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Knoxville

$54+ Cheap flights from Indiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
IND — TYS
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from Indiana to Knoxville

Cheapest flights from Indiana to Knoxville
Explore the most affordable flight options available from Indiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/282:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Thu 7/21:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Deal found 4/22$139
This Trip.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Sun 6/71:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Deal found 4/24$141
This Cheapflightsfares deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Sun 6/211:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Deal found 4/21$148
This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:47 pm
MDW
-
TYS
Nonstop1h 26m
Allegiant Air
Sun 5/311:22 pm
TYS
-
MDW
Nonstop1h 35m
Allegiant Air
Deal found 4/23$155
This Cheapflightsfares deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:48 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Thu 7/161:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Deal found 4/20$156
This Cheapflightsfares deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Thu 6/181:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Deal found 4/21$166
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:46 pm
MDW
-
TYS
Nonstop1h 28m
Multiple Airlines
Mon 6/812:40 pm
TYS
-
MDW
2 stops23h 32m
Multiple Airlines
Deal found 4/22$169
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:16 am
MDW
-
TYS
1 stop9h 39m
Allegiant Air
Thu 5/211:22 pm
TYS
-
MDW
Nonstop1h 35m
Allegiant Air
Deal found 4/19$170
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:30 pm
MDW
-
TYS
1 stop21h 01m
Allegiant Air
Thu 5/281:22 pm
TYS
-
MDW
Nonstop1h 35m
Allegiant Air
Deal found 4/20$171
This Cheapflightsfares deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Thu 6/181:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Deal found 4/21$175
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
ORD
-
TYS
1 stop6h 20m
Delta
Wed 5/277:51 am
TYS
-
ORD
1 stop6h 10m
Delta
Deal found 4/22$181
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:52 pm
ORD
-
TYS
1 stop23h 37m
Multiple Airlines
Mon 6/87:27 pm
TYS
-
ORD
1 stop28h 52m
Multiple Airlines
Deal found 4/23$187

Find flight deals from Indiana to Knoxville

Keep the following information in mind while searching for Indiana to Knoxville flight deals. Data was last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$139
(Cheapflightsfares)

One-way from

$54
(Kiwi.com)

Popular in

May

Cheapest in

July

Average price

$586
Provider with most accurate pricing for Indianapolis-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Knoxville McGhee Tyson flights.
Search Deals
From Indiana to Knoxville McGhee Tyson
Search Deals
One-way flight from Indiana to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Indiana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Wed 5/20

6:00 am-9:34 am

1 stop3h 34m

Knoxville McGhee Tyson

Wed 5/27

7:33 pm-12:33 am

1 stop5h 00m

$221

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Thu 7/9

6:29 pm-2:58 pm

1 stop20h 29m

Knoxville McGhee Tyson

Mon 7/13

7:20 pm-1:25 pm

1 stop18h 05m

$231

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Tue 5/19

1:59 pm-5:11 pm

1 stop3h 12m

Knoxville McGhee Tyson

Tue 5/26

5:40 am-10:47 am

1 stop5h 07m

$233

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 5/23

1:44 pm-9:25 pm

1 stop6h 41m

Knoxville McGhee Tyson

Mon 5/25

5:40 am-8:39 am

1 stop3h 59m

$241

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Wed 5/20

12:14 pm-12:26 pm

2 stops24h 12m

Knoxville McGhee Tyson

Wed 6/10

2:19 pm-9:28 am

1 stop19h 09m

$244

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Mon 5/11

9:30 pm-9:40 am

1 stop12h 10m

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-9:36 pm

1 stop23h 56m

$248

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 7/8

2:12 pm-5:12 pm

Nonstop2h 00m

Knoxville McGhee Tyson

Sun 7/12

6:30 am-7:29 am

Nonstop1h 59m

$249

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 8/29

7:12 am-10:08 am

Nonstop1h 56m

Knoxville McGhee Tyson

Thu 9/3

6:30 am-7:25 am

Nonstop1h 55m

$249

CincinnatiKnoxville

CVG - TYS

CVGTYS

Cincinnati Cinci./N. Kentucky

Tue 5/19

5:48 am-11:09 am

1 stop5h 21m

Knoxville McGhee Tyson

Sat 5/23

5:35 pm-9:17 pm

1 stop3h 42m

$255

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 6/4

9:30 pm-12:30 am

Nonstop2h 00m

Knoxville McGhee Tyson

Sun 6/7

6:30 am-7:29 am

Nonstop1h 59m

$264

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/19

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Indiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Knoxville

How far ahead should I book a flight from Indiana to Knoxville?

To ensure you get the cheapest price possible for a flight from Indiana to Knoxville, you should look to book at least 75 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Indiana to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $35). Flying from Indiana to Knoxville in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to TYS?

Find hourly flight availability from Indiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2026.

A simple way to save on the total cost of your ticket is to fly from Indiana to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight in the afternoon.

How much does it cost to fly round-trip from Indiana to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Indiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Indiana?

    If you book a flight to Knoxville from Indiana, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Indiana to Knoxville?

    Departing from Indiana to Knoxville will take you 2h. Airlines will cover a distance of 475 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Knoxville one-way?

    The cheapest airlines for a one-way flight from Indiana to Knoxville are Allegiant Air ($37), American Airlines ($99), and Delta ($99).

  • What are the most popular routes from Indiana to Knoxville?

    Most travelers choose Chicago O'Hare Intl - Knoxville McGhee Tyson, Chicago Midway - Knoxville McGhee Tyson or South Bend/Michiana - Knoxville McGhee Tyson when deciding on the best route from Indiana to Knoxville.

  • Can I find deals for flights from Indiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Indiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Knoxville.

  • Can I find deals for business class flights from Indiana to Knoxville?

    Yes. Cheapflights offers flight deals from Indiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $35). Flying from Indiana to Knoxville in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Indiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Knoxville

Discover the top 4 airlines that operate flights from Indiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$45Average$76FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$107Average$368FlexibilityNo cancel feeOn-time69%
DeltaCheapest$134Average$398FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$349FlexibilityNo cancel feeOn-time71%

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