HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Indiana

$53+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Indiana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$179
(Kiwi.com)

One-way from

$53
(Cheapflightsfares)

Popular in

March

Cheapest in

April

Average price

$258
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Indiana
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/213:22 pmTYS - MDW
1 stop9h 07mMultiple Airlines
Mon 11/242:11 pmMDW - TYS
Nonstop1h 25mMultiple Airlines
Deal found 11/11$180
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:09 pmTYS - ORD
1 stop21h 12mMultiple Airlines
Sun 1/187:35 amORD - TYS
1 stop9h 18mMultiple Airlines
Deal found 11/13$180
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:58 pmTYS - ORD
Nonstop2h 08mAmerican Airlines
Mon 12/153:08 pmORD - TYS
Nonstop1h 50mAmerican Airlines
Deal found 11/11$189
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:34 pmTYS - ORD
2 stops18h 34mMultiple Airlines
Thu 12/117:00 amORD - TYS
1 stop7h 57mMultiple Airlines
Deal found 11/11$190
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2112:45 pmTYS - MDW
Nonstop1h 36mMultiple Airlines
Sun 11/236:05 amMDW - TYS
2 stops14h 58mMultiple Airlines
Deal found 11/11$193
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:13 pmTYS - ORD
1 stop15h 49mMultiple Airlines
Sun 12/2111:34 amORD - TYS
1 stop9h 22mMultiple Airlines
Deal found 11/11$194
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - ORD
1 stop8h 20mMultiple Airlines
Sun 12/145:13 pmORD - TYS
1 stop25h 01mMultiple Airlines
Deal found 11/12$201
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:54 amTYS - ORD
Nonstop2h 06mAmerican Airlines
Fri 12/53:08 pmORD - TYS
Nonstop1h 50mAmerican Airlines
Deal found 11/12$204
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:09 pmTYS - ORD
1 stop21h 12mMultiple Airlines
Wed 12/174:01 pmORD - TYS
2 stops28h 55mMultiple Airlines
Deal found 11/11$206
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/121:05 pmTYS - ORD
1 stop25h 11mMultiple Airlines
Mon 12/157:00 amORD - TYS
1 stop7h 57mMultiple Airlines
Deal found 11/12$207
This Delta deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:57 pmTYS - SBN
1 stop5h 45mDelta
Sun 12/76:00 amSBN - TYS
1 stop4h 46mDelta
Deal found 11/13$209
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:59 pmTYS - MDW
1 stop4h 48mDelta
Sun 12/146:00 amMDW - TYS
1 stop3h 46mDelta
Deal found 11/11$209

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Knoxville

Fly to

Indiana

Route

Depart

Return

Price

KnoxvilleCincinnati

TYS - CVG

TYSCVG

Knoxville McGhee Tyson

Fri 1/30

12:55 pm-11:31 pm

1 stop10h 36m

Cincinnati Cinci./N. Kentucky

Sun 2/1

7:00 am-6:36 pm

1 stop11h 36m

$187

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 4/4

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Wed 4/8

7:15 am-10:08 am

Nonstop1h 53m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 5/9

8:23 pm-9:30 pm

Nonstop2h 07m

Chicago O'Hare Intl

Mon 5/11

8:20 pm-11:06 pm

Nonstop1h 46m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 2/3

11:10 am-12:05 pm

Nonstop1h 55m

Chicago O'Hare Intl

Wed 2/11

6:20 pm-9:02 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 2/7

6:45 am-7:48 am

Nonstop2h 03m

Chicago O'Hare Intl

Tue 2/10

6:20 pm-9:02 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/12

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Sun 2/15

7:35 am-10:19 am

Nonstop1h 44m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 1/14

1:59 pm-2:55 pm

Nonstop1h 56m

Chicago O'Hare Intl

Wed 1/21

2:00 pm-4:53 pm

Nonstop1h 53m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 12/20

6:13 pm-9:02 am

1 stop15h 49m

Chicago O'Hare Intl

Sun 12/21

11:34 am-9:56 pm

1 stop9h 22m

$194

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 12/4

3:57 pm-9:42 pm

1 stop5h 45m

South Bend/Michiana

Sun 12/7

6:00 am-10:46 am

1 stop4h 46m

$209

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Tue 12/9

3:57 pm-9:42 pm

1 stop5h 45m

South Bend/Michiana

Sun 12/14

8:10 am-11:47 am

1 stop3h 37m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s optimal to fly from Knoxville to Indiana in the evening. By choosing this option you can save up to 34% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated November 13, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
698 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $189, United Airlines can have you in Indiana from Knoxville in 1h 55m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Indiana one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $81. Allegiant Air flights start at $122 while deals on Delta start at $126 one-way.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - Indianapolis as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Newark flights
Nashville to Orlando flights
Memphis to LaGuardia flights
Memphis to John F Kennedy Intl flights
Chattanooga to LaGuardia flights
Nashville to Las Vegas flights
Nashville to Denver flights
Nashville to Dallas/Fort Worth flights
Nashville to Miami flights
Nashville to Los Angeles flights
Nashville to Fort Lauderdale flights
Knoxville to LaGuardia flights
Memphis to Hobby flights
Nashville to O'Hare Intl flights
Nashville to Sky Harbor Intl flights
Nashville to Hobby flights
Nashville to Reagan-National flights
Memphis to Newark flights
Memphis to Denver flights
Memphis to Orlando flights
Nashville to Seattle flights
Nashville to Dulles Intl flights
Chattanooga to John F Kennedy Intl flights
Nashville to Salt Lake City flights
Knoxville to O'Hare Intl flights
Knoxville to John F Kennedy Intl flights
Memphis to O'Hare Intl flights
Memphis to Las Vegas flights
Memphis to George Bush Intcntl flights
Nashville to George Bush Intcntl flights
Memphis to Dallas/Fort Worth flights
Nashville to Boston flights
Chattanooga to Newark flights
Memphis to Miami flights
Nashville to Ontario flights
Memphis to Atlanta flights
Memphis to Los Angeles flights
Nashville to Baltimore flights
Chattanooga to Orlando flights
Knoxville to Newark flights
Nashville to Love Field flights
Nashville to Honolulu flights
Nashville to Tampa flights
Knoxville to Hobby flights
Memphis to Dulles Intl flights
Memphis to Reagan-National flights
Nashville to Santa Ana flights
Nashville to San Francisco flights

Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$76FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$208Average$325FlexibilityNo cancel feeOn-time69%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.