HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$513+ Cheap flights from Panama to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — FLO
mar. 15 — mar. 221
dom. 3/15
dom. 3/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Florence

Cheapest flights from Panama to Florence
Explore the most affordable flight options available from Panama to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 13, 2026.

This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/271:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
sáb. 5/302:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$513
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/231:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
vie. 5/292:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$535
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/241:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
sáb. 5/302:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$562

Find flight deals from Panama to Florence

Keep the following information in mind while searching for Panama to Florence flight deals. Data was last updated febrero 13, 2026.

Round-trip from

$513
(American Airlines)
From Panama to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 13, 2026.
Use the filters below to find and compare flights from Panama to Florence that are best for you.

Fly from

Panama

Fly to

Florence

Route

Depart

Return

Price

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

mié. 5/27

1:14 pm-2:10 pm

2 stops23h 56m

Florence

sáb. 5/30

2:35 pm-12:14 pm

2 stops22h 39m

$513

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

sáb. 5/23

1:14 pm-2:10 pm

2 stops23h 56m

Florence

vie. 5/29

2:35 pm-12:14 pm

2 stops22h 39m

$535

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

dom. 5/24

1:14 pm-2:10 pm

2 stops23h 56m

Florence

sáb. 5/30

2:35 pm-12:14 pm

2 stops22h 39m

$562

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Panama to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Florence

What is the cheapest month to book a flight from Panama to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama to Florence, South Carolina (average of $148). Flying from Panama to Florence, South Carolina in June is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Panama?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Panama to Florence.

  • How long is the flight from Panama to Florence, South Carolina?

    A quick flight from Panama to Florence, South Carolina can take about 23h 56m. American Airlines provides one of the quickest options available for as low as $513. The distance from Panama to Florence, South Carolina is about 1734 mi.

  • Can I find deals for flights from Panama to Florence that include hotel bookings?

    Yes. In addition to deals on Panama to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Florence.

  • Can I find deals for business class flights from Panama to Florence?

    Yes. Cheapflights offers flight deals from Panama to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama to Florence, South Carolina (average of $148). Flying from Panama to Florence, South Carolina in June is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.