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$179+ Cheap flights from San Francisco to Greenville (SFO - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — GSP
Jan 8 — Jan 151
Thu 1/8
Thu 1/15
1 adult, Economy
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Find cheap flights from San Francisco to Greenville with Cheapflights

1. Tell us where you want to go

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2. Select your favorite providers

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Cheapflights Tip: The best prices from San Francisco to Greenville are usually found in April or September, booked 33 days in advance, depart on a Saturday or Wednesday and return on a Wednesday

Cheap flight deals from San Francisco to Greenville

Cheapest flights from San Francisco to Greenville
Explore the most affordable flight options available from San Francisco to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 9, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:30 amSFO - GSP
2 stops29h 45mMultiple Airlines
Fri 12/1910:01 amGSP - SFO
1 stop13h 29mMultiple Airlines
Deal found 12/8$526
This Southwest deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:10 pmSFO - GSP
2 stops11h 50mSouthwest
Wed 12/317:40 amGSP - SFO
2 stops12h 45mSouthwest
Deal found 12/7$633
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:43 amSFO - GSP
2 stops21h 10mMultiple Airlines
Mon 12/1510:01 amGSP - SFO
1 stop12h 52mMultiple Airlines
Deal found 12/9$878
This Southwest deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:25 pmSFO - GSP
1 stop9h 20mSouthwest
Fri 12/1910:40 amGSP - SFO
1 stop7h 05mSouthwest
Deal found 12/8$897
This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:40 amSFO - GSP
1 stop7h 09mUnited Airlines
Tue 12/164:23 pmGSP - SFO
1 stop18h 27mUnited Airlines
Deal found 12/8$981
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:22 amSFO - GSP
1 stop8h 57mAmerican Airlines
Sun 12/285:00 amGSP - SFO
1 stop9h 09mAmerican Airlines
Deal found 12/9$991
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 pmSFO - GSP
1 stop11h 24mUnited Airlines
Sun 12/288:34 amGSP - SFO
1 stop18h 29mUnited Airlines
Deal found 12/9$1,035
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amSFO - GSP
1 stop15h 18mAmerican Airlines
Mon 12/156:00 amGSP - SFO
1 stop12h 05mAmerican Airlines
Deal found 12/9$1,050

Find flight deals from San Francisco to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 9, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$342
(American Airlines)

One-way from

$179
(Trip.com)

Popular in

January

Cheapest in

April

Average price

$424
Provider with most accurate pricing for San Francisco-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Greenville flights.
Search Deals
From San Francisco to Greenville
Search Deals
One-way flight from San Francisco to Greenville
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

San Francisco

Fly to

Greenville

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 1/10

6:00 am-3:50 pm

1 stop6h 50m

Greenville

Sat 1/17

4:40 pm-11:12 pm

1 stop9h 32m

$342

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 1/10

9:30 pm-10:10 am

1 stop9h 40m

Greenville

Sat 1/17

10:50 am-8:05 pm

2 stops12h 15m

$390

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 1/12

12:10 pm-10:24 pm

1 stop7h 14m

Greenville

Thu 1/15

8:22 am-12:55 pm

1 stop7h 33m

$393

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 1/12

9:10 am-8:56 pm

2 stops8h 46m

Greenville

Thu 1/15

6:00 am-1:50 pm

1 stop10h 50m

$398

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 3/11

6:00 am-7:47 pm

1 stop10h 47m

Greenville

Tue 3/17

11:28 am-10:30 pm

1 stop14h 02m

$443

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 3/11

8:30 am-10:40 pm

2 stops11h 10m

Greenville

Tue 3/17

1:50 pm-10:05 pm

1 stop11h 15m

$452

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 4/4

9:20 pm-1:15 pm

1 stop12h 55m

Greenville

Sat 4/11

8:00 am-2:25 pm

1 stop9h 25m

$472

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 4/7

7:45 am-9:40 pm

2 stops10h 55m

Greenville

Sun 4/12

6:30 am-12:05 pm

2 stops8h 35m

$477

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 12/15

6:30 am-4:48 pm

2 stops31h 18m

$179

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 12/30

6:00 am-10:53 am

3 stops49h 53m

$207

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 16 results
1
2

Compare providers for flights from San Francisco to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Greenville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Francisco-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Francisco-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Greenville

How far ahead should I book a flight from San Francisco to Greenville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Greenville. Price data was last updated on December 5, 2025.

To ensure you get the cheapest price possible for a flight from San Francisco to Greenville, you should look to book at least 30 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from San Francisco to Greenville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $149). Flying from San Francisco to Greenville in December is currently the most expensive (average of $307). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated December 9, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from San Francisco to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Southwest
8.0
Very good
4,254 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Delta
7.9
Good
8,011 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
United Airlines
7.4
Good
9,089 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
American Airlines
7.2
Good
11,045 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Greenville?

    American Airlines, Southwest, and Delta can get you from San Francisco to Greenville in just under 6h 50m. Your travel time can differ by up to 2h 50m. San Francisco and Greenville are separated by a distance of 2227 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Francisco to Greenville round-trip?

    Cheapflights users have booked flights from San Francisco to Greenville round-trip from $236. Other airlines that can offer you cheap pricing are Delta, from $278, and Southwest, from $313. American Airlines is currently priced 51% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from San Francisco to Greenville one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $102. Delta flights start at $147 while deals on American Airlines start at $168 one-way.

  • Can I find deals for flights from San Francisco to Greenville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Greenville.

  • Can I find deals for business class flights from San Francisco to Greenville?

    Yes. Cheapflights offers flight deals from San Francisco to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Greenville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $149). Flying from San Francisco to Greenville in December is currently the most expensive (average of $307). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 4 airlines flying from San Francisco to Greenville

Discover the top 4 airlines that operate flights from San Francisco to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$418FlexibilityNo cancel feeOn-time71%
DeltaCheapest$294Average$499FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$313Average$434FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$424Average$576FlexibilityNo cancel feeOn-time69%

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