HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Fort Myers

$150+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
mai 12 — mai 191
ti. 5/12
ti. 5/19
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Fort Myers with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Fort Myers

Cheapest flights from Knoxville to Fort Myers
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on april 12, 2026.

This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 5/57:00 am
TYS
-
RSW
1 stop7h 12m
American Airlines
ti. 5/124:39 pm
RSW
-
TYS
1 stop6h 17m
American Airlines
Deal found 4/9$265
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 5/512:50 pm
TYS
-
RSW
1 stop8h 45m
Southwest
ti. 5/1212:55 pm
RSW
-
TYS
1 stop6h 45m
Southwest
Deal found 4/7$270
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/145:00 am
TYS
-
RSW
1 stop4h 36m
American Airlines
ti. 5/196:50 pm
RSW
-
TYS
1 stop4h 06m
American Airlines
Deal found 4/10$278
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/16:07 pm
TYS
-
RSW
1 stop4h 43m
American Airlines
lø. 6/66:00 am
RSW
-
TYS
1 stop4h 36m
American Airlines
Deal found 4/7$291
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 5/155:00 am
TYS
-
RSW
1 stop4h 36m
American Airlines
on. 5/207:41 pm
RSW
-
TYS
1 stop4h 14m
American Airlines
Deal found 4/9$292
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/146:35 am
TYS
-
RSW
1 stop9h 40m
Southwest
on. 5/2012:55 pm
RSW
-
TYS
2 stops7h 55m
Southwest
Deal found 4/9$297
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 7/43:40 pm
TYS
-
RSW
1 stop7h 13m
American Airlines
lø. 7/113:59 pm
RSW
-
TYS
1 stop5h 57m
American Airlines
Deal found 4/10$299
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/137:05 am
TYS
-
RSW
2 stops8h 35m
Southwest
on. 5/209:20 am
RSW
-
TYS
2 stops11h 30m
Southwest
Deal found 4/9$302
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/237:45 am
TYS
-
RSW
1 stop11h 00m
Southwest
ti. 5/266:45 am
RSW
-
TYS
2 stops10h 25m
Southwest
Deal found 4/8$303
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/165:40 am
TYS
-
RSW
1 stop4h 07m
Delta
on. 5/206:45 am
RSW
-
TYS
1 stop6h 25m
Delta
Deal found 4/9$306
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/145:40 am
TYS
-
RSW
1 stop4h 07m
Delta
on. 5/205:59 pm
RSW
-
TYS
1 stop5h 57m
Delta
Deal found 4/10$307

Find flight deals from Knoxville to Fort Myers

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated april 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$265
(American Airlines)

One-way from

$150
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$465
Provider with most accurate pricing for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flights.
Search Deals
From Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated april 12, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

