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$55+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/31. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Cheap flight deals from Missouri to Florida Keys

Keep the following information in mind while searching for Missouri to Florida Keys flight deals. Data was last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$171
(Kiwi.com)

One-way from

$55
(Frontier)

Popular in

March

Cheapest in

September

Average price

$419
Provider with most accurate pricing for Lambert-St Louis-Miami flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Miami flights.
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From Missouri to Florida Keys
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One-way flight from Missouri to Florida Keys
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Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:46 pmMCI - MIA
1 stop11h 00mFrontier
Thu 12/116:00 amMIA - MCI
1 stop14h 14mFrontier
Deal found 11/2$171
This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:09 pmMCI - MIA
1 stop8h 10mFrontier
Mon 12/85:30 amMIA - MCI
1 stop7h 21mFrontier
Deal found 11/4$176
This Frontier deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:09 pmMCI - MIA
1 stop8h 10mFrontier
Fri 12/125:30 amMIA - MCI
1 stop6h 48mFrontier
Deal found 11/2$180
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:48 pmMCI - MIA
2 stops23h 51mMultiple Airlines
Mon 12/86:05 amMIA - MCI
1 stop6h 46mMultiple Airlines
Deal found 11/2$183
This Frontier deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:49 pmMCI - MIA
1 stop10h 30mFrontier
Mon 11/175:05 amMIA - MCI
1 stop6h 12mFrontier
Deal found 11/2$184
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:12 amMCI - MIA
1 stop25h 16mMultiple Airlines
Tue 11/1810:15 pmMIA - MCI
2 stops15h 13mMultiple Airlines
Deal found 11/3$189
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:46 pmMCI - MIA
2 stops19h 36mFrontier
Fri 12/125:30 amMIA - MCI
1 stop6h 48mFrontier
Deal found 11/3$190
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:48 pmMCI - MIA
2 stops23h 51mFrontier
Fri 12/125:30 amMIA - MCI
1 stop6h 48mFrontier
Deal found 11/2$192
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:46 pmMCI - MIA
1 stop11h 00mFrontier
Sat 12/138:09 pmMIA - MCI
2 stops24h 41mFrontier
Deal found 11/2$194
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:48 pmMCI - MIA
2 stops23h 51mFrontier
Thu 12/116:00 amMIA - MCI
1 stop14h 14mFrontier
Deal found 11/2$197
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:09 pmMCI - MIA
1 stop8h 10mFrontier
Thu 12/116:00 amMIA - MCI
1 stop14h 14mFrontier
Deal found 11/2$200
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:45 pmSTL - MIA
1 stop9h 34mFrontier
Mon 11/176:00 amMIA - STL
1 stop28h 07mFrontier
Deal found 11/3$220

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Missouri to Florida Keys that are best for you.

Fly from

Missouri

Fly to

Florida Keys

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

11:30 am-6:30 pm

1 stop6h 00m

Key West

Wed 3/25

6:31 am-10:29 am

1 stop4h 58m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 12/6

6:00 am-1:51 pm

1 stop6h 51m

Key West

Tue 12/9

7:00 am-1:18 pm

2 stops7h 18m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 12/2

2:05 pm-11:50 pm

2 stops8h 45m

Key West

Tue 12/9

7:00 am-3:37 pm

2 stops9h 37m

$233

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 12/6

2:09 pm-11:07 pm

2 stops7h 58m

Key West

Wed 12/10

7:00 am-1:18 pm

2 stops7h 18m

$233

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 1/26

5:11 pm-1:30 pm

2 stops19h 19m

Key West

Fri 1/30

1:06 pm-10:33 pm

1 stop10h 27m

$236

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sun 12/14

1:57 pm-8:06 pm

1 stop5h 09m

Key West

Sat 12/20

6:20 pm-11:42 pm

1 stop6h 22m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 12/15

9:30 am-4:07 pm

1 stop5h 37m

Key West

Sat 12/20

11:57 am-5:51 pm

1 stop6h 54m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 1/9

6:02 pm-11:56 pm

1 stop4h 54m

Key West

Tue 1/13

12:00 pm-5:22 pm

1 stop6h 22m

$241

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 11/19

6:00 am-8:15 am

1 stop25h 15m

Key West

Sat 11/22

5:28 pm-8:05 am

1 stop15h 37m

$243

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sun 1/11

6:00 am-2:54 pm

2 stops7h 54m

Key West

Sat 1/17

6:06 am-3:04 pm

2 stops9h 58m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florida Keys

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, April is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $189). Flying from Missouri to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Florida Keys?

    Departing from Missouri to Florida Keys will take you 4h 43m. Missouri and Florida Keys are separated by a distance of 1102 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $189). Flying from Missouri to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$386FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$239Average$486FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$457FlexibilityNo cancel feeOn-time69%

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