$587+ Cheap flights from Portland, ME to Florence, SC (PWM - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Nov 17 — Nov 241
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Florence
Cheapest
Best
Last-minute
One-way
Cheapest flights from Portland to FlorenceExplore the most affordable flight options available from Portland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 18, 2026.
Explore the most affordable flight options available from Portland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 18, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:32 pm -
2 stops7h 22m
Fri 11/272:35 pm -
2 stops9h 22m
Deal found 10/13![American Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Fri 11/275:09 am -
2 stops10h 26m
Deal found 10/13![American Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:01 pm -
2 stops8h 53m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/13![American Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/13![American Airlines logo]()
$811
Best flights from Portland to FlorenceDiscover carefully curated flight deals from Portland to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 18, 2026.
Discover carefully curated flight deals from Portland to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 18, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Fri 11/275:09 am -
2 stops10h 26m
Deal found 10/13![American Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/13![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
2 stops8h 09m
Fri 11/272:35 pm -
1 stop8h 17m
Deal found 10/13![American Airlines logo]()
$881
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:01 pm -
2 stops8h 53m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/18![American Airlines logo]()
$912
Last-minute flights from Portland to FlorenceDiscover last-minute flight deals from Portland to Florence. Data last updated October 18, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Florence. Data last updated October 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:32 pm -
2 stops7h 22m
Fri 11/272:35 pm -
2 stops9h 22m
Deal found 10/13![American Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:01 pm -
2 stops8h 53m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/13![American Airlines logo]()
$755
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Fri 11/275:09 am -
2 stops10h 26m
Deal found 10/13![American Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:26 am -
2 stops8h 43m
Sat 11/285:09 am -
2 stops9h 31m
Deal found 10/13![American Airlines logo]()
$811
One-way flights from Portland to FlorenceSearch for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated October 18, 2026.
Search for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated October 18, 2026.
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/165:53 am -
2 stops9h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![American Airlines logo]()
$587
Find flight deals from Portland to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $471 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 18, 2026.
Use the filters below to find and compare flights from Portland to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Fri 4/16
5:53 am-3:50 pm
2 stops9h 57m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$587
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Sun 11/22
5:26 am-2:09 pm
2 stops8h 43m
Florence
Fri 11/27
5:09 am-3:35 pm
2 stops10h 26m
$719
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Sun 11/22
5:26 am-2:09 pm
2 stops8h 43m
Florence
Sat 11/28
5:09 am-2:40 pm
2 stops9h 31m
$811
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Sat 11/21
6:00 am-2:09 pm
2 stops8h 09m
Florence
Fri 11/27
2:35 pm-10:52 pm
1 stop8h 17m
$881
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Sat 11/21
3:01 pm-11:54 pm
2 stops8h 53m
Florence
Sat 11/28
5:09 am-2:40 pm
2 stops9h 31m
$912
Sorted by cheapest first
Compare providers for flights from Portland to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Florence in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland, Maine-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland, Maine-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.
PWM-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Portland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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