$40+ Cheap flights from Charleston to Key West (CHS - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Key West
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to Key WestExplore the most affordable flight options available from Charleston to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from Charleston to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This Breeze Airways deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop3h 24m
Wed 10/2810:04 am -
1 stop3h 20m
Deal found 9/23![Breeze Airways logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop3h 24m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop3h 24m
Tue 10/271:16 pm -
1 stop24h 08m
Deal found 9/23![Breeze Airways logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/33:42 pm -
1 stop18h 37m
Mon 10/510:59 am -
1 stop21h 39m
Deal found 9/18![Breeze Airways logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:42 pm -
1 stop18h 37m
Wed 10/2110:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Tue 10/61:16 pm -
1 stop24h 08m
Deal found 9/18![Breeze Airways logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Fri 10/910:59 am -
1 stop21h 39m
Deal found 9/18![Breeze Airways logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:58 pm -
1 stop15h 38m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/18![Breeze Airways logo]()
$188
Best flights from Charleston to Key WestDiscover carefully curated flight deals from Charleston to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from Charleston to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Wed 10/710:04 am -
2 stops30h 07m
Deal found 9/19![Breeze Airways logo]()
$278
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:12 am -
1 stop5h 46m
Wed 11/411:14 am -
2 stops7h 32m
Deal found 9/20![American Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:31 pm -
1 stop4h 27m
Fri 12/252:50 pm -
1 stop6h 22m
Deal found 9/21![Delta logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:13 pm -
2 stops14h 06m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/18![Breeze Airways logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:58 pm -
1 stop15h 38m
Fri 10/911:59 am -
2 stops20h 39m
Deal found 9/18![Breeze Airways logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:58 pm -
1 stop14h 23m
Thu 12/3110:59 am -
1 stop21h 49m
Deal found 9/19![Breeze Airways logo]()
$358
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:25 am -
1 stop5h 21m
Tue 10/67:40 am -
1 stop5h 20m
Deal found 9/18![Delta logo]()
$491
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:31 pm -
1 stop4h 27m
Thu 12/247:15 am -
1 stop27h 05m
Deal found 9/21![Delta logo]()
$497
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:40 am -
1 stop4h 06m
Mon 10/52:00 pm -
1 stop6h 17m
Deal found 9/18![Delta logo]()
$517
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:32 pm -
1 stop5h 28m
Thu 10/16:19 pm -
1 stop3h 52m
Deal found 9/22![Delta logo]()
$544
Last-minute flights from Charleston to Key WestDiscover last-minute flight deals from Charleston to Key West. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Key West. Data last updated September 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop3h 24m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/33:42 pm -
1 stop18h 37m
Mon 10/510:59 am -
1 stop21h 39m
Deal found 9/18![Breeze Airways logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Tue 10/61:16 pm -
1 stop24h 08m
Deal found 9/18![Breeze Airways logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop3h 24m
Fri 10/910:59 am -
1 stop21h 39m
Deal found 9/18![Breeze Airways logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:58 pm -
1 stop15h 38m
Wed 10/710:04 am -
1 stop3h 20m
Deal found 9/18![Breeze Airways logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:58 pm -
1 stop15h 38m
Fri 10/910:59 am -
1 stop21h 39m
Deal found 9/18![Breeze Airways logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:42 pm -
1 stop18h 37m
Wed 10/2110:04 am -
1 stop3h 20m
Deal found 9/19![Breeze Airways logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop3h 24m
Tue 11/31:16 pm -
1 stop24h 08m
Deal found 9/22![Breeze Airways logo]()
$141
One-way flights from Charleston to Key WestSearch for one-way flight options from Charleston to Key West. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from Charleston to Key West. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop3h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Breeze Airways logo]()
$40
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop3h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Breeze Airways logo]()
$58
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:42 pm -
1 stop18h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Breeze Airways logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:42 pm -
1 stop18h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Breeze Airways logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:58 pm -
1 stop15h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Breeze Airways logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:13 pm -
2 stops14h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Breeze Airways logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
3 stops28h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$231
Find flight deals from Charleston to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $130 (Breeze Airways) |
One-way from | $40 (Kiwi.com) |
Popular in | October |
Cheapest in | September |
Average price | $138 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from Charleston to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Sat 10/24
3:42 pm-10:19 am
1 stop18h 37m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$102
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Mon 10/12
8:58 pm-12:36 pm
1 stop15h 38m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$173
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Wed 11/4
4:10 pm-10:19 am
2 stops42h 09m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$188
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Sun 10/11
10:13 pm-12:19 pm
2 stops14h 06m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$189
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Wed 11/4
6:00 am-10:14 am
3 stops28h 14m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$231
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Sat 10/10
6:20 am-11:21 am
2 stops29h 01m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Mon 10/12
3:27 pm-9:24 am
3 stops41h 57m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$268
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Wed 9/30
6:00 am-10:19 am
3 stops28h 19m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$274
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Sat 10/3
6:00 am-9:24 am
1 stop3h 24m
Key West
Wed 10/7
10:04 am-4:11 pm
2 stops30h 07m
$278
Quickest round-trip
CharlestonKey West
CHS Charleston - EYW Key West
CHSEYW
Charleston
Sat 9/26
6:00 am-9:24 am
1 stop3h 24m
Key West
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$282
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Charleston to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Key West in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Charleston with our price prediction graph.
CHS-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Key West
What is the cheapest month to book a flight from Charleston to Key West?
Currently, September is the cheapest month in which you can book a flight from Charleston to Key West (average of $138). Flying from Charleston to Key West in October is currently the most expensive (average of $624). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Charleston to Key West?
Airfare is below average for this route at the moment.
Charleston to Key West flights typically cost between $300 and $506 in October.The cheapest round-trip price found within the last 5 days was $130 on Breeze Airways (Oct 21-Oct 28).
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 23, 2026.
Read through reviews of airlines operating flights from Charleston to Key West, such as Breeze Airways,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.4
Food
6.8
Overall
8.2
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Boarding
8.4
Food
6.8
Overall
8.2
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Boarding
8.4
Food
6.8
Overall
8.2
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Boarding
8.4
Food
6.8
Overall
8.2
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Related info for your journey
Find useful and relevant information for your journey from Charleston to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Charleston to Key West by cabin class
Find flights from Charleston to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Charleston and Key West flights
Browse other Charleston and Key West flight options. Last updated on September 23, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Charleston to Key West
Discover the top 3 airlines that operate flights from Charleston to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$104 | Average$211 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$327 | Average$472 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$515 | FlexibilityNo cancel fee | On-timeN/A |