In terms of precipitation, rainfall in Florence, South Carolina ranges from 2.5 - 5.4 inches per month. July is typically the wettest month, when rainfall can reach 5.4 in. November is typically the driest time to visit Florence, South Carolina when rainfall is around 2.5 in.

If weather is an important factor for your trip to Florence, South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

What is the cheapest time of day to fly from PWM to FLO?

When flying from Portland, Maine to Florence, South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Can I find deals for flights from Portland to Florence that include hotel bookings?

Yes. In addition to deals on Portland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Portland to Florence?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Florence.

Can I find deals for business class flights from Portland to Florence?

Yes. Cheapflights offers flight deals from Portland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$358+ Cheap Flights from Portland, ME to Florence, SC

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One-way flights from Portland to Florence
Search for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Tue 9/302:02 pmPWM - FLO

2 stops9h 14mAmerican Airlines

Deal found 9/14

$358

Thu 10/26:05 pmPWM - FLO

1 stop6h 08mAmerican Airlines

Deal found 9/14

$383

Fly from

Fly to

Route

Depart

Return

Price

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Tue 9/30

2:02 pm-11:16 pm

2 stops9h 14m

$358

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 10/1

2:02 pm-11:16 pm

2 stops9h 14m

$358

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 10/2

6:05 pm-12:13 am

1 stop6h 08m

$383

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Portland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Florence

What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Florence, South Carolina (average of $366). Flying from Portland, Maine to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Can I find deals for flights from Portland to Florence that include hotel bookings?
Yes. In addition to deals on Portland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Portland to Florence?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Florence.
Can I find deals for business class flights from Portland to Florence?
Yes. Cheapflights offers flight deals from Portland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?
Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Florence, South Carolina (average of $366). Flying from Portland, Maine to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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$358+ Cheap flights from Portland, ME to Florence, SC (PWM - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Portland to Florence with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Portland to Florence

One-way flights from Portland to FlorenceSearch for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Search for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

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Use the filters below to find and compare flights from Portland to Florence that are best for you.

Best time to book a flight from Portland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Portland to Florence

What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Portland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

Can I find deals for flights from Portland to Florence that include hotel bookings?

How can I find direct flights from Portland to Florence?

Can I find deals for business class flights from Portland to Florence?

What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?

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One-way flights from Portland to Florence
Search for one-way flight options from Portland to Florence. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.