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$139+ Cheap flights from South Carolina to Gainesville (GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GNV
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to Gainesville

Keep the following information in mind while searching for South Carolina to Gainesville flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$219
(Delta)

One-way from

$139
(Delta)
From South Carolina to Gainesville Regional
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One-way flight from South Carolina to Gainesville Regional
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Find flight deals from South Carolina to Gainesville

Cheapest flights from South Carolina to Gainesville
Explore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/225:30 amCLT - GNV
1 stop3h 56mDelta
sáb. 10/255:57 pmGNV - CLT
1 stop5h 53mDelta
Deal found 9/17$219
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1010:31 pmCLT - GNV
Nonstop1h 46mAmerican Airlines
mar. 10/146:58 pmGNV - CLT
Nonstop1h 44mAmerican Airlines
Deal found 9/15$229
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/228:25 amCLT - GNV
Nonstop1h 44mAmerican Airlines
sáb. 10/254:46 pmGNV - CLT
Nonstop1h 45mAmerican Airlines
Deal found 9/17$243
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/105:30 amCLT - GNV
1 stop3h 56mDelta
mar. 10/147:07 pmGNV - CLT
1 stop4h 43mDelta
Deal found 9/15$249
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/87:20 pmCLT - GNV
1 stop4h 35mAmerican Airlines
dom. 10/126:30 amGNV - CLT
Nonstop1h 45mAmerican Airlines
Deal found 9/15$264
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/49:30 pmCLT - GNV
Nonstop1h 43mAmerican Airlines
lun. 10/66:30 amGNV - CLT
Nonstop1h 45mAmerican Airlines
Deal found 9/16$279
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/278:35 amCLT - GNV
Nonstop1h 46mAmerican Airlines
lun. 9/296:00 amGNV - CLT
Nonstop1h 44mAmerican Airlines
Deal found 9/14$283
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/275:30 amCLT - GNV
1 stop3h 55mDelta
lun. 9/294:01 pmGNV - CLT
1 stop5h 42mDelta
Deal found 9/14$303
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/107:58 pmCLT - GNV
1 stop3h 57mAmerican Airlines
dom. 10/126:30 amGNV - CLT
Nonstop1h 45mAmerican Airlines
Deal found 9/16$305
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/87:05 amGSP - GNV
1 stop5h 42mDelta
mar. 11/117:04 pmGNV - GSP
1 stop4h 51mDelta
Deal found 9/15$317
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/812:47 pmGSP - GNV
1 stop3h 34mAmerican Airlines
mar. 11/116:00 amGNV - GSP
2 stops9h 07mAmerican Airlines
Deal found 9/15$322
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/198:35 amCLT - GNV
Nonstop1h 46mAmerican Airlines
mar. 9/236:00 amGNV - CLT
Nonstop1h 44mAmerican Airlines
Deal found 9/16$324

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

South Carolina

Fly to

Gainesville

Route

Depart

Return

Price

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

mié. 10/22

5:30 am-9:26 am

1 stop3h 56m

Gainesville Regional

sáb. 10/25

5:57 pm-11:50 pm

1 stop5h 53m

$219

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

vie. 10/10

10:31 pm-12:17 am

Nonstop1h 46m

Gainesville Regional

mar. 10/14

6:58 pm-8:42 pm

Nonstop1h 44m

$229

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

vie. 10/10

7:10 am-8:53 am

Nonstop1h 43m

Gainesville Regional

dom. 10/12

6:30 am-8:15 am

Nonstop1h 45m

$229

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

mié. 10/22

8:25 am-10:09 am

Nonstop1h 44m

Gainesville Regional

sáb. 10/25

9:18 am-11:02 am

Nonstop1h 44m

$243

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

vie. 10/10

5:30 am-9:26 am

1 stop3h 56m

Gainesville Regional

dom. 10/12

10:11 am-1:42 pm

1 stop3h 31m

$249

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

vie. 10/10

5:30 am-9:26 am

1 stop3h 56m

Gainesville Regional

mar. 10/14

7:07 pm-11:50 pm

1 stop4h 43m

$249

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

mié. 10/8

7:20 pm-11:55 pm

1 stop4h 35m

Gainesville Regional

dom. 10/12

6:30 am-8:15 am

Nonstop1h 45m

$264

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

sáb. 10/4

9:30 pm-11:13 pm

Nonstop1h 43m

Gainesville Regional

lun. 10/6

6:30 am-8:15 am

Nonstop1h 45m

$279

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

sáb. 11/8

7:05 am-12:47 pm

1 stop5h 42m

Gainesville Regional

mar. 11/11

7:04 pm-11:55 pm

1 stop4h 51m

$317

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

sáb. 11/8

12:47 pm-4:21 pm

1 stop3h 34m

Gainesville Regional

mar. 11/11

6:00 am-3:07 pm

2 stops9h 07m

$322

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 31 results
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Best time to book a flight from South Carolina to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Gainesville

What is the cheapest month to book a flight from South Carolina to Gainesville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $359). Flying from South Carolina to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to GNV?

Find hourly flight availability from South Carolina to Gainesville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Gainesville as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Gainesville from South Carolina?

    Most people fly into Gainesville Regional (GNV) if they book a flight to Gainesville from South Carolina. Gainesville Regional is conveniently located just 4.2 mi from Gainesville’s city center.

  • How long is the flight from South Carolina to Gainesville?

    For as low as $229, Delta can have you in Gainesville from South Carolina in 1h 46m. Airlines will cover a distance of 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from South Carolina to Gainesville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Gainesville.

  • Can I find deals for business class flights from South Carolina to Gainesville?

    Yes. Cheapflights offers flight deals from South Carolina to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Gainesville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $359). Flying from South Carolina to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Gainesville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Gainesville

Discover the top 2 airlines that operate flights from South Carolina to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$296Average$477FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$356Average$492FlexibilityNo cancel feeOn-time71%

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