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Florida Keys

$64+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — EYW
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Priceline deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:45 pmMCI - MIA
1 stop7h 15mFrontier
Mon 12/295:30 amMIA - MCI
1 stop5h 38mFrontier
Deal found 12/16$203
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:33 amMCI - MIA
1 stop24h 33mMultiple Airlines
Tue 1/69:59 pmMIA - MCI
2 stops20h 11mMultiple Airlines
Deal found 12/17$226
This Priceline deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:45 pmMCI - MIA
1 stop7h 15mFrontier
Wed 12/315:30 amMIA - MCI
1 stop5h 38mFrontier
Deal found 12/17$234
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:48 amSTL - MIA
1 stop25h 18mMultiple Airlines
Tue 1/69:59 pmMIA - STL
2 stops25h 34mMultiple Airlines
Deal found 12/17$248
This Frontier deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:48 amSTL - MIA
1 stop7h 42mFrontier
Thu 1/15:30 amMIA - STL
1 stop5h 10mFrontier
Deal found 12/16$258
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:27 pmSTL - MIA
2 stops43h 39mMultiple Airlines
Wed 1/77:09 pmMIA - STL
1 stop20h 39mMultiple Airlines
Deal found 12/16$264
This Travelocity deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:10 pmSTL - MIA
1 stop30h 25mFrontier
Tue 12/305:30 amMIA - STL
1 stop5h 10mFrontier
Deal found 12/16$267
This Priceline deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:48 amSTL - MIA
1 stop7h 42mFrontier
Sun 1/45:30 amMIA - STL
1 stop5h 10mFrontier
Deal found 12/15$268
This Super.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:19 pmSTL - MIA
1 stop11h 16mFrontier
Thu 1/15:30 amMIA - STL
1 stop5h 10mFrontier
Deal found 12/16$271
This Frontier deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:43 pmSTL - MIA
1 stop8h 17mFrontier
Sun 1/45:30 amMIA - STL
1 stop5h 10mFrontier
Deal found 12/15$277
This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - MIA
2 stops21h 44mSpirit Airlines
Tue 1/69:59 pmMIA - MCI
2 stops20h 11mSpirit Airlines
Deal found 12/17$277
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 pmSTL - MIA
Nonstop2h 57mAmerican Airlines
Thu 1/17:00 amMIA - STL
1 stop7h 14mAmerican Airlines
Deal found 12/16$293

Find flight deals from Missouri to Florida Keys

Keep the following information in mind while searching for Missouri to Florida Keys flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$153
(Kiwi.com)

One-way from

$64
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$439
Provider with most accurate pricing for Lambert-St Louis-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Miami flights.
Search Deals
From Missouri to Florida Keys
Search Deals
One-way flight from Missouri to Florida Keys
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Florida Keys that are best for you.

Fly from

Missouri

Fly to

Florida Keys

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 1/28

8:22 pm-11:56 am

2 stops14h 34m

Key West

Thu 2/5

9:46 am-10:23 am

1 stop25h 37m

$208

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 2/10

3:54 pm-9:47 pm

1 stop4h 53m

Key West

Wed 2/25

11:47 am-5:27 pm

1 stop6h 40m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 2/10

1:00 pm-7:40 pm

1 stop5h 40m

Key West

Wed 2/25

6:07 pm-11:36 pm

1 stop6h 29m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

1:36 pm-11:56 pm

2 stops9h 20m

Key West

Wed 3/25

6:45 am-10:32 am

1 stop4h 47m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 1/28

9:33 am-7:10 pm

2 stops8h 37m

Key West

Sat 1/31

6:06 am-3:04 pm

2 stops9h 58m

$233

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Thu 1/8

12:45 pm-9:47 pm

1 stop8h 02m

Key West

Thu 1/15

7:08 am-12:15 pm

1 stop6h 07m

$248

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Thu 1/8

11:26 am-1:30 pm

1 stop25h 04m

Key West

Sun 1/11

12:51 pm-10:09 am

2 stops22h 18m

$249

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Thu 2/26

11:19 am-7:20 pm

1 stop7h 01m

Key West

Tue 3/3

4:02 pm-10:05 pm

1 stop7h 03m

$251

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Wed 2/18

5:11 pm-12:53 am

1 stop6h 42m

Miami

Wed 2/25

6:00 am-11:18 am

1 stop6h 18m

$259

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Wed 2/18

5:11 pm-12:53 am

1 stop6h 42m

Miami

Tue 2/24

10:33 am-4:22 pm

1 stop6h 49m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florida Keys

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, April is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $189). Flying from Missouri to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Florida Keys?

    Departing from Missouri to Florida Keys will take you 4h 53m. Missouri and Florida Keys are separated by a distance of 1102 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Florida Keys one-way?

    One-way options have recently been found by users for as low as $53 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $65 and American Airlines from $89 one-way.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $189). Flying from Missouri to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$395FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$227Average$497FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$378FlexibilityNo cancel feeOn-time69%

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