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$159+ Cheap flights from Greenville (GSP) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Greenville to Iowa

Cheapest flights from Greenville to Iowa
Explore the most affordable flight options available from Greenville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:40 amGSP - MLI
2 stops8h 14mUnited Airlines
Mon 12/291:00 pmMLI - GSP
1 stop6h 47mUnited Airlines
Deal found 12/21$415
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:44 pmGSP - MLI
1 stop4h 30mAmerican Airlines
Mon 12/293:21 pmMLI - GSP
1 stop7h 31mAmerican Airlines
Deal found 12/21$457
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amGSP - DSM
1 stop5h 47mAmerican Airlines
Sat 12/276:30 amDSM - GSP
1 stop15h 59mAmerican Airlines
Deal found 12/22$592
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:34 amGSP - CID
1 stop6h 40mUnited Airlines
Wed 12/315:28 pmCID - GSP
1 stop26h 19mUnited Airlines
Deal found 12/22$707
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:07 pmGSP - DSM
1 stop13h 08mAmerican Airlines
Sat 12/276:30 amDSM - GSP
1 stop12h 01mAmerican Airlines
Deal found 12/21$750
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:36 pmGSP - DSM
1 stop5h 04mUnited Airlines
Fri 12/266:46 pmDSM - GSP
1 stop25h 01mUnited Airlines
Deal found 12/21$777
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:40 amGSP - DSM
2 stops11h 50mUnited Airlines
Sat 12/276:46 pmDSM - GSP
2 stops23h 30mUnited Airlines
Deal found 12/21$817
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:00 amGSP - MLI
2 stops10h 05mAmerican Airlines
Wed 12/313:21 pmMLI - GSP
1 stop19h 07mAmerican Airlines
Deal found 12/22$918
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:20 pmGSP - DSM
1 stop7h 17mAmerican Airlines
Fri 12/263:27 pmDSM - GSP
2 stops7h 31mAmerican Airlines
Deal found 12/21$942

Find flight deals from Greenville to Iowa

Keep the following information in mind while searching for Greenville to Iowa flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$281
(Kiwi.com)

One-way from

$159
(Delta)

Popular in

April

Cheapest in

October

Average price

$629
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Iowa
Search Deals
One-way flight from Greenville to Iowa
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Greenville to Iowa that are best for you.

Fly from

Greenville

Fly to

Iowa

Route

Depart

Return

Price

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Thu 2/19

2:12 pm-6:29 pm

2 stops29h 17m

Omaha Eppley Airfield

Sun 2/22

9:11 am-3:54 pm

1 stop5h 43m

$294

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 2/5

4:55 pm-9:21 pm

1 stop29h 26m

Des Moines

Thu 2/12

3:32 pm-5:32 pm

1 stop25h 00m

$316

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Sat 1/17

6:35 am-10:12 am

1 stop4h 37m

Moline Quad-City

Wed 1/21

3:45 pm-8:47 pm

1 stop4h 02m

$339

GreenvilleCedar Rapids

GSP - CID

GSPCID

Greenville

Sat 2/14

6:30 am-10:44 am

1 stop5h 14m

Cedar Rapids

Wed 2/18

6:35 am-2:16 pm

2 stops6h 41m

$344

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Wed 2/18

6:12 am-5:38 pm

2 stops12h 26m

Omaha Eppley Airfield

Sat 2/21

3:02 pm-9:59 pm

1 stop5h 57m

$368

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Thu 2/19

10:45 am-9:10 pm

2 stops11h 25m

Omaha Eppley Airfield

Sun 2/22

5:30 am-7:05 pm

2 stops12h 35m

$390

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 2/14

6:30 am-10:53 am

1 stop5h 23m

Des Moines

Wed 2/18

3:24 pm-8:41 pm

1 stop4h 17m

$394

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 2/5

11:49 am-9:50 pm

2 stops11h 01m

Des Moines

Thu 2/12

9:04 am-11:59 pm

2 stops13h 55m

$456

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Mon 1/5

8:34 am-12:13 pm

1 stop4h 39m

Moline Quad-City

Fri 1/9

5:29 pm-10:16 am

1 stop15h 47m

$463

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 1/5

7:20 am-11:24 am

1 stop5h 04m

Des Moines

Thu 1/8

7:34 am-5:12 pm

1 stop8h 38m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 31 results
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Best time to book a flight from Greenville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Iowa

What is the cheapest month to book a flight from Greenville to Iowa?

Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to IA?

Find hourly flight availability from Greenville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

It’s typically best to fly out from Greenville to Iowa in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 23, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Greenville to Iowa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,105 reviews
Delta
7.9
Good
8,014 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,014 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Iowa?

    If you book a flight to Iowa from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville.

  • How long is the flight from Greenville to Iowa?

    A quick flight from Greenville to Iowa can take about 4h 37m. United Airlines provides one of the quickest options available for as low as $339. Airlines will cover a distance of 637 mi.

  • What are the most popular routes from Greenville to Iowa?

    The most popular route from Greenville to Iowa is Greenville - Des Moines. You may also consider Greenville - Cedar Rapids or Greenville - Omaha Eppley Airfield.

  • Can I find deals for flights from Greenville to Iowa that include hotel bookings?

    Yes. In addition to deals on Greenville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Iowa.

  • Can I find deals for business class flights from Greenville to Iowa?

    Yes. Cheapflights offers flight deals from Greenville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Iowa?

    Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Iowa

Discover the top 3 airlines that operate flights from Greenville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$376FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$368FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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