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$110+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Knoxville to Fort Myers

Cheapest flights from Knoxville to Fort Myers
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:39 pmTYS - RSW
1 stop5h 32mDelta
Thu 12/255:35 amRSW - TYS
1 stop4h 56mDelta
Deal found 11/12$314
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:09 pmTYS - RSW
1 stop6h 20mAmerican Airlines
Wed 12/2410:27 amRSW - TYS
1 stop5h 56mAmerican Airlines
Deal found 11/11$319
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:12 pmTYS - RSW
1 stop4h 28mAmerican Airlines
Wed 12/2410:27 amRSW - TYS
1 stop5h 56mAmerican Airlines
Deal found 11/11$329
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:40 amTYS - RSW
1 stop4h 04mDelta
Thu 12/117:49 pmRSW - TYS
1 stop3h 39mDelta
Deal found 11/11$334
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:07 amTYS - RSW
1 stop5h 59mAmerican Airlines
Tue 11/181:11 pmRSW - TYS
1 stop5h 43mAmerican Airlines
Deal found 11/11$369
This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:53 pmTYS - RSW
2 stops23h 27mMultiple Airlines
Thu 12/118:29 pmRSW - TYS
2 stops15h 26mMultiple Airlines
Deal found 11/11$388
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/281:25 pmTYS - RSW
1 stop7h 16mAmerican Airlines
Tue 12/26:21 pmRSW - TYS
1 stop4h 30mAmerican Airlines
Deal found 11/12$393
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1710:23 amTYS - RSW
1 stop6h 09mDelta
Tue 12/234:51 pmRSW - TYS
1 stop4h 24mDelta
Deal found 11/11$413
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:40 amTYS - RSW
1 stop4h 04mDelta
Tue 12/234:51 pmRSW - TYS
1 stop4h 24mDelta
Deal found 11/11$423
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:25 pmTYS - RSW
1 stop20h 35mUnited Airlines
Fri 12/126:40 pmRSW - TYS
1 stop16h 08mUnited Airlines
Deal found 11/11$514
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/282:59 pmTYS - RSW
2 stops17h 37mMultiple Airlines
Tue 12/211:09 amRSW - TYS
3 stops24h 54mMultiple Airlines
Deal found 11/12$529

Cheap flight deals from Knoxville to Fort Myers

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$259
(American Airlines)

One-way from

$110
(Kiwi.com)

Popular in

September

Cheapest in

August

Average price

$353
Provider with most accurate pricing for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flights.
Search Deals
From Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Knoxville

Fly to

Fort Myers

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 1/10

3:00 pm-7:59 pm

1 stop4h 59m

Fort Myers SW Florida Intl

Sat 1/17

3:07 pm-9:21 pm

1 stop6h 14m

$259

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/9

4:00 pm-7:59 pm

1 stop3h 59m

Fort Myers SW Florida Intl

Sun 1/11

8:40 am-3:20 pm

1 stop6h 40m

$299

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 2/6

8:30 am-1:39 pm

3 stops29h 09m

Fort Myers SW Florida Intl

Sun 2/8

2:34 pm-12:05 pm

2 stops21h 31m

$313

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 12/2

5:39 pm-11:11 pm

1 stop5h 32m

Fort Myers SW Florida Intl

Thu 12/25

5:35 am-10:31 am

1 stop4h 56m

$314

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 12/17

5:09 pm-11:29 pm

1 stop6h 20m

Fort Myers SW Florida Intl

Wed 12/24

10:27 am-4:23 pm

1 stop5h 56m

$319

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 12/10

5:40 am-9:44 am

1 stop4h 04m

Fort Myers SW Florida Intl

Thu 12/11

7:49 pm-11:28 pm

1 stop3h 39m

$334

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/9

8:30 am-1:39 pm

3 stops29h 09m

Fort Myers SW Florida Intl

Sun 1/11

7:22 am-5:28 pm

3 stops34h 06m

$335

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 1/12

2:57 pm-7:59 pm

1 stop5h 02m

Fort Myers SW Florida Intl

Fri 1/16

11:10 am-3:20 pm

1 stop4h 10m

$374

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 11/28

1:25 pm-8:41 pm

1 stop7h 16m

Fort Myers SW Florida Intl

Tue 12/2

6:21 pm-10:51 pm

1 stop4h 30m

$393

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 1/12

7:15 am-11:01 am

2 stops27h 46m

Fort Myers SW Florida Intl

Fri 1/16

11:58 am-11:09 am

2 stops23h 11m

$399

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 18 results
1
2

Compare providers for flights from Knoxville to Fort Myers

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Fort Myers in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Fort Myers flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Fort Myers flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Fort Myers flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Fort Myers flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Fort Myers flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Fort Myers

What is the cheapest month to book a flight from Knoxville to Fort Myers?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $44). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $88). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to RSW?

Find hourly flight availability from Knoxville to Fort Myers. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

When flying from Knoxville to Fort Myers, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 20% versus a flight in the morning.

Reviews of airlines servicing Fort Myers

Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated November 13, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Fort Myers?

    American Airlines and Delta can get you from Knoxville to Fort Myers in just under 4h 59m. Your travel time can differ by up to 33m. Knoxville and Fort Myers are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Fort Myers round-trip?

    Flying on Delta is currently your cheapest option to Fort Myers, with prices starting at $223. Another option worth looking into is American Airlines, starting at $248 round trip. Delta is 35% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Fort Myers that include hotel bookings?

    Yes. In addition to deals on Knoxville to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Fort Myers?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Fort Myers.

  • Can I find deals for business class flights from Knoxville to Fort Myers?

    Yes. Cheapflights offers flight deals from Knoxville to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Fort Myers?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $44). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $88). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Sanibel
North Fort Myers
Estero
Lehigh Acres

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Top 2 airlines flying from Knoxville to Fort Myers

Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$291FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$357FlexibilityNo cancel feeOn-time71%

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