HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$575+ Cheap flights from Santa Ana, CA to Florence, SC (SNA - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — FLO
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Ana to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Ana to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$575
(American Airlines)

Popular in

January

Cheapest in

October

Average price

$466
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Florence flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Florence
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($109 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Santa Ana to Florence

Cheapest flights from Santa Ana to Florence
Explore the most affordable flight options available from Santa Ana to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/108:30 amSNA - FLO
2 stops11h 23mAmerican Airlines
Sat 12/1311:16 amFLO - SNA
2 stops10h 02mAmerican Airlines
Deal found 10/15$575

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Santa Ana to Florence that are best for you.

Fly from

Santa Ana

Fly to

Florence

Route

Depart

Return

Price

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

9:30 am-10:53 pm

2 stops10h 23m

Florence

Sat 12/13

5:15 am-2:09 pm

2 stops11h 54m

$575

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

  • Most accurate provider: When it comes to deals on Santa Ana, California-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Florence

What is the cheapest month to book a flight from Santa Ana, California to Florence, South Carolina?

Currently, February is the cheapest month in which you can book a flight from Santa Ana, California to Florence, South Carolina (average of $113). Flying from Santa Ana, California to Florence, South Carolina in March is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Florence, South Carolina?

    For as low as $575, American Airlines can have you in Florence, South Carolina from Santa Ana, California in 10h 23m. The distance between Santa Ana, California and Florence, South Carolina is about 2172 mi.

  • Can I find deals for flights from Santa Ana to Florence that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Florence.

  • Can I find deals for business class flights from Santa Ana to Florence?

    Yes. Cheapflights offers flight deals from Santa Ana to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Florence, South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Santa Ana, California to Florence, South Carolina (average of $113). Flying from Santa Ana, California to Florence, South Carolina in March is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Ana to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Charlotte flights
San Francisco to Charlotte flights
Ontario to Charlotte flights
Santa Ana to Charlotte flights
San Diego to Charlotte flights
San Francisco to Savannah flights
Los Angeles to Charleston flights
San Francisco to Charleston flights
San Jose to Charlotte flights
Las Vegas to Charlotte flights
Ontario to Charleston flights
Los Angeles to Myrtle Beach flights
Oakland to Charlotte flights
Los Angeles to Columbia flights
Sacramento to Charlotte flights
San Diego to Charleston flights
Ontario to Columbia flights
Reno to Charlotte flights
San Diego to Savannah flights
San Francisco to Columbia flights
Burbank to Charlotte flights
Los Angeles to Savannah flights
Santa Ana to Charleston flights
Las Vegas to Charleston flights
San Francisco to Myrtle Beach flights
San Francisco to Greenville flights
Ontario to Savannah flights
Fresno to Charlotte flights
Los Angeles to Greenville flights
San Jose to Savannah flights
Sacramento to Savannah flights
San Diego to Greenville flights
Sacramento to Greenville flights
Santa Ana to Savannah flights
Santa Ana to Greenville flights
Long Beach to Charlotte flights
Ontario to Myrtle Beach flights
San Jose to Myrtle Beach flights
Ontario to Greenville flights
Burbank to Greenville flights
Sacramento to Charleston flights
Santa Barbara to Greenville flights
Fresno to Columbia flights
San Jose to Charleston flights
San Jose to Greenville flights
Burbank to Savannah flights
Santa Barbara to Charlotte flights
Sacramento to Myrtle Beach flights
Palm Springs to Charlotte flights
Oakland to Charleston flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.