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$55+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated September 16, 2025.

Round-trip from

$98
(Cheapflightsfares)

One-way from

$55
(Cheapflightsfares)

Popular in

March

Cheapest in

April

Average price

$273

Good round-trip deal

$39 or less

Good one-way deal

$56 or less
From Knoxville McGhee Tyson to Indiana
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One-way flight from Knoxville McGhee Tyson to Indiana
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Highest demand for flights based on searches. 10% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Knoxville McGhee Tyson to Indiana.
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Price to beat on a one-way flight from Knoxville McGhee Tyson to Indiana.
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Find flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Mon 9/227:50 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/15$98
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Fri 9/267:50 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/15$103
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:23 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/278:24 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/14$105
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Mon 9/293:16 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/15$110
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:50 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Fri 10/312:06 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/14$116
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Mon 9/293:16 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/14$122
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Fri 9/267:50 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/14$132
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1310:46 amTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/2012:08 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/15$138
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:59 pmTYS - MDW
1 stop24h 14mMultiple Airlines
Mon 10/278:24 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Deal found 9/16$151
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:44 pmTYS - MDW
Nonstop1h 32mMultiple Airlines
Mon 11/39:32 amMDW - TYS
1 stop11h 23mMultiple Airlines
Deal found 9/15$159
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/310:44 amTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/612:08 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/14$160
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/193:04 pmTYS - ORD
Nonstop2h 00mAmerican Airlines
Sat 11/226:34 pmORD - TYS
Nonstop1h 47mAmerican Airlines
Deal found 9/14$189

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Knoxville

Fly to

Indiana

Route

Depart

Return

Price

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 11/20

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Sun 11/23

7:20 am-10:05 am

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 10/9

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sun 10/12

8:00 pm-10:50 pm

Nonstop1h 50m

$192

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 10/31

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Sun 11/2

7:20 am-10:05 am

Nonstop1h 45m

$194

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 9/27

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Tue 9/30

10:35 am-1:25 pm

Nonstop1h 50m

$199

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Fri 10/24

7:43 pm-11:36 pm

1 stop3h 53m

South Bend/Michiana

Mon 10/27

7:55 pm-11:50 pm

1 stop3h 55m

$209

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Wed 2/18

7:30 am-1:50 pm

1 stop6h 20m

South Bend/Michiana

Sat 2/21

12:13 pm-6:14 pm

1 stop6h 01m

$209

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 11/13

5:25 am-11:31 am

1 stop6h 06m

South Bend/Michiana

Sat 11/15

2:45 pm-8:00 pm

1 stop5h 15m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/24

12:47 pm-6:25 pm

1 stop6h 38m

Chicago Midway

Tue 10/28

5:04 pm-11:07 pm

1 stop5h 03m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 11/20

5:25 am-9:52 am

1 stop5h 27m

Chicago Midway

Sun 11/23

5:34 pm-11:52 pm

1 stop5h 18m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 10/15

12:47 pm-6:25 pm

1 stop6h 38m

Chicago Midway

Wed 10/22

6:00 am-10:45 am

1 stop3h 45m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 58 results
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Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $286). Flying from Knoxville to Indiana in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Knoxville to Indiana, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated September 16, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $189, United Airlines can have you in Indiana from Knoxville in 2h 04m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Indiana one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $55. American Airlines flights start at $179 while deals on Delta start at $199 one-way.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - Indianapolis as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $286). Flying from Knoxville to Indiana in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$78FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$287FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$329FlexibilityNo cancel feeOn-time69%

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