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$280+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Mar 18 — Mar 251
Wed 3/18
Wed 3/25
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 16, 2026.

This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/261:40 pm
PTY
-
GSP
1 stop9h 41m
American Airlines
Thu 4/164:28 pm
GSP
-
PTY
2 stops21h 18m
American Airlines
Deal found 2/13$458
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:40 pm
PTY
-
GSP
2 stops20h 04m
American Airlines
Mon 3/308:05 pm
GSP
-
PTY
2 stops17h 35m
American Airlines
Deal found 2/13$492
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:00 am
PTY
-
GSP
1 stop11h 11m
United Airlines
Mon 6/14:55 pm
GSP
-
PTY
1 stop22h 19m
United Airlines
Deal found 2/12$576
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/133:10 pm
PTY
-
GSP
2 stops18h 29m
American Airlines
Fri 3/207:26 pm
GSP
-
PTY
1 stop19h 54m
American Airlines
Deal found 2/13$647
This Mytrip deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/262:55 pm
PTY
-
GSP
3 stops32h 04m
Multiple Airlines
Thu 4/168:31 pm
GSP
-
PTY
3 stops42h 44m
Multiple Airlines
Deal found 2/13$1,141

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$458
(American Airlines)

One-way from

$280
(American Airlines)

Popular in

April

Cheapest in

June

Average price

$500
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
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From Panama City Tocumen Intl to Greenville
Search Deals
One-way flight from Panama City Tocumen Intl to Greenville
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/26

1:40 pm-10:15 am

2 stops19h 35m

Greenville

Thu 4/16

4:28 pm-12:46 pm

2 stops21h 18m

$458

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/19

1:40 pm-10:44 am

2 stops20h 04m

Greenville

Mon 3/30

8:05 pm-12:40 pm

2 stops17h 35m

$492

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 5/10

1:49 pm-11:01 am

2 stops20h 12m

$280

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/5

5:50 pm-5:53 pm

2 stops24h 03m

$321

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/5

4:05 pm-12:22 am

1 stop8h 17m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/13

  • Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City to Greenville?

Currently, June is the cheapest month in which you can book a flight from Panama City to Greenville (average of $209). Flying from Panama City to Greenville in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Greenville?

    For as low as $458, American Airlines can have you in Greenville from Panama City in 19h 35m. There are 1792 mi between Panama City and Greenville.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Greenville?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Greenville (average of $209). Flying from Panama City to Greenville in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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