28 am
MYR
-
EYW
1 stop24h 03m
Multiple Airlines
Wed 4/2211:51 am
EYW
-
MYR
1 stop26h 31m
Multiple Airlines
Deal found 3/1$281
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:27 am
MYR
-
EYW
1 stop25h 59m
Multiple Airlines
Fri 5/15:48 pm
EYW
-
MYR
1 stop25h 50m
Multiple Airlines
Deal found 3/1$282

Find flight deals from Myrtle Beach to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$254
(Kiwi.com)

One-way from

$144
(Kiwi.com)

Popular in

February

Cheapest in

January

Average price

$552
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From Myrtle Beach Intl to Key West
Search Deals
One-way flight from Myrtle Beach Intl to Key West
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 3/23

6:18 pm-12:21 pm

1 stop18h 03m

Key West

Mon 3/30

9:49 am-5:33 pm

2 stops31h 44m

$275

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 4/26

2:23 pm-12:26 pm

2 stops22h 03m

Key West

Thu 4/30

4:22 pm-12:20 pm

1 stop19h 58m

$279

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 4/26

10:27 am-12:26 pm

1 stop25h 59m

Key West

Fri 5/1

5:48 pm-7:38 pm

1 stop25h 50m

$282

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 5/24

3:53 pm-11:30 am

1 stop19h 37m

Key West

Fri 5/29

12:10 pm-9:05 am

1 stop20h 55m

$293

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 3/17

10:26 am-7:12 pm

2 stops8h 46m

Key West

Tue 3/24

3:56 pm-10:56 pm

2 stops7h 00m

$309

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 3/18

6:28 pm-9:06 am

2 stops14h 38m

Key West

Sun 3/22

12:25 pm-2:13 pm

1 stop25h 48m

$309

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 3/10

12:39 pm-11:11 am

1 stop22h 32m

Key West

Thu 3/12

9:46 am-2:22 pm

1 stop4h 36m

$322

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 4/4

3:29 pm-9:06 am

2 stops17h 37m

Key West

Wed 4/8

11:51 am-11:05 am

1 stop23h 14m

$325

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 5/24

3:53 pm-11:30 am

1 stop19h 37m

Key West

Fri 5/29

12:10 pm-8:44 am

2 stops20h 34m

$339
Quickest round-trip

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 5/29

1:01 pm-6:49 pm

1 stop5h 48m

Key West

Wed 6/3

4:37 pm-9:47 pm

1 stop5h 10m

$383

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Key West in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Key West

What is the cheapest month to book a flight from Myrtle Beach to Key West?

Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $96). Flying from Myrtle Beach to Key West in February is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated March 6, 2026.
See what other customers who have flown with Delta and American Airlines from Myrtle Beach to Key West have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,258 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
8,258 reviews
Delta
7.9
Good
8,258 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.1
Good
11,392 reviews
Delta
7.9
Good
8,258 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Key West?

    There are many flights that can get you from Myrtle Beach to Key West in 8h 46m. Fly via Breeze Airways or American Airlines to get the fastest option. There are 653 mi between Myrtle Beach and Key West. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to Key West round-trip?

    According to our current data, Delta ($223), and American Airlines ($258) offers the cheapest pricing from Myrtle Beach to Key West. Users have found that Delta is 48% cheaper than the other options available to this destination.

  • Can I find deals for flights from Myrtle Beach to Key West that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Key West.

  • Can I find deals for business class flights from Myrtle Beach to Key West?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Key West?

    Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $96). Flying from Myrtle Beach to Key West in February is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Key West

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Fort Lauderdale flights
Charlotte to Miami flights
Charlotte to Orlando flights
Charlotte to Tampa flights
Charlotte to West Palm Beach flights
Charleston to Fort Lauderdale flights
Charlotte to Sarasota flights
Charleston to Miami flights
Charlotte to Jacksonville flights
Charlotte to Panama City flights
Charlotte to Fort Myers flights
Greenville to Miami flights
Charleston to Tampa flights
Charlotte to Key West flights
Myrtle Beach to Fort Lauderdale flights
Columbia to Miami flights
Myrtle Beach to Orlando flights
Charleston to Orlando flights
Myrtle Beach to Miami flights
Columbia to Orlando flights
Savannah to Miami flights
Charlotte to Pensacola flights
Greenville to Tampa flights
Charlotte to Melbourne flights
Greenville to Fort Lauderdale flights
Charlotte to Daytona Beach flights
Charleston to Sarasota flights
Myrtle Beach to Tampa flights
Augusta to Miami flights
Columbia to Fort Lauderdale flights
Greenville to Orlando flights
Myrtle Beach to West Palm Beach flights
Charleston to West Palm Beach flights
Greenville to West Palm Beach flights
Charleston to Key West flights
Greenville to Orlando Sanford Intl flights
Charleston to Pensacola flights
Greenville to Sarasota flights
Greenville to Fort Myers flights
Greenville to Jacksonville flights
Savannah to West Palm Beach flights
Columbia to Tampa flights
Greenville to Pensacola flights
Augusta to Fort Lauderdale flights
Myrtle Beach to Fort Myers flights
Savannah to Fort Myers flights
Charleston to Fort Myers flights
Charlotte to Tallahassee flights
Greenville to St Petersburg flights

Top 2 airlines flying from Myrtle Beach to Key West

Discover the top 2 airlines that operate flights from Myrtle Beach to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$408FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$435FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.