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$135+ Cheap flights from Greenville (GSP) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Greenville to Iowa

Cheapest flights from Greenville to Iowa
Explore the most affordable flight options available from Greenville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:35 pmGSP - CID
1 stop7h 47mAmerican Airlines
Wed 1/71:26 pmCID - GSP
1 stop6h 30mAmerican Airlines
Deal found 12/10$309
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:35 pmGSP - CID
1 stop7h 47mAmerican Airlines
Tue 1/63:41 pmCID - GSP
2 stops6h 55mAmerican Airlines
Deal found 12/10$381
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:00 amGSP - DSM
1 stop5h 47mAmerican Airlines
Mon 12/296:52 pmDSM - GSP
1 stop15h 09mAmerican Airlines
Deal found 12/10$410
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:54 pmGSP - DSM
1 stop8h 32mMultiple Airlines
Mon 12/221:56 pmDSM - GSP
1 stop17h 57mMultiple Airlines
Deal found 12/11$411
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:54 pmGSP - DSM
1 stop8h 32mAllegiant Air
Mon 12/228:05 amDSM - GSP
2 stops35h 43mAllegiant Air
Deal found 12/11$485
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amGSP - DSM
1 stop5h 49mAmerican Airlines
Tue 12/306:52 pmDSM - GSP
1 stop15h 09mAmerican Airlines
Deal found 12/11$487
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:07 pmGSP - DSM
1 stop13h 08mAmerican Airlines
Thu 12/2512:53 pmDSM - GSP
1 stop4h 46mAmerican Airlines
Deal found 12/10$507
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:20 pmGSP - DSM
2 stops8h 45mSouthwest
Thu 12/256:15 amDSM - GSP
2 stops8h 50mSouthwest
Deal found 12/10$514
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:23 pmGSP - OMA
1 stop7h 36mAmerican Airlines
Tue 12/307:34 pmOMA - GSP
1 stop14h 27mAmerican Airlines
Deal found 12/11$574
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:36 pmGSP - DSM
1 stop5h 04mUnited Airlines
Sat 12/278:00 amDSM - GSP
1 stop11h 47mUnited Airlines
Deal found 12/11$578
This Southwest deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:20 pmGSP - DSM
2 stops8h 45mSouthwest
Mon 12/226:35 amDSM - GSP
2 stops12h 05mSouthwest
Deal found 12/11$597
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:36 pmGSP - MLI
1 stop4h 45mUnited Airlines
Tue 12/305:33 pmMLI - GSP
1 stop16h 23mUnited Airlines
Deal found 12/11$614

Find flight deals from Greenville to Iowa

Keep the following information in mind while searching for Greenville to Iowa flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(United Airlines)

One-way from

$135
(United Airlines)

Popular in

April

Cheapest in

October

Average price

$629
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Iowa
Search Deals
One-way flight from Greenville to Iowa
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Greenville to Iowa that are best for you.

Fly from

Greenville

Fly to

Iowa

Route

Depart

Return

Price

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Thu 2/5

6:35 am-10:12 am

1 stop4h 37m

Moline Quad-City

Sat 2/7

3:45 pm-8:42 pm

1 stop3h 57m

$269

GreenvilleCedar Rapids

GSP - CID

GSPCID

Greenville

Thu 1/15

6:35 am-10:47 am

1 stop5h 12m

Cedar Rapids

Sun 1/18

8:00 am-7:29 pm

2 stops10h 29m

$284

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 1/20

5:34 pm-9:50 pm

1 stop5h 16m

Des Moines

Wed 1/21

3:04 pm-9:57 pm

1 stop5h 53m

$293

GreenvilleMoline

GSP - MLI

GSPMLI

Greenville

Thu 2/5

12:09 pm-10:23 pm

2 stops11h 14m

Moline Quad-City

Sat 2/7

11:28 am-8:48 pm

2 stops8h 20m

$299

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 1/16

7:20 am-11:24 am

1 stop5h 04m

Des Moines

Tue 1/20

5:35 am-11:03 am

1 stop4h 28m

$328

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 1/26

6:35 am-10:55 am

1 stop5h 20m

Des Moines

Wed 1/28

11:30 am-4:52 pm

1 stop4h 22m

$329

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 1/16

10:32 am-4:24 pm

2 stops6h 52m

Des Moines

Tue 1/20

11:42 am-8:48 pm

2 stops8h 06m

$338

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 1/26

11:15 am-7:20 pm

2 stops9h 05m

Des Moines

Wed 1/28

8:35 am-7:50 pm

2 stops10h 15m

$339

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 1/8

11:30 am-7:34 pm

1 stop9h 04m

Des Moines

Thu 1/15

7:34 am-5:12 pm

1 stop8h 38m

$341

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 1/16

7:20 am-11:24 am

1 stop5h 04m

Des Moines

Sat 1/31

12:25 pm-6:04 pm

1 stop4h 39m

$352

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 35 results
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Best time to book a flight from Greenville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Iowa

What is the cheapest month to book a flight from Greenville to Iowa?

Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to IA?

Find hourly flight availability from Greenville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from Greenville to Iowa in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Greenville to Iowa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Iowa?

    If you book a flight to Iowa from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville.

  • How long is the flight from Greenville to Iowa?

    A quick flight from Greenville to Iowa can take about 4h 37m. United Airlines provides one of the quickest options available for as low as $269. Airlines will cover a distance of 637 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Greenville to Iowa?

    The most popular route from Greenville to Iowa is Greenville - Des Moines. You may also consider Greenville - Cedar Rapids or Greenville - Moline Quad-City.

  • Can I find deals for flights from Greenville to Iowa that include hotel bookings?

    Yes. In addition to deals on Greenville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Iowa.

  • Can I find deals for business class flights from Greenville to Iowa?

    Yes. Cheapflights offers flight deals from Greenville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Iowa?

    Currently, June is the cheapest month in which you can book a flight from Greenville to Iowa (average of $208). Flying from Greenville to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Iowa

Discover the top 3 airlines that operate flights from Greenville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$312FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$372FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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