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$594+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Jun 26 — Jul 31
Fri 6/26
Fri 7/3
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 27, 2026.

This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:15 pm
PTY
-
GSP
1 stop9h 44m
American Airlines
Tue 8/187:00 am
GSP
-
PTY
1 stop6h 24m
American Airlines
Deal found 5/22$594
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/69:45 am
PTY
-
GSP
2 stops23h 10m
United Airlines
Mon 7/135:43 pm
GSP
-
PTY
2 stops21h 31m
United Airlines
Deal found 5/22$664
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:55 am
PTY
-
GSP
1 stop12h 51m
United Airlines
Sat 12/57:00 am
GSP
-
PTY
1 stop7h 45m
United Airlines
Deal found 5/26$673
This AranGrant deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:45 am
PTY
-
GSP
1 stop12h 30m
Copa Airlines
Tue 9/227:00 am
GSP
-
PTY
1 stop13h 31m
Copa Airlines
Deal found 5/25$979
This AranGrant deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:16 pm
PTY
-
GSP
2 stops22h 25m
GOL
Tue 9/224:49 pm
GSP
-
PTY
2 stops20h 35m
GOL
Deal found 5/25$983

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$594
(American Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
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From Panama City Tocumen Intl to Greenville
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 27, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 6/17

1:15 pm-11:59 pm

1 stop9h 44m

Greenville

Tue 8/18

7:00 am-12:24 pm

1 stop6h 24m

$594

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 7/6

10:55 pm-11:34 pm

1 stop23h 39m

Greenville

Mon 7/13

7:49 pm-4:04 am

1 stop9h 15m

$664

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/15

9:45 am-11:15 pm

1 stop12h 30m

Greenville

Tue 9/22

7:00 am-7:31 pm

1 stop13h 31m

$979

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/15

1:16 pm-12:41 pm

2 stops22h 25m

Greenville

Tue 9/22

4:49 pm-12:24 pm

2 stops20h 35m

$983

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/22

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Greenville?

    For as low as $594, American Airlines can have you in Greenville from Panama City in 9h 44m. There are 1792 mi between Panama City and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Seneca

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