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$169+ Cheap flights from San Francisco to Greenville (SFO - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — GSP
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Greenville are usually found in April or September, booked 33 days in advance, depart on a Saturday or Wednesday and return on a Wednesday

Cheap flight deals from San Francisco to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$337
(American Airlines)

One-way from

$169
(Delta)

Popular in

November

Cheapest in

April

Average price

$410
From San Francisco to Greenville
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One-way flight from San Francisco to Greenville
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Highest demand for flights based on searches. 12% potential increase in price ($69 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Francisco to Greenville

Cheapest flights from San Francisco to Greenville
Explore the most affordable flight options available from San Francisco to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/69:50 pmSFO - GSP
1 stop9h 19mDelta
Wed 10/85:30 amGSP - SFO
1 stop7h 28mDelta
Deal found 9/12$278
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:50 amSFO - GSP
1 stop7h 53mAmerican Airlines
Fri 11/146:00 amGSP - SFO
1 stop8h 21mAmerican Airlines
Deal found 9/12$281
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/89:50 pmSFO - GSP
1 stop8h 09mDelta
Wed 10/151:45 pmGSP - SFO
1 stop8h 11mDelta
Deal found 9/13$337
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:00 pmSFO - GSP
2 stops9h 15mAmerican Airlines
Tue 11/117:35 amGSP - SFO
1 stop9h 03mAmerican Airlines
Deal found 9/15$342
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:15 amSFO - GSP
1 stop7h 24mUnited Airlines
Mon 11/172:55 pmGSP - SFO
1 stop9h 10mUnited Airlines
Deal found 9/14$348
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:25 pmSFO - GSP
1 stop9h 35mSouthwest
Mon 11/173:05 pmGSP - SFO
2 stops10h 25mSouthwest
Deal found 9/14$353
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/227:00 amSFO - GSP
1 stop7h 05mAmerican Airlines
Fri 10/245:30 pmGSP - SFO
1 stop7h 26mAmerican Airlines
Deal found 9/13$358
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:05 pmSFO - GSP
1 stop10h 40mSouthwest
Fri 11/144:15 pmGSP - SFO
2 stops10h 20mSouthwest
Deal found 9/12$364
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/611:58 pmSFO - GSP
2 stops10h 42mAmerican Airlines
Wed 10/84:46 pmGSP - SFO
1 stop9h 13mAmerican Airlines
Deal found 9/12$369
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2312:00 pmSFO - GSP
1 stop29h 06mMultiple Airlines
Mon 10/2710:01 amGSP - SFO
1 stop13h 37mMultiple Airlines
Deal found 9/15$370
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2511:48 amSFO - GSP
1 stop29h 18mMultiple Airlines
Mon 9/297:26 pmGSP - SFO
2 stops28h 55mMultiple Airlines
Deal found 9/14$379

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

San Francisco

Fly to

Greenville

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 11/4

5:50 am-7:50 pm

2 stops11h 00m

Greenville

Mon 11/17

3:05 pm-10:30 pm

2 stops10h 25m

$358

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 10/24

12:51 pm-10:51 pm

1 stop7h 00m

Greenville

Tue 10/28

2:05 pm-8:44 pm

1 stop9h 39m

$358

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 11/1

9:05 pm-10:45 am

1 stop10h 40m

Greenville

Fri 11/14

4:15 pm-11:35 pm

2 stops10h 20m

$364

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 11/14

9:25 pm-9:45 am

1 stop9h 20m

Greenville

Mon 11/17

3:05 pm-10:30 pm

2 stops10h 25m

$374

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 9/25

11:48 am-8:06 pm

1 stop29h 18m

Greenville

Mon 9/29

7:26 pm-9:21 pm

2 stops28h 55m

$379

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 10/17

11:00 pm-11:46 am

1 stop9h 46m

Greenville

Wed 10/22

2:46 pm-9:47 pm

1 stop10h 01m

$392

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 11/7

9:25 pm-9:45 am

1 stop9h 20m

Greenville

Tue 11/18

3:05 pm-10:30 pm

2 stops10h 25m

$397

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 10/24

6:20 pm-9:55 am

2 stops12h 35m

Greenville

Tue 10/28

6:05 am-1:30 pm

1 stop10h 25m

$397

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 10/17

11:00 pm-11:46 am

1 stop9h 46m

Greenville

Sat 10/25

4:29 pm-10:57 pm

1 stop9h 28m

$403

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 10/6

9:50 pm-10:09 am

1 stop9h 19m

Greenville

Wed 10/8

5:30 am-9:58 am

1 stop7h 28m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 20 results
1
2

Best time to book a flight from San Francisco to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Greenville

How far ahead should I book a flight from San Francisco to Greenville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Greenville. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from San Francisco to Greenville, you should look to book at least 30 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from San Francisco to Greenville?

Currently, August is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $321). Flying from San Francisco to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 15, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from San Francisco to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Greenville?

    Southwest and American Airlines can get you from San Francisco to Greenville in just under 7h. Your travel time can differ by up to 4h. San Francisco and Greenville are separated by a distance of 2227 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Francisco to Greenville round-trip?

    Cheapflights users have booked flights from San Francisco to Greenville round-trip from $236. Other airlines that can offer you cheap pricing are Delta, from $278, and Southwest, from $313. American Airlines is currently priced 50% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from San Francisco to Greenville one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $169. American Airlines flights start at $169 while deals on Southwest start at $174 one-way.

  • Can I find deals for flights from San Francisco to Greenville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Greenville.

  • Can I find deals for business class flights from San Francisco to Greenville?

    Yes. Cheapflights offers flight deals from San Francisco to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Greenville?

    Currently, August is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $321). Flying from San Francisco to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 4 airlines flying from San Francisco to Greenville

Discover the top 4 airlines that operate flights from San Francisco to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$445FlexibilityNo cancel feeOn-time71%
DeltaCheapest$278Average$471FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$313Average$434FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$446Average$576FlexibilityNo cancel feeOn-time69%

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