HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Iowa

$159+ Cheap flights from Greenville (GSP) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Feb 18 — Feb 251
Wed 2/18
Wed 2/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Iowa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Iowa

Keep the following information in mind while searching for Greenville to Iowa flight deals. Data was last updated January 19, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$339
(United Airlines)

One-way from

$159
(Delta)

Popular in

April

Cheapest in

October

Average price

$384
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Iowa
Search Deals
One-way flight from Greenville to Iowa
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Greenville to Iowa

Cheapest flights from Greenville to Iowa
Explore the most affordable flight options available from Greenville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 19, 2026.

This United Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:30 am
GSP
-
MLI
1 stop6h 16m
United Airlines
Wed 2/183:52 pm
MLI
-
GSP
1 stop3h 49m
United Airlines
Deal found 1/17$339
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:36 am
GSP
-
DSM
1 stop6h 54m
United Airlines
Tue 5/122:58 pm
DSM
-
GSP
1 stop6h 16m
United Airlines
Deal found 1/18$341
This United Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:30 am
GSP
-
CID
1 stop6h 45m
United Airlines
Wed 2/181:10 pm
CID
-
GSP
2 stops9h 49m
United Airlines
Deal found 1/17$344
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/26:35 am
GSP
-
OMA
1 stop4h 55m
United Airlines
Fri 2/63:00 pm
OMA
-
GSP
1 stop5h 57m
United Airlines
Deal found 1/18$359
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:52 am
GSP
-
OMA
1 stop6h 30m
American Airlines
Sun 5/105:07 pm
OMA
-
GSP
1 stop5h 50m
American Airlines
Deal found 1/16$364
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:40 am
GSP
-
DSM
1 stop6h 25m
American Airlines
Mon 3/231:52 pm
DSM
-
GSP
1 stop6h 56m
American Airlines
Deal found 1/18$364
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:19 pm
GSP
-
OMA
1 stop4h 36m
American Airlines
Thu 4/305:07 pm
OMA
-
GSP
1 stop5h 50m
American Airlines
Deal found 1/16$372
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:40 am
GSP
-
OMA
1 stop5h 24m
Delta
Mon 2/166:08 pm
OMA
-
GSP
1 stop4h 35m
Delta
Deal found 1/16$374
This Southwest deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:25 pm
GSP
-
OMA
2 stops5h 50m
Southwest
Sun 5/31:00 pm
OMA
-
GSP
2 stops9h 20m
Southwest
Deal found 1/16$375
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1311:08 am
GSP
-
OMA
1 stop6h 28m
American Airlines
Mon 2/161:58 pm
OMA
-
GSP
2 stops8h 56m
American Airlines
Deal found 1/16$379
This United Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:30 am
GSP
-
OMA
1 stop4h 59m
United Airlines
Wed 2/183:22 pm
OMA
-
GSP
1 stop4h 19m
United Airlines
Deal found 1/17$387
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:45 am
GSP
-
DSM
1 stop4h 29m
Delta
Tue 7/217:25 am
DSM
-
GSP
1 stop5h 52m
Delta
Deal found 1/18$387

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 19, 2026.
Use the filters below to find and compare flights from Greenville to Iowa that are best for you.

