HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$520+ Cheap flights from Portland to Florence, SC (PDX - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — FLO
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Portland to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Portland to Florence

Cheapest flights from Portland to Florence
Explore the most affordable flight options available from Portland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1211:59 pm
PDX
-
FLO
2 stops14h 51m
American Airlines
Tue 3/176:15 am
FLO
-
PDX
2 stops13h 53m
American Airlines
Deal found 1/27$520
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:00 am
PDX
-
FLO
2 stops13h 43m
American Airlines
Sun 2/155:16 am
FLO
-
PDX
2 stops10h 46m
American Airlines
Deal found 1/27$631
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:40 pm
PDX
-
FLO
2 stops14h 41m
American Airlines
Mon 3/25:16 am
FLO
-
PDX
2 stops14h 57m
American Airlines
Deal found 1/26$698

Find flight deals from Portland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PDX) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$520
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Florence flights.
Search Deals
From Portland to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Portland to Florence that are best for you.

Fly from

Portland

Fly to

Florence

Route

Depart

Return

Price

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Thu 3/12

11:59 pm-5:50 pm

2 stops14h 51m

Florence

Tue 3/17

6:15 am-5:08 pm

2 stops13h 53m

$520

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Wed 2/11

6:00 am-10:43 pm

2 stops13h 43m

Florence

Sun 2/15

5:16 am-1:02 pm

2 stops10h 46m

$631

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Mon 2/23

11:40 pm-5:21 pm

2 stops14h 41m

Florence

Mon 3/2

5:16 am-5:13 pm

2 stops14h 57m

$698

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

  • Most accurate provider: When it comes to deals on Portland-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Florence

What is the cheapest month to book a flight from Portland to Florence, South Carolina?

Currently, April is the cheapest month in which you can book a flight from Portland to Florence, South Carolina (average of $190). Flying from Portland to Florence, South Carolina in March is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Portland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland to Florence, South Carolina?

    American Airlines can get you from Portland to Florence, South Carolina in just under 14h 51m. Your travel time can differ by up to . The distance between Portland and Florence, South Carolina is about 2371 mi.

  • Can I find deals for flights from Portland to Florence that include hotel bookings?

    Yes. In addition to deals on Portland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Florence.

  • Can I find deals for business class flights from Portland to Florence?

    Yes. Cheapflights offers flight deals from Portland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland to Florence, South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Portland to Florence, South Carolina (average of $190). Flying from Portland to Florence, South Carolina in March is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Portland to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Portland to Charlotte flights
Portland to Charleston flights
Portland to Savannah flights
Boise to Charlotte flights
Boise to Charleston flights
Portland to Myrtle Beach flights
Portland to Greenville flights
Boise to Savannah flights
Eugene to Charleston flights
Boise to Myrtle Beach flights
Portland to Columbia flights
Boise to Greenville flights
Redmond to Charlotte flights
Eugene to Charlotte flights
Eugene to Savannah flights
Portland to Augusta flights
Portland to Hilton Head Island flights
Medford to Charlotte flights
Medford to Greenville flights
Redmond to Greenville flights
Yakima to Charleston flights
Redmond to Myrtle Beach flights
Medford to Columbia flights
Eugene to Greenville flights
Redmond to Savannah flights
Eugene to Columbia flights
Yakima to Hilton Head Island flights
Pendleton to Charlotte flights
Eugene to Augusta flights
Yakima to Charlotte flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Cookie settings©2026 Cheapflights