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$204+ Cheap flights from South Carolina to Gainesville (GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GNV
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from South Carolina to Gainesville

Cheapest flights from South Carolina to Gainesville
Explore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:58 pmCLT - GNV
Nonstop1h 39mAmerican Airlines
Sun 12/284:59 pmGNV - CLT
Nonstop1h 47mAmerican Airlines
Deal found 12/24$429
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:10 amCLT - GNV
Nonstop1h 56mAmerican Airlines
Wed 12/3111:23 amGNV - CLT
Nonstop1h 40mAmerican Airlines
Deal found 12/26$482
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 amCLT - GNV
1 stop3h 28mDelta
Wed 12/315:21 pmGNV - CLT
1 stop6h 25mDelta
Deal found 12/26$491
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:00 amCLT - GNV
1 stop4h 16mDelta
Fri 12/266:55 pmGNV - CLT
1 stop3h 16mDelta
Deal found 12/24$501
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/289:07 amCLT - GNV
Nonstop1h 45mAmerican Airlines
Wed 12/316:30 amGNV - CLT
Nonstop1h 49mAmerican Airlines
Deal found 12/25$805

Find flight deals from South Carolina to Gainesville

Keep the following information in mind while searching for South Carolina to Gainesville flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$215
(American Airlines)

One-way from

$204
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Gainesville Regional flights.
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From South Carolina to Gainesville Regional
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One-way flight from South Carolina to Gainesville Regional
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

South Carolina

Fly to

Gainesville

Route

Depart

Return

Price

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sun 1/25

9:45 pm-11:30 pm

Nonstop1h 45m

Gainesville Regional

Sun 2/1

6:35 am-8:19 am

Nonstop1h 44m

$215

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Mon 2/2

9:45 pm-11:30 pm

Nonstop1h 45m

Gainesville Regional

Sat 2/7

6:35 am-8:19 am

Nonstop1h 44m

$215

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Mon 2/2

9:59 am-4:04 pm

1 stop6h 05m

Gainesville Regional

Sat 2/7

1:15 pm-6:10 pm

1 stop4h 55m

$235

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Fri 1/23

6:55 pm-11:57 pm

1 stop5h 02m

Gainesville Regional

Fri 1/30

6:35 am-8:19 am

Nonstop1h 44m

$235

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Fri 1/23

6:59 pm-10:29 pm

1 stop3h 30m

Gainesville Regional

Fri 1/30

1:15 pm-6:10 pm

1 stop4h 55m

$245

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 1/10

5:25 am-9:24 am

1 stop3h 59m

Gainesville Regional

Wed 1/14

6:00 am-10:50 am

1 stop4h 50m

$290

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Fri 1/9

5:40 am-9:24 am

1 stop3h 44m

Gainesville Regional

Tue 1/13

6:00 am-11:08 am

1 stop5h 08m

$405

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Sat 1/10

5:40 am-9:24 am

1 stop3h 44m

Gainesville Regional

Wed 1/14

6:27 pm-9:52 pm

1 stop3h 25m

$405

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Fri 1/9

1:45 pm-11:57 pm

2 stops10h 12m

Gainesville Regional

Tue 1/13

6:35 am-11:25 am

1 stop4h 50m

$412

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Fri 3/13

5:40 am-9:29 am

1 stop3h 49m

Gainesville Regional

Mon 3/16

4:59 pm-9:52 pm

1 stop4h 53m

$523

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 22 results
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Best time to book a flight from South Carolina to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Gainesville

What is the cheapest month to book a flight from South Carolina to Gainesville?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $49). Flying from South Carolina to Gainesville in December is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to GNV?

Find hourly flight availability from South Carolina to Gainesville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 26, 2025.

When flying from South Carolina to Gainesville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 20% versus a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Gainesville from South Carolina?

    Most people fly into Gainesville Regional (GNV) if they book a flight to Gainesville from South Carolina. Gainesville Regional is conveniently located just 4.2 mi from Gainesville’s city center.

  • How long is the flight from South Carolina to Gainesville?

    For as low as $215, American Airlines can have you in Gainesville from South Carolina in 1h 45m. Airlines will cover a distance of 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from South Carolina to Gainesville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Gainesville.

  • Can I find deals for business class flights from South Carolina to Gainesville?

    Yes. Cheapflights offers flight deals from South Carolina to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Gainesville?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $49). Flying from South Carolina to Gainesville in December is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Alternative routes for South Carolina to Gainesville

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Top airline flying from South Carolina to Gainesville

Discover the top airline that operate flights from South Carolina to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$296Average$476FlexibilityNo cancel feeOn-timeN/A

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