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$65+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
oct. 16 — oct. 231
jue. 10/16
jue. 10/23
1 adult, Economy
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Cheap flight deals from Missouri to Florida Keys

Keep the following information in mind while searching for Missouri to Florida Keys flight deals. Data was last updated septiembre 16, 2025.

Round-trip from

$168
(Frontier)

One-way from

$65
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$319
From Missouri to Florida Keys
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One-way flight from Missouri to Florida Keys
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Highest demand for flights based on searches. 5% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 16, 2025.

This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/87:45 pmSTL - MIA
1 stop9h 34mFrontier
dom. 11/168:25 amMIA - STL
1 stop9h 57mFrontier
Deal found 9/13$168
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/145:23 amSTL - MIA
Nonstop2h 47mAmerican Airlines
mar. 10/2110:01 pmMIA - STL
Nonstop2h 55mAmerican Airlines
Deal found 9/15$169
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/33:01 pmMCI - MIA
1 stop8h 43mFrontier
sáb. 10/116:00 amMIA - MCI
1 stop12h 55mFrontier
Deal found 9/14$174
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/245:40 amMCI - MIA
1 stop6h 55mSouthwest
vie. 11/286:00 amMIA - MCI
1 stop6h 20mSouthwest
Deal found 9/15$179
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/247:52 pmSTL - MIA
1 stop9h 27mFrontier
vie. 10/315:05 amMIA - STL
1 stop11h 52mFrontier
Deal found 9/14$182
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/911:37 amMCI - MIA
1 stop11h 57mFrontier
vie. 10/105:15 amMIA - MCI
1 stop6h 27mFrontier
Deal found 9/15$182
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/314:52 pmSTL - MIA
1 stop6h 42mFrontier
dom. 11/25:05 amMIA - STL
1 stop6h 07mFrontier
Deal found 9/15$183
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1011:37 amMCI - MIA
1 stop11h 57mFrontier
dom. 10/125:15 amMIA - MCI
1 stop6h 27mFrontier
Deal found 9/16$184
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/257:52 pmSTL - MIA
1 stop9h 27mFrontier
dom. 11/25:00 amMIA - STL
1 stop28h 07mFrontier
Deal found 9/16$185
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/227:02 pmMCI - MIA
1 stop10h 17mFrontier
lun. 10/275:15 amMIA - MCI
1 stop6h 27mFrontier
Deal found 9/14$185
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/227:02 pmMCI - MIA
1 stop10h 17mFrontier
dom. 10/265:15 amMIA - MCI
1 stop6h 27mFrontier
Deal found 9/15$186
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/295:15 pmMCI - MIA
1 stop5h 57mFrontier
jue. 10/25:30 amMIA - MCI
1 stop11h 50mFrontier
Deal found 9/15$187

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from Missouri to Florida Keys that are best for you.

Fly from

Missouri

Fly to

Florida Keys

Route

Depart

Return

Price

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

mar. 10/14

6:00 am-4:50 pm

1 stop9h 50m

Miami

mar. 10/21

7:55 am-3:45 pm

1 stop8h 50m

$184

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

mar. 10/14

10:40 am-10:15 pm

1 stop10h 35m

Miami

mié. 10/22

1:15 pm-6:35 pm

1 stop6h 20m

$194

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

sáb. 11/8

5:15 pm-12:29 am

1 stop6h 14m

Miami

sáb. 11/15

8:05 am-1:51 pm

1 stop6h 46m

$197

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

mar. 10/14

1:30 pm-6:34 pm

1 stop4h 04m

Miami

mar. 10/21

6:00 am-10:26 am

1 stop5h 26m

$197

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

sáb. 12/6

5:12 pm-12:46 am

1 stop6h 34m

Miami

mié. 12/10

7:00 am-10:41 am

1 stop4h 41m

$197

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

lun. 11/24

11:44 am-6:20 pm

1 stop5h 36m

Miami

vie. 11/28

6:00 am-10:04 am

1 stop5h 04m

$197

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

sáb. 10/11

5:25 pm-12:29 am

1 stop6h 04m

Miami

sáb. 10/18

6:00 am-9:15 am

1 stop4h 15m

$198

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

mar. 10/7

12:20 pm-8:35 pm

1 stop7h 15m

Miami

vie. 10/10

7:30 pm-12:10 am

1 stop5h 40m

$199

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

mié. 2/18

4:15 pm-10:00 pm

1 stop4h 45m

Miami

mar. 2/24

7:15 am-5:30 pm

1 stop11h 15m

$204

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

lun. 3/9

2:15 pm-9:47 pm

1 stop6h 32m

Miami

mié. 3/11

7:00 am-2:00 pm

1 stop8h 00m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florida Keys

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EOA?

Find hourly flight availability from Missouri to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 16, 2025.

When flying from Missouri to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Florida Keys?

    Departing from Missouri to Florida Keys will take you 6h 14m. Missouri and Florida Keys are separated by a distance of 1069 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$395FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$245Average$483FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$246Average$488FlexibilityNo cancel feeOn-time71%

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