Fly from

Greenville

Fly to

Iowa

Route

Depart

Return

Price

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Sat 2/14

6:30 am-11:46 am

1 stop6h 16m

Moline Quad-City

Wed 2/18

3:52 pm-8:41 pm

1 stop3h 49m

$339

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Sat 2/21

6:30 am-11:46 am

1 stop6h 16m

Moline Quad-City

Wed 2/25

3:52 pm-8:41 pm

1 stop3h 49m

$339

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

7:41 am-1:48 pm

1 stop7h 07m

Des Moines

Tue 5/12

11:58 am-7:49 pm

1 stop6h 51m

$341

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

6:36 am-12:30 pm

1 stop6h 54m

Des Moines

Tue 5/12

2:58 pm-10:14 pm

1 stop6h 16m

$341

GreenvilleCedar Rapids

GSP - CID

GSPCID

Greenville

Sat 2/14

6:30 am-12:15 pm

1 stop6h 45m

Cedar Rapids

Wed 2/18

11:30 am-11:59 pm

2 stops11h 29m

$344

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Mon 2/2

6:35 am-10:30 am

1 stop4h 55m

Omaha Eppley Airfield

Fri 2/6

3:00 pm-9:57 pm

1 stop5h 57m

$359

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Thu 5/7

10:52 am-4:22 pm

1 stop6h 30m

Omaha Eppley Airfield

Sun 5/10

5:07 pm-11:57 pm

1 stop5h 50m

$364

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 3/18

7:40 am-1:05 pm

1 stop6h 25m

Des Moines

Mon 3/23

1:52 pm-9:48 pm

1 stop6h 56m

$364

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Fri 2/13

5:40 am-10:04 am

1 stop5h 24m

Omaha Eppley Airfield

Mon 2/16

6:08 pm-11:43 pm

1 stop4h 35m

$374

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Thu 4/30

6:25 pm-11:15 pm

2 stops5h 50m

Omaha Eppley Airfield

Sun 5/3

1:00 pm-11:20 pm

2 stops9h 20m

$375

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/16

Showing 1-10 of 29 results
1
2
3

Best time to book a flight from Greenville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Iowa

What is the cheapest month to book a flight from Greenville to Iowa?

Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated January 19, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Greenville to Iowa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,075 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,075 reviews
Delta
7.9
Good
8,075 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,177 reviews
Delta
7.9
Good
8,075 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,160 reviews
Delta
7.9
Good
8,075 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Iowa?

    If you book a flight to Iowa from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville.

  • How long is the flight from Greenville to Iowa?

    A quick flight from Greenville to Iowa can take about 6h 16m. United Airlines provides one of the quickest options available for as low as $339. Airlines will cover a distance of 637 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Greenville to Iowa?

    The most popular route from Greenville to Iowa is Greenville - Omaha Eppley Airfield. You may also consider Greenville - Des Moines or Greenville - Moline Quad-City.

  • Can I find deals for flights from Greenville to Iowa that include hotel bookings?

    Yes. In addition to deals on Greenville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Iowa.

  • Can I find deals for business class flights from Greenville to Iowa?

    Yes. Cheapflights offers flight deals from Greenville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Iowa?

    Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to Las Vegas flights
Charlotte to Denver flights
Charlotte to Newark flights
Charlotte to LaGuardia flights
Charlotte to Dallas/Fort Worth flights
Charlotte to Hobby flights
Charlotte to Orlando flights
Charlotte to Fort Lauderdale flights
Charlotte to O'Hare Intl flights
Charlotte to Miami flights
Charlotte to George Bush Intcntl flights
Charlotte to Boston flights
Charlotte to Seattle flights
Charlotte to Los Angeles flights
Charlotte to New Orleans flights
Charlotte to Sky Harbor Intl flights
Charlotte to Salt Lake City flights
Charlotte to Tampa flights
Greenville to LaGuardia flights
Greenville to Newark flights
Charleston to LaGuardia flights
Charlotte to San Francisco flights
Charleston to Newark flights
Charlotte to Dulles Intl flights
Charlotte to Love Field flights
Charlotte to Nashville flights
Savannah to LaGuardia flights
Savannah to John F Kennedy Intl flights
Charleston to John F Kennedy Intl flights
Charleston to Las Vegas flights
Charlotte to Reagan-National flights
Charleston to Denver flights
Charlotte to Philadelphia flights
Charleston to O'Hare Intl flights
Charlotte to Baltimore flights
Charlotte to Detroit flights
Charleston to Miami flights
Charlotte to San Diego flights
Charlotte to Atlanta flights
Charleston to Boston flights
Charlotte to Honolulu flights
Charlotte to West Palm Beach flights
Greenville to John F Kennedy Intl flights
Columbia to LaGuardia flights
Greenville to Denver flights
Charleston to Fort Lauderdale flights
Charleston to Hobby flights
Savannah to Hobby flights
Charleston to New Orleans flights

Top 3 airlines flying from Greenville to Iowa

Discover the top 3 airlines that operate flights from Greenville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$377FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$359FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.