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$445+ Cheap flights from Portland, ME to Florence, SC (PWM - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
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Cheap flight deals from Portland to Florence

Cheapest flights from Portland to Florence
Explore the most affordable flight options available from Portland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:24 am
PWM
-
FLO
2 stops10h 23m
American Airlines
Wed 5/135:20 am
FLO
-
PWM
2 stops9h 49m
American Airlines
Deal found 4/22$445
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:24 am
PWM
-
FLO
2 stops12h 18m
American Airlines
Sat 5/95:20 am
FLO
-
PWM
2 stops9h 47m
American Airlines
Deal found 4/20$465
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
PWM
-
FLO
2 stops9h 50m
American Airlines
Sat 5/94:16 pm
FLO
-
PWM
2 stops17h 38m
American Airlines
Deal found 4/19$522
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:24 am
PWM
-
FLO
2 stops11h 23m
American Airlines
Tue 5/126:15 am
FLO
-
PWM
1 stop6h 23m
American Airlines
Deal found 4/23$537
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/910:50 am
PWM
-
FLO
2 stops10h 57m
American Airlines
Sun 5/174:16 pm
FLO
-
PWM
1 stop6h 30m
American Airlines
Deal found 4/23$619
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
PWM
-
FLO
2 stops9h 50m
American Airlines
Mon 5/114:16 pm
FLO
-
PWM
1 stop6h 30m
American Airlines
Deal found 4/22$634

Find flight deals from Portland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$445
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
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Provider most trusted by Cheapflights users for Portland-Florence flights.
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From Portland to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Portland to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 5/6

10:24 am-9:47 pm

2 stops11h 23m

Florence

Sat 5/9

4:16 pm-9:54 am

2 stops17h 38m

$465

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Tue 5/5

10:24 am-10:42 pm

2 stops12h 18m

Florence

Sat 5/9

5:20 am-3:07 pm

2 stops9h 47m

$465

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Fri 5/8

10:24 am-9:47 pm

2 stops11h 23m

Florence

Tue 5/12

4:02 pm-9:54 am

2 stops17h 52m

$465

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 5/9

11:24 am-9:47 pm

2 stops10h 23m

Florence

Wed 5/13

4:16 pm-10:46 pm

1 stop6h 30m

$517

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 5/9

10:50 am-9:47 pm

2 stops10h 57m

Florence

Sun 5/17

4:16 pm-10:46 pm

1 stop6h 30m

$619
Quickest round-trip

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/7

6:00 am-3:50 pm

2 stops9h 50m

Florence

Mon 5/11

4:16 pm-10:46 pm

1 stop6h 30m

$634

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/19

Sorted by cheapest first

Compare providers for flights from Portland to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Florence in April.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Portland, Maine-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland, Maine-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Portland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Portland, Maine to Florence, South Carolina in about 11h 23m. The time it takes to get you to your destination can typically vary by up to . The distance between Portland, Maine and Florence, South Carolina is about 825 mi.

  • Can I find deals for flights from Portland to Florence that include hotel bookings?

    Yes. In addition to deals on Portland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Florence.

  • Can I find deals for business class flights from Portland to Florence?

    Yes. Cheapflights offers flight deals from Portland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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