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$91+ Cheap flights from Knoxville (TYS) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Apr 21 — Apr 281
Tue 4/21
Tue 4/28
1 adult, Economy
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Cheap flight deals from Knoxville to Indiana

Cheapest flights from Knoxville to Indiana
Explore the most affordable flight options available from Knoxville to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
SBN
1 stop12h 34m
Allegiant Air
Sun 5/108:13 pm
SBN
-
TYS
1 stop26h 11m
Allegiant Air
Deal found 3/20$206
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
-
ORD
1 stop26h 22m
Multiple Airlines
Wed 4/221:27 pm
ORD
-
TYS
1 stop30h 15m
Multiple Airlines
Deal found 3/21$211
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
SBN
1 stop12h 34m
Allegiant Air
Mon 5/47:29 pm
SBN
-
TYS
1 stop19h 29m
Allegiant Air
Deal found 3/18$215
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:25 pm
TYS
-
ORD
1 stop29h 52m
Multiple Airlines
Wed 4/227:15 pm
ORD
-
TYS
1 stop24h 27m
Multiple Airlines
Deal found 3/18$217
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
-
ORD
1 stop13h 11m
Multiple Airlines
Sun 5/35:05 am
ORD
-
TYS
1 stop14h 30m
Multiple Airlines
Deal found 3/21$218
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/161:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Sun 7/192:48 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 3/18$220
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:40 pm
TYS
-
SBN
1 stop12h 19m
Allegiant Air
Mon 5/187:29 pm
SBN
-
TYS
1 stop19h 29m
Allegiant Air
Deal found 3/22$226
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
-
ORD
1 stop27h 08m
Multiple Airlines
Wed 4/221:27 pm
ORD
-
TYS
1 stop30h 15m
Multiple Airlines
Deal found 3/21$229
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/161:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Thu 7/232:48 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 3/18$231
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/911:27 am
TYS
-
ORD
1 stop8h 08m
Multiple Airlines
Sun 4/1212:00 pm
ORD
-
TYS
2 stops33h 24m
Multiple Airlines
Deal found 3/19$231
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/231:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Sun 7/262:48 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 3/19$233
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:25 pm
TYS
-
ORD
1 stop8h 59m
Multiple Airlines
Fri 4/177:15 pm
ORD
-
TYS
1 stop15h 51m
Multiple Airlines
Deal found 3/22$233

Find flight deals from Knoxville to Indiana

Keep the following information in mind while searching for Knoxville to Indiana flight deals. Data was last updated March 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$206
(Kiwi.com)

One-way from

$99
(Kiwi.com)

Popular in

January

Cheapest in

May

Average price

$444
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Indiana
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($152 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Knoxville to Indiana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-9:59 am

1 stop12h 34m

South Bend/Michiana

Sun 5/10

8:13 pm-10:24 pm

1 stop26h 11m

$206

KnoxvilleSouth Bend

TYS - SBN

TYSSBN

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-9:59 am

1 stop12h 19m

South Bend/Michiana

Mon 5/18

7:29 pm-2:58 pm

1 stop19h 29m

$226
Quickest round-trip

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 4/30

7:00 am-7:56 am

Nonstop1h 56m

Chicago O'Hare Intl

Sun 5/3

2:12 pm-4:59 pm

Nonstop1h 47m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 5/21

8:20 am-9:28 am

Nonstop2h 08m

Chicago O'Hare Intl

Tue 5/26

2:12 pm-5:12 pm

Nonstop2h 00m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 7/29

8:20 am-9:28 am

Nonstop2h 08m

Chicago O'Hare Intl

Tue 8/4

9:35 pm-12:35 am

Nonstop2h 00m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/1

5:06 pm-6:20 pm

Nonstop2h 14m

Chicago O'Hare Intl

Fri 5/8

5:24 pm-8:18 pm

Nonstop1h 54m

$250

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/1

1:15 pm-3:23 pm

1 stop27h 08m

Chicago O'Hare Intl

Fri 5/8

7:45 pm-11:06 am

1 stop14h 21m

$251

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 4/30

2:45 pm-9:15 pm

1 stop7h 30m

Chicago Midway

Sun 5/3

6:00 am-3:15 pm

1 stop8h 15m

$269

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 5/11

7:33 pm-11:59 pm

1 stop5h 26m

Chicago O'Hare Intl

Thu 5/28

8:10 am-1:10 pm

1 stop4h 00m

$269

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 4/17

6:45 pm-11:30 pm

1 stop5h 45m

Chicago Midway

Sat 4/18

7:25 am-3:20 pm

1 stop6h 55m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/22

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Knoxville to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indiana

What is the cheapest month to book a flight from Knoxville to Indiana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IN?

Find hourly flight availability from Knoxville to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 22, 2026.

It’s optimal to fly from Knoxville to Indiana at noon. By choosing this option you can save up to 86% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated March 22, 2026.
See what other customers who have flown with Delta,United Airlines, andAllegiant Air from Knoxville to Indiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,315 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,315 reviews
Delta
7.9
Good
8,315 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,455 reviews
Delta
7.9
Good
8,315 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.3
Good
711 reviews
Delta
7.9
Good
8,315 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,487 reviews
Delta
7.9
Good
8,315 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Indiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Indiana. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Indiana?

    For as low as $249, Allegiant Air can have you in Indiana from Knoxville in 1h 56m. There are 475 mi between Knoxville and Indiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Indiana one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $38. Delta flights start at $125 while deals on American Airlines start at $129 one-way.

  • What are the most popular routes from Knoxville to Indiana?

    When deciding which route to take from Knoxville to Indiana consider Knoxville McGhee Tyson - Chicago O'Hare Intl, Knoxville McGhee Tyson - Chicago Midway or Knoxville McGhee Tyson - South Bend/Michiana as they are the most popular.

  • Can I find deals for flights from Knoxville to Indiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indiana.

  • Can I find deals for business class flights from Knoxville to Indiana?

    Yes. Cheapflights offers flight deals from Knoxville to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indiana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Indiana (average of $31). Flying from Knoxville to Indiana in January is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Indiana

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Top 4 airlines flying from Knoxville to Indiana

Discover the top 4 airlines that operate flights from Knoxville to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$31Average$76FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$213Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%

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