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$229+ Cheap flights from South Carolina to Gainesville (GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GNV
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from South Carolina to Gainesville

Cheapest flights from South Carolina to Gainesville
Explore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:16 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Sat 2/286:24 am
GNV
-
CLT
Nonstop1h 56m
American Airlines
Deal found 2/9$325
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:16 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Tue 3/314:54 pm
GNV
-
CLT
Nonstop1h 50m
American Airlines
Deal found 2/9$333
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:25 am
CLT
-
GNV
1 stop3h 59m
Delta
Sat 2/2810:13 am
GNV
-
CLT
1 stop5h 51m
Delta
Deal found 2/9$345
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2512:57 pm
CLT
-
GNV
1 stop5h 16m
Delta
Sun 3/16:00 am
GNV
-
CLT
1 stop5h 00m
Delta
Deal found 2/10$355
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:45 pm
CLT
-
GNV
Nonstop1h 42m
American Airlines
Mon 3/303:08 pm
GNV
-
CLT
Nonstop1h 51m
American Airlines
Deal found 2/10$364
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:40 pm
CLT
-
GNV
Nonstop1h 40m
American Airlines
Tue 4/76:25 am
GNV
-
CLT
1 stop7h 19m
American Airlines
Deal found 2/10$374
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 am
CLT
-
GNV
1 stop3h 59m
Delta
Sat 4/116:00 am
GNV
-
CLT
1 stop4h 48m
Delta
Deal found 2/8$384
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:30 am
CLT
-
GNV
1 stop3h 59m
Delta
Mon 3/307:00 pm
GNV
-
CLT
1 stop4h 58m
Delta
Deal found 2/10$394
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:45 pm
CLT
-
GNV
Nonstop1h 42m
American Airlines
Mon 4/65:45 pm
GNV
-
CLT
Nonstop1h 50m
American Airlines
Deal found 2/10$395
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:40 am
GSP
-
GNV
1 stop3h 44m
Delta
Sun 3/16:00 am
GNV
-
GSP
1 stop5h 13m
Delta
Deal found 2/10$417
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:42 am
GSP
-
GNV
1 stop3h 42m
Delta
Sun 5/37:03 pm
GNV
-
GSP
1 stop4h 53m
Delta
Deal found 2/9$489
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:49 pm
GSP
-
GNV
2 stops10h 10m
American Airlines
Sun 3/16:24 am
GNV
-
GSP
1 stop5h 36m
American Airlines
Deal found 2/10$593

Find flight deals from South Carolina to Gainesville

Keep the following information in mind while searching for South Carolina to Gainesville flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$325
(American Airlines)

One-way from

$229
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Gainesville Regional flights.
Search Deals
From South Carolina to Gainesville Regional
Search Deals
One-way flight from South Carolina to Gainesville Regional
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

South Carolina

Fly to

Gainesville

Route

Depart

Return

Price

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Tue 2/24

10:16 pm-11:56 pm

Nonstop1h 40m

Gainesville Regional

Sat 2/28

6:24 am-8:20 am

Nonstop1h 56m

$325

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 4/4

8:45 pm-10:27 pm

Nonstop1h 42m

Gainesville Regional

Tue 4/7

6:05 am-7:55 am

Nonstop1h 50m

$333

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Thu 2/26

5:25 am-9:24 am

1 stop3h 59m

Gainesville Regional

Mon 3/2

7:00 pm-11:49 pm

1 stop4h 49m

$345

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Tue 2/24

5:25 am-9:24 am

1 stop3h 59m

Gainesville Regional

Sat 2/28

10:13 am-4:04 pm

1 stop5h 51m

$345

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 2/25

12:57 pm-6:13 pm

1 stop5h 16m

Gainesville Regional

Sun 3/1

6:00 am-11:00 am

1 stop5h 00m

$355

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 3/28

8:45 pm-10:27 pm

Nonstop1h 42m

Gainesville Regional

Mon 3/30

3:08 pm-4:59 pm

Nonstop1h 51m

$364

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 4/1

5:30 am-9:29 am

1 stop3h 59m

Gainesville Regional

Sat 4/11

6:00 am-10:48 am

1 stop4h 48m

$384

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 3/28

5:30 am-9:29 am

1 stop3h 59m

Gainesville Regional

Mon 3/30

7:00 pm-11:58 pm

1 stop4h 58m

$394

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 4/4

5:30 am-9:29 am

1 stop3h 59m

Gainesville Regional

Mon 4/6

4:59 pm-8:18 pm

1 stop3h 19m

$394

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Wed 2/25

5:40 am-9:24 am

1 stop3h 44m

Gainesville Regional

Sun 3/1

6:00 am-11:13 am

1 stop5h 13m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 19 results
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Best time to book a flight from South Carolina to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Gainesville

What is the cheapest month to book a flight from South Carolina to Gainesville?

Currently, April is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $51). Flying from South Carolina to Gainesville in March is currently the most expensive (average of $75). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Gainesville from South Carolina?

    Most people fly into Gainesville Regional (GNV) if they book a flight to Gainesville from South Carolina. Gainesville Regional is conveniently located just 4.2 mi from Gainesville’s city center.

  • How long is the flight from South Carolina to Gainesville?

    For as low as $325, American Airlines can have you in Gainesville from South Carolina in 1h 40m. Airlines will cover a distance of 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from South Carolina to Gainesville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Gainesville.

  • Can I find deals for business class flights from South Carolina to Gainesville?

    Yes. Cheapflights offers flight deals from South Carolina to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Gainesville?

    Currently, April is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $51). Flying from South Carolina to Gainesville in March is currently the most expensive (average of $75). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Alternative routes for South Carolina to Gainesville

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Top airline flying from South Carolina to Gainesville

Discover the top airline that operate flights from South Carolina to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$296Average$476FlexibilityNo cancel feeOn-timeN/A

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