HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Gainesville

$223+ Cheap flights from South Carolina to Gainesville (GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GNV
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Gainesville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from South Carolina to Gainesville

Cheapest flights from South Carolina to Gainesville
Explore the most affordable flight options available from South Carolina to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/225:54 pmCLT - GNV
Nonstop1h 40mAmerican Airlines
Sat 11/296:36 amGNV - CLT
Nonstop1h 44mAmerican Airlines
Deal found 11/4$317
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/62:38 pmCLT - GNV
Nonstop1h 43mAmerican Airlines
Tue 11/114:59 pmGNV - CLT
Nonstop1h 46mAmerican Airlines
Deal found 11/5$354
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:30 amCLT - GNV
1 stop3h 56mDelta
Tue 11/113:46 pmGNV - CLT
1 stop4h 28mDelta
Deal found 11/5$374
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:30 amCLT - GNV
1 stop3h 56mDelta
Thu 11/276:00 amGNV - CLT
1 stop4h 07mDelta
Deal found 11/3$387
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:41 amCLT - GNV
Nonstop1h 45mAmerican Airlines
Sun 11/166:36 amGNV - CLT
Nonstop1h 44mAmerican Airlines
Deal found 11/4$391
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:47 amCLT - GNV
1 stop5h 14mDelta
Sun 11/167:04 pmGNV - CLT
1 stop4h 46mDelta
Deal found 11/6$411
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/222:38 pmCLT - GNV
Nonstop1h 43mAmerican Airlines
Fri 11/2811:16 amGNV - CLT
Nonstop1h 42mAmerican Airlines
Deal found 11/4$414
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:45 pmCLT - GNV
1 stop5h 14mAmerican Airlines
Sat 11/298:00 pmGNV - CLT
Nonstop1h 49mAmerican Airlines
Deal found 11/4$418
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:59 amGSP - GNV
1 stop4h 59mDelta
Wed 12/176:00 amGNV - GSP
1 stop5h 15mDelta
Deal found 11/5$497
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/161:50 pmGSP - GNV
2 stops10h 08mAmerican Airlines
Wed 12/176:00 amGNV - GSP
1 stop3h 56mAmerican Airlines
Deal found 11/5$502
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:33 amGSP - GNV
1 stop3h 31mAmerican Airlines
Sun 11/236:00 amGNV - GSP
1 stop5h 04mAmerican Airlines
Deal found 11/5$508
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:35 amGSP - GNV
1 stop3h 51mDelta
Tue 11/256:00 amGNV - GSP
1 stop3h 02mDelta
Deal found 11/5$552

Cheap flight deals from South Carolina to Gainesville

Keep the following information in mind while searching for South Carolina to Gainesville flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$235
(American Airlines)

One-way from

$223
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Gainesville Regional flights.
Search Deals
From South Carolina to Gainesville Regional
Search Deals
One-way flight from South Carolina to Gainesville Regional
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

