$316+ Cheap flights from St. Louis (STL) to Guayaquil (GYE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GYE
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Guayaquil with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Guayaquil
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Cheapest flights from St. Louis to GuayaquilExplore the most affordable flight options available from St. Louis to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from St. Louis to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:21 am
STL
- GYE
1 stop16h 19m
American Airlines
Wed 11/116:00 am
GYE
- STL
1 stop10h 50m
American Airlines
Deal found 4/7![American Airlines logo]()
$695
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:13 pm
STL
- GYE
1 stop14h 42m
Delta
Wed 11/115:00 pm
GYE
- STL
2 stops21h 20m
Delta
Deal found 4/7![Delta logo]()
$700
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:15 am
STL
- GYE
1 stop17h 22m
American Airlines
Thu 5/286:00 am
GYE
- STL
1 stop16h 58m
American Airlines
Deal found 4/5![American Airlines logo]()
$705
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
STL
- GYE
2 stops16h 37m
American Airlines
Wed 7/226:00 am
GYE
- STL
1 stop16h 21m
American Airlines
Deal found 4/5![American Airlines logo]()
$787
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
STL
- GYE
2 stops11h 31m
United Airlines
Tue 5/512:22 pm
GYE
- STL
2 stops21h 08m
United Airlines
Deal found 4/4![United Airlines logo]()
$794
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:24 am
STL
- GYE
1 stop8h 07m
American Airlines
Tue 5/56:05 am
GYE
- STL
2 stops16h 02m
American Airlines
Deal found 4/4![American Airlines logo]()
$799
This BusinessClass deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:55 pm
STL
- GYE
2 stops18h 36m
GOL
Wed 5/132:31 pm
GYE
- STL
2 stops20h 56m
GOL
Deal found 4/6![GOL logo]()
$931
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
STL
- GYE
2 stops11h 31m
United Airlines
Wed 4/1512:22 pm
GYE
- STL
2 stops21h 03m
United Airlines
Deal found 4/4![United Airlines logo]()
$993
This LATAM Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:59 am
STL
- GYE
2 stops21h 55m
LATAM Airlines
Fri 4/249:05 am
GYE
- STL
2 stops23h 25m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,191
Best flights from St. Louis to GuayaquilDiscover carefully curated flight deals from St. Louis to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from St. Louis to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:15 am
STL
- GYE
1 stop17h 22m
American Airlines
Thu 5/286:00 am
GYE
- STL
1 stop16h 58m
American Airlines
Deal found 4/5![American Airlines logo]()
$705
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
STL
- GYE
2 stops11h 31m
United Airlines
Tue 5/512:22 pm
GYE
- STL
2 stops21h 08m
United Airlines
Deal found 4/4![United Airlines logo]()
$794
This BusinessClass deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:06 am
STL
- GYE
1 stop26h 25m
GOL
Wed 5/132:31 pm
GYE
- STL
2 stops20h 56m
GOL
Deal found 4/6![GOL logo]()
$947
This LATAM Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:59 am
STL
- GYE
2 stops21h 55m
LATAM Airlines
Fri 4/249:05 am
GYE
- STL
2 stops23h 25m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,191
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
STL
- GYE
2 stops16h 37m
American Airlines
Wed 7/226:00 am
GYE
- STL
1 stop16h 21m
American Airlines
Deal found 4/5![American Airlines logo]()
$787
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:06 am
STL
- GYE
1 stop10h 06m
American Airlines
Tue 5/56:05 am
GYE
- STL
1 stop16h 19m
American Airlines
Deal found 4/4![American Airlines logo]()
$794
Last-minute flights from St. Louis to GuayaquilDiscover last-minute flight deals from St. Louis to Guayaquil. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Guayaquil. Data last updated April 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
STL
- GYE
2 stops11h 31m
United Airlines
Wed 4/1512:22 pm
GYE
- STL
2 stops21h 03m
United Airlines
Deal found 4/4![United Airlines logo]()
$993
This LATAM Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
STL
- GYE
2 stops24h 54m
LATAM Airlines
Wed 4/159:03 pm
GYE
- STL
2 stops20h 41m
LATAM Airlines
Deal found 4/5![LATAM Airlines logo]()
$1,304
This LATAM Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:59 am
STL
- GYE
2 stops21h 55m
LATAM Airlines
Fri 4/249:05 am
GYE
- STL
2 stops23h 25m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,191
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
STL
- GYE
2 stops11h 31m
United Airlines
Tue 5/512:22 pm
GYE
- STL
2 stops21h 08m
United Airlines
Deal found 4/4![United Airlines logo]()
$794
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:24 am
STL
- GYE
1 stop8h 07m
American Airlines
Tue 5/56:05 am
GYE
