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$302+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Popular in

December

Cheapest in

June

Average price

$585
Highest demand for flights based on searches. 6% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Panama City to Greenville

One-way flights from Panama City to Greenville
Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated August 20, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/910:05 pmPTY - GSP
3 stops35h 23mMultiple Airlines
Deal found 8/19$302
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:31 pmPTY - GSP
2 stops19h 24mAmerican Airlines
Deal found 8/19$304
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/262:10 pmPTY - GSP
1 stop8h 42mDelta
Deal found 8/19$311
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:30 pmPTY - GSP
1 stop23h 12mUnited Airlines
Deal found 8/19$325
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/91:45 pmPTY - GSP
2 stops19h 31mAmerican Airlines
Deal found 8/19$326
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/263:30 pmPTY - GSP
1 stop23h 16mUnited Airlines
Deal found 8/20$331
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2510:00 amPTY - GSP
1 stop11h 00mUnited Airlines
Deal found 8/20$336
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/263:30 pmPTY - GSP
2 stops18h 22mAmerican Airlines
Deal found 8/20$340
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/253:30 pmPTY - GSP
2 stops19h 11mAmerican Airlines
Deal found 8/20$367
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:11 pmPTY - GSP
3 stops43h 11mMultiple Airlines
Deal found 8/19$612
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2610:33 pmPTY - GSP
3 stops45h 01mMultiple Airlines
Deal found 8/20$645
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2511:13 pmPTY - GSP
3 stops42h 47mMultiple Airlines
Deal found 8/20$1,678

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/9

10:05 pm-10:28 am

3 stops35h 23m

$302

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:31 pm-11:55 am

2 stops19h 24m

$304

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/9

2:05 pm-11:34 pm

1 stop8h 29m

$311

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

2:10 pm-11:52 pm

1 stop8h 42m

$311

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:30 pm-3:42 pm

1 stop23h 12m

$325

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/9

1:45 pm-10:16 am

2 stops19h 31m

$326

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/26

3:30 pm-3:46 pm

1 stop23h 16m

$331

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 8/25

10:00 am-10:00 pm

1 stop11h 00m

$336

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/26

3:30 pm-10:52 am

2 stops18h 22m

$340

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 8/25

3:30 pm-11:41 am

2 stops19h 11m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City to Greenville?

Currently, January is the cheapest month in which you can book a flight from Panama City to Greenville (average of $329). Flying from Panama City to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Greenville (average of $329). Flying from Panama City to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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