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$160+ Cheap flights from Greenville (GSP) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Greenville to Iowa

Cheapest flights from Greenville to Iowa
Explore the most affordable flight options available from Greenville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:36 am
GSP
-
CID
1 stop6h 16m
United Airlines
Fri 5/2910:00 am
CID
-
GSP
1 stop6h 00m
United Airlines
Deal found 3/8$314
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:40 pm
GSP
-
DSM
1 stop5h 08m
Delta
Tue 5/127:34 am
DSM
-
GSP
1 stop6h 16m
Delta
Deal found 3/6$337
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:20 am
GSP
-
DSM
2 stops7h 10m
American Airlines
Tue 5/1211:09 am
DSM
-
GSP
1 stop7h 37m
American Airlines
Deal found 3/6$342
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 am
GSP
-
DSM
1 stop6h 59m
United Airlines
Mon 4/273:21 pm
DSM
-
GSP
1 stop4h 26m
United Airlines
Deal found 3/7$346
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:07 pm
GSP
-
DSM
2 stops12h 10m
United Airlines
Sat 4/116:20 am
DSM
-
GSP
1 stop4h 24m
United Airlines
Deal found 3/9$352
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:30 am
GSP
-
DSM
1 stop7h 16m
American Airlines
Fri 4/103:00 pm
DSM
-
GSP
1 stop5h 38m
American Airlines
Deal found 3/10$353
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:30 am
GSP
-
DSM
1 stop6h 59m
United Airlines
Wed 4/81:10 pm
DSM
-
GSP
1 stop6h 37m
United Airlines
Deal found 3/6$355
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:20 am
GSP
-
DSM
2 stops7h 10m
American Airlines
Mon 4/2711:09 am
DSM
-
GSP
2 stops7h 52m
American Airlines
Deal found 3/7$356
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:46 am
GSP
-
MLI
1 stop7h 10m
United Airlines
Sat 8/292:29 pm
MLI
-
GSP
1 stop5h 48m
United Airlines
Deal found 3/8$359
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:30 am
GSP
-
CID
1 stop7h 14m
United Airlines
Wed 8/266:25 am
CID
-
GSP
1 stop6h 13m
United Airlines
Deal found 3/8$359
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:30 am
GSP
-
MLI
1 stop4h 39m
United Airlines
Sat 3/2810:46 am
MLI
-
GSP
1 stop5h 05m
United Airlines
Deal found 3/9$360
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:05 pm
GSP
-
OMA
2 stops6h 15m
Southwest
Sat 6/65:10 pm
OMA
-
GSP
1 stop4h 40m
Southwest
Deal found 3/8$376

Find flight deals from Greenville to Iowa

Keep the following information in mind while searching for Greenville to Iowa flight deals. Data was last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$314
(United Airlines)

One-way from

$160
(United Airlines)

Popular in

March

Cheapest in

October

Average price

$786
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Iowa
Search Deals
One-way flight from Greenville to Iowa
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($140 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Greenville to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

5:20 am-1:46 pm

2 stops9h 26m

Des Moines

Tue 5/12

8:56 am-4:50 pm

2 stops6h 54m

$347

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/8

12:07 pm-11:17 pm

2 stops12h 10m

Des Moines

Sat 4/11

6:20 am-11:44 am

1 stop4h 24m

$352

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Tue 8/25

5:43 pm-12:14 am

1 stop7h 31m

Moline Quad-City

Sat 8/29

3:44 pm-9:17 pm

1 stop4h 33m

$359

GreenvilleCedar Rapids

GSP - CID

GSPCID

Greenville

Sat 8/22

6:30 am-10:30 am

1 stop5h 00m

Cedar Rapids

Wed 8/26

2:34 pm-9:17 pm

1 stop5h 43m

$359

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/1

6:30 am-10:44 am

1 stop5h 14m

Des Moines

Wed 4/8

6:20 am-2:12 pm

2 stops6h 52m

$360
Quickest round-trip

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 5/7

8:45 am-1:37 pm

1 stop5h 52m

Des Moines

Sun 5/10

6:41 pm-11:43 pm

1 stop4h 02m

$381

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Fri 4/17

10:52 am-4:22 pm

1 stop6h 30m

Omaha Eppley Airfield

Sun 4/19

5:07 pm-11:57 pm

1 stop5h 50m

$387

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 7/10

5:05 pm-10:26 pm

1 stop6h 21m

Des Moines

Tue 7/21

7:25 am-2:17 pm

1 stop5h 52m

$387

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Mon 5/11

3:59 pm-11:15 pm

1 stop8h 16m

Omaha Eppley Airfield

Thu 5/14

6:30 am-2:50 pm

1 stop7h 20m

$391

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Mon 5/11

6:25 am-4:10 pm

1 stop10h 45m

Omaha Eppley Airfield

Thu 5/14

1:55 pm-10:15 pm

2 stops7h 20m

$400

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 38 resultsSorted by cheapest first
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Best time to book a flight from Greenville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Iowa

What is the cheapest month to book a flight from Greenville to Iowa?

Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $207). Flying from Greenville to Iowa in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated March 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Greenville to Iowa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,409 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,413 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Iowa?

    If you book a flight to Iowa from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville.

  • How long is the flight from Greenville to Iowa?

    A quick flight from Greenville to Iowa can take about 5h 08m. Delta provides one of the quickest options available for as low as $337. Airlines will cover a distance of 771 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Greenville to Iowa?

    The most popular route from Greenville to Iowa is Greenville - Des Moines. You may also consider Greenville - Omaha Eppley Airfield or Greenville - Cedar Rapids.

  • Can I find deals for flights from Greenville to Iowa that include hotel bookings?

    Yes. In addition to deals on Greenville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Iowa.

  • Can I find deals for business class flights from Greenville to Iowa?

    Yes. Cheapflights offers flight deals from Greenville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Iowa?

    Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $207). Flying from Greenville to Iowa in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Iowa

Discover the top 3 airlines that operate flights from Greenville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$376FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$371FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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