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$68+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
SBN
1 stop12h 34m
Allegiant Air
Sun 5/108:13 pm
SBN
-
TYS
1 stop26h 11m
Allegiant Air
Deal found 3/22$185
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:50 pm
TYS
-
MDW
2 stops7h 55m
Southwest
Tue 4/2812:50 pm
MDW
-
TYS
2 stops7h 00m
Southwest
Deal found 3/24$192
This Cheapflightsfares deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:22 pm
TYS
-
MDW
Nonstop1h 35m
Allegiant Air
Sun 5/242:47 pm
MDW
-
TYS
Nonstop1h 26m
Allegiant Air
Deal found 3/24$199
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:35 pm
TYS
-
MDW
1 stop6h 50m
Southwest
Tue 6/911:25 am
MDW
-
TYS
2 stops7h 55m
Southwest
Deal found 3/23$203
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 pm
TYS
-
CVG
1 stop29h 00m
Multiple Airlines
Mon 4/2710:00 am
CVG
-
TYS
1 stop12h 24m
Multiple Airlines
Deal found 3/23$203
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
-
ORD
1 stop27h 22m
Multiple Airlines
Thu 4/302:05 pm
ORD
-
TYS
1 stop26h 25m
Multiple Airlines
Deal found 3/24$204
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:10 am
TYS
-
MDW
1 stop6h 50m
Multiple Airlines
Sun 4/267:30 am
MDW
-
TYS
1 stop27h 25m
Multiple Airlines
Deal found 3/25$208
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:37 pm
TYS
-
IND
1 stop24h 14m
Multiple Airlines
Mon 4/207:14 pm
IND
-
TYS
1 stop14h 26m
Multiple Airlines
Deal found 3/24$210
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:25 pm
TYS
-
ORD
1 stop8h 59m
Multiple Airlines
Wed 4/298:52 pm
ORD
-
TYS
1 stop24h 41m
Multiple Airlines
Deal found 3/25$210
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
-
ORD
1 stop26h 22m
Multiple Airlines
Wed 4/221:27 pm
ORD
-
TYS
1 stop30h 15m
Multiple Airlines
Deal found 3/21$211
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:51 am
TYS
-
MDW
1 stop5h 51m
Delta
Mon 5/116:23 am
MDW
-
TYS
1 stop5h 47m
Delta
Deal found 3/23$213
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:50 am
TYS
-
ORD
1 stop5h 59m
Delta
Mon 4/201:36 pm
ORD
-
TYS
1 stop6h 44m
Delta
Deal found 3/24$213

Find flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated March 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$185
(Kiwi.com)

One-way from

$68
(Kiwi.com)

Popular in

January

Cheapest in

May

Average price

$444
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Indiana
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($152 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 4/21

8:15 am-5:05 pm

2 stops9h 50m

Chicago Midway

Tue 4/28

9:10 am-7:40 pm

2 stops9h 30m

$192

KnoxvilleCincinnati

TYS - CVG

TYSCVG

Knoxville McGhee Tyson

Mon 4/20

6:20 pm-11:20 pm

1 stop29h 00m

Cincinnati Cinci./N. Kentucky

Mon 4/27

10:00 am-10:24 pm

1 stop12h 24m

$203

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 6/6

1:35 pm-7:25 pm

1 stop6h 50m

Chicago Midway

Tue 6/9

11:50 am-8:20 pm

1 stop7h 30m

$204

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-9:59 am

1 stop12h 19m

South Bend/Michiana

Mon 5/18

7:29 pm-2:58 pm

1 stop19h 29m

$226

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-9:59 am

1 stop12h 19m

South Bend/Michiana

Sun 5/17

6:41 pm-9:48 pm

1 stop27h 07m

$227

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 4/17

5:54 pm-11:59 pm

1 stop7h 05m

Chicago O'Hare Intl

Mon 4/20

1:36 pm-9:20 pm

1 stop6h 44m

$230

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 5/5

5:50 pm-10:15 pm

1 stop5h 25m

Chicago Midway

Wed 5/6

10:15 am-7:40 pm

2 stops8h 25m

$231

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 5/1

6:45 pm-11:30 pm

1 stop5h 45m

Chicago Midway

Sat 5/2

2:15 pm-6:30 pm

1 stop3h 15m

$231

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 5/9

7:51 am-12:42 pm

1 stop5h 51m

Chicago Midway

Sun 5/10

9:22 am-2:20 pm

1 stop3h 58m

$241

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Sun 4/12

11:27 am-3:54 pm

1 stop28h 27m

South Bend/Michiana

Thu 4/16

6:41 pm-9:48 pm

1 stop27h 07m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/23

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.

It’s optimal to fly from Knoxville to Indiana at noon. By choosing this option you can save up to 86% on the cost of your flight, compared to a flight in the morning.

How much does it cost to fly round-trip from Knoxville to Indiana?

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated March 26, 2026.
See what other customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,331 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,331 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,484 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.3
Good
710 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,496 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $230, Southwest can have you in Indiana from Knoxville in 7h 05m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Indiana one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $38. Delta flights start at $125 while deals on American Airlines start at $129 one-way.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - Indianapolis as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Indiana

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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$76FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$213Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%

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