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$123+ Cheap flights from San Francisco to Greenville (SFO - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — GSP
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
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Find cheap flights from San Francisco to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from San Francisco to Greenville are usually found in September or April, booked 33 days in advance, depart on a Saturday or Wednesday and return on a Wednesday

Find flight deals from San Francisco to Greenville

Cheapest flights from San Francisco to Greenville
Explore the most affordable flight options available from San Francisco to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:50 amSFO - GSP
1 stop8h 45mDelta
Tue 1/133:00 pmGSP - SFO
1 stop7h 50mDelta
Deal found 10/22$287
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:50 amSFO - GSP
1 stop8h 45mDelta
Sun 1/1812:00 pmGSP - SFO
1 stop8h 25mDelta
Deal found 10/22$291
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/189:25 pmSFO - GSP
1 stop9h 35mSouthwest
Tue 12/167:40 amGSP - SFO
1 stop8h 40mSouthwest
Deal found 10/21$303
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/69:25 pmSFO - GSP
1 stop9h 20mSouthwest
Sat 12/131:55 pmGSP - SFO
2 stops9h 25mSouthwest
Deal found 10/21$317
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:50 amSFO - GSP
1 stop8h 45mDelta
Wed 1/146:45 amGSP - SFO
2 stops14h 07mDelta
Deal found 10/22$320
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1912:30 pmSFO - GSP
1 stop8h 15mDelta
Mon 11/247:27 amGSP - SFO
1 stop9h 48mDelta
Deal found 10/19$331
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:45 amSFO - GSP
1 stop7h 00mDelta
Tue 12/165:35 amGSP - SFO
1 stop10h 01mDelta
Deal found 10/21$332
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1812:00 pmSFO - GSP
2 stops9h 15mAmerican Airlines
Tue 12/166:00 amGSP - SFO
1 stop8h 20mAmerican Airlines
Deal found 10/20$337
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/612:25 amSFO - GSP
1 stop7h 26mAmerican Airlines
Wed 12/176:00 amGSP - SFO
1 stop8h 20mAmerican Airlines
Deal found 10/21$347

Cheap flight deals from San Francisco to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$252
(Southwest)

One-way from

$123
(Southwest)

Popular in

November

Cheapest in

September

Average price

$489
Provider with most accurate pricing for San Francisco-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Greenville flights.
Search Deals
From San Francisco to Greenville
Search Deals
One-way flight from San Francisco to Greenville
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($63 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

San Francisco

Fly to

Greenville

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/7

2:05 pm-11:36 pm

1 stop6h 31m

Greenville

Sun 1/18

12:00 pm-5:25 pm

1 stop8h 25m

$286

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/7

6:00 am-5:43 pm

1 stop8h 43m

Greenville

Wed 1/21

10:14 am-5:25 pm

1 stop10h 11m

$287

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 1/6

9:30 pm-9:27 am

1 stop8h 57m

Greenville

Tue 1/13

5:05 pm-11:51 pm

1 stop9h 46m

$287

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 1/1

5:50 am-5:35 pm

1 stop8h 45m

Greenville

Sun 1/18

12:00 pm-5:25 pm

1 stop8h 25m

$295

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 11/18

4:30 pm-10:00 am

2 stops14h 30m

Greenville

Tue 12/16

3:05 pm-9:20 pm

2 stops9h 15m

$313

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 12/6

9:25 pm-9:45 am

1 stop9h 20m

Greenville

Sat 12/13

1:55 pm-8:20 pm

2 stops9h 25m

$317

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/7

1:00 pm-11:00 am

2 stops19h 00m

Greenville

Tue 1/13

3:00 pm-7:50 pm

1 stop7h 50m

$320

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 1/8

4:15 pm-11:00 am

2 stops15h 45m

Greenville

Wed 1/21

5:45 am-10:35 am

1 stop7h 50m

$320

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 12/31

5:50 am-5:35 pm

1 stop8h 45m

Greenville

Thu 1/15

6:45 am-5:52 pm

2 stops14h 07m

$320

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 1/9

6:00 am-9:27 am

2 stops24h 27m

Greenville

Wed 1/14

5:05 pm-11:51 pm

1 stop9h 46m

$325

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 21 results
1
2
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Compare providers for flights from San Francisco to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Greenville

How far ahead should I book a flight from San Francisco to Greenville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Greenville. Price data was last updated on October 17, 2025.

To ensure you get the cheapest price possible for a flight from San Francisco to Greenville, you should look to book at least 30 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from San Francisco to Greenville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $164). Flying from San Francisco to Greenville in December is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 22, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from San Francisco to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,235 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
7,981 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,988 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,029 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Greenville?

    Delta and Southwest can get you from San Francisco to Greenville in just under 6h 31m. Your travel time can differ by up to 7h 59m. San Francisco and Greenville are separated by a distance of 2227 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Francisco to Greenville round-trip?

    Cheapflights users have booked flights from San Francisco to Greenville round-trip from $236. Other airlines that can offer you cheap pricing are Delta, from $278, and Southwest, from $313. American Airlines is currently priced 50% below the average price you’ll pay for this route.

  • Can I find deals for flights from San Francisco to Greenville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Greenville.

  • Can I find deals for business class flights from San Francisco to Greenville?

    Yes. Cheapflights offers flight deals from San Francisco to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Greenville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $164). Flying from San Francisco to Greenville in December is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 4 airlines flying from San Francisco to Greenville

Discover the top 4 airlines that operate flights from San Francisco to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$437FlexibilityNo cancel feeOn-time71%
DeltaCheapest$278Average$483FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$313Average$434FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$506Average$598FlexibilityNo cancel feeOn-time69%

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