South Carolina

Fly to

Gainesville

Route

Depart

Return

Price

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Fri 1/30

6:55 pm-11:57 pm

1 stop5h 02m

Gainesville Regional

Mon 2/2

6:00 am-10:45 am

1 stop4h 45m

$255

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 11/26

2:38 pm-4:21 pm

Nonstop1h 43m

Gainesville Regional

Sat 11/29

6:36 am-8:20 am

Nonstop1h 44m

$317

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 11/22

1:24 pm-3:04 pm

Nonstop1h 40m

Gainesville Regional

Sat 11/29

6:36 am-8:20 am

Nonstop1h 44m

$317

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Fri 2/20

6:30 pm-11:56 pm

1 stop5h 26m

Gainesville Regional

Sun 2/22

6:00 am-11:35 am

1 stop5h 35m

$325

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 11/26

2:38 pm-4:21 pm

Nonstop1h 43m

Gainesville Regional

Thu 11/27

8:00 am-9:44 am

Nonstop1h 44m

$354

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 11/26

5:30 am-9:26 am

1 stop3h 56m

Gainesville Regional

Thu 11/27

6:00 am-10:07 am

1 stop4h 07m

$387

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 11/22

2:38 pm-4:21 pm

Nonstop1h 43m

Gainesville Regional

Fri 11/28

11:16 am-12:58 pm

Nonstop1h 42m

$414

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sun 11/23

1:24 pm-3:04 pm

Nonstop1h 40m

Gainesville Regional

Sat 11/29

6:36 am-8:20 am

Nonstop1h 44m

$414

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Tue 12/16

7:59 am-12:58 pm

1 stop4h 59m

Gainesville Regional

Wed 12/17

6:00 am-11:15 am

1 stop5h 15m

$497

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Tue 12/16

1:50 pm-11:58 pm

2 stops10h 08m

Gainesville Regional

Wed 12/17

6:00 am-9:56 am

1 stop3h 56m

$502

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 20 results
1
2

Best time to book a flight from South Carolina to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Gainesville

What is the cheapest month to book a flight from South Carolina to Gainesville?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $49). Flying from South Carolina to Gainesville in January is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to GNV?

Find hourly flight availability from South Carolina to Gainesville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

When flying from South Carolina to Gainesville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 20% versus a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Gainesville from South Carolina?

    Most people fly into Gainesville Regional (GNV) if they book a flight to Gainesville from South Carolina. Gainesville Regional is conveniently located just 4.2 mi from Gainesville’s city center.

  • How long is the flight from South Carolina to Gainesville?

    For as low as $497, American Airlines can have you in Gainesville from South Carolina in 4h 59m. Airlines will cover a distance of 359 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from South Carolina to Gainesville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Gainesville.

  • Can I find deals for business class flights from South Carolina to Gainesville?

    Yes. Cheapflights offers flight deals from South Carolina to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Gainesville?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Gainesville (average of $49). Flying from South Carolina to Gainesville in January is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Gainesville

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Fort Lauderdale flights
John F Kennedy Intl to Fort Lauderdale flights
John F Kennedy Intl to Miami flights
John F Kennedy Intl to Orlando flights
Newark to Miami flights
LaGuardia to Fort Lauderdale flights
LaGuardia to Miami flights
Newark to Orlando flights
John F Kennedy Intl to West Palm Beach flights
Boston to Fort Lauderdale flights
Newark to West Palm Beach flights
LaGuardia to Orlando flights
John F Kennedy Intl to Tampa flights
Dulles Intl to Miami flights
Newark to Tampa flights
LaGuardia to Tampa flights
Dallas/Fort Worth to Orlando flights
Baltimore to Fort Lauderdale flights
LaGuardia to West Palm Beach flights
Reagan-National to Miami flights
Philadelphia to Orlando flights
Boston to Miami flights
Boston to Orlando flights
O'Hare Intl to Orlando flights
Boston to Tampa flights
O'Hare Intl to Fort Lauderdale flights
Los Angeles to Orlando flights
Dulles Intl to Orlando flights
Los Angeles to Miami flights
O'Hare Intl to Tampa flights
O'Hare Intl to Miami flights
Reagan-National to Orlando flights
Dallas/Fort Worth to Fort Lauderdale flights
Los Angeles to Fort Lauderdale flights
Detroit to Fort Lauderdale flights
Minneapolis to Orlando flights
Philadelphia to Fort Lauderdale flights
Boston to West Palm Beach flights
Detroit to Orlando flights
Boston to Fort Myers flights
Minneapolis to Miami flights
Denver to Orlando flights
Denver to Miami flights
Providence to Orlando flights
Philadelphia to Miami flights
Dallas/Fort Worth to Miami flights
Cleveland to Orlando flights
John F Kennedy Intl to Fort Myers flights
White Plains to Orlando flights
Baltimore to Miami flights

Top airline flying from South Carolina to Gainesville

Discover the top airline that operate flights from South Carolina to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$296Average$477FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.