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Key Largo

$466+ Cheap flights from Florence, SC (FLO) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MIA
Jun 25 — Jul 21
Thu 6/25
Thu 7/2
1 adult, Economy
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Cheap flight deals from Florence to Key Largo

Cheapest flights from Florence to Key Largo
Explore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.

This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:09 am
FLO
-
MIA
1 stop6h 06m
American Airlines
Sat 10/105:16 pm
MIA
-
FLO
1 stop6h 47m
American Airlines
Deal found 5/24$511
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:05 am
FLO
-
MIA
1 stop6h 37m
American Airlines
Wed 6/109:55 am
MIA
-
FLO
1 stop4h 15m
American Airlines
Deal found 5/22$525
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/272:35 pm
FLO
-
MIA
1 stop4h 23m
American Airlines
Sat 7/49:55 am
MIA
-
FLO
1 stop4h 15m
American Airlines
Deal found 5/24$543
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:05 am
FLO
-
MIA
1 stop6h 15m
American Airlines
Mon 9/79:07 am
MIA
-
FLO
1 stop5h 49m
American Airlines
Deal found 5/25$559
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/272:35 pm
FLO
-
MIA
1 stop5h 28m
American Airlines
Thu 7/27:57 am
MIA
-
FLO
1 stop6h 13m
American Airlines
Deal found 5/24$565
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:05 am
FLO
-
MIA
1 stop4h 10m
American Airlines
Thu 7/27:10 pm
MIA
-
FLO
1 stop4h 23m
American Airlines
Deal found 5/24$587
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:05 am
FLO
-
MIA
2 stops11h 20m
American Airlines
Fri 7/37:10 pm
MIA
-
FLO
1 stop4h 23m
American Airlines
Deal found 5/24$591
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:35 pm
FLO
-
MIA
1 stop5h 28m
American Airlines
Tue 6/97:40 am
MIA
-
FLO
1 stop6h 30m
American Airlines
Deal found 5/21$600
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:05 am
FLO
-
MIA
1 stop6h 37m
American Airlines
Wed 6/1711:13 am
MIA
-
FLO
2 stops10h 47m
American Airlines
Deal found 5/21$702
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:05 am
FLO
-
MIA
2 stops9h 48m
American Airlines
Sat 6/139:45 am
MIA
-
FLO
2 stops12h 15m
American Airlines
Deal found 5/25$870

Find flight deals from Florence to Key Largo

Keep the following information in mind while searching for Florence to Key Largo flight deals. Data was last updated May 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$511
(American Airlines)

One-way from

$466
(American Airlines)
Provider with most accurate pricing for Florence-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Miami flights.
Search Deals
From Florence to Key Largo
Search Deals
One-way flight from Florence to Key Largo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Florence to Key Largo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Wed 9/2

6:24 am-11:13 am

1 stop4h 49m

Miami

Mon 9/7

9:07 am-2:56 pm

1 stop5h 49m

$511

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 10/4

6:31 pm-12:32 am

1 stop6h 01m

Miami

Sat 10/10

6:20 am-10:26 am

1 stop4h 06m

$511

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 6/6

5:05 am-11:42 am

1 stop6h 37m

Miami

Wed 6/10

9:55 am-2:10 pm

1 stop4h 15m

$525

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Tue 6/9

5:05 am-9:17 am

1 stop4h 12m

Miami

Sat 6/13

8:40 am-2:10 pm

1 stop5h 30m

$525

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 6/28

5:05 am-9:15 am

1 stop4h 10m

Miami

Sat 7/4

7:57 am-2:10 pm

1 stop6h 13m

$565
Quickest round-trip

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 6/28

5:05 am-9:15 am

1 stop4h 10m

Miami

Thu 7/2

7:10 pm-11:33 pm

1 stop4h 23m

$587

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sun 6/28

5:05 am-9:15 am

1 stop4h 10m

Miami

Fri 7/3

5:23 pm-11:33 pm

1 stop6h 10m

$587

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 6/27

5:05 am-4:25 pm

2 stops11h 20m

Miami

Thu 7/2

9:55 am-2:10 pm

1 stop4h 15m

$591

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Sat 6/27

5:05 am-4:25 pm

2 stops11h 20m

Miami

Fri 7/3

7:10 pm-11:33 pm

1 stop4h 23m

$591

FlorenceMiami

FLO - MIA

FLOMIA

Florence

Fri 6/5

2:35 pm-8:03 pm

1 stop5h 28m

Miami

Tue 6/9

7:40 am-2:10 pm

1 stop6h 30m

$600

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/21

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Best time to book a flight from Florence to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Key Largo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Key Largo?

    Most people fly from Florence (FLO) if they book a flight from Florence to Key Largo. On average, Florence has 0 outbound flights to Key Largo per day from 0 airlines. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Key Largo?

    For as low as $511, American Airlines can have you in Key Largo from Florence, South Carolina in 4h 49m. There are 580 mi between Florence, South Carolina and Key Largo.

  • Can I find deals for flights from Florence to Key Largo that include hotel bookings?

    Yes. In addition to deals on Florence to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Key Largo.

  • Can I find deals for business class flights from Florence to Key Largo?

    Yes. Cheapflights offers flight deals from Florence to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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