on. 5/13

8:15 am-3:40 pm

1 stop7h 25m

Fort Myers SW Florida Intl

on. 5/20

2:40 pm-8:50 pm

1 stop6h 10m

$265

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

lø. 5/23

7:45 am-6:45 pm

1 stop11h 00m

Fort Myers SW Florida Intl

ti. 5/26

2:40 pm-8:50 pm

1 stop6h 10m

$324

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

ti. 5/5

7:05 am-3:40 pm

2 stops8h 35m

Fort Myers SW Florida Intl

ti. 5/12

6:45 am-5:10 pm

2 stops10h 25m

$357

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

lø. 5/16

6:40 am-4:15 pm

1 stop9h 35m

Fort Myers SW Florida Intl

on. 5/20

12:55 pm-8:50 pm

2 stops7h 55m

$366

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

to. 5/14

6:35 am-4:45 pm

2 stops10h 10m

Fort Myers SW Florida Intl

on. 5/20

12:55 pm-8:50 pm

2 stops7h 55m

$374

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

fr. 5/22

8:05 am-8:05 pm

1 stop12h 00m

Fort Myers SW Florida Intl

ti. 5/26

6:45 am-5:10 pm

2 stops10h 25m

$382
Quickest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

ma. 5/4

7:00 pm-11:34 pm

1 stop4h 34m

Fort Myers SW Florida Intl

to. 5/7

6:45 am-1:10 pm

1 stop6h 25m

$413

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

fr. 5/22

12:15 pm-9:50 pm

1 stop9h 35m

Fort Myers SW Florida Intl

ma. 5/25

9:10 am-8:20 pm

1 stop11h 10m

$478

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

on. 4/15

7:05 am-5:10 pm

1 stop10h 05m

Fort Myers SW Florida Intl

fr. 4/17

10:15 am-8:20 pm

2 stops10h 05m

$526
Cheapest one-way

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

ma. 5/4

6:20 pm-5:00 pm

2 stops22h 40m

$150

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Fort Myers

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Fort Myers in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Fort Myers flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Fort Myers flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Fort Myers flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Fort Myers flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Fort Myers flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Fort Myers

What is the cheapest month to book a flight from Knoxville to Fort Myers?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $37). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Fort Myers?

Reviews of airlines servicing Fort Myers

Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated april 12, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,408 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,408 reviews
Delta
7.9
Good
8,408 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.1
Good
11,570 reviews
Delta
7.9
Good
8,408 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Fort Myers?

    Southwest can get you from Knoxville to Fort Myers in just under 7h 25m. Your travel time can differ by up to . Knoxville and Fort Myers are separated by a distance of 653 mi.

  • What are the cheapest airlines flying from Knoxville to Fort Myers round-trip?

    Flying on Delta is currently your cheapest option to Fort Myers, with prices starting at $223. Another option worth looking into is American Airlines, starting at $248 round trip. Delta is 40% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Fort Myers that include hotel bookings?

    Yes. In addition to deals on Knoxville to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Fort Myers?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Fort Myers.

  • Can I find deals for business class flights from Knoxville to Fort Myers?

    Yes. Cheapflights offers flight deals from Knoxville to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Fort Myers?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $37). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
North Fort Myers
Estero
Sanibel
Lehigh Acres

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Fort Myers

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Miami flights
Nashville to Orlando flights
Memphis to Miami flights
Memphis to Orlando flights
Nashville to Fort Lauderdale flights
Chattanooga to Orlando flights
Nashville to Tampa flights
Memphis to Fort Lauderdale flights
Knoxville to Orlando flights
Chattanooga to Miami flights
Knoxville to Orlando Sanford Intl flights
Nashville to Panama City flights
Nashville to West Palm Beach flights
Knoxville to Miami flights
Memphis to Jacksonville flights
Knoxville to Fort Lauderdale flights
Nashville to Sarasota flights
Memphis to Orlando Sanford Intl flights
Nashville to Jacksonville flights
Chattanooga to Orlando Sanford Intl flights
Memphis to Sarasota flights
Nashville to Fort Myers flights
Chattanooga to West Palm Beach flights
Nashville to Key West flights
Memphis to Tampa flights
Chattanooga to Fort Lauderdale flights
Memphis to Key West flights
Knoxville to Tampa flights
Chattanooga to Fort Myers flights
Chattanooga to Tampa flights
Nashville to Pensacola flights
Memphis to Panama City flights
Knoxville to Key West flights
Chattanooga to Valparaiso flights
Memphis to Fort Myers flights
Memphis to Pensacola flights
Chattanooga to Sarasota flights
Blountville to Orlando flights
Memphis to West Palm Beach flights
Nashville to Daytona Beach flights
Knoxville to Panama City flights
Knoxville to St Petersburg flights
Knoxville to Pensacola flights
Memphis to Valparaiso flights
Chattanooga to Panama City flights
Chattanooga to Jacksonville flights
Chattanooga to Pensacola flights
Knoxville to West Palm Beach flights

Top 2 airlines flying from Knoxville to Fort Myers

Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated april 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$392FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$400FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.