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$130+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Knoxville to Fort Myers

Cheapest flights from Knoxville to Fort Myers
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:20 pm
TYS
-
RSW
1 stop5h 15m
Delta
Sat 12/55:40 pm
RSW
-
TYS
1 stop6h 06m
Delta
Deal found 2/8$259
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:00 am
TYS
-
RSW
1 stop4h 36m
American Airlines
Tue 4/284:39 pm
RSW
-
TYS
1 stop6h 17m
American Airlines
Deal found 2/10$279
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:30 am
TYS
-
RSW
1 stop27h 11m
Multiple Airlines
Tue 3/312:21 pm
RSW
-
TYS
2 stops21h 49m
Multiple Airlines
Deal found 2/8$297
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:00 pm
TYS
-
RSW
1 stop5h 18m
Delta
Wed 9/95:35 am
RSW
-
TYS
1 stop3h 36m
Delta
Deal found 2/9$299
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/912:15 pm
TYS
-
RSW
1 stop9h 30m
Southwest
Tue 4/1410:30 am
RSW
-
TYS
1 stop10h 20m
Southwest
Deal found 2/10$308
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:15 pm
TYS
-
RSW
2 stops10h 35m
Southwest
Tue 4/289:20 am
RSW
-
TYS
2 stops11h 30m
Southwest
Deal found 2/10$313
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/157:30 am
TYS
-
RSW
1 stop10h 49m
Multiple Airlines
Tue 3/247:35 am
RSW
-
TYS
2 stops27h 05m
Multiple Airlines
Deal found 2/9$322
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
TYS
-
RSW
1 stop12h 19m
Multiple Airlines
Tue 4/149:54 pm
RSW
-
TYS
2 stops46h 48m
Multiple Airlines
Deal found 2/10$327
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/156:38 pm
TYS
-
RSW
1 stop5h 58m
Delta
Tue 3/246:32 am
RSW
-
TYS
1 stop4h 45m
Delta
Deal found 2/9$333
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:10 am
TYS
-
RSW
2 stops13h 00m
Southwest
Sat 6/278:05 am
RSW
-
TYS
2 stops11h 30m
Southwest
Deal found 2/10$348

Find flight deals from Knoxville to Fort Myers

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(American Airlines)

One-way from

$130
(Southwest)

Popular in

March

Cheapest in

February

Average price

$247
Provider with most accurate pricing for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Fort Myers SW Florida Intl flights.
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From Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Fort Myers SW Florida Intl
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Knoxville

Fly to

Fort Myers

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sun 3/1

6:30 am-9:41 am

1 stop27h 11m

Fort Myers SW Florida Intl

Tue 3/3

12:21 pm-10:10 am

2 stops21h 49m

$297

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 4/9

12:15 pm-9:45 pm

1 stop9h 30m

Fort Myers SW Florida Intl

Tue 4/14

10:30 am-8:50 pm

1 stop10h 20m

$308

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 4/24

12:15 pm-10:50 pm

2 stops10h 35m

Fort Myers SW Florida Intl

Tue 4/28

9:20 am-8:50 pm

2 stops11h 30m

$313

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sun 3/15

7:30 am-6:19 pm

1 stop10h 49m

Fort Myers SW Florida Intl

Tue 3/24

7:35 am-10:40 am

2 stops27h 05m

$322

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 4/9

6:00 am-6:19 pm

1 stop12h 19m

Fort Myers SW Florida Intl

Tue 4/14

9:54 pm-8:42 pm

2 stops46h 48m

$327

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 6/17

8:10 am-9:10 pm

2 stops13h 00m

Fort Myers SW Florida Intl

Sat 6/27

8:05 am-7:35 pm

2 stops11h 30m

$348

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 5/9

7:45 am-6:45 pm

1 stop11h 00m

Fort Myers SW Florida Intl

Fri 5/15

11:50 am-9:15 pm

1 stop9h 25m

$349

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 2/24

2:38 pm-8:43 pm

1 stop6h 05m

Fort Myers SW Florida Intl

Sat 2/28

5:35 am-9:04 am

1 stop3h 29m

$369

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/8

8:15 am-8:35 pm

2 stops12h 20m

$130

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 4/20

5:00 am-9:36 am

1 stop4h 36m

$133

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/8

Showing 1-10 of 17 results
1
2

Compare providers for flights from Knoxville to Fort Myers

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Fort Myers in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Fort Myers flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Fort Myers flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Fort Myers flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Fort Myers flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Fort Myers flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Fort Myers

What is the cheapest month to book a flight from Knoxville to Fort Myers?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $44). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Fort Myers

Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated February 11, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,180 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,180 reviews
Delta
7.9
Good
8,180 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,265 reviews
Delta
7.9
Good
8,180 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Fort Myers?

    Southwest can get you from Knoxville to Fort Myers in just under 9h 30m. Your travel time can differ by up to . Knoxville and Fort Myers are separated by a distance of 653 mi.

  • What are the cheapest airlines flying from Knoxville to Fort Myers round-trip?

    Flying on Delta is currently your cheapest option to Fort Myers, with prices starting at $198. Another option worth looking into is American Airlines, starting at $248 round trip. Delta is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to Fort Myers that include hotel bookings?

    Yes. In addition to deals on Knoxville to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Fort Myers?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Fort Myers.

  • Can I find deals for business class flights from Knoxville to Fort Myers?

    Yes. Cheapflights offers flight deals from Knoxville to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Fort Myers?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Fort Myers (average of $44). Flying from Knoxville to Fort Myers in November is currently the most expensive (average of $90). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Sanibel
North Fort Myers
Estero
Lehigh Acres

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Top 2 airlines flying from Knoxville to Fort Myers

Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$368FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$400FlexibilityNo cancel feeOn-time71%

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