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Florida Keys

$87+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Jun 23 — Jun 301
Mon 6/23
Mon 6/30
1 adult, Economy
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Cheap flight deals from Missouri to Florida Keys

Keep the following information in mind while searching for Missouri to Florida Keys flight deals. Data was last updated June 18, 2025.

Round-trip from

$198
(Cheapflightsfares)

One-way from

$87
(FlightHub)

Popular in

March

Cheapest in

September

Average price

$414
From Missouri to Florida Keys
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One-way flight from Missouri to Florida Keys
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/128:44 amSTL - MIA
1 stop9h 09mSpirit Airlines
Sun 9/217:58 pmMIA - STL
1 stop12h 51mSpirit Airlines
Deal found 6/17$198
This Frontier deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/272:27 pmSTL - MIA
1 stop14h 18mFrontier
Sun 6/296:00 amMIA - STL
1 stop8h 40mFrontier
Deal found 6/15$200
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/88:05 amSTL - MIA
Nonstop2h 50mSouthwest
Thu 7/174:35 pmMIA - STL
Nonstop2h 55mSouthwest
Deal found 6/17$201
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/281:29 pmSTL - MIA
1 stop6h 49mDelta
Tue 7/297:23 pmMIA - STL
1 stop5h 30mDelta
Deal found 6/17$211
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/15:26 amSTL - MIA
Nonstop2h 48mAmerican Airlines
Sat 9/610:09 pmMIA - STL
Nonstop2h 50mAmerican Airlines
Deal found 6/18$214
This FlightHub deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/511:00 amSTL - MIA
1 stop8h 39mMultiple Airlines
Thu 7/104:51 pmMIA - STL
1 stop18h 01mMultiple Airlines
Deal found 6/17$215
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/216:56 pmSGF - MIA
1 stop4h 59mDelta
Tue 7/293:55 pmMIA - SGF
1 stop7h 15mDelta
Deal found 6/15$217
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:02 amSTL - EYW
1 stop6h 58mAmerican Airlines
Wed 9/1012:00 pmEYW - STL
1 stop7h 32mAmerican Airlines
Deal found 6/15$223
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/295:15 amMCI - MIA
2 stops9h 25mSouthwest
Wed 8/66:55 amMIA - MCI
1 stop5h 40mSouthwest
Deal found 6/18$240
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/75:08 amMCI - MIA
Nonstop3h 12mAmerican Airlines
Fri 7/1110:02 pmMIA - MCI
Nonstop3h 16mAmerican Airlines
Deal found 6/16$241
This Orbitz deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/48:01 pmMCI - MIA
1 stop9h 29mMultiple Airlines
Tue 7/88:55 pmMIA - MCI
1 stop17h 42mMultiple Airlines
Deal found 6/16$243
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:10 amMCI - MIA
1 stop6h 37mUnited Airlines
Sat 10/41:15 pmMIA - MCI
2 stops9h 30mUnited Airlines
Deal found 6/17$245

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2025.
Use the filters below to find and compare flights from Missouri to Florida Keys that are best for you.

Fly from

Missouri

Fly to

Florida Keys

Route

Depart

Return

Price

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Fri 9/12

8:44 am-6:53 pm

1 stop9h 09m

Miami

Sun 9/21

7:58 pm-7:49 am

1 stop12h 51m

$198

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Fri 6/27

2:27 pm-5:45 am

1 stop14h 18m

Miami

Sun 6/29

6:00 am-1:40 pm

1 stop8h 40m

$200

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 7/8

8:05 am-11:55 am

Nonstop2h 50m

Miami

Thu 7/17

4:35 pm-6:30 pm

Nonstop2h 55m

$201

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Fri 7/11

7:29 pm-6:30 am

1 stop10h 01m

Miami

Thu 7/17

4:51 pm-9:52 am

1 stop18h 01m

$209

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Mon 7/28

1:29 pm-7:33 pm

1 stop5h 04m

Miami

Thu 7/31

5:30 am-9:41 am

1 stop5h 11m

$211

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Mon 9/1

5:26 am-9:14 am

Nonstop2h 48m

Miami

Sat 9/6

10:09 pm-11:59 pm

Nonstop2h 50m

$214

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Mon 7/21

6:56 pm-12:55 am

1 stop4h 59m

Miami

Tue 7/29

3:55 pm-10:10 pm

1 stop7h 15m

$217

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 9/3

6:02 am-2:00 pm

1 stop6h 58m

Key West

Wed 9/10

12:00 pm-6:32 pm

1 stop7h 32m

$223

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Tue 7/29

5:15 am-3:40 pm

2 stops9h 25m

Miami

Wed 8/6

6:55 am-11:35 am

1 stop5h 40m

$240

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Mon 7/7

5:08 am-9:20 am

Nonstop3h 12m

Miami

Fri 7/11

10:02 pm-12:18 am

Nonstop3h 16m

$241

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/17

Showing 1-10 of 58 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florida Keys

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EOA?

Find hourly flight availability from Missouri to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 18, 2025.

When flying from Missouri to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated June 18, 2025.
See what other customers who have flown with Alaska Airlines, Southwest and Delta from Missouri to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,280 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,964 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,810 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Allegiant Air
7.3
Good
722 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to Florida Keys one-way?

    One-way options have recently been found by users for as low as $87 on Spirit Airlines. Other airlines that offer cheap prices include American Airlines from $88 and Southwest from $89 one-way.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$392FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$237Average$426FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$487FlexibilityNo cancel feeOn-time69%

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