HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Fort Myers

$217+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Fort Myers with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Fort Myers

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 18, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$217
(Kiwi.com)

Popular in

October

Cheapest in

August

Average price

$252
From Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Knoxville to Fort Myers

Cheapest flights from Knoxville to Fort Myers
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:45 amTYS - RSW
1 stop4h 15mDelta
Sat 9/275:35 amRSW - TYS
1 stop4h 50mDelta
Deal found 8/16$249
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:08 pmTYS - RSW
1 stop6h 27mDelta
Mon 9/228:00 amRSW - TYS
1 stop5h 07mDelta
Deal found 8/18$274
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/255:45 amTYS - RSW
1 stop3h 58mDelta
Mon 9/15:35 amRSW - TYS
1 stop5h 07mDelta
Deal found 8/16$284
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:08 pmTYS - RSW
1 stop6h 27mDelta
Wed 9/175:35 amRSW - TYS
1 stop5h 21mDelta
Deal found 8/18$293
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:36 pmTYS - RSW
1 stop15h 25mDelta
Wed 1/75:35 amRSW - TYS
1 stop3h 38mDelta
Deal found 8/17$318
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:08 amTYS - RSW
1 stop4h 01mAmerican Airlines
Thu 1/811:56 amRSW - TYS
1 stop3h 45mAmerican Airlines
Deal found 8/17$319
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1812:03 pmTYS - RSW
1 stop5h 35mAmerican Airlines
Sat 8/238:23 amRSW - TYS
1 stop6h 06mAmerican Airlines
Deal found 8/16$324
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/195:45 amTYS - RSW
1 stop3h 57mDelta
Sat 8/236:15 pmRSW - TYS
1 stop5h 33mDelta
Deal found 8/18$328
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1912:03 pmTYS - RSW
1 stop5h 35mAmerican Airlines
Sat 8/239:58 amRSW - TYS
1 stop4h 31mAmerican Airlines
Deal found 8/18$329
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2111:15 amTYS - RSW
1 stop4h 05mAmerican Airlines
Sat 8/234:14 pmRSW - TYS
1 stop6h 01mAmerican Airlines
Deal found 8/17$334
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/229:55 amTYS - RSW
1 stop6h 02mUnited Airlines
Sun 8/245:13 pmRSW - TYS
1 stop6h 31mUnited Airlines
Deal found 8/18$339
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/199:55 amTYS - RSW
1 stop6h 02mUnited Airlines
Tue 9/234:39 pmRSW - TYS
1 stop6h 06mUnited Airlines
Deal found 8/18$349

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Knoxville

Fly to

Fort Myers

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 9/23

5:05 am-12:19 pm

1 stop7h 14m

Fort Myers SW Florida Intl

Sat 9/27

4:35 pm-11:03 pm

1 stop6h 28m

$249

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 9/23

5:45 am-10:00 am

1 stop4h 15m

Fort Myers SW Florida Intl

Sat 9/27

5:35 am-10:25 am

1 stop4h 50m

$249

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 9/12

7:11 pm-12:35 am

1 stop5h 24m

Fort Myers SW Florida Intl

Sun 9/14

7:00 am-10:56 am

1 stop3h 56m

$249

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 9/19

8:35 am-2:16 pm

1 stop5h 41m

Fort Myers SW Florida Intl

Tue 9/23

9:00 am-1:07 pm

1 stop4h 07m

$249

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 10/16

8:10 pm-12:39 am

1 stop4h 29m

Fort Myers SW Florida Intl

Sun 10/19

8:14 am-2:43 pm

1 stop6h 29m

$249

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 9/15

6:08 pm-12:35 am

1 stop6h 27m

Fort Myers SW Florida Intl

Mon 9/22

8:00 am-1:07 pm

1 stop5h 07m

$274

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 9/16

6:08 pm-12:35 am

1 stop6h 27m

Fort Myers SW Florida Intl

Wed 9/17

5:35 am-10:56 am

1 stop5h 21m

$293

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 12/30

6:36 pm-10:01 am

1 stop15h 25m

Fort Myers SW Florida Intl

Wed 1/7

5:35 am-9:13 am

1 stop3h 38m

$318

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 12/30

6:36 pm-10:01 am

1 stop15h 25m

Fort Myers SW Florida Intl

Thu 1/8

5:35 am-9:13 am

1 stop3h 38m

$318

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 12/31

5:08 am-9:09 am

1 stop4h 01m

Fort Myers SW Florida Intl

Wed 1/7

10:26 am-2:13 pm

1 stop3h 47m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Fort Myers

What is the cheapest month to book a flight from Knoxville to Fort Myers?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $205). Flying from Knoxville to Fort Myers in June is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to RSW?

Find hourly flight availability from Knoxville to Fort Myers. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

When flying from Knoxville to Fort Myers, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 21% versus a flight in the morning.

Reviews of airlines servicing Fort Myers

Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated August 18, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Fort Myers?

    American Airlines and Delta can get you from Knoxville to Fort Myers in just under 4h 15m. Your travel time can differ by up to 2h 59m. Knoxville and Fort Myers are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Fort Myers round-trip?

    Flying on Delta is currently your cheapest option to Fort Myers, with prices starting at $223. Another option worth looking into is American Airlines, starting at $248 round trip. Delta is 35% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Fort Myers that include hotel bookings?

    Yes. In addition to deals on Knoxville to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Fort Myers?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Fort Myers.

  • Can I find deals for business class flights from Knoxville to Fort Myers?

    Yes. Cheapflights offers flight deals from Knoxville to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Fort Myers?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $205). Flying from Knoxville to Fort Myers in June is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Sanibel
North Fort Myers
Estero
Lehigh Acres

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Fort Myers

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Fort Lauderdale flights
Nashville to Orlando flights
Nashville to Miami flights
Memphis to Orlando flights
Nashville to Tampa flights
Memphis to Miami flights
Knoxville to Orlando Sanford Intl flights
Knoxville to Miami flights
Knoxville to Orlando flights
Memphis to Fort Lauderdale flights
Nashville to Panama City flights
Knoxville to Fort Lauderdale flights
Nashville to Fort Myers flights
Nashville to Jacksonville flights
Blountville to Jacksonville flights
Nashville to West Palm Beach flights
Nashville to Pensacola flights
Chattanooga to Orlando flights
Nashville to Key West flights
Memphis to St Petersburg flights
Chattanooga to Miami flights
Memphis to Sarasota flights
Memphis to Tampa flights
Nashville to Sarasota flights
Chattanooga to Tampa flights
Memphis to Orlando Sanford Intl flights
Chattanooga to Fort Lauderdale flights
Chattanooga to Orlando Sanford Intl flights
Memphis to Pensacola flights
Knoxville to Tampa flights
Nashville to Valparaiso flights
Knoxville to Key West flights
Memphis to Panama City flights
Memphis to Key West flights
Knoxville to Pensacola flights
Chattanooga to Sarasota flights
Chattanooga to Key West flights
Nashville to St Petersburg flights
Blountville to Orlando flights
Chattanooga to Daytona Beach flights
Knoxville to Jacksonville flights
Nashville to Gainesville flights
Memphis to Valparaiso flights
Memphis to Jacksonville flights
Knoxville to Panama City flights
Nashville to Daytona Beach flights
Chattanooga to Jacksonville flights
Chattanooga to Fort Myers flights
Memphis to Fort Myers flights
Knoxville to St Petersburg flights

Top 2 airlines flying from Knoxville to Fort Myers

Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$288FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$350FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.