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$88+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Fort Myers

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$217
(American Airlines)

One-way from

$88
(American Airlines)

Popular in

October

Cheapest in

September

Average price

$251
From Knoxville McGhee Tyson to Fort Myers SW Florida Intl
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One-way flight from Knoxville McGhee Tyson to Fort Myers SW Florida Intl
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Highest demand for flights based on searches. 7% potential increase in price ($27 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Fort Myers

Cheapest flights from Knoxville to Fort Myers
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/47:20 pmTYS - RSW
1 stop4h 09mAmerican Airlines
Sat 11/85:20 pmRSW - TYS
1 stop6h 31mAmerican Airlines
Deal found 9/11$217
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:00 amTYS - RSW
1 stop5h 18mAmerican Airlines
Tue 10/214:44 pmRSW - TYS
1 stop6h 23mAmerican Airlines
Deal found 9/9$259
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/198:35 pmTYS - RSW
1 stop4h 04mDelta
Sun 10/265:38 amRSW - TYS
1 stop3h 42mDelta
Deal found 9/11$316
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:00 amTYS - RSW
1 stop6h 19mUnited Airlines
Sun 10/1212:25 pmRSW - TYS
1 stop8h 15mUnited Airlines
Deal found 9/10$343
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:45 amTYS - RSW
1 stop4h 16mDelta
Tue 10/78:14 amRSW - TYS
1 stop5h 36mDelta
Deal found 9/10$359
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/42:25 pmTYS - RSW
2 stops9h 13mUnited Airlines
Sat 11/85:08 pmRSW - TYS
1 stop6h 36mUnited Airlines
Deal found 9/11$364
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:00 amTYS - RSW
1 stop8h 44mUnited Airlines
Mon 11/246:40 pmRSW - TYS
1 stop5h 19mUnited Airlines
Deal found 9/10$393
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/129:55 amTYS - RSW
1 stop6h 02mUnited Airlines
Sat 9/136:25 pmRSW - TYS
1 stop5h 32mUnited Airlines
Deal found 9/11$396
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:45 amTYS - RSW
1 stop4h 02mDelta
Mon 9/298:00 amRSW - TYS
1 stop5h 07mDelta
Deal found 9/10$397
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/162:00 pmTYS - RSW
1 stop6h 18mUnited Airlines
Tue 9/234:39 pmRSW - TYS
1 stop6h 06mUnited Airlines
Deal found 9/11$399

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Knoxville

Fly to

Fort Myers

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 10/14

5:00 am-10:18 am

1 stop5h 18m

Fort Myers SW Florida Intl

Tue 10/21

4:44 pm-11:07 pm

1 stop6h 23m

$259

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 10/6

7:00 am-1:19 pm

1 stop6h 19m

Fort Myers SW Florida Intl

Sun 10/12

12:25 pm-8:40 pm

1 stop8h 15m

$343

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 10/1

5:45 am-10:01 am

1 stop4h 16m

Fort Myers SW Florida Intl

Tue 10/7

8:14 am-1:50 pm

1 stop5h 36m

$359

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 11/4

2:25 pm-11:38 pm

2 stops9h 13m

Fort Myers SW Florida Intl

Sat 11/8

5:08 pm-11:44 pm

1 stop6h 36m

$364

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 11/19

7:00 am-3:44 pm

1 stop8h 44m

Fort Myers SW Florida Intl

Mon 11/24

6:40 pm-11:59 pm

1 stop5h 19m

$393

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 9/26

1:52 pm-7:15 pm

1 stop5h 23m

Fort Myers SW Florida Intl

Sun 9/28

7:00 am-10:56 am

1 stop3h 56m

$397

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 10/6

7:00 am-1:19 pm

1 stop6h 19m

Fort Myers SW Florida Intl

Sat 10/11

4:35 pm-1:25 pm

1 stop20h 50m

$397

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 9/16

2:00 pm-11:07 pm

2 stops9h 07m

Fort Myers SW Florida Intl

Tue 9/23

4:39 pm-10:45 pm

1 stop6h 06m

$404

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 9/26

7:00 am-3:57 pm

2 stops8h 57m

Fort Myers SW Florida Intl

Tue 9/30

7:05 am-1:35 pm

1 stop6h 30m

$410

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 10/2

7:00 am-2:43 pm

1 stop7h 43m

Fort Myers SW Florida Intl

Tue 10/7

7:05 am-1:35 pm

1 stop6h 30m

$423

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Fort Myers

What is the cheapest month to book a flight from Knoxville to Fort Myers?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $205). Flying from Knoxville to Fort Myers in June is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to RSW?

Find hourly flight availability from Knoxville to Fort Myers. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Knoxville to Fort Myers, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 21% versus a flight in the morning.

Reviews of airlines servicing Fort Myers

Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Fort Myers?

    American Airlines, United Airlines, and Delta can get you from Knoxville to Fort Myers in just under 4h 16m. Your travel time can differ by up to 2h 03m. Knoxville and Fort Myers are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Fort Myers round-trip?

    Flying on Delta is currently your cheapest option to Fort Myers, with prices starting at $223. Another option worth looking into is American Airlines, starting at $248 round trip. Delta is 34% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Fort Myers that include hotel bookings?

    Yes. In addition to deals on Knoxville to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Fort Myers?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Fort Myers.

  • Can I find deals for business class flights from Knoxville to Fort Myers?

    Yes. Cheapflights offers flight deals from Knoxville to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Fort Myers?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $205). Flying from Knoxville to Fort Myers in June is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Sanibel
North Fort Myers
Estero
Lehigh Acres

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Top 2 airlines flying from Knoxville to Fort Myers

Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$312FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$357FlexibilityNo cancel feeOn-time71%

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