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$491+ Cheap flights from Santa Ana, CA to Florence, SC (SNA - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — FLO
Jan 2 — Jan 91
Fri 1/2
Fri 1/9
1 adult, Economy
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Cheap flight deals from Santa Ana to Florence

Cheapest flights from Santa Ana to Florence
Explore the most affordable flight options available from Santa Ana to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 3, 2025.

This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Wed 12/3112:51 pmFLO - SNA
2 stops8h 48mAmerican Airlines
Deal found 12/1$617
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Fri 1/21:07 pmFLO - SNA
2 stops10h 06mAmerican Airlines
Deal found 12/1$659
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Wed 12/315:15 amFLO - SNA
2 stops13h 06mAmerican Airlines
Deal found 12/1$664
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Thu 1/15:15 amFLO - SNA
2 stops13h 06mAmerican Airlines
Deal found 12/1$706
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Thu 1/15:15 amFLO - SNA
2 stops9h 41mAmerican Airlines
Deal found 12/1$748
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 amSNA - FLO
2 stops8h 20mAmerican Airlines
Thu 1/112:51 pmFLO - SNA
2 stops11h 57mAmerican Airlines
Deal found 12/1$753

Find flight deals from Santa Ana to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$491
(American Airlines)

Popular in

January

Cheapest in

October

Average price

$663
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Florence flight deals.
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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Florence flights.
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From Santa Ana J. Wayne/Orange Cnty to Florence
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($131 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($47 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Santa Ana to Florence that are best for you.

Fly from

Santa Ana

Fly to

Florence

Route

Depart

Return

Price

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Tue 1/27

10:53 am-10:43 pm

2 stops8h 50m

Florence

Sat 1/31

6:15 am-4:10 pm

2 stops12h 55m

$491

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 2/12

7:45 am-5:49 pm

1 stop7h 04m

Florence

Sun 2/15

9:30 am-7:03 pm

2 stops12h 33m

$544

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 2/11

10:53 am-10:43 pm

2 stops8h 50m

Florence

Tue 2/17

5:58 pm-8:56 am

2 stops17h 58m

$557

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Tue 2/10

9:45 am-10:43 pm

2 stops9h 58m

Florence

Mon 2/16

5:15 am-3:44 pm

2 stops13h 29m

$645

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 2/11

9:45 am-10:43 pm

2 stops9h 58m

Florence

Mon 2/16

5:15 am-3:44 pm

2 stops13h 29m

$645

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 12/25

7:45 am-6:05 pm

1 stop7h 20m

Florence

Fri 1/2

1:07 pm-8:13 pm

2 stops10h 06m

$659

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 12/25

7:45 am-6:05 pm

1 stop7h 20m

Florence

Thu 1/1

5:15 am-11:52 am

2 stops9h 37m

$659

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/24

7:45 am-6:05 pm

1 stop7h 20m

Florence

Wed 12/31

5:15 am-3:21 pm

2 stops13h 06m

$664

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 2/12

7:45 am-5:49 pm

1 stop7h 04m

Florence

Mon 2/16

5:15 am-3:44 pm

2 stops13h 29m

$669

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

  • Most accurate provider: When it comes to deals on Santa Ana, California-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Florence

What is the cheapest month to book a flight from Santa Ana, California to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Santa Ana, California to Florence, South Carolina (average of $112). Flying from Santa Ana, California to Florence, South Carolina in November is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Florence, South Carolina?

    For as low as $491, American Airlines can have you in Florence, South Carolina from Santa Ana, California in 9h 58m. The distance between Santa Ana, California and Florence, South Carolina is about 2172 mi.

  • Can I find deals for flights from Santa Ana to Florence that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Florence.

  • Can I find deals for business class flights from Santa Ana to Florence?

    Yes. Cheapflights offers flight deals from Santa Ana to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Santa Ana, California to Florence, South Carolina (average of $112). Flying from Santa Ana, California to Florence, South Carolina in November is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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