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$292+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Aug 30 — Sep 61
Sun 8/30
Sun 9/6
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2026.

This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:16 pm
PTY
-
GSP
2 stops22h 25m
American Airlines
Mon 9/284:49 pm
GSP
-
PTY
2 stops20h 37m
American Airlines
Deal found 7/28$586
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:30 am
PTY
-
GSP
1 stop13h 17m
United Airlines
Mon 11/22:19 pm
GSP
-
PTY
2 stops29h 43m
United Airlines
Deal found 7/26$594
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:30 pm
PTY
-
GSP
1 stop23h 19m
United Airlines
Mon 9/2811:30 am
GSP
-
PTY
1 stop9h 01m
United Airlines
Deal found 7/28$604
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:36 pm
PTY
-
GSP
2 stops22h 03m
Multiple Airlines
Mon 8/244:55 pm
GSP
-
PTY
1 stop25h 24m
Multiple Airlines
Deal found 7/28$665
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:10 am
PTY
-
GSP
2 stops20h 47m
Multiple Airlines
Mon 8/244:55 pm
GSP
-
PTY
1 stop25h 24m
Multiple Airlines
Deal found 7/27$683
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:25 am
PTY
-
GSP
2 stops12h 14m
Multiple Airlines
Mon 8/244:55 pm
GSP
-
PTY
1 stop28h 24m
Multiple Airlines
Deal found 7/27$688
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:10 am
PTY
-
GSP
2 stops20h 47m
Multiple Airlines
Thu 8/278:37 am
GSP
-
PTY
1 stop12h 42m
Multiple Airlines
Deal found 7/27$695
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:10 am
PTY
-
GSP
2 stops20h 47m
Multiple Airlines
Thu 8/278:37 am
GSP
-
PTY
1 stop12h 42m
Multiple Airlines
Deal found 7/27$696
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:16 pm
PTY
-
GSP
1 stop8h 14m
American Airlines
Sun 12/65:15 am
GSP
-
PTY
1 stop8h 33m
American Airlines
Deal found 7/29$697
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:25 am
PTY
-
GSP
2 stops12h 14m
Multiple Airlines
Thu 8/278:37 am
GSP
-
PTY
1 stop12h 42m
Multiple Airlines
Deal found 7/27$700

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$586
(American Airlines)

One-way from

$292
(Kiwi.com)
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
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From Panama City Tocumen Intl to Greenville
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One-way flight from Panama City Tocumen Intl to Greenville
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 8/20

10:55 pm-7:45 pm

1 stop19h 50m

Greenville

Mon 8/24

8:29 pm-4:04 am

1 stop8h 35m

$714

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 8/19

10:55 pm-9:07 pm

2 stops21h 12m

Greenville

Mon 8/24

2:18 pm-4:04 am

2 stops14h 46m

$734
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 8/21

2:20 pm-10:59 pm

1 stop7h 39m

Greenville

Mon 8/24

6:55 am-12:55 pm

1 stop7h 00m

$746

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 8/21

3:30 pm-1:32 pm

2 stops21h 02m

Greenville

Tue 8/25

6:30 am-4:04 am

2 stops22h 34m

$746

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sat 8/15

3:30 pm-9:36 am

2 stops17h 06m

Greenville

Tue 8/18

6:30 am-4:04 am

2 stops22h 34m

$759

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 8/14

3:30 pm-1:32 pm

2 stops21h 02m

Greenville

Tue 8/18

2:18 pm-2:14 pm

2 stops24h 56m

$759
Cheapest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 8/13

10:10 am-4:07 pm

2 stops28h 57m

$322
Quickest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 8/14

4:25 am-5:39 pm

2 stops12h 14m

$405

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 8/13

10:55 pm-11:03 pm

1 stop23h 08m

$429

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/18

9:45 am-11:03 pm

1 stop12h 18m

$429

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 14 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Greenville?

    For as low as $594, American Airlines can have you in Greenville from Panama City in 13h 17m. There are 1792 mi between Panama City and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Seneca

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