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$57+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
May 15 — May 221
Fri 5/15
Fri 5/22
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:15 pm
TYS
-
IND
1 stop20h 34m
Multiple Airlines
Sat 5/26:37 pm
IND
-
TYS
1 stop17h 47m
Multiple Airlines
Deal found 4/11$195
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:15 pm
TYS
-
MDW
2 stops31h 16m
Multiple Airlines
Sun 5/242:47 pm
MDW
-
TYS
Nonstop1h 26m
Multiple Airlines
Deal found 4/11$195
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
SBN
1 stop12h 34m
Allegiant Air
Sun 5/36:41 pm
SBN
-
TYS
1 stop27h 07m
Allegiant Air
Deal found 4/11$196
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
IND
1 stop26h 34m
Multiple Airlines
Thu 5/712:26 pm
IND
-
TYS
1 stop8h 24m
Multiple Airlines
Deal found 4/11$199
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
SBN
1 stop12h 34m
Allegiant Air
Mon 5/47:29 pm
SBN
-
TYS
1 stop19h 29m
Allegiant Air
Deal found 4/14$199
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:15 pm
TYS
-
IND
1 stop20h 34m
Multiple Airlines
Wed 5/612:14 pm
IND
-
TYS
2 stops27h 27m
Multiple Airlines
Deal found 4/11$202
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:56 pm
TYS
-
ORD
1 stop9h 21m
Multiple Airlines
Sat 5/21:27 pm
ORD
-
TYS
1 stop30h 08m
Multiple Airlines
Deal found 4/11$206
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
IND
2 stops13h 07m
Multiple Airlines
Sat 5/26:37 pm
IND
-
TYS
1 stop17h 47m
Multiple Airlines
Deal found 4/11$208
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:22 pm
TYS
-
MDW
Nonstop1h 35m
Multiple Airlines
Sun 5/3112:27 pm
MDW
-
TYS
2 stops32h 34m
Multiple Airlines
Deal found 4/13$209
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 pm
TYS
-
MDW
2 stops26h 11m
Multiple Airlines
Thu 5/282:47 pm
MDW
-
TYS
Nonstop1h 26m
Multiple Airlines
Deal found 4/11$212
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:30 am
TYS
-
ORD
1 stop17h 54m
Multiple Airlines
Sat 5/21:27 pm
ORD
-
TYS
1 stop30h 08m
Multiple Airlines
Deal found 4/11$213
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:40 pm
TYS
-
ORD
1 stop9h 44m
Multiple Airlines
Mon 5/46:00 am
ORD
-
TYS
1 stop10h 30m
Multiple Airlines
Deal found 4/13$214

Find flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated April 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$195
(Kiwi.com)

One-way from

$57
(Trip.com)

Popular in

March

Cheapest in

May

Average price

$353
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Indiana
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-9:59 am

1 stop12h 34m

South Bend/Michiana

Mon 5/4

7:29 pm-2:58 pm

1 stop19h 29m

$199

KnoxvilleCincinnati

TYS - CVG

TYSCVG

Knoxville McGhee Tyson

Mon 4/27

6:20 pm-11:20 pm

1 stop29h 00m

Cincinnati Cinci./N. Kentucky

Fri 5/1

7:46 pm-1:09 pm

2 stops17h 23m

$231

KnoxvilleCincinnati

TYS - CVG

TYSCVG

Knoxville McGhee Tyson

Thu 7/9

3:53 pm-11:29 pm

1 stop7h 36m

Cincinnati Cinci./N. Kentucky

Sun 7/12

9:32 pm-2:16 pm

1 stop16h 44m

$232

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 5/13

2:55 pm-9:45 pm

1 stop7h 50m

Chicago Midway

Wed 5/20

3:00 pm-7:40 pm

1 stop3h 40m

$249
Quickest round-trip

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 5/7

6:01 pm-6:55 pm

Nonstop1h 54m

Chicago O'Hare Intl

Sun 5/10

2:05 pm-4:54 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 7/11

6:30 am-7:29 am

Nonstop1h 59m

Chicago O'Hare Intl

Sat 7/18

2:02 pm-4:51 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 6/5

6:30 am-7:29 am

Nonstop1h 59m

Chicago O'Hare Intl

Sat 6/6

6:07 pm-8:56 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 5/12

8:15 am-4:45 pm

2 stops9h 30m

Chicago Midway

Tue 5/19

3:00 pm-7:40 pm

1 stop3h 40m

$254

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 9/2

5:30 am-8:34 am

1 stop4h 04m

Chicago O'Hare Intl

Wed 9/16

8:00 am-3:07 pm

1 stop6h 07m

$264

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/29

11:44 am-4:29 pm

1 stop5h 45m

Chicago O'Hare Intl

Wed 6/3

7:07 am-2:33 pm

1 stop6h 26m

$264

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 15, 2026.

It’s optimal to fly from Knoxville to Indiana at noon. By choosing this option you can save up to 86% on the cost of your flight, compared to a flight in the morning.

How much does it cost to fly round-trip from Knoxville to Indiana?

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated April 15, 2026.
See what other customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,406 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,406 reviews
Delta
7.9
Good
8,406 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,589 reviews
Delta
7.9
Good
8,406 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.3
Good
707 reviews
Delta
7.9
Good
8,406 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,581 reviews
Delta
7.9
Good
8,406 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $249, Allegiant Air can have you in Indiana from Knoxville in 1h 54m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Indiana one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $38. Delta flights start at $125 while deals on American Airlines start at $129 one-way.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Indianapolis or Knoxville McGhee Tyson - Chicago Midway as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$76FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$213Average$338FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%

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