$283+ Cheap flights from South Carolina to Gainesville (GNV)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GNV
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Gainesville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Gainesville
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Cheapest flights from South Carolina to GainesvilleExplore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:08 pm -
1 stop3h 51m
Mon 10/127:34 pm -
1 stop3h 47m
Deal found 9/10![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:40 am -
1 stop5h 05m
Sun 12/137:34 pm -
1 stop3h 58m
Deal found 9/13![American Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:05 am -
1 stop4h 43m
Sun 10/117:03 pm -
1 stop3h 48m
Deal found 9/13![Delta logo]()
$417
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:30 am -
Nonstop1h 39m
Wed 10/281:49 pm -
Nonstop1h 45m
Deal found 9/14![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Tue 10/136:39 pm -
1 stop4h 17m
Deal found 9/10![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:53 pm -
Nonstop1h 35m
Sun 10/259:44 am -
Nonstop1h 51m
Deal found 9/11![American Airlines logo]()
$464
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:29 am -
Nonstop1h 52m
Sun 10/187:34 pm -
Nonstop1h 53m
Deal found 9/11![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:29 am -
Nonstop1h 52m
Sat 10/247:34 pm -
Nonstop1h 53m
Deal found 9/13![American Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop3h 31m
Wed 9/306:05 am -
1 stop5h 03m
Deal found 9/10![Delta logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:40 am -
Nonstop1h 39m
Wed 9/3010:53 am -
Nonstop1h 42m
Deal found 9/11![American Airlines logo]()
$485
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Sat 10/106:00 am -
2 stops8h 00m
Deal found 9/10![American Airlines logo]()
$546
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:08 pm -
1 stop3h 51m
Sun 11/16:20 am -
1 stop4h 07m
Deal found 9/14![American Airlines logo]()
$553
Best flights from South Carolina to GainesvilleDiscover carefully curated flight deals from South Carolina to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from South Carolina to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
1 stop3h 54m
Sat 10/246:03 am -
1 stop3h 58m
Deal found 9/14![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:08 pm -
1 stop3h 51m
Mon 10/127:34 pm -
1 stop3h 47m
Deal found 9/10![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:40 am -
1 stop5h 05m
Sun 12/137:34 pm -
1 stop3h 58m
Deal found 9/13![American Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:05 am -
1 stop4h 43m
Sun 10/117:03 pm -
1 stop3h 48m
Deal found 9/13![Delta logo]()
$417
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Tue 10/136:39 pm -
1 stop4h 17m
Deal found 9/10![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:25 pm -
1 stop4h 06m
Sun 10/41:26 pm -
1 stop3h 54m
Deal found 9/14![Delta logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:21 pm -
1 stop5h 38m
Sun 11/226:10 am -
Nonstop1h 49m
Deal found 9/10![American Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop3h 31m
Wed 9/306:05 am -
1 stop5h 03m
Deal found 9/10![Delta logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:15 pm -
Nonstop1h 37m
Wed 10/145:00 pm -
Nonstop1h 48m
Deal found 9/12![American Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:05 am -
1 stop4h 34m
Sun 10/46:57 pm -
1 stop4h 03m
Deal found 9/14![Delta logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:30 pm -
Nonstop1h 37m
Tue 10/206:00 am -
1 stop6h 03m
Deal found 9/15![American Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:10 am -
1 stop4h 38m
Tue 10/206:03 am -
1 stop5h 03m
Deal found 9/15![Delta logo]()
$494
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:45 pm -
Nonstop1h 41m
Mon 10/266:15 am -
Nonstop1h 49m
Deal found 9/14![American Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/219:47 am -
1 stop5h 21m
Mon 10/267:03 pm -
1 stop4h 51m
Deal found 9/13![Delta logo]()
$504
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:21 pm -
Nonstop1h 37m
Wed 9/306:00 am -
1 stop4h 20m
Deal found 9/11![American Airlines logo]()
$495
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop3h 34m
Sun 10/184:31 pm -
1 stop5h 14m
Deal found 9/13![Delta logo]()
$504
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:47 pm -
1 stop4h 12m
Sun 10/256:00 am -
1 stop6h 03m
Deal found 9/15![American Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Sat 10/106:00 am -
2 stops8h 00m
Deal found 9/10![American Airlines logo]()
$546
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop5h 48m
Fri 10/94:02 pm -
1 stop4h 19m
Deal found 9/11![Delta logo]()
$605
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:08 pm -
1 stop3h 51m
Sun 11/16:20 am -
1 stop4h 07m
Deal found 9/14![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:32 pm -
1 stop4h 35m
Fri 10/97:34 pm -
1 stop3h 47m
Deal found 9/12![American Airlines logo]()
$605
Last-minute flights from South Carolina to GainesvilleDiscover last-minute flight deals from South Carolina to Gainesville. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Gainesville. Data last updated September 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop3h 31m
