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There are no direct flights to Greenville Mid-Delta Airport (GLH), except from Dallas/Fort Worth International Airport (DFW). So if you want to keep your stopover time to a minimum, you can use the Layover Duration filter on your Cheapflight search to only see flights with shorter layovers. For example, you may find flights from White Plains Airport (HPN) with American Airlines connecting to Contour Airlines that stop in Charlotte for under 1 hour and in DFW for under 2 hours. If you are flying from Los Angeles International Airport (LAX), your connection from American to Contour in Dallas could take under 2 hours as well.
If you are flying to Greenville out of Houston, Orlando, Atlanta, Charlotte, or Washington DC and plan on renting a car, you may want to consider flying to Jackson-Evers International Airport (JAN). It is the nearest commercial airport to Greenville after Greenville Mid-Delta Airport (GLH), and there are direct flights from those cities to JAN. The major rental companies, such as Avis, Budget, and Dollar, all have counters in Terminal 1 by the baggage claim area, and it is about a 2-hour drive to Greenville.
If you want to bring your cat or dog with you on your trip to Greenville, you can do so on Contour flights. Your four-legged companion must be able to move around comfortably in a pet carrier that can fit under the seat in front of you and will be considered a carry-on item. The airline allows two pets onboard with passengers, so you should contact them as soon as possible to book and find out more about any fees or additional rules.