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$85+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/181:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Sun 6/212:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Deal found 1/27$187
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:45 am
TYS
-
ORD
Nonstop2h 02m
United Airlines
Sun 2/227:35 am
ORD
-
TYS
Nonstop1h 44m
United Airlines
Deal found 1/27$189
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:36 pm
TYS
-
ORD
2 stops15h 11m
Multiple Airlines
Tue 3/38:16 pm
ORD
-
TYS
1 stop12h 54m
Multiple Airlines
Deal found 1/27$200
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:45 am
TYS
-
ORD
Nonstop2h 02m
United Airlines
Tue 2/176:00 pm
ORD
-
TYS
Nonstop1h 37m
United Airlines
Deal found 1/26$204
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:45 am
TYS
-
SBN
1 stop4h 28m
United Airlines
Sat 2/216:07 am
SBN
-
TYS
1 stop4h 12m
United Airlines
Deal found 1/27$209
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:54 pm
TYS
-
MDW
1 stop5h 34m
Delta
Sat 5/910:35 am
MDW
-
TYS
1 stop3h 31m
Delta
Deal found 1/25$209
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:41 pm
TYS
-
ORD
1 stop6h 15m
Delta
Mon 2/236:30 am
ORD
-
TYS
1 stop4h 41m
Delta
Deal found 1/26$209
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:00 am
TYS
-
ORD
1 stop13h 37m
Multiple Airlines
Sat 2/284:42 pm
ORD
-
TYS
2 stops28h 25m
Multiple Airlines
Deal found 1/26$211
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1312:50 pm
TYS
-
MDW
1 stop5h 40m
Southwest
Sat 5/169:15 am
MDW
-
TYS
2 stops8h 15m
Southwest
Deal found 1/25$214
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/134:02 pm
TYS
-
ORD
Nonstop2h 02m
American Airlines
Mon 2/165:55 pm
ORD
-
TYS
Nonstop1h 45m
American Airlines
Deal found 1/27$219
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/131:00 pm
TYS
-
ORD
1 stop6h 59m
Delta
Tue 2/176:45 am
ORD
-
TYS
1 stop6h 06m
Delta
Deal found 1/26$224
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/612:55 pm
TYS
-
IND
1 stop10h 20m
Allegiant Air
Sun 2/89:00 am
IND
-
TYS
1 stop14h 10m
Allegiant Air
Deal found 1/26$227

Find flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$187
(Kiwi.com)

One-way from

$85
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$268
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Indiana
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Knoxville

Fly to

Indiana

Route

Depart

Return

Price

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/26

7:51 am-8:59 am

Nonstop2h 08m

Chicago O'Hare Intl

Mon 3/2

1:52 pm-4:31 pm

Nonstop1h 39m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 4/15

10:49 am-11:53 am

Nonstop2h 04m

Chicago O'Hare Intl

Sun 4/19

7:15 am-10:08 am

Nonstop1h 53m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/26

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Sun 3/1

6:00 pm-8:37 pm

Nonstop1h 37m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 2/20

4:02 pm-5:04 pm

Nonstop2h 02m

Chicago O'Hare Intl

Sun 2/22

8:02 am-10:45 am

Nonstop1h 43m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 4/9

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sun 4/12

7:15 am-10:08 am

Nonstop1h 53m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/1

7:33 pm-8:40 pm

Nonstop2h 07m

Chicago O'Hare Intl

Sat 5/2

1:51 pm-4:35 pm

Nonstop1h 44m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 4/10

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sun 4/12

7:45 pm-10:29 pm

Nonstop1h 44m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 2/20

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Sun 2/22

7:35 am-10:19 am

Nonstop1h 44m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/26

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Sat 2/28

6:00 pm-8:37 pm

Nonstop1h 37m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 4/18

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Mon 4/20

2:06 pm-4:52 pm

Nonstop1h 46m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 60 results
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Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 28, 2026.

It’s optimal to fly from Knoxville to Indiana at noon. By choosing this option you can save up to 86% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated January 28, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,122 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,122 reviews
Delta
7.9
Good
8,122 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,206 reviews
Delta
7.9
Good
8,122 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,200 reviews
Delta
7.9
Good
8,122 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
706 reviews
Delta
7.9
Good
8,122 reviews

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $189, American Airlines can have you in Indiana from Knoxville in 2h 04m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - Indianapolis as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in March is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Indiana

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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$78FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$208Average$273FlexibilityNo cancel feeOn-time69%
DeltaCheapest$208Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$268FlexibilityNo cancel feeOn-time71%

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