Wed 9/306:05 am -
1 stop5h 03m
Deal found 9/10![Delta logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:40 am -
Nonstop1h 39m
Wed 9/3010:53 am -
Nonstop1h 42m
Deal found 9/11![American Airlines logo]()
$485
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:32 pm -
1 stop6h 18m
Wed 9/306:00 am -
2 stops10h 44m
Deal found 9/10![American Airlines logo]()
$576
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:08 pm -
1 stop3h 51m
Mon 10/127:34 pm -
1 stop3h 47m
Deal found 9/10![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Tue 10/136:39 pm -
1 stop4h 17m
Deal found 9/10![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Sat 10/106:00 am -
2 stops8h 00m
Deal found 9/10![American Airlines logo]()
$546
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:05 am -
1 stop4h 43m
Sun 10/117:03 pm -
1 stop3h 48m
Deal found 9/13![Delta logo]()
$417
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:29 am -
Nonstop1h 52m
Sat 10/247:34 pm -
Nonstop1h 53m
Deal found 9/13![American Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:53 pm -
Nonstop1h 35m
Sun 10/259:44 am -
Nonstop1h 51m
Deal found 9/11![American Airlines logo]()
$464
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:29 am -
Nonstop1h 52m
Sun 10/187:34 pm -
Nonstop1h 53m
Deal found 9/11![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:30 am -
Nonstop1h 39m
Wed 10/281:49 pm -
Nonstop1h 45m
Deal found 9/14![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:08 pm -
1 stop3h 51m
Sun 11/16:20 am -
1 stop4h 07m
Deal found 9/14![American Airlines logo]()
$553
One-way flights from South Carolina to GainesvilleSearch for one-way flight options from South Carolina to Gainesville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from South Carolina to Gainesville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:05 am -
1 stop4h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$283
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:10 am -
1 stop4h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$284
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop3h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$293
This KAYAK deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:02 pm -
1 stop5h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$372
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:25 pm -
2 stops17h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:55 am -
2 stops24h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:27 pm -
1 stop4h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:45 am -
1 stop3h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$413
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:32 pm -
2 stops7h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:30 am -
Nonstop1h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![American Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:30 pm -
Nonstop1h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:10 pm -
Nonstop1h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$439
Find flight deals from South Carolina to Gainesville
Keep the following information in mind while searching for South Carolina to Gainesville flight deals. Data was last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $387 (American Airlines) |
One-way from | $283 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleGainesville
GSP Greenville - GNV Gainesville Regional
GSPGNV
Greenville
Fri 11/20
8:05 am-12:46 pm
1 stop4h 41m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$283
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Thu 3/11
6:45 am-12:22 pm
1 stop5h 37m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Fri 12/11
4:59 pm-10:54 pm
1 stop5h 55m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Sat 3/13
6:45 am-12:22 pm
1 stop5h 37m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Sun 3/14
6:45 am-12:22 pm
1 stop5h 37m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Mon 9/28
8:10 am-12:39 pm
1 stop4h 29m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Thu 12/17
8:05 am-12:50 pm
1 stop4h 45m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Sat 12/12
7:25 pm-12:50 pm
2 stops17h 25m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$379
CharlotteGainesville
CLT Charlotte Douglas - GNV Gainesville Regional
CLTGNV
Charlotte Douglas
Sat 11/14
11:55 am-12:46 pm
2 stops24h 51m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$380
GreenvilleGainesville
GSP Greenville - GNV Gainesville Regional
GSPGNV
Greenville
Wed 10/21
5:40 am-9:34 am
1 stop3h 54m
Gainesville Regional
Sat 10/24
6:03 am-10:01 am
1 stop3h 58m
$387
Showing 1-10 of 36 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Gainesville
Have a flexible travel schedule? Discover the best time to fly to Gainesville from South Carolina with our price prediction graph.
GSP-GNV
CLT-GNV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Gainesville
USSC-GNV
GSP-GNV
CLT-GNV
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Gainesville?
Book flights to Gainesville if you plan to visit one of these locationsLake City
Alachua
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