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$49+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$158
(Kiwi.com)

One-way from

$49
(Cheapflightsfares)

Popular in

March

Cheapest in

April

Average price

$288
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
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From Knoxville McGhee Tyson to Indiana
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One-way flight from Knoxville McGhee Tyson to Indiana
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Highest demand for flights based on searches. 10% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:23 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/278:24 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 10/15$127
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1710:44 amTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/2012:08 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 10/15$150
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:23 pmTYS - MDW
2 stops25h 16mMultiple Airlines
Mon 11/32:45 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Deal found 10/16$158
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:02 pmTYS - MDW
Nonstop1h 35mMultiple Airlines
Sun 11/1610:12 amMDW - TYS
1 stop26h 45mMultiple Airlines
Deal found 10/16$173
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:59 pmTYS - MDW
2 stops29h 48mMultiple Airlines
Mon 10/278:24 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Deal found 10/15$176
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:29 pmTYS - ORD
Nonstop2h 04mAmerican Airlines
Mon 12/1511:42 amORD - TYS
Nonstop1h 45mAmerican Airlines
Deal found 10/15$189
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:26 amTYS - ORD
Nonstop2h 04mUnited Airlines
Wed 11/510:35 amORD - TYS
Nonstop1h 42mUnited Airlines
Deal found 10/15$194
This FlightHub deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/31:23 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 11/104:12 pmMDW - TYS
Nonstop1h 25mAllegiant Air
Deal found 10/16$199
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:52 pmTYS - ORD
Nonstop2h 01mUnited Airlines
Mon 11/35:50 pmORD - TYS
Nonstop1h 43mUnited Airlines
Deal found 10/15$199
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:45 amTYS - MDW
2 stops11h 17mAllegiant Air
Mon 11/32:45 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 10/15$200
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:54 amTYS - ORD
1 stop11h 33mMultiple Airlines
Sun 11/165:25 amORD - TYS
1 stop16h 34mMultiple Airlines
Deal found 10/14$204
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:44 pmTYS - MDW
Nonstop1h 32mMultiple Airlines
Tue 11/41:56 pmMDW - TYS
2 stops24h 46mMultiple Airlines
Deal found 10/16$205

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Knoxville

Fly to

Indiana

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/31

5:44 pm-6:16 pm

Nonstop1h 32m

Chicago Midway

Mon 11/3

9:32 am-9:55 pm

1 stop11h 23m

$152

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/14

2:02 pm-2:37 pm

Nonstop1h 35m

Chicago Midway

Sun 11/16

10:12 am-1:57 pm

1 stop26h 45m

$173

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 3/4

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Sun 3/8

6:13 pm-8:54 pm

Nonstop1h 41m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 11/13

6:45 am-7:38 am

Nonstop1h 53m

Chicago O'Hare Intl

Sun 11/16

7:20 am-10:05 am

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 11/8

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Sat 11/15

7:20 am-10:05 am

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/19

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Tue 2/24

7:35 am-10:19 am

Nonstop1h 44m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 11/13

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Thu 11/20

7:20 am-10:05 am

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 1/26

6:45 am-7:48 am

Nonstop2h 03m

Chicago O'Hare Intl

Mon 2/2

7:42 am-10:32 am

Nonstop1h 50m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 11/11

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Tue 11/18

10:35 am-1:17 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 11/5

6:45 am-7:38 am

Nonstop1h 53m

Chicago O'Hare Intl

Sat 11/8

7:20 am-10:05 am

Nonstop1h 45m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 60 results
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Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s optimal to fly from Knoxville to Indiana in the evening. By choosing this option you can save up to 39% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated October 16, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Allegiant Air
7.2
Good
693 reviews
Delta
8.0
Very good
7,984 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $189, United Airlines can have you in Indiana from Knoxville in 2h 02m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - Indianapolis as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$78FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$377FlexibilityNo cancel feeOn-time69%

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