- STL
2 stops16h 02m
American Airlines
Deal found 4/4![American Airlines logo]()
$799
This BusinessClass deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:55 pm
STL
- GYE
2 stops18h 36m
GOL
Wed 5/132:31 pm
GYE
- STL
2 stops20h 56m
GOL
Deal found 4/6![GOL logo]()
$931
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:15 am
STL
- GYE
1 stop17h 22m
American Airlines
Thu 5/286:00 am
GYE
- STL
1 stop16h 58m
American Airlines
Deal found 4/5![American Airlines logo]()
$705
This Mytrip deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:05 pm
STL
- GYE
2 stops19h 50m
Multiple Airlines
Thu 5/2811:59 pm
GYE
- STL
3 stops18h 37m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$2,251
One-way flights from St. Louis to GuayaquilSearch for one-way flight options from St. Louis to Guayaquil. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from St. Louis to Guayaquil. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:23 pm
STL
- GYE
3 stops36h 00m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:50 am
STL
- GYE
2 stops20h 05m
Delta
Deal found 4/5![Delta logo]()
$432
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:06 am
STL
- GYE
1 stop26h 25m
American Airlines
Deal found 4/4![American Airlines logo]()
$448
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:42 am
STL
- GYE
2 stops19h 13m
Delta
Deal found 4/4![Delta logo]()
$452
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:24 am
STL
- GYE
1 stop15h 48m
American Airlines
Deal found 4/4![American Airlines logo]()
$463
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:09 am
STL
- GYE
2 stops37h 29m
United Airlines
Deal found 4/5![United Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:09 am
STL
- GYE
2 stops55h 22m
United Airlines
Deal found 4/7![United Airlines logo]()
$483
Find flight deals from St. Louis to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $705 (American Airlines) |
One-way from | $316 (eDestinos) |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from St. Louis to Guayaquil that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Thu 5/21
5:15 am-10:37 pm
1 stop17h 22m
Guayaquil Jose Joaquin de Olmedo
Thu 5/28
6:00 am-10:58 pm
1 stop16h 58m
$705
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Wed 7/8
6:00 am-10:37 pm
2 stops16h 37m
Guayaquil Jose Joaquin de Olmedo
Wed 7/22
6:00 am-10:21 pm
1 stop16h 21m
$787
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Tue 4/28
6:00 am-5:31 pm
2 stops11h 31m
Guayaquil Jose Joaquin de Olmedo
Tue 5/5
12:22 pm-9:30 am
2 stops21h 08m
$794
Quickest round-trip
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Tue 4/28
11:06 am-9:12 pm
1 stop10h 06m
Guayaquil Jose Joaquin de Olmedo
Tue 5/5
6:05 am-10:24 pm
1 stop16h 19m
$794
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Wed 5/6
11:06 am-1:31 pm
1 stop26h 25m
Guayaquil Jose Joaquin de Olmedo
Wed 5/13
2:31 pm-11:27 am
2 stops20h 56m
$947
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Mon 4/20
9:59 am-7:54 am
2 stops21h 55m
Guayaquil Jose Joaquin de Olmedo
Fri 4/24
9:05 am-8:30 am
2 stops23h 25m
$1,191
Cheapest one-way
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Sat 4/25
8:23 pm-8:23 am
3 stops36h 00m
$316
Quickest one-way
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Sun 4/26
1:02 pm-6:55 am
2 stops17h 53m
$432
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Sat 4/25
11:42 am-6:55 am
2 stops19h 13m
$452
St. LouisGuayaquil
STL - GYE
STLGYE
Lambert-St Louis
Sat 4/25
10:09 am-11:38 pm
2 stops37h 29m
$473
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Guayaquil
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Guayaquil in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Guayaquil flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from St. Louis with our price prediction graph.
STL-GYE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Guayaquil
Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated April 9, 2026.
See what other customers who have flown with American Airlines from St. Louis to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Overall
7.1
Entertainment
6.9
Comfort
7.2
Boarding
7.5
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Crew
7.9
Overall
7.1
Entertainment
6.9
Comfort
7.2
Boarding
7.5
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Other flights to Guayaquil
Explore flights to Guayaquil departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
St. Louis and Guayaquil flights
Browse other St. Louis and Guayaquil flight options. Last updated on April 9, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from St. Louis to Guayaquil
Discover the top airline that operate flights from St. Louis to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$516 | Average$996 | FlexibilityNo cancel fee | On-time71% |