$429+ Cheap flights from Florence, SC (FLO) to Key Largo, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MIA
Sep 26 — Oct 31
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Florence to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to Key Largo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Florence to Key LargoExplore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
Explore the most affordable flight options available from Florence to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:19 pm -
1 stop6h 33m
Tue 10/136:32 pm -
1 stop4h 40m
Deal found 8/22![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
1 stop4h 52m
Wed 9/306:48 pm -
1 stop4h 10m
Deal found 8/24![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop4h 10m
Wed 9/98:15 am -
1 stop5h 03m
Deal found 8/22![American Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:09 am -
1 stop4h 00m
Sat 10/107:40 am -
1 stop6h 29m
Deal found 8/25![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:22 am -
1 stop6h 49m
Sat 9/128:52 am -
1 stop4h 26m
Deal found 8/24![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:09 am -
1 stop6h 06m
Sun 10/258:40 am -
1 stop5h 29m
Deal found 8/26![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:24 am -
1 stop4h 52m
Thu 10/18:15 am -
1 stop5h 03m
Deal found 8/24![American Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:43 pm -
1 stop6h 56m
Sun 9/135:20 pm -
1 stop6h 37m
Deal found 8/25![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:22 am -
1 stop4h 51m
Sat 8/295:20 pm -
1 stop5h 39m
Deal found 8/23![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:35 pm -
1 stop5h 55m
Sun 11/229:50 am -
1 stop4h 19m
Deal found 8/25![American Airlines logo]()
$651
Best flights from Florence to Key LargoDiscover carefully curated flight deals from Florence to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
Discover carefully curated flight deals from Florence to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop4h 10m
Wed 9/98:15 am -
1 stop5h 03m
Deal found 8/22![American Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/82:35 pm -
1 stop4h 05m
Sat 11/145:55 pm -
1 stop5h 04m
Deal found 8/26![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:09 am -
1 stop4h 00m
Sat 10/107:40 am -
1 stop6h 29m
Deal found 8/24![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:22 am -
1 stop6h 49m
Sat 9/128:52 am -
1 stop4h 26m
Deal found 8/24![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:35 pm -
1 stop5h 55m
Tue 11/245:26 pm -
1 stop6h 28m
Deal found 8/25![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:43 pm -
1 stop6h 56m
Sun 9/135:20 pm -
1 stop6h 37m
Deal found 8/25![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
1 stop4h 52m
Wed 9/3012:00 pm -
2 stops10h 58m
Deal found 8/24![American Airlines logo]()
$603
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:24 am -
1 stop4h 52m
Sun 9/208:15 am -
1 stop5h 55m
Deal found 8/22![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:35 pm -
1 stop5h 55m
Sun 11/229:50 am -
1 stop4h 19m
Deal found 8/25![American Airlines logo]()
$651
Last-minute flights from Florence to Key LargoDiscover last-minute flight deals from Florence to Key Largo. Data last updated August 27, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Key Largo. Data last updated August 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:22 am -
1 stop4h 51m
Sat 8/295:20 pm -
1 stop5h 39m
Deal found 8/23![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop4h 10m
Wed 9/98:15 am -
1 stop5h 03m
Deal found 8/22![American Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:22 am -
1 stop6h 49m
Sat 9/128:52 am -
1 stop4h 26m
Deal found 8/24![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:43 pm -
1 stop6h 56m
Sun 9/135:20 pm -
1 stop6h 37m
Deal found 8/25![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
1 stop4h 52m
Wed 9/306:48 pm -
1 stop4h 10m
Deal found 8/24![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:24 am -
1 stop4h 52m
Thu 10/18:15 am -
1 stop5h 03m
Deal found 8/24![American Airlines logo]()
$597
One-way flights from Florence to Key LargoSearch for one-way flight options from Florence to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
Search for one-way flight options from Florence to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:43 pm -
1 stop6h 56m
Deal found 8/24![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/313:22 pm -
1 stop4h 51m
Deal found 8/22![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:24 am -
2 stops6h 05m
Deal found 8/22![American Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:09 am -
2 stops6h 48m
Deal found 8/26![American Airlines logo]()
$765
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/292:35 pm -
2 stops6h 29m
Deal found 8/23![American Airlines logo]()
$1,200
Find flight deals from Florence to Key Largo
Keep the following information in mind while searching for Florence to Key Largo flight deals. Data was last updated August 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $472 (American Airlines) |
One-way from | $429 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
Use the filters below to find and compare flights from Florence to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Sat 9/5
9:00 am-1:10 pm
1 stop4h 10m
Miami
Wed 9/9
8:15 am-1:18 pm
1 stop5h 03m
$504
Quickest round-trip
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Sun 11/8
2:35 pm-6:40 pm
1 stop4h 05m
Miami
Sat 11/14
5:55 pm-10:59 pm
1 stop5h 04m
$521
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Sun 10/4
5:09 am-9:09 am
1 stop4h 00m
Miami
Sat 10/10
7:40 am-2:09 pm
1 stop6h 29m
$521
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Tue 9/8
6:22 am-1:11 pm
1 stop6h 49m
Miami
Sat 9/12
8:52 am-1:18 pm
1 stop4h 26m
$535
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Fri 11/20
2:35 pm-8:30 pm
1 stop5h 55m
Miami
Tue 11/24
5:26 pm-11:54 pm
1 stop6h 28m
$602
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Wed 9/9
1:43 pm-8:39 pm
1 stop6h 56m
Miami
Sun 9/13
5:20 pm-11:57 pm
1 stop6h 37m
$602
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Wed 9/23
6:24 am-11:16 am
1 stop4h 52m
Miami
Wed 9/30
12:00 pm-10:58 pm
2 stops10h 58m
$603
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Wed 9/16
6:24 am-11:16 am
1 stop4h 52m
Miami
Sun 9/20
8:15 am-2:10 pm
1 stop5h 55m
$610
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Thu 11/19
2:35 pm-8:30 pm
1 stop5h 55m
Miami
Sun 11/22
9:50 am-2:09 pm
1 stop4h 19m
$651
Cheapest one-way
FlorenceMiami
FLO Florence - MIA Miami
FLOMIA
Florence
Mon 8/31
3:22 pm-8:13 pm
1 stop4h 51m
$471
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Florence to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Florence with our price prediction graph.
FLO-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Key Largo
FLO-KE9
FLO-MIA
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florence to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Florence
Popular flights
Top destinations