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Key West

$120+ Cheap flights from Myrtle Beach to Key West (MYR - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
Dec 22 — Dec 291
Mon 12/22
Mon 12/29
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Myrtle Beach Intl to Key West are usually found in September or August, booked 13 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Find flight deals from Myrtle Beach to Key West

Cheapest flights from Myrtle Beach to Key West
Explore the most affordable flight options available from Myrtle Beach to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 22, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:54 amMYR - EYW
1 stop25h 26mSpirit Airlines
Sat 12/272:30 pmEYW - MYR
1 stop27h 38mSpirit Airlines
Deal found 11/20$234
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:54 amMYR - EYW
1 stop25h 26mMultiple Airlines
Sat 12/203:36 pmEYW - MYR
1 stop17h 13mMultiple Airlines
Deal found 11/20$242
This Mytrip deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:59 pmMYR - EYW
2 stops16h 21mMultiple Airlines
Wed 12/107:53 pmEYW - MYR
1 stop15h 24mMultiple Airlines
Deal found 11/21$246
This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amMYR - EYW
1 stop6h 05mAmerican Airlines
Wed 12/176:33 pmEYW - MYR
1 stop4h 16mAmerican Airlines
Deal found 11/21$249
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:54 amMYR - EYW
2 stops22h 21mMultiple Airlines
Sat 12/272:30 pmEYW - MYR
1 stop27h 38mMultiple Airlines
Deal found 11/20$260
This Delta deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/82:40 pmMYR - EYW
1 stop5h 26mDelta
Sat 12/136:10 pmEYW - MYR
1 stop5h 33mDelta
Deal found 11/21$264
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:29 pmMYR - EYW
1 stop6h 49mAmerican Airlines
Tue 12/96:33 pmEYW - MYR
1 stop4h 04mAmerican Airlines
Deal found 11/20$265
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:54 amMYR - EYW
1 stop27h 36mMultiple Airlines
Tue 12/911:45 amEYW - MYR
2 stops30h 03mMultiple Airlines
Deal found 11/20$266
This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:23 amMYR - EYW
2 stops6h 37mAmerican Airlines
Sat 12/138:00 amEYW - MYR
1 stop5h 59mAmerican Airlines
Deal found 11/21$269

Cheap flight deals from Myrtle Beach to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$230
(Kiwi.com)

One-way from

$120
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$425
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From Myrtle Beach Intl to Key West
Search Deals
One-way flight from Myrtle Beach Intl to Key West
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($82 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 22, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Myrtle Beach

Fly to

Key West

Route

Depart

Return

Price

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 12/20

9:54 am-11:20 am

1 stop25h 26m

Key West

Sat 12/27

2:30 pm-6:08 pm

1 stop27h 38m

$234

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 12/17

9:54 am-11:20 am

1 stop25h 26m

Key West

Sat 12/20

3:36 pm-8:49 am

1 stop17h 13m

$242

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 2/11

5:29 pm-9:47 pm

1 stop4h 18m

Key West

Wed 2/18

6:28 pm-10:59 pm

1 stop4h 31m

$245

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 12/13

2:44 pm-9:50 pm

1 stop7h 06m

Key West

Wed 12/17

4:04 pm-8:50 pm

1 stop4h 46m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 12/6

2:15 pm-8:15 am

1 stop18h 00m

Key West

Wed 12/10

10:47 am-8:49 am

1 stop22h 02m

$250

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 12/13

6:00 am-12:05 pm

1 stop6h 05m

Key West

Tue 12/16

7:00 am-2:44 pm

2 stops7h 44m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 1/18

6:23 am-4:49 pm

2 stops10h 26m

Key West

Tue 2/10

1:33 pm-8:54 pm

2 stops7h 21m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 12/31

9:54 am-11:20 am

1 stop25h 26m

$120

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 12/30

9:54 am-1:30 pm

1 stop27h 36m

$120

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/29

9:54 am-11:20 am

1 stop25h 26m

$121

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 15 results
1
2

Compare providers for flights from Myrtle Beach to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Key West in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Key West

How far ahead should I book a flight from Myrtle Beach to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Myrtle Beach to Key West. Price data was last updated on November 21, 2025.

The best time to book flights from Myrtle Beach to Key West is 12 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Myrtle Beach to Key West?

Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $64). Flying from Myrtle Beach to Key West in April is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to EYW?

Find hourly flight availability from Myrtle Beach to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 22, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Key West is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated November 22, 2025.
See what other customers who have flown with Delta and American Airlines from Myrtle Beach to Key West have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,000 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
8,000 reviews
Delta
7.9
Good
8,000 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,000 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Key West?

    There are many flights that can get you from Myrtle Beach to Key West in 4h 18m. Fly via Spirit Airlines or American Airlines to get the fastest option. There are 653 mi between Myrtle Beach and Key West. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to Key West round-trip?

    According to our current data, Delta ($223), and American Airlines ($279) offers the cheapest pricing from Myrtle Beach to Key West. Users have found that Delta is 50% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Myrtle Beach to Key West one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $120. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Myrtle Beach to Key West for a low price.

  • Can I find deals for flights from Myrtle Beach to Key West that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Key West.

  • Can I find deals for business class flights from Myrtle Beach to Key West?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Key West?

    Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Key West (average of $64). Flying from Myrtle Beach to Key West in April is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Myrtle Beach to Key West

Discover the top 2 airlines that operate flights from Myrtle Beach to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$476FlexibilityNo cancel feeOn-time71%

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